Click here to switch to the map view.

The map label for this gene is gppA [H]

Identifier: 153952042

GI number: 153952042

Start: 1418378

End: 1419838

Strand: Direct

Name: gppA [H]

Synonym: JJD26997_1606

Alternate gene names: 153952042

Gene position: 1418378-1419838 (Clockwise)

Preceding gene: 153951285

Following gene: 153952056

Centisome position: 76.87

GC content: 29.02

Gene sequence:

>1461_bases
ATGGCAAAAAAAACAGCCGTTGTTGATCTTGGCTCAAACTCCATTAGAATGGTGATTTTTGAAAAAACTTCTAGATATGG
TTTTTATACAACTTGCGAATACAAACGCAAAGTAAGACTTGGAGAAAATGCTTATAATAATGGCAAAATTCTCCAAGAAG
AAGCCATGCAAAGAGCCGAAGATGCTTTAGCTTTTTTCAAACAATGCGCTTTAAAACATAAGTGCAAAAAAATATTTATC
GTAGGCACATCAGCCTTAAGAGATGCCCCAAATTCAAAAAATTTCATTAAAAGAATCAAAGATAATCTATCTTTAAATAT
ACGCTGTATAGATGGAAAAAGCGAAAGTTATTTAGGCGGTCTTGCAGCTTTAAATTTATTAAGTCCTTTTAAGGATGGAA
CCACTTTAGACATAGGTGGTGGTTCTAGTGAATTATGTTTAATAAAAAATAATAGAATTATTTCTTGCATATCTCTTGAT
ATTGGCACTGTTAGGCTAAAAGAATTGTTCTATGATACTGGAAAAATGGATTCTTTAGAAGAATTTATAAAACCAATTTT
AGAACAAATTCCTAAAGAATTTTGCAATCAAAACCTTATCGCGATAGGCGGAAGCTTAAGAGCAATATCTAATTCCATCA
TGCAAAAAAATTCCTATCCACTGAAAAATTTACATGATTTTCGCTATATGCTAGATGAAGAAAAAGGACATATTTTAAAA
ATTTTTAATTCAAACTTAGACTCTTTAATCAATTTTGGCATAAAAAAGGATCGTTTTGATACCATTAAAAAAGGTATATT
TATTTTTTTAAAGATTGCAGAAAAAATAAAAGCCAAACAAGTTATCACGAGTGGAGTTGGAATCAGAGAAGGAGTTTATT
TGCAAGATTTGCTTCGTCCTAAAATCACATTTCCACCAAATTTCAATCCTAGTTTAAAATGTTTACAAGATAAATTTTTA
CAATCAAAACAAAAAAATAAAACTCCACATTTTGCTCTGCAAATTTTTACAACCCTTAAAAATCTTCATAAACTTAACGA
TAACTATAAGCATGCTTTACTAAATGCTGCTAAATTATGTCATATTGGAGAATATTTAAATTTCTATTTTGCTAATGAAC
ACTCTGCTCATTTTGTACTAGGTGGATTAAATTATGGATTTTCACATAAAGAAAAAGCTTTAATTGCTAGCATTATTAAG
CTTAATGGAAAAAAAGTTAACCCTTATCATCTTGAACCCTATAAACAACTTTTACCCAATATTCATACCATTTCATGGCT
TAATTTTATTTTGTGCCTAGCTAAAACTTTAAGCACAAATGAAGATAAGATTGATTTTGCTTTTGCAAACAATACTCTTT
ACATATATCAAGAAAACAAAATTCTCAATTTACCCAAAGATGAACTCAAAAAAATTGCAAAACCAGCTACCATAGCATTA
GCAATCAATCAAAAAATTTAA

Upstream 100 bases:

>100_bases
CCTGTATTGTTGCTTGCCCATATGAATGTATCATTCCTGATCCTGATAATGTAGAAACTATAGAAGAATTAAAACTCAAA
CATAGAGATAGAGAATTTTA

Downstream 100 bases:

>100_bases
GATTTTGAATTCTTTTTTTATTCTCTTCAAAAAAAGAATCAAAATTTTTCTCTGTTTTTTCTGTATGTTTTATTGTTTGT
TCTTCTGGAATTTCAACACT

Product: Ppx/GppA family phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MAKKTAVVDLGSNSIRMVIFEKTSRYGFYTTCEYKRKVRLGENAYNNGKILQEEAMQRAEDALAFFKQCALKHKCKKIFI
VGTSALRDAPNSKNFIKRIKDNLSLNIRCIDGKSESYLGGLAALNLLSPFKDGTTLDIGGGSSELCLIKNNRIISCISLD
IGTVRLKELFYDTGKMDSLEEFIKPILEQIPKEFCNQNLIAIGGSLRAISNSIMQKNSYPLKNLHDFRYMLDEEKGHILK
IFNSNLDSLINFGIKKDRFDTIKKGIFIFLKIAEKIKAKQVITSGVGIREGVYLQDLLRPKITFPPNFNPSLKCLQDKFL
QSKQKNKTPHFALQIFTTLKNLHKLNDNYKHALLNAAKLCHIGEYLNFYFANEHSAHFVLGGLNYGFSHKEKALIASIIK
LNGKKVNPYHLEPYKQLLPNIHTISWLNFILCLAKTLSTNEDKIDFAFANNTLYIYQENKILNLPKDELKKIAKPATIAL
AINQKI

Sequences:

