Click here to switch to the map view.

The map label for this gene is lpxC [H]

Identifier: 153951460

GI number: 153951460

Start: 140648

End: 141532

Strand: Direct

Name: lpxC [H]

Synonym: JJD26997_0145

Alternate gene names: 153951460

Gene position: 140648-141532 (Clockwise)

Preceding gene: 153951237

Following gene: 153952600

Centisome position: 7.62

GC content: 31.07

Gene sequence:

>885_bases
ATGAAACAATTAACTTTAGTAAAAACTGTCAAAGGTGTAGGTATAGGACTTCATAAGGGTGAACCCATAGAAATTACTTT
AGAACCTTTAGAAGCAAATAGTGGTATAGTATTTTTTAGAAGTGATCTTAATGCAAGCTATAAGGCAAGTCCTGAAAATG
TGATCAATACTCAAATGGCAACTGTTTTAGGAGATGATCGTGGATTTATTTCTACAATAGAGCATTTAATGAGTGCGATT
AATGCTTATGGAATCGATAATGTACGCATAGTTTTAAATGCAAATGAAGCTCCTGTTATGGATGGATCAAGTATTAGTTT
TTGTATGATGCTTGATGAAGCAGGGGTAAAAGAACTTGATGCGCCTAAAAAAATTATGGTAATTAAAAAGCCTATAGAAG
TAAGAGATGGTAATAAATTTGTGCGTTTAACTCCTACTAAAGAACCCCGTATTAATTACACAATTAAATTTGACAATGCT
GTTATAGGTGAACAAAGTTACAATTTTGAATTTAGCAAAAAAAATTATATAGAAAACATAGCAAGGGCTAGAACTTTTGG
TTTTTTAAAAGATGTTCAAGCTCTTAGGAGTATGAATTTAGCACTAGGTGGAAGTTTAGAAAATACTATAGTGGTAGATG
AAAATCGTATTTTAAATCCTGAAGGTTTGCGTTTCAAAGATGAGTTTGTAAGACATAAAATTTTAGATGCAATTGGAGAT
TTAACCTTACTTGGATATCGTGTTTTTGGGGATTATACTTCATATGCTGGGAGTCATCATTTAAATCATTTACTCACTAA
AGAAGTTTTAAAAGATAAAGATGCTTATGAAATCGTAAGCCTTGAAAAAACAACCCAAAAAGCTTATGAAAAGGTATTTG
CATAA

Upstream 100 bases:

>100_bases
TTGAAACGCGTCCTGAACAATGGCAAGATAAAAAATGGATAGAAAATAATATTTACAATGTTTTAAATGATGGTAAAAAG
ATAATTTTAGGAAAAAATTA

Downstream 100 bases:

>100_bases
AAACCTCTCTTTTGCTTAATGCTTTATCTAAGCCTTTAATGATCGGAATTTATCAAGATGATAAACTTATAAAAACTTAT
AAAAGTGAAGAAAAAGCAAG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MKQLTLVKTVKGVGIGLHKGEPIEITLEPLEANSGIVFFRSDLNASYKASPENVINTQMATVLGDDRGFISTIEHLMSAI
NAYGIDNVRIVLNANEAPVMDGSSISFCMMLDEAGVKELDAPKKIMVIKKPIEVRDGNKFVRLTPTKEPRINYTIKFDNA
VIGEQSYNFEFSKKNYIENIARARTFGFLKDVQALRSMNLALGGSLENTIVVDENRILNPEGLRFKDEFVRHKILDAIGD
LTLLGYRVFGDYTSYAGSHHLNHLLTKEVLKDKDAYEIVSLEKTTQKAYEKVFA

Sequences:

>Translated_294_residues
MKQLTLVKTVKGVGIGLHKGEPIEITLEPLEANSGIVFFRSDLNASYKASPENVINTQMATVLGDDRGFISTIEHLMSAI
NAYGIDNVRIVLNANEAPVMDGSSISFCMMLDEAGVKELDAPKKIMVIKKPIEVRDGNKFVRLTPTKEPRINYTIKFDNA
VIGEQSYNFEFSKKNYIENIARARTFGFLKDVQALRSMNLALGGSLENTIVVDENRILNPEGLRFKDEFVRHKILDAIGD
LTLLGYRVFGDYTSYAGSHHLNHLLTKEVLKDKDAYEIVSLEKTTQKAYEKVFA
>Mature_294_residues
MKQLTLVKTVKGVGIGLHKGEPIEITLEPLEANSGIVFFRSDLNASYKASPENVINTQMATVLGDDRGFISTIEHLMSAI
NAYGIDNVRIVLNANEAPVMDGSSISFCMMLDEAGVKELDAPKKIMVIKKPIEVRDGNKFVRLTPTKEPRINYTIKFDNA
VIGEQSYNFEFSKKNYIENIARARTFGFLKDVQALRSMNLALGGSLENTIVVDENRILNPEGLRFKDEFVRHKILDAIGD
LTLLGYRVFGDYTSYAGSHHLNHLLTKEVLKDKDAYEIVSLEKTTQKAYEKVFA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=291, Percent_Identity=41.9243986254296, Blast_Score=248, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32911; Mature: 32911

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLTLVKTVKGVGIGLHKGEPIEITLEPLEANSGIVFFRSDLNASYKASPENVINTQMA
CCCEEHHHHHCCCEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHH
TVLGDDRGFISTIEHLMSAINAYGIDNVRIVLNANEAPVMDGSSISFCMMLDEAGVKELD
EEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCHHCC
APKKIMVIKKPIEVRDGNKFVRLTPTKEPRINYTIKFDNAVIGEQSYNFEFSKKNYIENI
CCCEEEEEECCEEEECCCEEEEEECCCCCCEEEEEEECCEEECCCCCCEEECHHHHHHHH
ARARTFGFLKDVQALRSMNLALGGSLENTIVVDENRILNPEGLRFKDEFVRHKILDAIGD
HHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEECCCCEECCCCCCHHHHHHHHHHHHHHCC
LTLLGYRVFGDYTSYAGSHHLNHLLTKEVLKDKDAYEIVSLEKTTQKAYEKVFA
HHHEEEHEECCHHHHCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQLTLVKTVKGVGIGLHKGEPIEITLEPLEANSGIVFFRSDLNASYKASPENVINTQMA
CCCEEHHHHHCCCEEECCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHH
TVLGDDRGFISTIEHLMSAINAYGIDNVRIVLNANEAPVMDGSSISFCMMLDEAGVKELD
EEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCHHCC
APKKIMVIKKPIEVRDGNKFVRLTPTKEPRINYTIKFDNAVIGEQSYNFEFSKKNYIENI
CCCEEEEEECCEEEECCCEEEEEECCCCCCEEEEEEECCEEECCCCCCEEECHHHHHHHH
ARARTFGFLKDVQALRSMNLALGGSLENTIVVDENRILNPEGLRFKDEFVRHKILDAIGD
HHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEECCCCEECCCCCCHHHHHHHHHHHHHHCC
LTLLGYRVFGDYTSYAGSHHLNHLLTKEVLKDKDAYEIVSLEKTTQKAYEKVFA
HHHEEEHEECCHHHHCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA