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The map label for this gene is folC [H]

Identifier: 153951776

GI number: 153951776

Start: 577683

End: 578855

Strand: Direct

Name: folC [H]

Synonym: JJD26997_0635

Alternate gene names: 153951776

Gene position: 577683-578855 (Clockwise)

Preceding gene: 153951565

Following gene: 153951074

Centisome position: 31.31

GC content: 26.68

Gene sequence:

>1173_bases
ATGAGTAATATAATGAAAGTTGAGAATTTTTTAGCTCAAAAAAGTATAAATTACGATAAAATCGACCGTTTTTTGATGTT
TAGAATGTATGAAAAATATAAGAAATATTTTAAAAATATTCCTATAATCCAACTTATAGGTACAAATGGTAAAGGTAGCA
CGGGTAGATATTTAACCCAACTTTTAGAAAATTTAAATTATAAAATAGGGCATTATACTAGCCCTCATATTTTTAGTTTT
AATGAAAGATTTTATCTTAATGGTAAGATTGCAAGTGATGAAGAATTAGAACAAGCTCATATAAGACTTGAAGAAATTTT
TAAACAAGACTTGCAAAAATTAAGTTATTTTGAATATACTACTTTTTTAGCCATGATTTTATTTCAAAAATGCGATTTCA
TTGTTTTAGAAGCAGGAGTGGGTGGAGAATATGATGCTACTTCTGTTTTTGAAAGAAAAATGAATATTTTCACAAGAATT
GGATTTGACCATGTTCAAATTTTAGGCAATTCTTTAGAAGATATTGCAAGAACCAAGCTTAAAGTTATGGCGCCTATAGC
GCTTATAAGCGATGAGCAAGAGCAAAATGTTTTAAAATTGGTAAAAAAAATTGCTTTTTTAAAAAAAGCTGATTTGCAAG
TTTCTTCTTTAAATCCTTTTTTGAAAGAAAATTTTGAGATTTATTGTAAAAAGTTTGTTTTACCTTGTTTTTTAAAGCAC
AATTTAAAGCTTGCATTAAAAGCTTGCGAAATTTTAACTTCGCAAGAAAAAACTTTAAAAGCTTTAAAAAAGCTACAAGA
GTTAAATTTACAAGGAAGATGCCAAGAAATTTCTCCAAATTTTTTTATTGATGTGGGTCATAATCCCATGGCTGCTGAGG
CTATGCTTGATAAATTTCAAGGAGAAAAAATAAATCTTATTTATAATGCTTATTTGGATAAGGATATTTTTCAAATTTTA
AATACATTAAAGCCTGTTATTGATACAATACAAATATATAAATATAAGAGCGCAGAACGAAAGCTAGCTGATGATGAAAT
TTATAGTATTGCATCAAAGCTAGGCATACAATGCAAAGAATTTGTAAAATTAGAAGAAAATAAAAAAAATCTAGTTTTTG
GTTCTTTTATGCTGGTAGAAAATTTTTTAAAGGAGTGGTGTGGTAAAAAATAA

Upstream 100 bases:

>100_bases
GATATTATAACCCCTAAAATTCATGTGGCTTATCTTGATAAGCAAAGTAAGCCAAATATTAATATTTTAGATGAATTAAT
AAAGCAAATTGCAGCAGTTG

Downstream 100 bases:

>100_bases
ATTCACTATTACCATTACAGATATTAACGGTTCAAGACATTTTTATTTAAATCAAATAATCAAAAAAATAGTTTTTTATA
CTATTGCTTTTATTGTTTTA

Product: folC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSNIMKVENFLAQKSINYDKIDRFLMFRMYEKYKKYFKNIPIIQLIGTNGKGSTGRYLTQLLENLNYKIGHYTSPHIFSF
NERFYLNGKIASDEELEQAHIRLEEIFKQDLQKLSYFEYTTFLAMILFQKCDFIVLEAGVGGEYDATSVFERKMNIFTRI
GFDHVQILGNSLEDIARTKLKVMAPIALISDEQEQNVLKLVKKIAFLKKADLQVSSLNPFLKENFEIYCKKFVLPCFLKH
NLKLALKACEILTSQEKTLKALKKLQELNLQGRCQEISPNFFIDVGHNPMAAEAMLDKFQGEKINLIYNAYLDKDIFQIL
NTLKPVIDTIQIYKYKSAERKLADDEIYSIASKLGIQCKEFVKLEENKKNLVFGSFMLVENFLKEWCGKK

Sequences:

