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The map label for this gene is penA [H]

Identifier: 153952665

GI number: 153952665

Start: 1246793

End: 1248601

Strand: Direct

Name: penA [H]

Synonym: JJD26997_1406

Alternate gene names: 153952665

Gene position: 1246793-1248601 (Clockwise)

Preceding gene: 153951288

Following gene: 153951100

Centisome position: 67.57

GC content: 31.01

Gene sequence:

>1809_bases
ATGCGAGAATATAAAAAAAATAGGGTTTCAAAAGTTGCCTTTGCCTACTGTATAGCACTTTTGTTTATGATTATTTTTAT
CAGCTCTACTTTTTTTCTTACATCAAAACGTCATATACCTAACACTGAAAAAGATCAATACGATCTTGCTCTAAGAGGAT
CGATTATAACCAAAGATAATTTTACTATCACAAGTTCTAAACAAATTTATCGTGCTGAAATTGATCTTAGAAGCATTAAC
AAAGATAAATTTGATCTATTTTTAAAGCTTTTTCAAATTTATAGCGGGATAAGCAACGATCAAGTAGCAGATATTAAAAA
AAGAATGCAAAATCAAAAAAAACGCTCTTATAATTTTGTTCTTTTGCAAAACTTAGATTCCAAGCAAGCAAGCTATCTTA
AAGACCTTGCTAAAAAACTTTATATACAAGGTTTTTTCAAAGCTTTTACAAATAACTCTGGAAGAGTTGAAACAAGAGGA
TTAAATATCATCGAACATGAAGAAGATAGAATTTACATGTCAAAAGATTCTTTTACTCCTATTATCGGTTATACCAAAAT
GATATTAGATCCAGAAAGTGGAATTTTAAAAAATATAGGAGTTAAAGGTTTAGAAAAATACTACAATGAATGTCTAAGTC
CTGTTCAAAATGAAAAAATTCAAGGACTTAAAGATATAGGTGGAAATATTATTTTAAATCTAAATTCACTACAGCAAAAA
AAGATCAATGGTTGTGATTTATATCTAAATCTTTCTTTAAAACTGCAAAAAAGTATAGAGAAAGCTATAGATCAAAGAAA
TGAGGATTTAAAAGCCAATGAAATCATCGTTGGTGTAATGGAAAGCAAAACAGGAAGAATTTTAGCTTTAGCAAGCTCAA
GGCGTTATGACCCGCAAAATCGCGGAAAGGATCTATCGGTTCTTAATGCAAGTGCTATAGAATACGGCTATGAAGCAGGT
TCTGTTATCAAGCCTTTTATCTTTACAACAGCCTTAAGACTTGGTAAAATAAAAATGGATGAAGTGATTAATACTTATGG
CGGTTCTTATAAGCTAGGACGTTTTACCATCAAAGACGATCACAAAATGAACAAAATGACCATGGAAGAAGTTATAAGAT
ATTCTTCAAATATAGGCATGATACAAATTGCCAAAAGACTTAACAACATAGAAATCATATCAGGACTTAAAATATTTAAA
TTTGGCGAAAAGAGTGGTATTGATCTACCTTATGAACAAAAAGGAGAAATTCCAAATCCTAAACGCTTAAGGGATATAGA
AAAATCTGTTTTAAGTTATGGTTATGGACTTAAAACAACCTTTATACAACTCCTTGCAGCTTATAATGTTTTCAATAATG
ATGGATTTTATATCACACCCCGTTTAGCTGAAAAATTCTATCAAAATGGACGCTTTACAAATCTTGATGATGATGTAAAA
AAAGAAAAAATTCTTTCCAGCGAAGCCGCTAAAGCGATGCAAAATGTTCTTATAAATGTTATAGAAAAAGGAACAGGAAA
AAAGGCAATTACACAAGGTGTTATTGCAGGAGGTAAAACAGGAACAGCAAGAATAGCCGAAAGACAAGGTTATACCTCCA
ATCGCTACAATGCTTCCTTTTTTGGTTTTGCAAATGATTTAAATCACGCCTATACCATAGGAGTTCTCGTAAGACATCCT
ACTAAACCTTATAGTTATTATGCTGCGCAAAGTGCTTTGCCTATGTTCAAAGATGTTGTTGATATTTTAATCAATGAAGA
ATTTCTAACGCCTATACAAGACAATAACCAAACTAGTACAAACAACTAG

Upstream 100 bases:

