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The map label for this gene is ilvD [H]

Identifier: 154244028

GI number: 154244028

Start: 75294

End: 77147

Strand: Reverse

Name: ilvD [H]

Synonym: Xaut_0070

Alternate gene names: 154244028

Gene position: 77147-75294 (Counterclockwise)

Preceding gene: 154244030

Following gene: 154244026

Centisome position: 1.45

GC content: 69.26

Gene sequence:

>1854_bases
ATGCCCCAGTACCGCTCCCGCACCTCCACTCACGGTCGCAACATGGCCGGCGCCCGCGGCCTGTGGCGCGCCACCGGCAT
GAAGGACGGGGATTTCGGCAAGCCCATCATCGCCGTGGTGAACTCCTTCACCCAGTTCGTGCCCGGCCACGTGCACCTGA
AGGATCTCGGCCAGTTGGTGGCCCGCGAGATCGAGAAGGCCGGCGGCGTCGCCAAGGAATTCAACACCATCGCGGTGGAT
GACGGCATCGCCATGGGCCATGACGGCATGCTCTATTCCCTGCCGTCCCGCGAGATCATCGCCGACAGCGTGGAGTACAT
GGTCAACGCGCACTGCGCCGACGCCATGGTGTGCATCTCCAACTGCGACAAGATCACCCCCGGCATGCTGATGGCCGCCA
TGCGGCTCAACATCCCGGCGGTGTTCGTCTCCGGCGGCCCCATGGAGGCCGGCAAGGTGCTGCTCTCCACCGGCGAGAAG
AAGGTGGACCTCATCGACGCCATGATCGCGGCGGCCGACGACAAGGTCACCGACGCCGACGTGCAGGTGATGGAGCGCTC
CGCCTGCCCCACCTGCGGCTCGTGCTCCGGCATGTTCACCGCCAATTCCATGAACTGCCTCACCGAGGCGCTGGGCCTGG
CTCTGCCCGGCAATGGCTCCACGCTCGCCACCCACGCCGACCGCGAGCGGCTGTTCGTGGAGGCCGGCCACCTCATCGTC
GACCTCGCCCGCCGTTATTACGAGCAGGACGATGCCAGCGTCCTGCCGCGCTCCGTGGCCTCGTTCAAGGCGTTCGAGAA
CGCCATGACCCTGGACATCTCCATGGGCGGCTCCACCAACACGGTGCTGCACCTGCTCGCCGCCGCCAACGAGGGCGAGG
TGCCCTTCACCATGGCCGACATCGACCGGCTGTCGCGCCGGGTGCCGGTGCTGTGCAAGGTGGCGCCCGCGGTGGCCAAC
ATCCACATGGAGGACGTGCACCGCGCCGGCGGCATCATGGCCATCCTCGGCGAGCTGGATCGCGGCGGCCTCATCCATAC
CGACCTGCCCACCGTGCACGCCGCTACCATGGCCGACGCGCTGGACCGCTGGGACGTGAAGCGCACCAAGAGCGAGAGCG
TCGCCACCTTCTTCCGCGCCGCGCCGGGCGGGGTGCCCACACAGGTGGCGTTCAGCCAGTCCCGCCGCTGGGACGACCTC
GATCTCGACCGCGAGACCGGCGTCATCCGCGACGTGGCCCATGCCTATTCCAAGGACGGCGGCCTCGCCGTGCTGTACGG
CAACATCGCGCTGGACGGCTGCATCGTGAAGACGGCGGGCGTGGACGCATCGATCCTGAAGTTCACCGGCAAGGCGCGCA
TCTTCGAGAGCCAGGACGCGGCGGTGGAAGCCATCCTCTCCACCGGGCGCATCCAGGCGGGCGACGTGGTGCTGATCCGC
TACGAGGGTCCGCGCGGCGGGCCGGGCATGCAGGAGATGCTCTATCCCACGTCCTACCTGAAGTCGAAGGGCCTCGGGAA
GGCGTGCGCGCTGGTCACCGACGGGCGCTTCTCGGGCGGCTCCTCGGGCCTGTCCATCGGCCATGTCTCGCCGGAAGCGG
CGGAGGGCGGGGCCATCGGGCTGGTGGAGGAAGGCGACACCATCGAGATCGACATCCCGAACCGCATCATCCGCGTGGCG
GTGTCCGACGAGGTGCTCAGCCAGCGCCGCGCCGCCATGGAGGCGAAGGGCGACGCCGCGTGGAAGCCCGCGGACCGCAA
GCGCGTGGTCTCCCAGGCGCTGCAGGCCTATGCAGCGCTCACCACCTCCGCCGCCCGCGGTGCGGTGCGCGACGTGAGCC
GCCTGCGGCGCTGA

Upstream 100 bases:

>100_bases
GCCTTTCACGCAGGCCCACATGGTTCTAAGACGGCCGGCAGCATTGCGCGCCGGGCCGAGAGCCATCGCGCACCACAACA
CATAAGAGGCAAGAGAGGAC

Downstream 100 bases:

