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The map label for this gene is serA [H]

Identifier: 153950933

GI number: 153950933

Start: 3049613

End: 3050563

Strand: Direct

Name: serA [H]

Synonym: YpsIP31758_2694

Alternate gene names: 153950933

Gene position: 3049613-3050563 (Clockwise)

Preceding gene: 153946832

Following gene: 153950308

Centisome position: 64.57

GC content: 59.73

Gene sequence:

>951_bases
ATGAGATTGGTCGTCACCGATCAGGCTTTCGGCAATACCGTTTATGAACAAGCAGCGGCCAACGCGGTTGGTGCCGATTT
CGCCGCCTATCAATGCCGCACTGAAGATGAAACGCGGGATGCCGTGCAGGGCGCAGATGTCGTGTTGAACAACTTCGCCC
CGATGACCGAGTGGGTGATGGCGGCCATGCCCCCCGGCGCGGTGATCGTGCGGTACGGCGTCGGTGTCGATAACATCGAT
CTCTCTGCGGCCAGAAAACGGGGTATGCGTATTTGTAATGTGCCGGATTACGGCATTGAAGAGGTTGCCGACCATGCCGC
CGCCATGACATTGGCGTTAGCACGCAAACTGGGGCGCTACGAGGCAGGGATCCGTAGCGGCAGGTGGGAAATTGACCAGA
TGGTCGATGGTGTGCGGTCATTGCGTGACACCACGGTAGGGCTGATCGGCCTTGGGCGCATCGCGCGCGCCTATGCAACA
CGAATGGCGGTTTTCGGGTGCCGCATCATCGGCTTCGACCCGTATGTCACTGAGACAGAAGCCCGTTCGGCGGGGATCGA
GCCGCTGCCACAGGATAAGGTCATCGCCTCAGCCCATATACTGTCGCTACATGTTCCGCTAACGCCTGAAACTCGCGACC
TGATCGATACCACCGCTATCGCACGTATGCCTGAGGGCGCGATCCTGATCAACTGCGCCCGTGGCGGGCTGGTGAATGAG
GCGGCCTTAATCGAGGCATTGACCCGTGGCCACCTATCGGGGGCCGGACTCGATGTCTTCGAGCAAGAACCCCTCCCAGC
TGATTCGGCCTTGCGTAAAGCGCCCCATCTCCTTCTCTCGCCCCATGCCGCTTTTTTCTCGGATGCGTCGGTCAAAAAAC
TGCAACAACTGGCTTCTGAAGAGGCCCTACGGGGACTGCGCGGTGAGCCACTGCGCTGCCCACTGACTTAA

Upstream 100 bases:

>100_bases
ATACAGTGGTCTACTCCGACGAGGCCGTTCCCTGGACCTACGGAACCCGGGCGCTGATGCGTAACCTTACTAAGCGGGGG
GTGCTGTGAGCGAATCAAAA

Downstream 100 bases:

>100_bases
GGAGAAGAGGATGAATGACCACAAAAAGCGGTCTGATCTCGAAAAGCGATCTGATCTCGAAAAACAGTCTTATCCCGAAA
AACAGTCTTATACCGAAAAA

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTEWVMAAMPPGAVIVRYGVGVDNID
LSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIARAYAT
RMAVFGCRIIGFDPYVTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGGLVNE
AALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASEEALRGLRGEPLRCPLT

Sequences:

>Translated_316_residues
MRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTEWVMAAMPPGAVIVRYGVGVDNID
LSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIARAYAT
RMAVFGCRIIGFDPYVTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGGLVNE
AALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASEEALRGLRGEPLRCPLT
>Mature_316_residues
MRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTEWVMAAMPPGAVIVRYGVGVDNID
LSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIARAYAT
RMAVFGCRIIGFDPYVTETEARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGGLVNE
AALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASEEALRGLRGEPLRCPLT

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=234, Percent_Identity=37.1794871794872, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=37.3493975903614, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=37.3493975903614, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=36.144578313253, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=36.144578313253, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=37.3493975903614, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=31.8548387096774, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1787645, Length=253, Percent_Identity=29.2490118577075, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082289, Length=227, Percent_Identity=33.4801762114537, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789279, Length=253, Percent_Identity=28.0632411067194, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081824, Length=224, Percent_Identity=30.8035714285714, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=33.7164750957854, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=32.156862745098, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=31.0077519379845, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=223, Percent_Identity=27.8026905829596, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322116, Length=223, Percent_Identity=26.9058295964126, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=229, Percent_Identity=27.5109170305677, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646446, Length=250, Percent_Identity=40.4, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646448, Length=250, Percent_Identity=40.4, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646452, Length=250, Percent_Identity=40.4, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646450, Length=250, Percent_Identity=40.4, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=40.4, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19921140, Length=238, Percent_Identity=35.2941176470588, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=31.0606060606061, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24585516, Length=288, Percent_Identity=29.5138888888889, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI28571528, Length=253, Percent_Identity=31.2252964426877, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=27.719298245614, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=27.719298245614, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=27.719298245614, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=27.719298245614, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=27.719298245614, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 33960; Mature: 33960

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTEWVM
CEEEEECHHHHHHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHHHHCCCHHHHHHH
AAMPPGAVIVRYGVGVDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRY
HHCCCCEEEEEECCCCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIARAYATRMAVFGCRIIGFDPYVTETE
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCH
ARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGGLVNE
HHHCCCCCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
AALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASE
HHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHCCCEEECCCHHHHCCHHHHHHHHHHHH
EALRGLRGEPLRCPLT
HHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRLVVTDQAFGNTVYEQAAANAVGADFAAYQCRTEDETRDAVQGADVVLNNFAPMTEWVM
CEEEEECHHHHHHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHHHHCCCHHHHHHH
AAMPPGAVIVRYGVGVDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRY
HHCCCCEEEEEECCCCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
EAGIRSGRWEIDQMVDGVRSLRDTTVGLIGLGRIARAYATRMAVFGCRIIGFDPYVTETE
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCH
ARSAGIEPLPQDKVIASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGGLVNE
HHHCCCCCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
AALIEALTRGHLSGAGLDVFEQEPLPADSALRKAPHLLLSPHAAFFSDASVKKLQQLASE
HHHHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHCCCEEECCCHHHHCCHHHHHHHHHHHH
EALRGLRGEPLRCPLT
HHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]