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The map label for this gene is lon [H]

Identifier: 153951882

GI number: 153951882

Start: 589844

End: 592219

Strand: Direct

Name: lon [H]

Synonym: JJD26997_0650

Alternate gene names: 153951882

Gene position: 589844-592219 (Clockwise)

Preceding gene: 153951092

Following gene: 153952173

Centisome position: 31.97

GC content: 29.59

Gene sequence:

>2376_bases
ATGCAGATTGAAGAGATACAAAATTATCCAGCAAATTTACCAGTATTGGTTGAAGATGAATTATTTTTATATCCTTTTAT
GATAACTCCTATTTTTATTAACGATTCATCCAATATGAAAGCTTTAGATCTTGCGATTAAAAATGATAGCATGCTTTTTG
TTGCACCTGCAAAGTTGGAAAATGGAAGAAATTTTGATGAAATTTATAATTGCGGAGTGATTGGGACCATCATGCGAAAA
GTTCCTTTACCTGATGGAAGAGTGAAAATACTTTTTCAAGGATATGCTAAGGGTAAAATTATAGAGCAAATTTCTAATAA
ACCTTTAGAAGCCAAGATAGAACTTATAAAAGAAGACTTTTTAGAAGGAACTAAAAAAGAAGCACTTCTTGAAGTTTTAA
AAGAGAAGGTAAAAAATTTAGCAAATATTAGTCATTATTTTTCTCCGGATCTTTTAAGAACAATTGAAGAAGGTTTTGAT
GCATCTAGGATTTGCGATTTGATTTTAAATACTGTGCGTATTAAAAAACAAGTTGCTTATGAGTTTTTTGTTTTAACAGA
TCTTGAGCAAAAATTAGTAAAATTAATAGATTTAATTGCCCAAGAAATAGAAGCCAATAAAATTCAAAAAGAAATTAAAA
ATAAAGTGCATTCTCGTATTGATAAGGTAAATAAAGAATATTTTTTAAAAGAACAATTAAGACAAATTCAAAAAGAGCTT
GGTTCTGATACGCAAAAAGAAGATGAGGTTAGAGAGTATCAAAAGCGTTTGGAGTTAAAGAAGAAATTTATGCACGAAGA
CGCTTATAAAGAAATCAAAAAACAAATTGAAAAATTTGAACGCATTCATCAAGATAATTCCGAAGCATCGATGATTCAAA
CTTATATAGAAACAGCATTAGATGTTCCTTTTGAAAAAATTTCTAAGAAAAAACTTGATATTAAAGAAGTTTCAAAACAG
CTCAACCATGACCATTATGCATTAAATAAACCAAAAGAACGCATAGAAGAATATTTTGCAGTTAGGGAGCTTTTAGAGAA
AAGAAAAATAGCAGAAAAAGATAGTGCTAAAGTTATACTTTGTCTTTATGGACCTCCTGGCGTGGGTAAAACTTCACTGG
CAAATTCTGTTTCAAAAGCTTTAAAAAGAGAGCTTATTCGTATAGCTTTAGGTGGACTTGAAGATGTTAATGAGCTACGT
GGTCATCGTAGAACTTATATAGGTGCTATGCCTGGACGTATTACCCAAGGACTCATAGAGGCAAAACAAATTAATCCTGT
AATTGTATTGGATGAAATTGATAAATTAAATCGCAGTTTTAGAGGTGATCCAAGTGCGGTGCTTTTAGAAATTTTAGATC
CAGAACAAAATTCTAAATTTAGGGATTATTATTTAAATTTTAATATTGATTTAAGTAAAGTCATTTTTATAGCAACGGCA
AATGATATTAGCAATATTCCTGCACCTTTAAGAGATAGAATGGAATTCATAGAACTTAGCTCTTATGCTCCAAGTGAAAA
ATTTCATATAATGAAAAAATATTTAATTCCAGATGAGCTTAAAAAACACGGCTTAAAATCCAATGAATTATCTATTGATG
ATGAAACTATAGAGCTAATCATTAGTGATTATACTCGTGAATCAGGAGTTAGAAATTTGCGTCGCAAAGTGGCAGAGTTG
TGTCGTAAGAGTGCTAAAAAACTACTTTTAGAAAATATTAACAAAGTCATTATTAATACAAAAAATTTGAATGAATTTTT
AGATAAAAAAGTTTTTGAAATAGAAAAAAATAATGGAGAAAATCAAGTAGGTCAGGTTAATGGTTTGGCTTGGACAAGTG
TAGGTGGAGATGTTTTAAAAGTAGAGGCTGTAAAAATTAAAGGTAAAGGAGAATTAACGCTCACGGGAAGTTTAGGTGAT
GTAATGAAAGAATCAGCTAGAATTGCTTTTAGCATGATAAAAGTTTTAATCGATGAAGGAAAAATAAAAATACCTAAAAA
AATGATTATTGATCCTAAAGTTAATGTTTATGATAGTTATAATATTCATATACATGTGCCAGATGGAGCTACTCCAAAAG
ATGGTCCAAGTGCAGGCATTACGATAAGCACAGCTATTGCTTCTATTTTTAGTGATAAAAAAGTTAAAGCAGATATTGCA
ATGACAGGTGAAATAGATTTAAAAGGAAAAGTTTTACCAATAGGCGGATTAAAAGAAAAATTAATTGCAGCTTATAAAGC
AGATATAAAAACAGCTTTAATCCCAAGAAAAAATTACGAAAGGGATTTAAAAGATATTCCTAGTGAGGTTAGAGATAATA
TGGAAATCATTGCTGTTGATACTTTTAGCGATGTTTTAAAATATACTTTAGTTTAA

