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The map label for this gene is ddc [H]

Identifier: 154244029

GI number: 154244029

Start: 77388

End: 78812

Strand: Direct

Name: ddc [H]

Synonym: Xaut_0071

Alternate gene names: 154244029

Gene position: 77388-78812 (Clockwise)

Preceding gene: 154244027

Following gene: 154244032

Centisome position: 1.46

GC content: 69.82

Gene sequence:

>1425_bases
ATGGACGGGGAGGCGTTCCGCCACTGGGCGCACAAGGCGGCGGACTGGGCGGCGGACTATCGCGCCGGCCTGCGCGACCG
GCCGGTGCGCGCCGGCACCACGCCGGGGGAGATCGTGGCCCAGCTGCCGGCTTCCGCTCCGGAAGAGGCCGAGCCCATGG
CCGACATCTTCGCGGATTTCGAGCGTATCCTGGTGCCGGGCATGACCCATTGGCAGCATCCGCGCTTCTTCGCCTACTTC
CCGGCCAATGCCAGCCCCGCGAGCGTGATCGGCGAGTTCCTGTCCTCCGCCATGGGCGCCCAGTGCCTGCTGTGGCAGAC
CTCCCCTGCCGCCACGGAGCTGGAGATTGTCGCCCTCGACTGGCTGCGCCAGGCGGTGGGCCTGCCGGAAGGGTTTTCCG
GCGTGATCCAGGATTCGGCGTCCTCGGCGACCTTGTGCGCCTTCCTCACCATGCGCGAGCGGGCGCTGGGCTTCACCGGC
AACCGAACCGGGCTTGCGGGCCGGCCGCAGCTGCGGGTCTACACCTCCAGCGAGGTGCATACCTCCATCGACCGGGCGGC
GTGGTTCTGCGGCATCGGCGACGACAATCTGGTGCGCATCCCCACCCAGGGCCCGCTCAGGAGCATGGTGCCGCAGGCGC
TGGAGGCGGCCATTCAGGCCGACAAGGCGGCCGGGTTCGTGCCGGCGGGCGTCGTCGCCTGCGTGGGTGGCACCAGCACC
GGCGCCATGGATGACGTGGCGGCCGTGGTGGAGGTGGCGCACCGGCATGGCCTGTTCGTCCATGTGGACGCGGCCTGGGC
GGGCTCAGCCATGGTGTGCCCGGAATTCCGGTCCCTGTGGGCGGGGGTGGAACAGGCCGACTCCATCGTGCTGAACCCGC
ACAAGTGGCTCGGGGTTCAGTTCGACTGCTCCGCCCATTTCCTCAGGAGCGCCGACGACCATCTGGCGACGCTCGCCATC
CAGCCGGAATATCTGAGGACCCACGCCCATGAGGGCGGGGATACCGGCATCGTCAATTTCAGCGAATGGACCATCCAGCT
CGGCCGCCGCTTCCGCGCGCTGAAACTGTGGTTCGTGCTGCGCGCCCATGGCCTGGAAGGCCTCAGGCAGATGATCCGCA
ACCATGTGGCCTGGTCGCAGGCGCTGGCCGCGCGCATCGCCTGCGAGCCGGGCTTCTCGCTGGCCTCGACGCCTGTGCTG
TCCCTGTTCTCCTTCCGCCACGATCCCGGCGACGGCCGCGACGGCGATGCCCACATGCTGGCCCTGCTGCAGGCCATCAA
TGACGGGGGGCAGCTCTATCTCACCCCGACCCGGGTGGACGGCCGCCTCGCCATCCGCTTCCAGGCCGGGTCCATGGACG
CCACCGCGGACGACGTGGACGCCGCTTTCCACATCATCCGCGACACCGCTCACGCCTTGTCCTGA

Upstream 100 bases:

>100_bases
GATCACGAGGGTGGGCACCGGACTGCGGCGGGACGCCGGTTTTCCAGCACGGCTGAAGTCGGCTATGTCCCGGCCAAACA
TCGAAAGATAAGGATAACAC

Downstream 100 bases:

