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The map label for this gene is guaB [H]

Identifier: 153952446

GI number: 153952446

Start: 603243

End: 604700

Strand: Direct

Name: guaB [H]

Synonym: JJD26997_0664

Alternate gene names: 153952446

Gene position: 603243-604700 (Clockwise)

Preceding gene: 153951202

Following gene: 153951448

Centisome position: 32.69

GC content: 38.13

Gene sequence:

>1458_bases
ATGAAAATTGTAAAAAGAGCTTTAACTTTTGAAGATGTATTATTACGTCCTGGGTATTCTGAAGTTCTACCTAAGGAAGT
AAAAATTCACACTAAGCTGACAAAAAATATCACTTTAAATATGCCTTTAATCTCTGCGGCTATGGATACAGTAACTGAAC
ATAGAGCTGCTATCATGATGGCAAGACTTGGAGGGCTTGGGGTGATTCATAAAAATATGGATATAGCCTCACAGGTTAGG
GAAGTAAAAAGAGTAAAAAAAAGCGAAAGTGGGGTGATTATCGATCCTATTTTTGTAAGTCCTAAAGCAAGTGTTGCAGA
GGCTTTAGAAATCATGGCAGAGTATAGAATTTCAGGTGTTCCTGTAGTAGATGAAGATAAGAAACTAATAGGCATACTTA
CCAATCGTGATTTAAGATTTGAGAGTGATTTTTCAAATTTGGTTGAAAATGTTATGACTAAAATGCCTTTAATCACTGCT
CCAAAAGGTTGCACTTTAGATGATGCGGAAAAAATTTTTAGCACCAACAAAGTAGAAAAACTTCCTATAGTAGATGAGCA
AGGACGCTTAGAAGGACTTATTACTATAAAAGATCTTAAAAAACGCAAAGAATATCCTGATGCCAATAAAGATAATTTTG
GAAGATTGCGTGTGGGTGCGGCTATAGGAGTAGGGCAAATGGATCGTGTGGATGCTTTAGTTGAAGCGGGCGTTGATGTT
ATTGTGCTTGATTCTGCACACGGACATTCTAAGGGTATTATTGATACAGTAAAAGCAATTAAAACTAAATATCCAAATTT
AGATCTTATAGCAGGAAATATCGCTACTGCAGCCGCAGCAAAAGCACTTTGTGAAGCAGGGGTAGATGCGGTTAAAGTAG
GTATTGGACCAGGAAGTATTTGTACTACACGTATTGTTTCAGGTATGGGTGTGCCTCAAATTTCGGCCATTGATGAATGT
GTGGAAGAAGCAAATAAATTTGGCGTTCCTGTGATAGCTGATGGCGGGATCAAATATTCAGGCGATATTGCAAAAGCTTT
AGCTGTAGGTGCGAGTTCTGTTATGATAGGATCGCTTTTAGCTGGAACAGATGAAAGTCCAGGAGAGCTTTTTACTTATC
AAGGAAGACAATATAAGTCTTATCGTGGTATGGGTTCGCTTGGGGCTATGCAAAAGGGAAGCTCAGATAGATATTTTCAG
CAAGGTACTGCTCAAGATAAACTTGTTCCTGAAGGTATAGAAGGGCGTGTTCCTTATGTGGGAAGTATAAGAAGCGTGGT
GCATCAACTTTTAGGAGGTTTGCGTTCTTCTATGGGTTATGTTGGGGCTAAAGATATAGAGGATTTTCAAAAAAGAGCCG
AATTTGTTGAAATCACTACTGCAGGGCTTAAAGAAAGCCATGTGCATGATGTTACTATCACTCATGAAGCACCAAATTAC
AAGGTCAATCATCAATGA

Upstream 100 bases:

>100_bases
TAATATATCAGCACAACTGATTTGCAAAGCTTATGATGAACAAACCTTGCTAGACGGGGCTTTAAGTTTAGAACAAATGA
TTAAAAATTAAGGATGAAAG

Downstream 100 bases:

>100_bases
GTTTTGAAGAAAATTTAAAACATGCTAATGAATCTTTGGAAAAATTAAACAATCAAGAACTTGCTTTAGATGAAAGTGTA
AAAATTTACAAAGAAGGTTT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMMARLGGLGVIHKNMDIASQVR
EVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITA
PKGCTLDDAEKIFSTNKVEKLPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
IVLDSAHGHSKGIIDTVKAIKTKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGMGVPQISAIDEC
VEEANKFGVPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQ
QGTAQDKLVPEGIEGRVPYVGSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
KVNHQ

Sequences:

>Translated_485_residues
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMMARLGGLGVIHKNMDIASQVR
EVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITA
PKGCTLDDAEKIFSTNKVEKLPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
IVLDSAHGHSKGIIDTVKAIKTKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGMGVPQISAIDEC
VEEANKFGVPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQ
QGTAQDKLVPEGIEGRVPYVGSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
KVNHQ
>Mature_485_residues
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMMARLGGLGVIHKNMDIASQVR
EVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGVPVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITA
PKGCTLDDAEKIFSTNKVEKLPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
IVLDSAHGHSKGIIDTVKAIKTKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSICTTRIVSGMGVPQISAIDEC
VEEANKFGVPVIADGGIKYSGDIAKALAVGASSVMIGSLLAGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQ
QGTAQDKLVPEGIEGRVPYVGSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
KVNHQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=45.8333333333333, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI217035146, Length=450, Percent_Identity=46.4444444444444, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI156616279, Length=450, Percent_Identity=46.4444444444444, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI34328928, Length=450, Percent_Identity=46.4444444444444, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI34328930, Length=450, Percent_Identity=46.4444444444444, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI217035152, Length=457, Percent_Identity=45.9518599562363, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI217035148, Length=450, Percent_Identity=45.7777777777778, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI217035150, Length=450, Percent_Identity=43.7777777777778, Blast_Score=335, Evalue=7e-92,
Organism=Homo sapiens, GI50541956, Length=371, Percent_Identity=31.8059299191375, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI50541954, Length=263, Percent_Identity=36.5019011406844, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI50541952, Length=263, Percent_Identity=36.5019011406844, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI50541948, Length=263, Percent_Identity=36.5019011406844, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI156104880, Length=376, Percent_Identity=31.6489361702128, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788855, Length=485, Percent_Identity=56.9072164948454, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=35.7466063348416, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=35.6, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=38.0614657210402, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=273, Percent_Identity=35.1648351648352, Blast_Score=182, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=485, Percent_Identity=42.0618556701031, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=43.6590436590437, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=42.2037422037422, Blast_Score=349, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6319352, Length=341, Percent_Identity=42.8152492668622, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6319353, Length=129, Percent_Identity=41.0852713178295, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641071, Length=479, Percent_Identity=43.2150313152401, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24641073, Length=479, Percent_Identity=43.2150313152401, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=43.2801822323462, Blast_Score=311, Evalue=5e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52228; Mature: 52228

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMM
CCHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHH
ARLGGLGVIHKNMDIASQVREVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGV
HHHCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCC
PVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITAPKGCTLDDAEKIFSTNKVEK
CEECCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHCCCCCCC
LPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
CCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCE
IVLDSAHGHSKGIIDTVKAIKTKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSI
EEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCCCHH
CTTRIVSGMGVPQISAIDECVEEANKFGVPVIADGGIKYSGDIAKALAVGASSVMIGSLL
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHH
AGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQQGTAQDKLVPEGIEGRVPYV
CCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCH
GSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCE
KVNHQ
ECCCC
>Mature Secondary Structure
MKIVKRALTFEDVLLRPGYSEVLPKEVKIHTKLTKNITLNMPLISAAMDTVTEHRAAIMM
CCHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEECCEEECCHHHHHHHHHHHHHHHHHHH
ARLGGLGVIHKNMDIASQVREVKRVKKSESGVIIDPIFVSPKASVAEALEIMAEYRISGV
HHHCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCC
PVVDEDKKLIGILTNRDLRFESDFSNLVENVMTKMPLITAPKGCTLDDAEKIFSTNKVEK
CEECCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHCCCCCCC
LPIVDEQGRLEGLITIKDLKKRKEYPDANKDNFGRLRVGAAIGVGQMDRVDALVEAGVDV
CCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCE
IVLDSAHGHSKGIIDTVKAIKTKYPNLDLIAGNIATAAAAKALCEAGVDAVKVGIGPGSI
EEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCCCHH
CTTRIVSGMGVPQISAIDECVEEANKFGVPVIADGGIKYSGDIAKALAVGASSVMIGSLL
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHH
AGTDESPGELFTYQGRQYKSYRGMGSLGAMQKGSSDRYFQQGTAQDKLVPEGIEGRVPYV
CCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCH
GSIRSVVHQLLGGLRSSMGYVGAKDIEDFQKRAEFVEITTAGLKESHVHDVTITHEAPNY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCE
KVNHQ
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]