>100_bases
TATCACTAAAGCTGAAAGTAGCATGAAATTTATGCTAGAAGTAAGAAATAAAGCAATCAGTGCTTATAAAGAAATCATAA
GAACTCAAATTTAAACCCTA

Downstream 100 bases:

>100_bases
TTTGATATATCTTTAGAAAATATCACCTCAACAGCACTTATAAGTTCTTCGGCAATCTTAGCAGCAAAAGTTGTATCATT
AAGTATTGAAATTTCTTCAG

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MREYKKNRVSKVAFAYCIALLFMIIFISSTFFLTSKRHIPNTEKDQYDLALRGSIITKDNFTITSSKQIYRAEIDLRSIN
KDKFDLFLKLFQIYSGISNDQVADIKKRMQNQKKRSYNFVLLQNLDSKQASYLKDLAKKLYIQGFFKAFTNNSGRVETRG
LNIIEHEEDRIYMSKDSFTPIIGYTKMILDPESGILKNIGVKGLEKYYNECLSPVQNEKIQGLKDIGGNIILNLNSLQQK
KINGCDLYLNLSLKLQKSIEKAIDQRNEDLKANEIIVGVMESKTGRILALASSRRYDPQNRGKDLSVLNASAIEYGYEAG
SVIKPFIFTTALRLGKIKMDEVINTYGGSYKLGRFTIKDDHKMNKMTMEEVIRYSSNIGMIQIAKRLNNIEIISGLKIFK
FGEKSGIDLPYEQKGEIPNPKRLRDIEKSVLSYGYGLKTTFIQLLAAYNVFNNDGFYITPRLAEKFYQNGRFTNLDDDVK
KEKILSSEAAKAMQNVLINVIEKGTGKKAITQGVIAGGKTGTARIAERQGYTSNRYNASFFGFANDLNHAYTIGVLVRHP
TKPYSYYAAQSALPMFKDVVDILINEEFLTPIQDNNQTSTNN

Sequences:

>Translated_602_residues
MREYKKNRVSKVAFAYCIALLFMIIFISSTFFLTSKRHIPNTEKDQYDLALRGSIITKDNFTITSSKQIYRAEIDLRSIN
KDKFDLFLKLFQIYSGISNDQVADIKKRMQNQKKRSYNFVLLQNLDSKQASYLKDLAKKLYIQGFFKAFTNNSGRVETRG
LNIIEHEEDRIYMSKDSFTPIIGYTKMILDPESGILKNIGVKGLEKYYNECLSPVQNEKIQGLKDIGGNIILNLNSLQQK
KINGCDLYLNLSLKLQKSIEKAIDQRNEDLKANEIIVGVMESKTGRILALASSRRYDPQNRGKDLSVLNASAIEYGYEAG
SVIKPFIFTTALRLGKIKMDEVINTYGGSYKLGRFTIKDDHKMNKMTMEEVIRYSSNIGMIQIAKRLNNIEIISGLKIFK
FGEKSGIDLPYEQKGEIPNPKRLRDIEKSVLSYGYGLKTTFIQLLAAYNVFNNDGFYITPRLAEKFYQNGRFTNLDDDVK
KEKILSSEAAKAMQNVLINVIEKGTGKKAITQGVIAGGKTGTARIAERQGYTSNRYNASFFGFANDLNHAYTIGVLVRHP
TKPYSYYAAQSALPMFKDVVDILINEEFLTPIQDNNQTSTNN
>Mature_602_residues
MREYKKNRVSKVAFAYCIALLFMIIFISSTFFLTSKRHIPNTEKDQYDLALRGSIITKDNFTITSSKQIYRAEIDLRSIN
KDKFDLFLKLFQIYSGISNDQVADIKKRMQNQKKRSYNFVLLQNLDSKQASYLKDLAKKLYIQGFFKAFTNNSGRVETRG
LNIIEHEEDRIYMSKDSFTPIIGYTKMILDPESGILKNIGVKGLEKYYNECLSPVQNEKIQGLKDIGGNIILNLNSLQQK
KINGCDLYLNLSLKLQKSIEKAIDQRNEDLKANEIIVGVMESKTGRILALASSRRYDPQNRGKDLSVLNASAIEYGYEAG
SVIKPFIFTTALRLGKIKMDEVINTYGGSYKLGRFTIKDDHKMNKMTMEEVIRYSSNIGMIQIAKRLNNIEIISGLKIFK
FGEKSGIDLPYEQKGEIPNPKRLRDIEKSVLSYGYGLKTTFIQLLAAYNVFNNDGFYITPRLAEKFYQNGRFTNLDDDVK
KEKILSSEAAKAMQNVLINVIEKGTGKKAITQGVIAGGKTGTARIAERQGYTSNRYNASFFGFANDLNHAYTIGVLVRHP
TKPYSYYAAQSALPMFKDVVDILINEEFLTPIQDNNQTSTNN