>100_bases
TCAAGACTGGATCCGGCAAAAGGAAAGGGGCGCCGCGGCGCCCCTTTTTGTTTGGTACAGGTGGTTCGGATCAGCGTGTG
CCGATCAACGGGTGCAGGTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MPQYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEK
KVDLIDAMIAAADDKVTDADVQVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHADRERLFVEAGHLIV
DLARRYYEQDDASVLPRSVASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMADIDRLSRRVPVLCKVAPAVAN
IHMEDVHRAGGIMAILGELDRGGLIHTDLPTVHAATMADALDRWDVKRTKSESVATFFRAAPGGVPTQVAFSQSRRWDDL
DLDRETGVIRDVAHAYSKDGGLAVLYGNIALDGCIVKTAGVDASILKFTGKARIFESQDAAVEAILSTGRIQAGDVVLIR
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDTIEIDIPNRIIRVA
VSDEVLSQRRAAMEAKGDAAWKPADRKRVVSQALQAYAALTTSAARGAVRDVSRLRR

Sequences:

>Translated_617_residues
MPQYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEK
KVDLIDAMIAAADDKVTDADVQVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHADRERLFVEAGHLIV
DLARRYYEQDDASVLPRSVASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMADIDRLSRRVPVLCKVAPAVAN
IHMEDVHRAGGIMAILGELDRGGLIHTDLPTVHAATMADALDRWDVKRTKSESVATFFRAAPGGVPTQVAFSQSRRWDDL
DLDRETGVIRDVAHAYSKDGGLAVLYGNIALDGCIVKTAGVDASILKFTGKARIFESQDAAVEAILSTGRIQAGDVVLIR
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDTIEIDIPNRIIRVA
VSDEVLSQRRAAMEAKGDAAWKPADRKRVVSQALQAYAALTTSAARGAVRDVSRLRR
>Mature_616_residues
PQYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEKK
VDLIDAMIAAADDKVTDADVQVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHADRERLFVEAGHLIVD
LARRYYEQDDASVLPRSVASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMADIDRLSRRVPVLCKVAPAVANI
HMEDVHRAGGIMAILGELDRGGLIHTDLPTVHAATMADALDRWDVKRTKSESVATFFRAAPGGVPTQVAFSQSRRWDDLD
LDRETGVIRDVAHAYSKDGGLAVLYGNIALDGCIVKTAGVDASILKFTGKARIFESQDAAVEAILSTGRIQAGDVVLIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDTIEIDIPNRIIRVAV
SDEVLSQRRAAMEAKGDAAWKPADRKRVVSQALQAYAALTTSAARGAVRDVSRLRR

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=73.1707317073171, Blast_Score=935, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=576, Percent_Identity=31.5972222222222, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1786464, Length=544, Percent_Identity=31.9852941176471, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1788157, Length=522, Percent_Identity=28.3524904214559, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=36.4532019704434, Blast_Score=348, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65563; Mature: 65431

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEKKVDLIDAMIAAADDKVTDAD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHH
VQVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHADRERLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDASVLPRSVASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHEECCCCCCCCEEHHH
IDRLSRRVPVLCKVAPAVANIHMEDVHRAGGIMAILGELDRGGLIHTDLPTVHAATMADA
HHHHHCCCCEEEEECHHHHHCCHHHHHHCCCCEEEEECCCCCCEEECCCCCHHHHHHHHH
LDRWDVKRTKSESVATFFRAAPGGVPTQVAFSQSRRWDDLDLDRETGVIRDVAHAYSKDG
HHHHCCHHCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCC
GLAVLYGNIALDGCIVKTAGVDASILKFTGKARIFESQDAAVEAILSTGRIQAGDVVLIR
CEEEEECCEEECCEEEEECCCCHHHHEECCCEEEECCCHHHHHHHHHCCCEEECCEEEEE
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCEEE
LVEEGDTIEIDIPNRIIRVAVSDEVLSQRRAAMEAKGDAAWKPADRKRVVSQALQAYAAL
EEECCCEEEEECCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TTSAARGAVRDVSRLRR
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEKKVDLIDAMIAAADDKVTDAD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHH
VQVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHADRERLFVEAGHLIV
HHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDASVLPRSVASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMAD
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHEECCCCCCCCEEHHH
IDRLSRRVPVLCKVAPAVANIHMEDVHRAGGIMAILGELDRGGLIHTDLPTVHAATMADA
HHHHHCCCCEEEEECHHHHHCCHHHHHHCCCCEEEEECCCCCCEEECCCCCHHHHHHHHH
LDRWDVKRTKSESVATFFRAAPGGVPTQVAFSQSRRWDDLDLDRETGVIRDVAHAYSKDG
HHHHCCHHCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCC
GLAVLYGNIALDGCIVKTAGVDASILKFTGKARIFESQDAAVEAILSTGRIQAGDVVLIR
CEEEEECCEEECCEEEEECCCCHHHHEECCCEEEECCCHHHHHHHHHCCCEEECCEEEEE
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCEEE
LVEEGDTIEIDIPNRIIRVAVSDEVLSQRRAAMEAKGDAAWKPADRKRVVSQALQAYAAL
EEECCCEEEEECCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TTSAARGAVRDVSRLRR
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA