Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 153952246

GI number: 153952246

Start: 818772

End: 820355

Strand: Direct

Name: serA [H]

Synonym: JJD26997_0922

Alternate gene names: 153952246

Gene position: 818772-820355 (Clockwise)

Preceding gene: 153952469

Following gene: 153951656

Centisome position: 44.38

GC content: 32.2

Gene sequence:

>1584_bases
ATGAAAAAAAAGATTATAGTATGTGATGCTATTTTGGATAAAGGTGTCGATATTCTAAGAAAAGCTGAAGATATTGAACT
TATAGAAGCTGCAAAAGTTCCAAAAGATGAACTTATGCAAATGCTAAGCGATGTTGAAGTTGCTATTACTAGAAGTTCTA
CGGATGTAGATGCAAATTTCTTAAATCATGCCAAAAAATTAAAAACACTTGTGCGTGCTGGGGTGGGTGTAGATAATGTT
GATATTCCAGAGTGTTCTAAACGAGGAGTGATTGTGATGAATGTTCCAACTGCAAATACTATTGCCGCAGTTGAACTTAC
AATGGCACATCTTTTAACATCGGCTAGAAGCTTTGTCAATGCTCATAATTTTTTAAAAATTGAAAGAAAATGGGAAAGAG
AAAAATGGTATGGCATTGAATTGATGAACAAAACTCTAGGGGTTATAGGTTTTGGAAACATAGGTTCAAGAGTAGCTATC
CGTGCTAAAGCATTTGGTATGAAAATTTTAGCCTATGATCCGTATATTTCTGCTTCTAAGATTACAGATTTAGATATGGA
ACAAGCAAAAAATTTGGATGAAATTTTAGAAAAAAGTGATTTTATTACCATTCACACACCAAAAACCAAAGAAACCAATG
GTATGATAGGAAAACAAGAAATTGCAAAAATGAAAGATGGAATAAGATTAATAAATTGTGCTCGTGGAGGATTGTACACA
GAAGAGGCTTTATACGAAGGTTTAAAAAGTGGTAAAATAGCATGGCTTGGCATAGATGTGTTTGATAAAGAACCCGCAAT
CAATCATCCTCTTTTAGACTTTGAAAATATTTCGGTTACTTCTCACTTAGGAGCAAATACTTTAGAAAGTCAAGACAATA
TCGCAAGAGAAGCTTGCGAGCAAGCATTAAATGCAGCACGAGGTGTGGCTTACCCTAATGCCTTAAATTTACCAATTAAA
ACTGAAGATTTACCACCTTTTGTAGCTCCTTATATAGAACTTGTTTCTAAAATGGCTTTTTTAGCTGTTCAAATTGATAA
AAATCCTATAAAAAGTATTAAATTAGAAGCTGAAGGAATTATTGGTGAGTATGCAAATTCTATGCTAACCTTTGCAGCTG
TTGGTGCTTTGGGTGGAATTTTAGGAGAAAAAATTAATTATGTTAATGCAGAATTTGTAGCCAAAGAAAAAGGAGTTGAA
TTATCTTGCGAAACTCTTCCAAACAGTGGTTATAATAATAAACTTAGCGTTAAAATTATCACTGAAAATTCAAATATTAG
TGTTTCAGGAACAGTATTTAATGAAAATGAACAACGCATAGTTGGATTAAATGGCTTTAAAATTGATTTTAAGCCAAAGG
GAAAAATGATTATTTTTAAAAACAAAGACATACCAGGAGTTATAGCTAAAATCAGTTCTGTTTTGGCAGCTAAAAATATC
AATATAGCTGATTTTAGACTTGGTAGAGATAGTTTTGGGTATGCTTTGGCTGTTGTTTTGATTGATGAAAAAGTTCAAAA
AGAAGTATTAGATGAGTTAAAACAATTAGAGGCGTGTGTATTTGTCCAATATGTTGAAATTTAA

Upstream 100 bases:

>100_bases
CAGAAATCTTTTTGGATACAGGTAATGAAAAACTTATAGATGATATTATCAAAGAATTAAAAAAATATAAAATAAATACA
GAAGTAAAGGAAATTTGGTT

Downstream 100 bases:

>100_bases
AATTTTAATTATAGAAGATGATGTAGATTTGAACGAACTACTTGTCTTAAAGTTAAAATCTAGTGATTATGAAGTTATAT
CTTTGGTGGATTTTTTTGGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKVPKDELMQMLSDVEVAITRSSTDVDANFLNHAKKLKTLVRAGVGVDNV
DIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVNAHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAI
RAKAFGMKILAYDPYISASKITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
EEALYEGLKSGKIAWLGIDVFDKEPAINHPLLDFENISVTSHLGANTLESQDNIAREACEQALNAARGVAYPNALNLPIK
TEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGIIGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVE
LSCETLPNSGYNNKLSVKIITENSNISVSGTVFNENEQRIVGLNGFKIDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
NIADFRLGRDSFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI

Sequences:

>Translated_527_residues
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKVPKDELMQMLSDVEVAITRSSTDVDANFLNHAKKLKTLVRAGVGVDNV
DIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVNAHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAI
RAKAFGMKILAYDPYISASKITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
EEALYEGLKSGKIAWLGIDVFDKEPAINHPLLDFENISVTSHLGANTLESQDNIAREACEQALNAARGVAYPNALNLPIK
TEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGIIGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVE
LSCETLPNSGYNNKLSVKIITENSNISVSGTVFNENEQRIVGLNGFKIDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
NIADFRLGRDSFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI
>Mature_527_residues
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKVPKDELMQMLSDVEVAITRSSTDVDANFLNHAKKLKTLVRAGVGVDNV
DIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVNAHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAI
RAKAFGMKILAYDPYISASKITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
EEALYEGLKSGKIAWLGIDVFDKEPAINHPLLDFENISVTSHLGANTLESQDNIAREACEQALNAARGVAYPNALNLPIK
TEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGIIGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVE
LSCETLPNSGYNNKLSVKIITENSNISVSGTVFNENEQRIVGLNGFKIDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
NIADFRLGRDSFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=410, Percent_Identity=35.3658536585366, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=34.2857142857143, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI4557497, Length=245, Percent_Identity=34.2857142857143, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI145580578, Length=226, Percent_Identity=34.5132743362832, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4557499, Length=226, Percent_Identity=34.5132743362832, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=226, Percent_Identity=34.5132743362832, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI6912396, Length=322, Percent_Identity=30.7453416149068, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1789279, Length=325, Percent_Identity=31.6923076923077, Blast_Score=155, Evalue=9e-39,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=30.4615384615385, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787645, Length=254, Percent_Identity=29.9212598425197, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788660, Length=290, Percent_Identity=28.6206896551724, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI87081824, Length=144, Percent_Identity=29.8611111111111, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=38.2352941176471, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=304, Percent_Identity=32.8947368421053, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=309, Percent_Identity=31.7152103559871, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324964, Length=289, Percent_Identity=31.1418685121107, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=326, Percent_Identity=29.1411042944785, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324980, Length=177, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=32.2147651006711, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=168, Percent_Identity=30.3571428571429, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=308, Percent_Identity=39.2857142857143, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI28574286, Length=317, Percent_Identity=31.2302839116719, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574284, Length=316, Percent_Identity=29.1139240506329, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585514, Length=316, Percent_Identity=29.1139240506329, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574282, Length=316, Percent_Identity=29.1139240506329, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45551003, Length=316, Percent_Identity=29.1139240506329, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45552429, Length=316, Percent_Identity=29.1139240506329, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646446, Length=226, Percent_Identity=33.1858407079646, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646448, Length=226, Percent_Identity=33.1858407079646, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646452, Length=226, Percent_Identity=33.1858407079646, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24646450, Length=226, Percent_Identity=33.1858407079646, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=33.1858407079646, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=301, Percent_Identity=31.2292358803987, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24585516, Length=298, Percent_Identity=28.1879194630872, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57951; Mature: 57951

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKVPKDELMQMLSDVEVAITRSSTDVDANF
CCCEEEEEHHHHHCCHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCHHH
LNHAKKLKTLVRAGVGVDNVDIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAIRAKAFGMKILAYDPYISASK
HHHEEEEEEHHCCCCCCCCEECCCCCCEEEECCCCCEEEEEEHHHCEEEEEECCCCCCCC
ITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
CCCCCHHHHCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCH
EEALYEGLKSGKIAWLGIDVFDKEPAINHPLLDFENISVTSHLGANTLESQDNIAREACE
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
QALNAARGVAYPNALNLPIKTEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGI
HHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCHH
IGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVELSCETLPNSGYNNKLSVKII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCEEEEEECCCCCCCCEEEEEEE
TENSNISVSGTVFNENEQRIVGLNGFKIDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
EECCCEEEEEEEECCCCCEEEECCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCC
NIADFRLGRDSFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI
CEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MKKKIIVCDAILDKGVDILRKAEDIELIEAAKVPKDELMQMLSDVEVAITRSSTDVDANF
CCCEEEEEHHHHHCCHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCEEEEEECCCCCCHHH
LNHAKKLKTLVRAGVGVDNVDIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVN
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AHNFLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAIRAKAFGMKILAYDPYISASK
HHHEEEEEEHHCCCCCCCCEECCCCCCEEEECCCCCEEEEEEHHHCEEEEEECCCCCCCC
ITDLDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYT
CCCCCHHHHCCHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCH
EEALYEGLKSGKIAWLGIDVFDKEPAINHPLLDFENISVTSHLGANTLESQDNIAREACE
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHH
QALNAARGVAYPNALNLPIKTEDLPPFVAPYIELVSKMAFLAVQIDKNPIKSIKLEAEGI
HHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCHH
IGEYANSMLTFAAVGALGGILGEKINYVNAEFVAKEKGVELSCETLPNSGYNNKLSVKII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEECCCCCEEEEEECCCCCCCCEEEEEEE
TENSNISVSGTVFNENEQRIVGLNGFKIDFKPKGKMIIFKNKDIPGVIAKISSVLAAKNI
EECCCEEEEEEEECCCCCEEEECCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCC
NIADFRLGRDSFGYALAVVLIDEKVQKEVLDELKQLEACVFVQYVEI
CEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]