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The map label for this gene is uvrA [H]

Identifier: 153951046

GI number: 153951046

Start: 1428024

End: 1430849

Strand: Direct

Name: uvrA [H]

Synonym: JJD26997_1617

Alternate gene names: 153951046

Gene position: 1428024-1430849 (Clockwise)

Preceding gene: 153952056

Following gene: 153952247

Centisome position: 77.4

GC content: 34.54

Gene sequence:

>2826_bases
ATGAACGATACCATAAAAATCATTGGTGCAAGAGAAAATAACCTAAAAAATATCCATCTTGAAATTCCAAAAAATAAACT
CATTGTTTTTACAGGACTGAGTGGAAGTGGAAAATCAACCCTTGCTTTTGGCACTCTTTATGCTGAAGGACAACGCCGTT
ATATAGAAAGTTTAAGCGCTTATGCCAGACAATTTTTAGATAAGGTAGGTAAACCTGATGTTGATAAAATCGAAGGTTTA
ACTCCAGCCATTGCCATAGATCAAAAAACCACTTCTAAAAATCCACGCTCGACCGTAGGAACCATCACTGAAATTTACGA
TTATTTAAGACTTCTATATGCAAGAGTAGGTATTCAACATTGTCATCAATGCGGACAAAAAATTTCATCTATGAGTGCAA
GTGATATAGTCAATGAAATTTTAAAATTTCCAAAAGGTGCAAAAATCATCATCTACGCCCCACTCATACGAGAAAAAAAA
GGAACTTATGCAGATTTGCTTGAAAATTTACGCAACAAAGGCTATGTAAGAGCTCAAATCGATGGAGTTTTAGTAAGACT
TGATGAAGAAATTGAACTGGCCAAAACCAAAAAACACACCATCAAACTTGTCATAGATAGGCTTGAAATTCAAGAAGATT
TACTTTCTCGTCTTGCAAGCGATATAGAAAAAGGCTTACAAGAAAGCTTTGGAGAAATAGAAATAGAAGTTTTAAATCAC
GAAGAAATAAACCTTAATAAACACTATCATTTTAGCGAGCATTCGGCTTGTTTTGATTGTAAAATTTCTTTTGTTCCACT
TGAACCTTTAAGTTTTTCTTTTAATTCTCCAAAAGGTGCGTGTGAAGCTTGTGATGGACTTGGAATTCGTTATACTTTAG
ATATGAAAAAAATCATCGATGAAAGTTTAAGCCTCGAAAATGGTGCTGTTAAAATCATGTATGGTTTTAACAAAAGTTAT
TATTACAAATTCCTAATCGCCTTTTGCGAACAAAATGAAATTCCTATCAAAATACCTTTTGCGCAATTAAGTGAAGAACA
AAAACGCCTTGTATTATATGGTAATGCTAAGATTATAGAATTTCTTTGGAAAAGAAATCGTCTAAAACGCACTTTTGAAG
GCGTAGTTAAAATGGCTTATGAAATGCTAAAAGATGAAAAAGATTTAGCTGAATATATGAGTGAAAAAATTTGCAAAGAC