>Translated_390_residues
MSNIMKVENFLAQKSINYDKIDRFLMFRMYEKYKKYFKNIPIIQLIGTNGKGSTGRYLTQLLENLNYKIGHYTSPHIFSF
NERFYLNGKIASDEELEQAHIRLEEIFKQDLQKLSYFEYTTFLAMILFQKCDFIVLEAGVGGEYDATSVFERKMNIFTRI
GFDHVQILGNSLEDIARTKLKVMAPIALISDEQEQNVLKLVKKIAFLKKADLQVSSLNPFLKENFEIYCKKFVLPCFLKH
NLKLALKACEILTSQEKTLKALKKLQELNLQGRCQEISPNFFIDVGHNPMAAEAMLDKFQGEKINLIYNAYLDKDIFQIL
NTLKPVIDTIQIYKYKSAERKLADDEIYSIASKLGIQCKEFVKLEENKKNLVFGSFMLVENFLKEWCGKK
>Mature_389_residues
SNIMKVENFLAQKSINYDKIDRFLMFRMYEKYKKYFKNIPIIQLIGTNGKGSTGRYLTQLLENLNYKIGHYTSPHIFSFN
ERFYLNGKIASDEELEQAHIRLEEIFKQDLQKLSYFEYTTFLAMILFQKCDFIVLEAGVGGEYDATSVFERKMNIFTRIG
FDHVQILGNSLEDIARTKLKVMAPIALISDEQEQNVLKLVKKIAFLKKADLQVSSLNPFLKENFEIYCKKFVLPCFLKHN
LKLALKACEILTSQEKTLKALKKLQELNLQGRCQEISPNFFIDVGHNPMAAEAMLDKFQGEKINLIYNAYLDKDIFQILN
TLKPVIDTIQIYKYKSAERKLADDEIYSIASKLGIQCKEFVKLEENKKNLVFGSFMLVENFLKEWCGKK

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=215, Percent_Identity=27.4418604651163, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66932984, Length=215, Percent_Identity=27.4418604651163, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788654, Length=306, Percent_Identity=29.7385620915033, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17553148, Length=146, Percent_Identity=34.2465753424658, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71984923, Length=146, Percent_Identity=34.2465753424658, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17553150, Length=146, Percent_Identity=34.2465753424658, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323760, Length=182, Percent_Identity=30.7692307692308, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324815, Length=315, Percent_Identity=28.8888888888889, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24641571, Length=148, Percent_Identity=32.4324324324324, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24581568, Length=159, Percent_Identity=32.7044025157233, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 45434; Mature: 45303

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIMKVENFLAQKSINYDKIDRFLMFRMYEKYKKYFKNIPIIQLIGTNGKGSTGRYLTQ
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
LLENLNYKIGHYTSPHIFSFNERFYLNGKIASDEELEQAHIRLEEIFKQDLQKLSYFEYT
HHHHCCCCCCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFLAMILFQKCDFIVLEAGVGGEYDATSVFERKMNIFTRIGFDHVQILGNSLEDIARTKL
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KVMAPIALISDEQEQNVLKLVKKIAFLKKADLQVSSLNPFLKENFEIYCKKFVLPCFLKH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHC
NLKLALKACEILTSQEKTLKALKKLQELNLQGRCQEISPNFFIDVGHNPMAAEAMLDKFQ
CHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHC
GEKINLIYNAYLDKDIFQILNTLKPVIDTIQIYKYKSAERKLADDEIYSIASKLGIQCKE
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCHHH
FVKLEENKKNLVFGSFMLVENFLKEWCGKK
HHHHHCCCCCEEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNIMKVENFLAQKSINYDKIDRFLMFRMYEKYKKYFKNIPIIQLIGTNGKGSTGRYLTQ
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
LLENLNYKIGHYTSPHIFSFNERFYLNGKIASDEELEQAHIRLEEIFKQDLQKLSYFEYT
HHHHCCCCCCCCCCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFLAMILFQKCDFIVLEAGVGGEYDATSVFERKMNIFTRIGFDHVQILGNSLEDIARTKL
HHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KVMAPIALISDEQEQNVLKLVKKIAFLKKADLQVSSLNPFLKENFEIYCKKFVLPCFLKH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHC
NLKLALKACEILTSQEKTLKALKKLQELNLQGRCQEISPNFFIDVGHNPMAAEAMLDKFQ
CHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHC
GEKINLIYNAYLDKDIFQILNTLKPVIDTIQIYKYKSAERKLADDEIYSIASKLGIQCKE
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHCCCHHH
FVKLEENKKNLVFGSFMLVENFLKEWCGKK
HHHHHCCCCCEEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]