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The map label for this gene is moeA [H]

Identifier: 153951841

GI number: 153951841

Start: 1652988

End: 1654178

Strand: Direct

Name: moeA [H]

Synonym: JJD26997_1872

Alternate gene names: 153951841

Gene position: 1652988-1654178 (Clockwise)

Preceding gene: 153951203

Following gene: 153951060

Centisome position: 89.59

GC content: 34.84

Gene sequence:

>1191_bases
ATGTTAATGTCTTATGAAGAAAGTTTAAAAATTTTACACTCTCATATTAAAACTTATGAAAAGATTGAAAAAATAGCTCT
TACAGAGTGTTTAGGACGCATTTTAGCTCAAGACATAAAAGCATCTAAAAATCAGCCCGAATTTCCAACTTCGGCTATGG
ATGGTTATGCGATCAAATTTGAAGATCAAGATAAGCCTTTAAAAATTTTAGGCCTCACACCTGCGGGCACTATGCCACAA
TTTAGCGTGCAAAATGGCACTTGTGTAAAAACCTTTACAGGTTCACTCATGAGCGAAGGAAGCGATACTTTAGCCCCTGT
TGAAAATGTACGCGTAGAAAATGATACTCTTTTTATAGAAAAAAAAGTTCCCCAAGCTTTTGCCGTGCGTGCGGTAGGAG
AAAACTATAAAAAAGATGAAATTTTACTCAAAAAAGGCACAAGGTTAAATTATAGCGAGATAGCTCTTTTAGCTGAACTT
GGATTTTTTCACATTAGTGTGTTTATAAAGCCTATTGTAGGGGTTTTAAGTAGCGGAAGTGAGATCAAGGATCTAGGAGA
AGCCTTAGAAAATCCTGCTCAAATCCGCTCTTCAAATCATATCGCCATAGCTAATTTAGCTAAAAATCTAAATTGCGATA
CAAGGGTTTTTCCTCTTTTAAAAGATGATGAAAAAGCCACTTTTTCTACCCTTGAAAGTGCTTTGCAAAGTTGTGATATT
TTGATTACAACGGGCGGGGTTTCTATGGGGGATTTTGACTTTTTAAAAAAAGCCATCAAAGAATACGAAATCATCATCGA
TAAAGCCGACATAAAACCAGGTAGACATATCAAAATAGCTAAGGCTAATGAAAAATTCATCATCGCATTACCAGGTTTTC
CTTACTCAGCTATGGTAATGTTTAATCTTTACGCAAGAGAGATTTTAAACTCTTGGTTACTTCAGCCTAAAGACTATATT
TGCAAAGCCTTTTTACAAGGAAGCTACAAGAAAAAAACACCTTATTTGGAATTTGTCGCTTGTAACATAAAGTTTGAAAA
TGGACGCATTTTAGCCAATCTTGAAGGCAAAAAAGAAGGCTCTAGTGCGATTATAAACAATCTTAACAATAAAGCCGCTC
TTATGGTGGTGCCAAAAGAATGTGAAATTTTAGAAAATGAAAGTTTAGTGGATATTATCTTTATGCCTTAA

Upstream 100 bases:

>100_bases
TGCACCCATTTGGAAGTATGATGTGATAAACAAAGAAAGAATTTATGTTAAAGAAAGATCAACCAAACTTTGCGGTGCAG
GACTTTTAAAAGGATAAAAA

Downstream 100 bases:

>100_bases
AATTATTTAAATAATTTTATTTCGATTTTAATCAACCCTAAATTTCAATAAGTTTCAAATTTGCAACCTCCTTTTAGTGG
AGTAATTAGCCCTAGCGAAG

Product: putative molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKASKNQPEFPTSAMDGYAIKFEDQDKPLKILGLTPAGTMPQ
FSVQNGTCVKTFTGSLMSEGSDTLAPVENVRVENDTLFIEKKVPQAFAVRAVGENYKKDEILLKKGTRLNYSEIALLAEL
GFFHISVFIKPIVGVLSSGSEIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
LITTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVMFNLYAREILNSWLLQPKDYI
CKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEGSSAIINNLNNKAALMVVPKECEILENESLVDIIFMP