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=419, Percent_Identity=25.5369928400955, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786854, Length=470, Percent_Identity=24.2553191489362, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 68459; Mature: 68459

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREYKKNRVSKVAFAYCIALLFMIIFISSTFFLTSKRHIPNTEKDQYDLALRGSIITKDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCEEEEEECCEEECCC
FTITSSKQIYRAEIDLRSINKDKFDLFLKLFQIYSGISNDQVADIKKRMQNQKKRSYNFV
EEEECCCCEEEEECCHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEE
LLQNLDSKQASYLKDLAKKLYIQGFFKAFTNNSGRVETRGLNIIEHEEDRIYMSKDSFTP
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCEEEEECCCCCC
IIGYTKMILDPESGILKNIGVKGLEKYYNECLSPVQNEKIQGLKDIGGNIILNLNSLQQK
HHCCEEEEECCCCCHHHHCCHHHHHHHHHHHHCHHHHHHHCCHHHCCCEEEEEECHHHHH
KINGCDLYLNLSLKLQKSIEKAIDQRNEDLKANEIIVGVMESKTGRILALASSRRYDPQN
CCCCEEEEEEEEHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCC
RGKDLSVLNASAIEYGYEAGSVIKPFIFTTALRLGKIKMDEVINTYGGSYKLGRFTIKDD
CCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCC
HKMNKMTMEEVIRYSSNIGMIQIAKRLNNIEIISGLKIFKFGEKSGIDLPYEQKGEIPNP
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCH
KRLRDIEKSVLSYGYGLKTTFIQLLAAYNVFNNDGFYITPRLAEKFYQNGRFTNLDDDVK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCHHHH
KEKILSSEAAKAMQNVLINVIEKGTGKKAITQGVIAGGKTGTARIAERQGYTSNRYNASF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCEE
FGFANDLNHAYTIGVLVRHPTKPYSYYAAQSALPMFKDVVDILINEEFLTPIQDNNQTST
EEECCCCCCEEEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHCHHHCCCCCCCCCCCC
NN
CC
>Mature Secondary Structure
MREYKKNRVSKVAFAYCIALLFMIIFISSTFFLTSKRHIPNTEKDQYDLALRGSIITKDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCEEEEEECCEEECCC
FTITSSKQIYRAEIDLRSINKDKFDLFLKLFQIYSGISNDQVADIKKRMQNQKKRSYNFV
EEEECCCCEEEEECCHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEE
LLQNLDSKQASYLKDLAKKLYIQGFFKAFTNNSGRVETRGLNIIEHEEDRIYMSKDSFTP
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCEEEEECCCCCC
IIGYTKMILDPESGILKNIGVKGLEKYYNECLSPVQNEKIQGLKDIGGNIILNLNSLQQK
HHCCEEEEECCCCCHHHHCCHHHHHHHHHHHHCHHHHHHHCCHHHCCCEEEEEECHHHHH
KINGCDLYLNLSLKLQKSIEKAIDQRNEDLKANEIIVGVMESKTGRILALASSRRYDPQN
CCCCEEEEEEEEHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCC
RGKDLSVLNASAIEYGYEAGSVIKPFIFTTALRLGKIKMDEVINTYGGSYKLGRFTIKDD
CCCCEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCC
HKMNKMTMEEVIRYSSNIGMIQIAKRLNNIEIISGLKIFKFGEKSGIDLPYEQKGEIPNP
CCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCH
KRLRDIEKSVLSYGYGLKTTFIQLLAAYNVFNNDGFYITPRLAEKFYQNGRFTNLDDDVK
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCCCCHHHH
KEKILSSEAAKAMQNVLINVIEKGTGKKAITQGVIAGGKTGTARIAERQGYTSNRYNASF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCEE
FGFANDLNHAYTIGVLVRHPTKPYSYYAAQSALPMFKDVVDILINEEFLTPIQDNNQTST
EEECCCCCCEEEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHCHHHCCCCCCCCCCCC
NN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]