>100_bases
GGCTCTCACCCCTGCGCGGGCGTCTCCGGTGCGGCGTGCCAGCTGCGCACCGGGGCGCGGGCGCGGCCCTGGGTCGATCC
GCTGAGGCCGTAATGGACGG

Product: aromatic-L-amino-acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MDGEAFRHWAHKAADWAADYRAGLRDRPVRAGTTPGEIVAQLPASAPEEAEPMADIFADFERILVPGMTHWQHPRFFAYF
PANASPASVIGEFLSSAMGAQCLLWQTSPAATELEIVALDWLRQAVGLPEGFSGVIQDSASSATLCAFLTMRERALGFTG
NRTGLAGRPQLRVYTSSEVHTSIDRAAWFCGIGDDNLVRIPTQGPLRSMVPQALEAAIQADKAAGFVPAGVVACVGGTST
GAMDDVAAVVEVAHRHGLFVHVDAAWAGSAMVCPEFRSLWAGVEQADSIVLNPHKWLGVQFDCSAHFLRSADDHLATLAI
QPEYLRTHAHEGGDTGIVNFSEWTIQLGRRFRALKLWFVLRAHGLEGLRQMIRNHVAWSQALAARIACEPGFSLASTPVL
SLFSFRHDPGDGRDGDAHMLALLQAINDGGQLYLTPTRVDGRLAIRFQAGSMDATADDVDAAFHIIRDTAHALS

Sequences:

>Translated_474_residues
MDGEAFRHWAHKAADWAADYRAGLRDRPVRAGTTPGEIVAQLPASAPEEAEPMADIFADFERILVPGMTHWQHPRFFAYF
PANASPASVIGEFLSSAMGAQCLLWQTSPAATELEIVALDWLRQAVGLPEGFSGVIQDSASSATLCAFLTMRERALGFTG
NRTGLAGRPQLRVYTSSEVHTSIDRAAWFCGIGDDNLVRIPTQGPLRSMVPQALEAAIQADKAAGFVPAGVVACVGGTST
GAMDDVAAVVEVAHRHGLFVHVDAAWAGSAMVCPEFRSLWAGVEQADSIVLNPHKWLGVQFDCSAHFLRSADDHLATLAI
QPEYLRTHAHEGGDTGIVNFSEWTIQLGRRFRALKLWFVLRAHGLEGLRQMIRNHVAWSQALAARIACEPGFSLASTPVL
SLFSFRHDPGDGRDGDAHMLALLQAINDGGQLYLTPTRVDGRLAIRFQAGSMDATADDVDAAFHIIRDTAHALS
>Mature_474_residues
MDGEAFRHWAHKAADWAADYRAGLRDRPVRAGTTPGEIVAQLPASAPEEAEPMADIFADFERILVPGMTHWQHPRFFAYF
PANASPASVIGEFLSSAMGAQCLLWQTSPAATELEIVALDWLRQAVGLPEGFSGVIQDSASSATLCAFLTMRERALGFTG
NRTGLAGRPQLRVYTSSEVHTSIDRAAWFCGIGDDNLVRIPTQGPLRSMVPQALEAAIQADKAAGFVPAGVVACVGGTST
GAMDDVAAVVEVAHRHGLFVHVDAAWAGSAMVCPEFRSLWAGVEQADSIVLNPHKWLGVQFDCSAHFLRSADDHLATLAI
QPEYLRTHAHEGGDTGIVNFSEWTIQLGRRFRALKLWFVLRAHGLEGLRQMIRNHVAWSQALAARIACEPGFSLASTPVL
SLFSFRHDPGDGRDGDAHMLALLQAINDGGQLYLTPTRVDGRLAIRFQAGSMDATADDVDAAFHIIRDTAHALS

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=483, Percent_Identity=37.4741200828157, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI132814448, Length=483, Percent_Identity=37.4741200828157, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI92110055, Length=491, Percent_Identity=34.4195519348269, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI197383062, Length=350, Percent_Identity=29.7142857142857, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI194294551, Length=391, Percent_Identity=29.6675191815857, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI58331246, Length=352, Percent_Identity=26.7045454545455, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI197276620, Length=353, Percent_Identity=27.7620396600567, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4503875, Length=353, Percent_Identity=27.7620396600567, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17534817, Length=488, Percent_Identity=35.4508196721311, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17534819, Length=488, Percent_Identity=35.4508196721311, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI71981211, Length=523, Percent_Identity=31.5487571701721, Blast_Score=241, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI71981217, Length=533, Percent_Identity=31.3320825515947, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17551992, Length=520, Percent_Identity=28.6538461538462, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI133931025, Length=481, Percent_Identity=27.6507276507277, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17555682, Length=408, Percent_Identity=30.1470588235294, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71993058, Length=374, Percent_Identity=30.4812834224599, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71993062, Length=360, Percent_Identity=31.3888888888889, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI193205882, Length=356, Percent_Identity=21.6292134831461, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24652373, Length=484, Percent_Identity=38.4297520661157, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI28573972, Length=480, Percent_Identity=36.875, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI24586044, Length=487, Percent_Identity=35.523613963039, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24585139, Length=483, Percent_Identity=35.8178053830228, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI221476190, Length=483, Percent_Identity=35.8178053830228, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24585143, Length=483, Percent_Identity=35.8178053830228, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17136190, Length=479, Percent_Identity=35.9081419624217, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24585135, Length=479, Percent_Identity=35.2818371607516, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI17136594, Length=351, Percent_Identity=29.0598290598291, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24657193, Length=415, Percent_Identity=27.9518072289157, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24657185, Length=415, Percent_Identity=27.9518072289157, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24657188, Length=415, Percent_Identity=27.9518072289157, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21356415, Length=321, Percent_Identity=27.4143302180685, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 51221; Mature: 51221

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00123 ALKALINE_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGEAFRHWAHKAADWAADYRAGLRDRPVRAGTTPGEIVAQLPASAPEEAEPMADIFADF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHH
ERILVPGMTHWQHPRFFAYFPANASPASVIGEFLSSAMGAQCLLWQTSPAATELEIVALD
HHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHH
WLRQAVGLPEGFSGVIQDSASSATLCAFLTMRERALGFTGNRTGLAGRPQLRVYTSSEVH
HHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHH
TSIDRAAWFCGIGDDNLVRIPTQGPLRSMVPQALEAAIQADKAAGFVPAGVVACVGGTST
HHHHHHEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCC
GAMDDVAAVVEVAHRHGLFVHVDAAWAGSAMVCPEFRSLWAGVEQADSIVLNPHKWLGVQ
CCHHHHHHHHHHHHHCCEEEEEECCCCCCEEECHHHHHHHCCHHHCCCEEECCCHHEEEE
FDCSAHFLRSADDHLATLAIQPEYLRTHAHEGGDTGIVNFSEWTIQLGRRFRALKLWFVL
ECCHHHHHHCCCCCEEEEEECHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
RAHGLEGLRQMIRNHVAWSQALAARIACEPGFSLASTPVLSLFSFRHDPGDGRDGDAHML
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
ALLQAINDGGQLYLTPTRVDGRLAIRFQAGSMDATADDVDAAFHIIRDTAHALS
HHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGEAFRHWAHKAADWAADYRAGLRDRPVRAGTTPGEIVAQLPASAPEEAEPMADIFADF
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHH
ERILVPGMTHWQHPRFFAYFPANASPASVIGEFLSSAMGAQCLLWQTSPAATELEIVALD
HHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHH
WLRQAVGLPEGFSGVIQDSASSATLCAFLTMRERALGFTGNRTGLAGRPQLRVYTSSEVH
HHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHH
TSIDRAAWFCGIGDDNLVRIPTQGPLRSMVPQALEAAIQADKAAGFVPAGVVACVGGTST
HHHHHHEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCC
GAMDDVAAVVEVAHRHGLFVHVDAAWAGSAMVCPEFRSLWAGVEQADSIVLNPHKWLGVQ
CCHHHHHHHHHHHHHCCEEEEEECCCCCCEEECHHHHHHHCCHHHCCCEEECCCHHEEEE
FDCSAHFLRSADDHLATLAIQPEYLRTHAHEGGDTGIVNFSEWTIQLGRRFRALKLWFVL
ECCHHHHHHCCCCCEEEEEECHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
RAHGLEGLRQMIRNHVAWSQALAARIACEPGFSLASTPVLSLFSFRHDPGDGRDGDAHML
HHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
ALLQAINDGGQLYLTPTRVDGRLAIRFQAGSMDATADDVDAAFHIIRDTAHALS
HHHHHHCCCCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]