Sequences:

>Translated_396_residues
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKASKNQPEFPTSAMDGYAIKFEDQDKPLKILGLTPAGTMPQ
FSVQNGTCVKTFTGSLMSEGSDTLAPVENVRVENDTLFIEKKVPQAFAVRAVGENYKKDEILLKKGTRLNYSEIALLAEL
GFFHISVFIKPIVGVLSSGSEIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
LITTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVMFNLYAREILNSWLLQPKDYI
CKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEGSSAIINNLNNKAALMVVPKECEILENESLVDIIFMP
>Mature_396_residues
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKASKNQPEFPTSAMDGYAIKFEDQDKPLKILGLTPAGTMPQ
FSVQNGTCVKTFTGSLMSEGSDTLAPVENVRVENDTLFIEKKVPQAFAVRAVGENYKKDEILLKKGTRLNYSEIALLAEL
GFFHISVFIKPIVGVLSSGSEIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
LITTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVMFNLYAREILNSWLLQPKDYI
CKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEGSSAIINNLNNKAALMVVPKECEILENESLVDIIFMP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=395, Percent_Identity=28.8607594936709, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI66932975, Length=395, Percent_Identity=28.8607594936709, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1787049, Length=366, Percent_Identity=28.6885245901639, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=293, Percent_Identity=30.7167235494881, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=153, Percent_Identity=36.6013071895425, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136978, Length=317, Percent_Identity=27.7602523659306, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24638841, Length=317, Percent_Identity=27.7602523659306, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44063; Mature: 44063

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKASKNQPEFPTSAMDGYAIKF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
EDQDKPLKILGLTPAGTMPQFSVQNGTCVKTFTGSLMSEGSDTLAPVENVRVENDTLFIE
CCCCCCEEEEEECCCCCCCCEECCCCCEEHHHHHHHHHCCCCCCCCHHHEEECCCEEEEE
KKVPQAFAVRAVGENYKKDEILLKKGTRLNYSEIALLAELGFFHISVFIKPIVGVLSSGS
ECCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
HHHHHHHHHCCCHHHCCCCCEEEEEHHHCCCCCCEEECEEECCCHHHHHHHHHHHHCCCE
LITTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVM
EEEECCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCEEEEEECCCCHHHHHH
FNLYAREILNSWLLQPKDYICKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEEECCCCCC
SSAIINNLNNKAALMVVPKECEILENESLVDIIFMP
CHHHHHCCCCCEEEEEECCHHCEECCCCEEEEEECC
>Mature Secondary Structure
MLMSYEESLKILHSHIKTYEKIEKIALTECLGRILAQDIKASKNQPEFPTSAMDGYAIKF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
EDQDKPLKILGLTPAGTMPQFSVQNGTCVKTFTGSLMSEGSDTLAPVENVRVENDTLFIE
CCCCCCEEEEEECCCCCCCCEECCCCCEEHHHHHHHHHCCCCCCCCHHHEEECCCEEEEE
KKVPQAFAVRAVGENYKKDEILLKKGTRLNYSEIALLAELGFFHISVFIKPIVGVLSSGS
ECCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EIKDLGEALENPAQIRSSNHIAIANLAKNLNCDTRVFPLLKDDEKATFSTLESALQSCDI
HHHHHHHHHCCCHHHCCCCCEEEEEHHHCCCCCCEEECEEECCCHHHHHHHHHHHHCCCE
LITTGGVSMGDFDFLKKAIKEYEIIIDKADIKPGRHIKIAKANEKFIIALPGFPYSAMVM
EEEECCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCEEEEEECCCCHHHHHH
FNLYAREILNSWLLQPKDYICKAFLQGSYKKKTPYLEFVACNIKFENGRILANLEGKKEG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCEEEEEECCCCCC
SSAIINNLNNKAALMVVPKECEILENESLVDIIFMP
CHHHHHCCCCCEEEEEECCHHCEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]