Upstream 100 bases:

>100_bases
AGACTTCAAGAAAGTGAATTTTATCAGCAAAGTATTATCAAACCTGAGCTTCCTTGGTATAGAAGTATATTTGAAAGATT
TTAATAAACAAGGAAAATAA

Downstream 100 bases:

>100_bases
TTTTATTTTGAGAATAAATGTATAAGAAAGCAAACTTTTTACAAGTTTGCTTTTTAAAAGATTATAGTCCTTCAAAAGGA
TTATTGATTACTTCTTTTCT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 791; Mature: 791

Protein sequence:

>791_residues
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPAKLENGRNFDEIYNCGVIGTIMRK
VPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDFLEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFD
ASRICDLILNTVRIKKQVAYEFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETALDVPFEKISKKKLDIKEVSKQ
LNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDSAKVILCLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELR
GHRRTYIGAMPGRITQGLIEAKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
NDISNIPAPLRDRMEFIELSSYAPSEKFHIMKKYLIPDELKKHGLKSNELSIDDETIELIISDYTRESGVRNLRRKVAEL
CRKSAKKLLLENINKVIINTKNLNEFLDKKVFEIEKNNGENQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGD
VMKESARIAFSMIKVLIDEGKIKIPKKMIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADIA
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVDTFSDVLKYTLV

Sequences:

>Translated_791_residues
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPAKLENGRNFDEIYNCGVIGTIMRK
VPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDFLEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFD
ASRICDLILNTVRIKKQVAYEFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETALDVPFEKISKKKLDIKEVSKQ
LNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDSAKVILCLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELR
GHRRTYIGAMPGRITQGLIEAKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
NDISNIPAPLRDRMEFIELSSYAPSEKFHIMKKYLIPDELKKHGLKSNELSIDDETIELIISDYTRESGVRNLRRKVAEL
CRKSAKKLLLENINKVIINTKNLNEFLDKKVFEIEKNNGENQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGD
VMKESARIAFSMIKVLIDEGKIKIPKKMIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADIA
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVDTFSDVLKYTLV
>Mature_791_residues
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPAKLENGRNFDEIYNCGVIGTIMRK
VPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDFLEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFD
ASRICDLILNTVRIKKQVAYEFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETALDVPFEKISKKKLDIKEVSKQ
LNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDSAKVILCLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELR
GHRRTYIGAMPGRITQGLIEAKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
NDISNIPAPLRDRMEFIELSSYAPSEKFHIMKKYLIPDELKKHGLKSNELSIDDETIELIISDYTRESGVRNLRRKVAEL
CRKSAKKLLLENINKVIINTKNLNEFLDKKVFEIEKNNGENQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGD
VMKESARIAFSMIKVLIDEGKIKIPKKMIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADIA
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVDTFSDVLKYTLV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=610, Percent_Identity=39.672131147541, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI31377667, Length=842, Percent_Identity=34.5605700712589, Blast_Score=465, Evalue=1e-131,
Organism=Escherichia coli, GI1786643, Length=782, Percent_Identity=39.5140664961637, Blast_Score=587, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17505831, Length=670, Percent_Identity=36.4179104477612, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17556486, Length=533, Percent_Identity=36.3977485928705, Blast_Score=357, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319449, Length=662, Percent_Identity=36.8580060422961, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221513036, Length=613, Percent_Identity=39.9673735725938, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24666867, Length=613, Percent_Identity=39.9673735725938, Blast_Score=471, Evalue=1e-132,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90088; Mature: 90088

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPAKLE
CCCHHHHCCCCCCCEEECCCEEEEEEEEEEEEEECCCCCEEEEEEEECCCEEEEECCCCC
NGRNFDEIYNCGVIGTIMRKVPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDF
CCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
LEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFDASRICDLILNTVRIKKQVAY
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DVPFEKISKKKLDIKEVSKQLNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDSAKVIL
CCCHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHEEEECCCCHHHHHHHH
AKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
HHHCCCEEEECCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEEEEEEHHHEEEEEEC
NDISNIPAPLRDRMEFIELSSYAPSEKFHIMKKYLIPDELKKHGLKSNELSIDDETIELI
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHH
ISDYTRESGVRNLRRKVAELCRKSAKKLLLENINKVIINTKNLNEFLDKKVFEIEKNNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHHHHEEEECCCCC
NQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGDVMKESARIAFSMIKVLIDEG
CCCCCCCCEEEECCCCCEEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KIKIPKKMIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADIA
CEECCHHEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCEEEEEE
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVD
EECCEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHCCCEEEEEE
TFSDVLKYTLV
CHHHHHHHHCC
>Mature Secondary Structure
MQIEEIQNYPANLPVLVEDELFLYPFMITPIFINDSSNMKALDLAIKNDSMLFVAPAKLE
CCCHHHHCCCCCCCEEECCCEEEEEEEEEEEEEECCCCCEEEEEEEECCCEEEEECCCCC
NGRNFDEIYNCGVIGTIMRKVPLPDGRVKILFQGYAKGKIIEQISNKPLEAKIELIKEDF
CCCCHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
LEGTKKEALLEVLKEKVKNLANISHYFSPDLLRTIEEGFDASRICDLILNTVRIKKQVAY
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
EFFVLTDLEQKLVKLIDLIAQEIEANKIQKEIKNKVHSRIDKVNKEYFLKEQLRQIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSDTQKEDEVREYQKRLELKKKFMHEDAYKEIKKQIEKFERIHQDNSEASMIQTYIETAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DVPFEKISKKKLDIKEVSKQLNHDHYALNKPKERIEEYFAVRELLEKRKIAEKDSAKVIL
CCCHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
CLYGPPGVGKTSLANSVSKALKRELIRIALGGLEDVNELRGHRRTYIGAMPGRITQGLIE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHEEEECCCCHHHHHHHH
AKQINPVIVLDEIDKLNRSFRGDPSAVLLEILDPEQNSKFRDYYLNFNIDLSKVIFIATA
HHHCCCEEEECCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEEEEEEHHHEEEEEEC
NDISNIPAPLRDRMEFIELSSYAPSEKFHIMKKYLIPDELKKHGLKSNELSIDDETIELI
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCCCCHHHHHHH
ISDYTRESGVRNLRRKVAELCRKSAKKLLLENINKVIINTKNLNEFLDKKVFEIEKNNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHHHHEEEECCCCC
NQVGQVNGLAWTSVGGDVLKVEAVKIKGKGELTLTGSLGDVMKESARIAFSMIKVLIDEG
CCCCCCCCEEEECCCCCEEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCC
KIKIPKKMIIDPKVNVYDSYNIHIHVPDGATPKDGPSAGITISTAIASIFSDKKVKADIA
CEECCHHEEECCCCEEEECEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHCCCCEEEEEE
MTGEIDLKGKVLPIGGLKEKLIAAYKADIKTALIPRKNYERDLKDIPSEVRDNMEIIAVD
EECCEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHCCCEEEEEE
TFSDVLKYTLV
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9742705; 10688204 [H]