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The map label for this gene is gldA [H]

Identifier: 154243969

GI number: 154243969

Start: 11359

End: 12504

Strand: Reverse

Name: gldA [H]

Synonym: Xaut_0011

Alternate gene names: 154243969

Gene position: 12504-11359 (Counterclockwise)

Preceding gene: 154243971

Following gene: 154243968

Centisome position: 0.24

GC content: 70.94

Gene sequence:

>1146_bases
ATGAAGGTGTTCGGCGCGCCGCGGCGCTATGTGCAGGGCAAGGGGGCGCTGGATCATCTGGGTCCCGAGCTGGCGCGCCT
CACCGACGCCGCTGCGCTGGTCATAGACCCCTTCATCGACGATCTGTTCGGCGCCCGCCTTCAGGCCTCGTGCAACGCGG
CGGGGGTGAGCCTTGCCCGCCTGCGCTTCGGCGGGGAAAGCTCACCCGCGGAGATCGACCGCCTGCTTGCAGCGCTGGGC
GACACCCCGCCCCCGCTGGTCGCGGCGGCGGGCGGCGGCAAGTGCATCGACGCGGGCAAGGCGCTCGCCAACCGCATCGG
CGCGAAGGTGGCGACCATCCCCACCATTGCCTCCACCGACGCGCCCACCAGCCACAATTACGTGCTCTATGACGACGACC
ACCGCCTGCTCGCGGTGGAGAAGCTGCCGGCCAATCCGGACCTGGTGCTGGTGGATACCCAGGTGATCGCCGAGGCGCCG
CGCCTTCTGTTCCTCGCCGGCATCGGCGATGCGGTGGTGAAGCTGTTCGAGGTGGAGCGCTGCGTGGCGGCGAAGGGCCG
CAACGTGTTCGGCGCCGATCCCGCCTTCTCCGCCCTGATCCTCGCCCGCGGCTGCTACGACGTGCTGCGCCGCCACGCCC
CGGCGGCGCTCGCCGCCGTGGACCGCAAGGCGGCCGACGACGCCCTTGACCTGGTGGTGGAAGCAACCGTGCTCATGAGC
GGCCTCAGCTTCGAGAGCGGCGGCCTGTCCATCGCCCATTCCATGACGCGGGGCCTCTCCGCCGTGCCGAAATATGCCCG
CGCGCTGCACGGGCTGGAGGTCGCCTACGGCGTGCTGGTGCAATTGGTGCTGGAGGGCCGTGACGCGGACTTCTTCGACG
ATCTCCTCGGCTTCTACGCCGCCATCGGCCTGCCCACGAGTCTTGTCGCCCTCGCCGGTGCGGCCCCCACGCCCGAGGAA
GCGGCCACCATCGCCCGCCTCACCCTCTCGGCGCCCCACGCCCGGCATTTCCCCCGGGTGCTGGAAGAGGCGGAGGTGGT
GCGCGCCATCCTCGCCATCGAGGAGGGGCGGTTCGCGGACGCGCTTGTGGAGGATGCAATGCAGGGGAGCAAATCCCCCA
GCACCGCACCCGGGCTGGCCGTGTGA

Upstream 100 bases:

>100_bases
AGATGCTTGATCTCTGATCATCATACACGATATATCATGTTCGGAACGACGCCCACGGGCGCGCCCCGCCAGACGCAGGA
CAGGAATTCGGAGGGTCCAG

Downstream 100 bases:

>100_bases
TATAGGGTGTATCCGGGTCCTTTCAGAAGCGTGGATGCCATGGCCGAGTTGCGGCAGATCGAGAAGGAAAATCTATCGGC
CCGCGTCTACGGCCGCATCC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: GDH; GLDH [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKVFGAPRRYVQGKGALDHLGPELARLTDAAALVIDPFIDDLFGARLQASCNAAGVSLARLRFGGESSPAEIDRLLAALG
DTPPPLVAAAGGGKCIDAGKALANRIGAKVATIPTIASTDAPTSHNYVLYDDDHRLLAVEKLPANPDLVLVDTQVIAEAP
RLLFLAGIGDAVVKLFEVERCVAAKGRNVFGADPAFSALILARGCYDVLRRHAPAALAAVDRKAADDALDLVVEATVLMS
GLSFESGGLSIAHSMTRGLSAVPKYARALHGLEVAYGVLVQLVLEGRDADFFDDLLGFYAAIGLPTSLVALAGAAPTPEE
AATIARLTLSAPHARHFPRVLEEAEVVRAILAIEEGRFADALVEDAMQGSKSPSTAPGLAV

Sequences:

>Translated_381_residues
MKVFGAPRRYVQGKGALDHLGPELARLTDAAALVIDPFIDDLFGARLQASCNAAGVSLARLRFGGESSPAEIDRLLAALG
DTPPPLVAAAGGGKCIDAGKALANRIGAKVATIPTIASTDAPTSHNYVLYDDDHRLLAVEKLPANPDLVLVDTQVIAEAP
RLLFLAGIGDAVVKLFEVERCVAAKGRNVFGADPAFSALILARGCYDVLRRHAPAALAAVDRKAADDALDLVVEATVLMS
GLSFESGGLSIAHSMTRGLSAVPKYARALHGLEVAYGVLVQLVLEGRDADFFDDLLGFYAAIGLPTSLVALAGAAPTPEE
AATIARLTLSAPHARHFPRVLEEAEVVRAILAIEEGRFADALVEDAMQGSKSPSTAPGLAV
>Mature_381_residues
MKVFGAPRRYVQGKGALDHLGPELARLTDAAALVIDPFIDDLFGARLQASCNAAGVSLARLRFGGESSPAEIDRLLAALG
DTPPPLVAAAGGGKCIDAGKALANRIGAKVATIPTIASTDAPTSHNYVLYDDDHRLLAVEKLPANPDLVLVDTQVIAEAP
RLLFLAGIGDAVVKLFEVERCVAAKGRNVFGADPAFSALILARGCYDVLRRHAPAALAAVDRKAADDALDLVVEATVLMS
GLSFESGGLSIAHSMTRGLSAVPKYARALHGLEVAYGVLVQLVLEGRDADFFDDLLGFYAAIGLPTSLVALAGAAPTPEE
AATIARLTLSAPHARHFPRVLEEAEVVRAILAIEEGRFADALVEDAMQGSKSPSTAPGLAV

Specific function: Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions [H]

COG id: COG0371

COG function: function code C; Glycerol dehydrogenase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87082352, Length=310, Percent_Identity=37.4193548387097, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1786815, Length=372, Percent_Identity=28.494623655914, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016205 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.6 [H]

Molecular weight: Translated: 39634; Mature: 39634

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFGAPRRYVQGKGALDHLGPELARLTDAAALVIDPFIDDLFGARLQASCNAAGVSLAR
CCCCCCCHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LRFGGESSPAEIDRLLAALGDTPPPLVAAAGGGKCIDAGKALANRIGAKVATIPTIASTD
EECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCC
APTSHNYVLYDDDHRLLAVEKLPANPDLVLVDTQVIAEAPRLLFLAGIGDAVVKLFEVER
CCCCCCEEEECCCCCEEEEEECCCCCCEEEEEHHHHHHCCCEEEEECHHHHHHHHHHHHH
CVAAKGRNVFGADPAFSALILARGCYDVLRRHAPAALAAVDRKAADDALDLVVEATVLMS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSFESGGLSIAHSMTRGLSAVPKYARALHGLEVAYGVLVQLVLEGRDADFFDDLLGFYA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AIGLPTSLVALAGAAPTPEEAATIARLTLSAPHARHFPRVLEEAEVVRAILAIEEGRFAD
HHCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALVEDAMQGSKSPSTAPGLAV
HHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVFGAPRRYVQGKGALDHLGPELARLTDAAALVIDPFIDDLFGARLQASCNAAGVSLAR
CCCCCCCHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LRFGGESSPAEIDRLLAALGDTPPPLVAAAGGGKCIDAGKALANRIGAKVATIPTIASTD
EECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCC
APTSHNYVLYDDDHRLLAVEKLPANPDLVLVDTQVIAEAPRLLFLAGIGDAVVKLFEVER
CCCCCCEEEECCCCCEEEEEECCCCCCEEEEEHHHHHHCCCEEEEECHHHHHHHHHHHHH
CVAAKGRNVFGADPAFSALILARGCYDVLRRHAPAALAAVDRKAADDALDLVVEATVLMS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLSFESGGLSIAHSMTRGLSAVPKYARALHGLEVAYGVLVQLVLEGRDADFFDDLLGFYA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AIGLPTSLVALAGAAPTPEEAATIARLTLSAPHARHFPRVLEEAEVVRAILAIEEGRFAD
HHCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALVEDAMQGSKSPSTAPGLAV
HHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571; 12193646 [H]