TGTGGTGGGCATCGTTTAAAACCAGAAAGTTTAGCTATAAAAGTAGCCAAAAAAGGTTTGGGTGAAATTTTGGATATGAG
CATAGAAGATAGTACGGCCTTTTTTGCAGATGAGAAAAATTTTTCCTATTTAAGTGAGCAGCAAAAACTTATTTCTAAAC
CCATTCTAAAAGAAATCAACGAAAGATTATTTTTCTTGTATGATGTGGGGCTAGGTTATCTTTCTTTAGGGCGTGACGCA
AGAACGATTAGCGGGGGTGAAGCACAAAGAATCCGCATAGCTTCACAAATTGGCAGTGGTTTAAGCGGGGTAATGTATGT
CTTAGATGAGCCTAGCATAGGACTTCATGAAAGAGATACTGCAAAACTGATTAAAACTTTAAGAAATTTACAACAAAAGG
GCAATACCCTAATTGTCGTAGAGCATGATAAAATGACCATAGAAGAAGCAGATTTTATTGTAGATATTGGCCCAAAAGCA
GGAAAATTTGGGGGTGAAGTTGTATTTAGTGGAACCTATAAGGAACTCTTAAAAAGCAAAAGCGAAACCGCACTTTATAT
GAATGGTAAAAAACAAATTTCACAACTTCAAAACAGAGCACAAAAAGAATGGCTTGAACTTAAAAATGTAAATATTAACA
ATATCCAAGATTTAAGCGTAAAATTTCCTTTACAAAATTTAGTCGCCATAACAGGAGTTTCAGGTTCTGGAAAAAGTTCT
TTGATACTTCAAACCTTACTTCCTTTTGCACAAGAGGAATTAAATCGTGCTAAAAAAGTTAAAAAACTTGGTGGAGTGCA
AATAGAAGGACTTGAAAAACTTGATAAAGTCATTTATCTTGATCAAAGCCCAATTGGGCGCACACCACGTTCAAATCCTG
CCACCTATACAGGCACTATGGATGAAATCAGAAATCTTTTTGCCGCCACCAAAGAAGCCAAAATGCGTGGTTATAAAGCA
GGACGCTTTTCTTTTAATGTCAAAGGTGGAAGATGTGAGAAATGTAGCGGAGATGGAGAAATCAAAATAGAAATGCATTT
TTTACCTGATGTTATGGTAGTTTGTGATACTTGCGGGGGCAAACGCTATAACGATGCCACGCTAGAAATCAAATATAAGG
GTAAAAACATCAGCGAAATTTTAAATATGAGTGTTTTAGAAGCGAGTGAATTTTTCACAGCCGTTCCTAAAATCAAGCAA
AAATTAGACACTCTAGTAAAAGTGGGTTTAGACTATCTAACTCTAGGACAAAATGCCACCACCTTAAGTGGGGGTGAAGC
ACAAAGAATCAAACTTGCTAAAGAATTAAGCCGTAGCGATACAGGAAAAACCCTTTATATACTTGATGAGCCTACAACAG
GACTGCATTTTGAAGATGTCAATAAACTCATCTTAGTTTTACAACATTTAGTTGATCTTAAAAATTCGGTTTTTGTGATA
GAGCATAATTTAGATGTGATTAAAAATGCGGATTATATCATCGATATGGGGCCTGAAGGTGGAGTTAAAGGAGGCAAGGT
TATTAGCACAGGAAGCGTGGAAAAAGTCTCTAAAGAACACAAAAAAACCCGTTCTTACACAGGGTATTATCTAGACTTAG
AGCTTAAAAATACACAAAAATCATAA

Upstream 100 bases:

>100_bases
TAATAAGCTAAATCTTATAAATTTTTAACTTGGATTTATCCAAGTTCTTTTAATATTATTATGCTAAAATCTTGGATTTA
TTTAATGTTTAGGAAAAACT

Downstream 100 bases:

>100_bases
TTCCATGTTTGATTTTTTATATAATAATATAAGTTATTTAGGACTTTTTATAGTGTGTTTTCTTTCAAGTACACTATTAC
CTTTAGCAAGCGAAGCCTTT

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 941; Mature: 941

Protein sequence:

>941_residues
MNDTIKIIGARENNLKNIHLEIPKNKLIVFTGLSGSGKSTLAFGTLYAEGQRRYIESLSAYARQFLDKVGKPDVDKIEGL
TPAIAIDQKTTSKNPRSTVGTITEIYDYLRLLYARVGIQHCHQCGQKISSMSASDIVNEILKFPKGAKIIIYAPLIREKK
GTYADLLENLRNKGYVRAQIDGVLVRLDEEIELAKTKKHTIKLVIDRLEIQEDLLSRLASDIEKGLQESFGEIEIEVLNH
EEINLNKHYHFSEHSACFDCKISFVPLEPLSFSFNSPKGACEACDGLGIRYTLDMKKIIDESLSLENGAVKIMYGFNKSY
YYKFLIAFCEQNEIPIKIPFAQLSEEQKRLVLYGNAKIIEFLWKRNRLKRTFEGVVKMAYEMLKDEKDLAEYMSEKICKD
CGGHRLKPESLAIKVAKKGLGEILDMSIEDSTAFFADEKNFSYLSEQQKLISKPILKEINERLFFLYDVGLGYLSLGRDA
RTISGGEAQRIRIASQIGSGLSGVMYVLDEPSIGLHERDTAKLIKTLRNLQQKGNTLIVVEHDKMTIEEADFIVDIGPKA
GKFGGEVVFSGTYKELLKSKSETALYMNGKKQISQLQNRAQKEWLELKNVNINNIQDLSVKFPLQNLVAITGVSGSGKSS
LILQTLLPFAQEELNRAKKVKKLGGVQIEGLEKLDKVIYLDQSPIGRTPRSNPATYTGTMDEIRNLFAATKEAKMRGYKA
GRFSFNVKGGRCEKCSGDGEIKIEMHFLPDVMVVCDTCGGKRYNDATLEIKYKGKNISEILNMSVLEASEFFTAVPKIKQ
KLDTLVKVGLDYLTLGQNATTLSGGEAQRIKLAKELSRSDTGKTLYILDEPTTGLHFEDVNKLILVLQHLVDLKNSVFVI
EHNLDVIKNADYIIDMGPEGGVKGGKVISTGSVEKVSKEHKKTRSYTGYYLDLELKNTQKS

Sequences:

>Translated_941_residues
MNDTIKIIGARENNLKNIHLEIPKNKLIVFTGLSGSGKSTLAFGTLYAEGQRRYIESLSAYARQFLDKVGKPDVDKIEGL
TPAIAIDQKTTSKNPRSTVGTITEIYDYLRLLYARVGIQHCHQCGQKISSMSASDIVNEILKFPKGAKIIIYAPLIREKK
GTYADLLENLRNKGYVRAQIDGVLVRLDEEIELAKTKKHTIKLVIDRLEIQEDLLSRLASDIEKGLQESFGEIEIEVLNH
EEINLNKHYHFSEHSACFDCKISFVPLEPLSFSFNSPKGACEACDGLGIRYTLDMKKIIDESLSLENGAVKIMYGFNKSY
YYKFLIAFCEQNEIPIKIPFAQLSEEQKRLVLYGNAKIIEFLWKRNRLKRTFEGVVKMAYEMLKDEKDLAEYMSEKICKD
CGGHRLKPESLAIKVAKKGLGEILDMSIEDSTAFFADEKNFSYLSEQQKLISKPILKEINERLFFLYDVGLGYLSLGRDA
RTISGGEAQRIRIASQIGSGLSGVMYVLDEPSIGLHERDTAKLIKTLRNLQQKGNTLIVVEHDKMTIEEADFIVDIGPKA
GKFGGEVVFSGTYKELLKSKSETALYMNGKKQISQLQNRAQKEWLELKNVNINNIQDLSVKFPLQNLVAITGVSGSGKSS
LILQTLLPFAQEELNRAKKVKKLGGVQIEGLEKLDKVIYLDQSPIGRTPRSNPATYTGTMDEIRNLFAATKEAKMRGYKA
GRFSFNVKGGRCEKCSGDGEIKIEMHFLPDVMVVCDTCGGKRYNDATLEIKYKGKNISEILNMSVLEASEFFTAVPKIKQ
KLDTLVKVGLDYLTLGQNATTLSGGEAQRIKLAKELSRSDTGKTLYILDEPTTGLHFEDVNKLILVLQHLVDLKNSVFVI
EHNLDVIKNADYIIDMGPEGGVKGGKVISTGSVEKVSKEHKKTRSYTGYYLDLELKNTQKS
>Mature_941_residues
MNDTIKIIGARENNLKNIHLEIPKNKLIVFTGLSGSGKSTLAFGTLYAEGQRRYIESLSAYARQFLDKVGKPDVDKIEGL
TPAIAIDQKTTSKNPRSTVGTITEIYDYLRLLYARVGIQHCHQCGQKISSMSASDIVNEILKFPKGAKIIIYAPLIREKK
GTYADLLENLRNKGYVRAQIDGVLVRLDEEIELAKTKKHTIKLVIDRLEIQEDLLSRLASDIEKGLQESFGEIEIEVLNH
EEINLNKHYHFSEHSACFDCKISFVPLEPLSFSFNSPKGACEACDGLGIRYTLDMKKIIDESLSLENGAVKIMYGFNKSY
YYKFLIAFCEQNEIPIKIPFAQLSEEQKRLVLYGNAKIIEFLWKRNRLKRTFEGVVKMAYEMLKDEKDLAEYMSEKICKD
CGGHRLKPESLAIKVAKKGLGEILDMSIEDSTAFFADEKNFSYLSEQQKLISKPILKEINERLFFLYDVGLGYLSLGRDA
RTISGGEAQRIRIASQIGSGLSGVMYVLDEPSIGLHERDTAKLIKTLRNLQQKGNTLIVVEHDKMTIEEADFIVDIGPKA
GKFGGEVVFSGTYKELLKSKSETALYMNGKKQISQLQNRAQKEWLELKNVNINNIQDLSVKFPLQNLVAITGVSGSGKSS
LILQTLLPFAQEELNRAKKVKKLGGVQIEGLEKLDKVIYLDQSPIGRTPRSNPATYTGTMDEIRNLFAATKEAKMRGYKA
GRFSFNVKGGRCEKCSGDGEIKIEMHFLPDVMVVCDTCGGKRYNDATLEIKYKGKNISEILNMSVLEASEFFTAVPKIKQ
KLDTLVKVGLDYLTLGQNATTLSGGEAQRIKLAKELSRSDTGKTLYILDEPTTGLHFEDVNKLILVLQHLVDLKNSVFVI
EHNLDVIKNADYIIDMGPEGGVKGGKVISTGSVEKVSKEHKKTRSYTGYYLDLELKNTQKS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=935, Percent_Identity=51.2299465240642, Blast_Score=901, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 105502; Mature: 105502

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTIKIIGARENNLKNIHLEIPKNKLIVFTGLSGSGKSTLAFGTLYAEGQRRYIESLSA
CCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEEEHHHHHHHHHHHHH
YARQFLDKVGKPDVDKIEGLTPAIAIDQKTTSKNPRSTVGTITEIYDYLRLLYARVGIQH
HHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CHQCGQKISSMSASDIVNEILKFPKGAKIIIYAPLIREKKGTYADLLENLRNKGYVRAQI
HHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHCCCCCHHHHHHHHHHCCEEEEEE
DGVLVRLDEEIELAKTKKHTIKLVIDRLEIQEDLLSRLASDIEKGLQESFGEIEIEVLNH
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
EEINLNKHYHFSEHSACFDCKISFVPLEPLSFSFNSPKGACEACDGLGIRYTLDMKKIID
CEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEEECHHHHHH
ESLSLENGAVKIMYGFNKSYYYKFLIAFCEQNEIPIKIPFAQLSEEQKRLVLYGNAKIIE
HHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHCCCCCEEEEECCHHHHH
FLWKRNRLKRTFEGVVKMAYEMLKDEKDLAEYMSEKICKDCGGHRLKPESLAIKVAKKGL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GEILDMSIEDSTAFFADEKNFSYLSEQQKLISKPILKEINERLFFLYDVGLGYLSLGRDA
HHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHCCCCC
RTISGGEAQRIRIASQIGSGLSGVMYVLDEPSIGLHERDTAKLIKTLRNLQQKGNTLIVV
CCCCCCCHHHEEEHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
EHDKMTIEEADFIVDIGPKAGKFGGEVVFSGTYKELLKSKSETALYMNGKKQISQLQNRA
ECCCEEEECCCEEEEECCCCCCCCCEEEECCHHHHHHCCCCCCEEEECCHHHHHHHHHHH
QKEWLELKNVNINNIQDLSVKFPLQNLVAITGVSGSGKSSLILQTLLPFAQEELNRAKKV
HHHHHHHCCCCCCCEEEEEEECCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KKLGGVQIEGLEKLDKVIYLDQSPIGRTPRSNPATYTGTMDEIRNLFAATKEAKMRGYKA
HHHCCCEEECHHHHCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCC
GRFSFNVKGGRCEKCSGDGEIKIEMHFLPDVMVVCDTCGGKRYNDATLEIKYKGKNISEI
CEEEEEECCCCCCCCCCCCEEEEEEEECCCEEHEEECCCCCEECCCEEEEEECCCCHHHH
LNMSVLEASEFFTAVPKIKQKLDTLVKVGLDYLTLGQNATTLSGGEAQRIKLAKELSRSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCC
TGKTLYILDEPTTGLHFEDVNKLILVLQHLVDLKNSVFVIEHNLDVIKNADYIIDMGPEG
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCEEEEECCCC
GVKGGKVISTGSVEKVSKEHKKTRSYTGYYLDLELKNTQKS
CCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MNDTIKIIGARENNLKNIHLEIPKNKLIVFTGLSGSGKSTLAFGTLYAEGQRRYIESLSA
CCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEEEHHHHHHHHHHHHH
YARQFLDKVGKPDVDKIEGLTPAIAIDQKTTSKNPRSTVGTITEIYDYLRLLYARVGIQH
HHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CHQCGQKISSMSASDIVNEILKFPKGAKIIIYAPLIREKKGTYADLLENLRNKGYVRAQI
HHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCHHCCCCCHHHHHHHHHHCCEEEEEE
DGVLVRLDEEIELAKTKKHTIKLVIDRLEIQEDLLSRLASDIEKGLQESFGEIEIEVLNH
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
EEINLNKHYHFSEHSACFDCKISFVPLEPLSFSFNSPKGACEACDGLGIRYTLDMKKIID
CEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEEECHHHHHH
ESLSLENGAVKIMYGFNKSYYYKFLIAFCEQNEIPIKIPFAQLSEEQKRLVLYGNAKIIE
HHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHCCCCCEEEEECCHHHHH
FLWKRNRLKRTFEGVVKMAYEMLKDEKDLAEYMSEKICKDCGGHRLKPESLAIKVAKKGL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GEILDMSIEDSTAFFADEKNFSYLSEQQKLISKPILKEINERLFFLYDVGLGYLSLGRDA
HHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHCCCCC
RTISGGEAQRIRIASQIGSGLSGVMYVLDEPSIGLHERDTAKLIKTLRNLQQKGNTLIVV
CCCCCCCHHHEEEHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
EHDKMTIEEADFIVDIGPKAGKFGGEVVFSGTYKELLKSKSETALYMNGKKQISQLQNRA
ECCCEEEECCCEEEEECCCCCCCCCEEEECCHHHHHHCCCCCCEEEECCHHHHHHHHHHH
QKEWLELKNVNINNIQDLSVKFPLQNLVAITGVSGSGKSSLILQTLLPFAQEELNRAKKV
HHHHHHHCCCCCCCEEEEEEECCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KKLGGVQIEGLEKLDKVIYLDQSPIGRTPRSNPATYTGTMDEIRNLFAATKEAKMRGYKA
HHHCCCEEECHHHHCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCC
GRFSFNVKGGRCEKCSGDGEIKIEMHFLPDVMVVCDTCGGKRYNDATLEIKYKGKNISEI
CEEEEEECCCCCCCCCCCCEEEEEEEECCCEEHEEECCCCCEECCCEEEEEECCCCHHHH
LNMSVLEASEFFTAVPKIKQKLDTLVKVGLDYLTLGQNATTLSGGEAQRIKLAKELSRSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCC
TGKTLYILDEPTTGLHFEDVNKLILVLQHLVDLKNSVFVIEHNLDVIKNADYIIDMGPEG
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHCCCCCEEEEECCCC
GVKGGKVISTGSVEKVSKEHKKTRSYTGYYLDLELKNTQKS
CCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]