>Translated_486_residues
MAKKTAVVDLGSNSIRMVIFEKTSRYGFYTTCEYKRKVRLGENAYNNGKILQEEAMQRAEDALAFFKQCALKHKCKKIFI
VGTSALRDAPNSKNFIKRIKDNLSLNIRCIDGKSESYLGGLAALNLLSPFKDGTTLDIGGGSSELCLIKNNRIISCISLD
IGTVRLKELFYDTGKMDSLEEFIKPILEQIPKEFCNQNLIAIGGSLRAISNSIMQKNSYPLKNLHDFRYMLDEEKGHILK
IFNSNLDSLINFGIKKDRFDTIKKGIFIFLKIAEKIKAKQVITSGVGIREGVYLQDLLRPKITFPPNFNPSLKCLQDKFL
QSKQKNKTPHFALQIFTTLKNLHKLNDNYKHALLNAAKLCHIGEYLNFYFANEHSAHFVLGGLNYGFSHKEKALIASIIK
LNGKKVNPYHLEPYKQLLPNIHTISWLNFILCLAKTLSTNEDKIDFAFANNTLYIYQENKILNLPKDELKKIAKPATIAL
AINQKI
>Mature_485_residues
AKKTAVVDLGSNSIRMVIFEKTSRYGFYTTCEYKRKVRLGENAYNNGKILQEEAMQRAEDALAFFKQCALKHKCKKIFIV
GTSALRDAPNSKNFIKRIKDNLSLNIRCIDGKSESYLGGLAALNLLSPFKDGTTLDIGGGSSELCLIKNNRIISCISLDI
GTVRLKELFYDTGKMDSLEEFIKPILEQIPKEFCNQNLIAIGGSLRAISNSIMQKNSYPLKNLHDFRYMLDEEKGHILKI
FNSNLDSLINFGIKKDRFDTIKKGIFIFLKIAEKIKAKQVITSGVGIREGVYLQDLLRPKITFPPNFNPSLKCLQDKFLQ
SKQKNKTPHFALQIFTTLKNLHKLNDNYKHALLNAAKLCHIGEYLNFYFANEHSAHFVLGGLNYGFSHKEKALIASIIKL
NGKKVNPYHLEPYKQLLPNIHTISWLNFILCLAKTLSTNEDKIDFAFANNTLYIYQENKILNLPKDELKKIAKPATIALA
INQKI

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=424, Percent_Identity=25, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788848, Length=437, Percent_Identity=23.5697940503432, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 55186; Mature: 55055

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKTAVVDLGSNSIRMVIFEKTSRYGFYTTCEYKRKVRLGENAYNNGKILQEEAMQRAE
CCCCEEEEEECCCCEEEEEEEECCCCCEEEEECHHHHEECCCCCCCCCCEEHHHHHHHHH
DALAFFKQCALKHKCKKIFIVGTSALRDAPNSKNFIKRIKDNLSLNIRCIDGKSESYLGG
HHHHHHHHHHHHHCCCEEEEEECHHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHH
LAALNLLSPFKDGTTLDIGGGSSELCLIKNNRIISCISLDIGTVRLKELFYDTGKMDSLE
HHHHHHHCCCCCCCEEEECCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHCCCCCHHHH
EFIKPILEQIPKEFCNQNLIAIGGSLRAISNSIMQKNSYPLKNLHDFRYMLDEEKGHILK
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
IFNSNLDSLINFGIKKDRFDTIKKGIFIFLKIAEKIKAKQVITSGVGIREGVYLQDLLRP
EECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCC
KITFPPNFNPSLKCLQDKFLQSKQKNKTPHFALQIFTTLKNLHKLNDNYKHALLNAAKLC
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
HIGEYLNFYFANEHSAHFVLGGLNYGFSHKEKALIASIIKLNGKKVNPYHLEPYKQLLPN
HHHHHHEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
IHTISWLNFILCLAKTLSTNEDKIDFAFANNTLYIYQENKILNLPKDELKKIAKPATIAL
CHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEECCCEECCCHHHHHHHCCCEEEEE
AINQKI
EEECCC
>Mature Secondary Structure 
AKKTAVVDLGSNSIRMVIFEKTSRYGFYTTCEYKRKVRLGENAYNNGKILQEEAMQRAE
CCCEEEEEECCCCEEEEEEEECCCCCEEEEECHHHHEECCCCCCCCCCEEHHHHHHHHH
DALAFFKQCALKHKCKKIFIVGTSALRDAPNSKNFIKRIKDNLSLNIRCIDGKSESYLGG
HHHHHHHHHHHHHCCCEEEEEECHHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHH
LAALNLLSPFKDGTTLDIGGGSSELCLIKNNRIISCISLDIGTVRLKELFYDTGKMDSLE
HHHHHHHCCCCCCCEEEECCCCCCEEEEECCCEEEEEEECCCHHHHHHHHHCCCCCHHHH
EFIKPILEQIPKEFCNQNLIAIGGSLRAISNSIMQKNSYPLKNLHDFRYMLDEEKGHILK
HHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
IFNSNLDSLINFGIKKDRFDTIKKGIFIFLKIAEKIKAKQVITSGVGIREGVYLQDLLRP
EECCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCC
KITFPPNFNPSLKCLQDKFLQSKQKNKTPHFALQIFTTLKNLHKLNDNYKHALLNAAKLC
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
HIGEYLNFYFANEHSAHFVLGGLNYGFSHKEKALIASIIKLNGKKVNPYHLEPYKQLLPN
HHHHHHEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
IHTISWLNFILCLAKTLSTNEDKIDFAFANNTLYIYQENKILNLPKDELKKIAKPATIAL
CHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEECCCEECCCHHHHHHHCCCEEEEE
AINQKI
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA