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The map label for this gene is hisB [H]

Identifier: 153952011

GI number: 153952011

Start: 1723828

End: 1724886

Strand: Direct

Name: hisB [H]

Synonym: JJD26997_1952

Alternate gene names: 153952011

Gene position: 1723828-1724886 (Clockwise)

Preceding gene: 153951357

Following gene: 153951253

Centisome position: 93.43

GC content: 34.37

Gene sequence:

>1059_bases
ATGAGTCAAAAAATCCTTTTTATAGATAGAGATGGCACTTTAATAGAGGAGCCAAAAAGCGATTTTCAAATCGATACTCT
TGAAAAATTGCGTTTTGAAAAAGATGCTATTCCCACTCTTTTAAAACTAAAAAAATTTGGATTTAAATTTGTCATGGTAA
GTAATCAAGATGGTCTTGGAACGCCAAGTTTTCCAAAGGAAAATTTTGAAATCGCTCATGAAAAAATGCTTGATATTTTA
AAAAGTTGCGGTATAGAATTTCAAGATATTTTTATTTGTCCGCATTTTGAAAATGAAAATTGTGCTTGTAGAAAACCTAA
AACCGCTATGTTAGAAGAATATATCAAGCACGAACTTTACGATAAAGAGCAAAGTTTTGTTATCGGGGATCGTGAGAGTG
ATATGATCTTGGCTTCAAATTTAGGCGTGCGTGGTTTAAAATACGGCGCACTTTCTTGGAAAGAAATAGAAAATGAAATT
TTAAGTTCTTTTAGAAGTGCGAGTTATCAAAGAACTACTAAAGAAACAGATATAAAAGTAAAAGTGTGCTTAAATGGGGG
CAAGGTTAGCATTAAAACAGGCATTGATTTTTTTGATCACATGCTAGAGCAAATCGCTGTGCATGGAGACATAGGGCTTG
AAATTTCTTGCAAAGGGGATTTAGAAATCGATGAGCATCATAGCGTTGAAGATGTAGCCTTAGCACTTGGAGCTTGTATC
AAAAAAGCCTTAGGAGATAAAATCGGCATTGCAAGATATGGCTTTACTTTGCCTATGGATGAGTGTTTGGCAAGTTGTGC
GATGGATTTTTGCAATCGTCCTCATTTAGTCTATAAAGCCAAATTTAAAAAATCTCATTTAGGAGCTTTGAGCACAGAAA
TGATCGAGCACTTTTTTTATTCTTTAAGCTATGCTATGGGCGTGAGTTTGCATTTAAAAGTTAAAGGCAAAAACGATCAT
CATAAAGCTGAAGGGCTTTTTAAAGCCTTTGCTAAAGCTTTGAAAATGGCAGTGAAAATAGAAAGTGAAAATTTAGCCAG
CTCCAAAGGAGTGATATGA

Upstream 100 bases:

>100_bases
AAGGCTTTCTAGCTTTAGGTAAAAGTGTTGAAATTTTAGCACAAAATGAGCATTTAGACGCACACAAAAATGCAGTAACT
TTTCGTTTAGAAAGCTTAAA

Downstream 100 bases:

>100_bases
GGAAATAATATGGAAACAAGAATAAATTTTAATTTAAAATCAACAACTAGAGAAGAAATTCGAGCGGATTTAATCAATGA
GTTTTTAAAGGAATTGCCAG

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSQKILFIDRDGTLIEEPKSDFQIDTLEKLRFEKDAIPTLLKLKKFGFKFVMVSNQDGLGTPSFPKENFEIAHEKMLDIL
KSCGIEFQDIFICPHFENENCACRKPKTAMLEEYIKHELYDKEQSFVIGDRESDMILASNLGVRGLKYGALSWKEIENEI
LSSFRSASYQRTTKETDIKVKVCLNGGKVSIKTGIDFFDHMLEQIAVHGDIGLEISCKGDLEIDEHHSVEDVALALGACI
KKALGDKIGIARYGFTLPMDECLASCAMDFCNRPHLVYKAKFKKSHLGALSTEMIEHFFYSLSYAMGVSLHLKVKGKNDH
HKAEGLFKAFAKALKMAVKIESENLASSKGVI

Sequences:

>Translated_352_residues
MSQKILFIDRDGTLIEEPKSDFQIDTLEKLRFEKDAIPTLLKLKKFGFKFVMVSNQDGLGTPSFPKENFEIAHEKMLDIL
KSCGIEFQDIFICPHFENENCACRKPKTAMLEEYIKHELYDKEQSFVIGDRESDMILASNLGVRGLKYGALSWKEIENEI
LSSFRSASYQRTTKETDIKVKVCLNGGKVSIKTGIDFFDHMLEQIAVHGDIGLEISCKGDLEIDEHHSVEDVALALGACI
KKALGDKIGIARYGFTLPMDECLASCAMDFCNRPHLVYKAKFKKSHLGALSTEMIEHFFYSLSYAMGVSLHLKVKGKNDH
HKAEGLFKAFAKALKMAVKIESENLASSKGVI
>Mature_351_residues
SQKILFIDRDGTLIEEPKSDFQIDTLEKLRFEKDAIPTLLKLKKFGFKFVMVSNQDGLGTPSFPKENFEIAHEKMLDILK
SCGIEFQDIFICPHFENENCACRKPKTAMLEEYIKHELYDKEQSFVIGDRESDMILASNLGVRGLKYGALSWKEIENEIL
SSFRSASYQRTTKETDIKVKVCLNGGKVSIKTGIDFFDHMLEQIAVHGDIGLEISCKGDLEIDEHHSVEDVALALGACIK
KALGDKIGIARYGFTLPMDECLASCAMDFCNRPHLVYKAKFKKSHLGALSTEMIEHFFYSLSYAMGVSLHLKVKGKNDHH
KAEGLFKAFAKALKMAVKIESENLASSKGVI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=56.3380281690141, Blast_Score=423, Evalue=1e-120,
Organism=Escherichia coli, GI1786399, Length=167, Percent_Identity=31.7365269461078, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=36.5740740740741, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 39610; Mature: 39479

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKILFIDRDGTLIEEPKSDFQIDTLEKLRFEKDAIPTLLKLKKFGFKFVMVSNQDGLG
CCCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
TPSFPKENFEIAHEKMLDILKSCGIEFQDIFICPHFENENCACRKPKTAMLEEYIKHELY
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHC
DKEQSFVIGDRESDMILASNLGVRGLKYGALSWKEIENEILSSFRSASYQRTTKETDIKV
CCCCCEEECCCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHCCHHCCCCCCCEEE
KVCLNGGKVSIKTGIDFFDHMLEQIAVHGDIGLEISCKGDLEIDEHHSVEDVALALGACI
EEEECCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
KKALGDKIGIARYGFTLPMDECLASCAMDFCNRPHLVYKAKFKKSHLGALSTEMIEHFFY
HHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
SLSYAMGVSLHLKVKGKNDHHKAEGLFKAFAKALKMAVKIESENLASSKGVI
HHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC
>Mature Secondary Structure 
SQKILFIDRDGTLIEEPKSDFQIDTLEKLRFEKDAIPTLLKLKKFGFKFVMVSNQDGLG
CCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
TPSFPKENFEIAHEKMLDILKSCGIEFQDIFICPHFENENCACRKPKTAMLEEYIKHELY
CCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHC
DKEQSFVIGDRESDMILASNLGVRGLKYGALSWKEIENEILSSFRSASYQRTTKETDIKV
CCCCCEEECCCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHCCHHCCCCCCCEEE
KVCLNGGKVSIKTGIDFFDHMLEQIAVHGDIGLEISCKGDLEIDEHHSVEDVALALGACI
EEEECCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
KKALGDKIGIARYGFTLPMDECLASCAMDFCNRPHLVYKAKFKKSHLGALSTEMIEHFFY
HHHHCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
SLSYAMGVSLHLKVKGKNDHHKAEGLFKAFAKALKMAVKIESENLASSKGVI
HHHHHHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA