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The map label for this gene is czcD [H]

Identifier: 153951662

GI number: 153951662

Start: 507709

End: 508659

Strand: Direct

Name: czcD [H]

Synonym: JJD26997_0567

Alternate gene names: 153951662

Gene position: 507709-508659 (Clockwise)

Preceding gene: 153951674

Following gene: 153952649

Centisome position: 27.52

GC content: 30.91

Gene sequence:

>951_bases
ATGTATAAATTTTTATCACACGAGCCTTTAGCTAACAAATCTTGTCATCATGATCACGAAGAACATTCTCACGAACATCA
TCATTCCCATGCTGATGCAAGGAGTATGGACAAAAAGATTTTAAAAATTTCTCTTTTAATGACTTTTTCTATGATGCTTG
TGCAATTTATTTATTCAATCCTTTCAAATTCTTTGGCACTTTTAAGCGATACTTTGCATATGTTTTCTGATGTTTTTGCC
TTAGCTCTTAGTTTTTTAGCCATCATAGCTGTAGAAAAATGGCAAGATCATCAAAAGACCTTTGGGTATTTTCGTCTTGA
AGTTTTGGTGGCTTTTATCAATGCTTTAACCATTATTTTATCGGCTTTATTTATCATTTATGAGGCTATAGAAAAATTTA
TTAATCCAAAAGAAATTGATGCTAAAACCATGATAATTGTAGCTATTTTAGGTTTTTTGGTAAATGGGATTAATGCTTTG
ATGATGTTTAAGGGTGCAAATTTAGAAAATGTCAATATGAAATCCGCTTTTTTACATATGATGAGCGATTTATTGGGTTC
TTTAGCGGTTATTATAGGTGGGATAGTGGTGTATTTTAGCGGTATTGTTTATATAGATACGATTTTAGCTATTATATTAT
CAATCTTGCTTTTAAGATGGGCGATTATCTTACTTAAACAAAGTGCCAATGTTTTGCTTGAAAGTTCTCCTGTGAATATA
GAAAAAGTAAGACAAGTTTTGCTTTTAAATCCTAGCGTGGATGAGGTGGTGGATTTGCATATTACTCAAATCACTAATAA
AATGCTAGTAGCCTCTATGCATTTAAAAGTGAGAATTTGTGATCTAAAGGAATTTGAAAAACTATCTCAGGATTTATCCC
ATAAGTTATTGCATGAATTTAAAATCGGGCACATTACTATACAACCTATAAGGAGTGAAAATGAAATTTAA

Upstream 100 bases:

>100_bases
GCTAGGCGAACGTTTTGACTTTTAATTTTTTATAAAAATAACAAATATTTATATCCTTTTTAGCTTAATATCTTAAAATG
TCAAGCAAAAAGGATATAAA

Downstream 100 bases:

>100_bases
AGTAAAAAATGTTAATTGTATGAATTGTGTAAATTTGATCAAAAATTCTCTTGAAGGTGAATTTGGAAATATAGAAGTGG
ATTTGGAGAAAAAAATTCTA

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MYKFLSHEPLANKSCHHDHEEHSHEHHHSHADARSMDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFA
LALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIILSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINAL
MMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIILSILLLRWAIILLKQSANVLLESSPVNI
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRICDLKEFEKLSQDLSHKLLHEFKIGHITIQPIRSENEI

Sequences:

>Translated_316_residues
MYKFLSHEPLANKSCHHDHEEHSHEHHHSHADARSMDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFA
LALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIILSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINAL
MMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIILSILLLRWAIILLKQSANVLLESSPVNI
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRICDLKEFEKLSQDLSHKLLHEFKIGHITIQPIRSENEI
>Mature_316_residues
MYKFLSHEPLANKSCHHDHEEHSHEHHHSHADARSMDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFA
LALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIILSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINAL
MMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIILSILLLRWAIILLKQSANVLLESSPVNI
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRICDLKEFEKLSQDLSHKLLHEFKIGHITIQPIRSENEI

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=313, Percent_Identity=25.8785942492013, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21359890, Length=299, Percent_Identity=26.7558528428094, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI20070323, Length=311, Percent_Identity=27.0096463022508, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI64762489, Length=337, Percent_Identity=26.1127596439169, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI222080086, Length=121, Percent_Identity=39.6694214876033, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI40255009, Length=121, Percent_Identity=39.6694214876033, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI289803013, Length=303, Percent_Identity=26.4026402640264, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI289803009, Length=303, Percent_Identity=26.4026402640264, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI289803007, Length=303, Percent_Identity=26.4026402640264, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI289803003, Length=303, Percent_Identity=26.4026402640264, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI21361112, Length=318, Percent_Identity=24.2138364779874, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI14210520, Length=217, Percent_Identity=28.110599078341, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI52351208, Length=122, Percent_Identity=33.6065573770492, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI52352803, Length=113, Percent_Identity=38.9380530973451, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786966, Length=265, Percent_Identity=34.7169811320755, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193210990, Length=316, Percent_Identity=26.8987341772152, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32564488, Length=269, Percent_Identity=30.1115241635688, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555794, Length=274, Percent_Identity=26.2773722627737, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17555796, Length=303, Percent_Identity=24.7524752475248, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320411, Length=158, Percent_Identity=36.7088607594937, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=128, Percent_Identity=30.46875, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=146, Percent_Identity=26.7123287671233, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656728, Length=348, Percent_Identity=28.735632183908, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656724, Length=348, Percent_Identity=28.735632183908, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656720, Length=348, Percent_Identity=28.735632183908, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656715, Length=348, Percent_Identity=28.735632183908, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357035, Length=348, Percent_Identity=28.735632183908, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645863, Length=114, Percent_Identity=41.2280701754386, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583858, Length=281, Percent_Identity=23.1316725978648, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24584409, Length=141, Percent_Identity=28.3687943262411, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574430, Length=147, Percent_Identity=27.891156462585, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35851; Mature: 35851

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKFLSHEPLANKSCHHDHEEHSHEHHHSHADARSMDKKILKISLLMTFSMMLVQFIYSI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSNSLALLSDTLHMFSDVFALALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINALMMFKGANLENVNMKSAFLHM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MSDLLGSLAVIIGGIVVYFSGIVYIDTILAIILSILLLRWAIILLKQSANVLLESSPVNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCH
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRICDLKEFEKLSQDLSHKLLHEF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHH
KIGHITIQPIRSENEI
CCCCEEEEECCCCCCC
>Mature Secondary Structure
MYKFLSHEPLANKSCHHDHEEHSHEHHHSHADARSMDKKILKISLLMTFSMMLVQFIYSI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSNSLALLSDTLHMFSDVFALALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINALMMFKGANLENVNMKSAFLHM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
MSDLLGSLAVIIGGIVVYFSGIVYIDTILAIILSILLLRWAIILLKQSANVLLESSPVNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCH
EKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVRICDLKEFEKLSQDLSHKLLHEF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHH
KIGHITIQPIRSENEI
CCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]