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The map label for this gene is glpK2 [H]

Identifier: 153950616

GI number: 153950616

Start: 3654210

End: 3655697

Strand: Reverse

Name: glpK2 [H]

Synonym: YpsIP31758_3247

Alternate gene names: 153950616

Gene position: 3655697-3654210 (Counterclockwise)

Preceding gene: 153947995

Following gene: 153946842

Centisome position: 77.4

GC content: 56.18

Gene sequence:

>1488_bases
ATGTCAACGCCAATCATTCTGGCTATTGATGAAGGGACAACCAACGCCAAAGCCATTGCGGTAGATCGTGCCGGGCGAGT
TCTGGCGAAAGCCTCGGTACCATTACAACTGGAACATCCTCAGCCCGGTTGGGCAGAACAGGATCCGCTGGCGATTTGGC
TGGCGGTTTCTCAGGTGGTTGAGGGGTGCCTAAATCAATTGGCGGGCGCACAGGTGGCGGGGATTGCCATCAGTAATCAG
CGTGAATCGGTACTGATTTGGGAACGGGAAACCGGCACGCCGCTCACGCCAGTCGTAAGCTGGCAGTGCCGTCGTTCAGA
GGCTTTCTGTCTGGCTTTGCGCCAATTACCGGCTGCGGCGATGGTTGCGGAACGGACTGGATTGCAGATTGATCCCCTGT
TTCCTGCGGCTAAAATTCATGGCATGTTGGCGCAGATCCCTCATGGCGCTGAACGTGCCGCTCACGGTGAGCTGTGTGTT
GGCACGCTTGATTGCTGGCTGACCTGGCAGTTTAGCGAAGGGCAAAGTTTCTCGACTGACTTCTCTAATGCGGCCCGGAC
CCAGCTGTTTAATATCCATTCAGGTCAATGGGACCCCGATTTACTGGCGCTGTTTGGTATCCCAAGTCTTTGCCTGCCCG
CCGTCTTACCCTCGGCATCCATCCACGGACACACCGCGCGCACCGGGATTCTCGGCCTGGAGCAGGGCGTGCCTATCGTG
GCACACATTGGTGATTCGCACGCCGCGCTGTACGGGCAAGGCGGCGACCAGGCCGGTGAAATCAAAGCCACTTATGGCAC
CGGCTCCTCTCTGATGATGACCCTAAAACAGGCCAGTGCACCAAGCCACGGCCTAAGCACCACCATTGCCTGGCATGACG
GCGAATTACGCTATGCCCTTGAAGGCAACATCACCCATACCGGCTCAGGAGTGGCATGGGTCTCGCGCATATTAGGGATC
AGTGATTTGTCACGTCTGACTGACATGGCAGAAAGCCAATCAGGTAATCAAGGCGTCTATTTTGTACCGGCATTATCAGG
ACTAGGTGCGCCTTATTGGGACAGTCAGGCGCGTGGTTTGTTCTGTGGTCTGACGGATGCCACGACACCGGCAGTACTGG
CGCGAGCGGCACTTGAATCAGTCGCTTATCAAATAGCCGATGTTTTCTTTGCGATGGAGAATGCGGCTCATCATCGCCTT
GAACGGCTGCGGGTTGATGGCGGTGCGACCAGTAATCGCTGGCTGATGCAGTTTCAGGCCGATTTATTACAGCGCACATT
GATACGTAATCACACGGCAGAAGTGTCAGCACTGGGTGCCGCGTATTTGGGCGGGAAAACCCTTGGCTGGTGGCAGGATA
GCCAACAACTGGCTGCGCTCCCCCGTGAAGTGGAATACATCGAACCGCGCATTCACAGTGCGGAGATGCAAGATAACTAT
AGCCTCTGGCAAACGGCCATCGCGCGTGCGCGTTTTCAGCCGAAATAA

Upstream 100 bases:

>100_bases
ATGCGATTGCCGCTGATCGGGCTGAGATGCGTGCCTATCATGGTTTTGATGCGGCAGGCATTGTGGCTCGTGCTCTGCGG
TTTTGCCGAGGGGAATAACG

Downstream 100 bases:

>100_bases
CCCACACTAGGAGTAAGCATATGTCAGCAATACCTCGCAAGTTAACTTTTGCGGTGATTATCGGCAATCGGGGTTTCTTC
CCAAGCTATCTGGTGAGCGA

Product: carbohydrate kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase 2; Glycerokinase 2; GK 2 [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSTPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQVVEGCLNQLAGAQVAGIAISNQ
RESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAAMVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCV
GTLDCWLTWQFSEGQSFSTDFSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQASAPSHGLSTTIAWHDGELRYALEGNITHTGSGVAWVSRILGI
SDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGLFCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRL
ERLRVDGGATSNRWLMQFQADLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
SLWQTAIARARFQPK

Sequences:

>Translated_495_residues
MSTPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQVVEGCLNQLAGAQVAGIAISNQ
RESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAAMVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCV
GTLDCWLTWQFSEGQSFSTDFSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQASAPSHGLSTTIAWHDGELRYALEGNITHTGSGVAWVSRILGI
SDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGLFCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRL
ERLRVDGGATSNRWLMQFQADLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
SLWQTAIARARFQPK
>Mature_494_residues
STPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQVVEGCLNQLAGAQVAGIAISNQR
ESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAAMVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCVG
TLDCWLTWQFSEGQSFSTDFSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIVA
HIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQASAPSHGLSTTIAWHDGELRYALEGNITHTGSGVAWVSRILGIS
DLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGLFCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRLE
RLRVDGGATSNRWLMQFQADLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNYS
LWQTAIARARFQPK

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=511, Percent_Identity=36.0078277886497, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI189409120, Length=506, Percent_Identity=36.1660079051383, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI4504007, Length=506, Percent_Identity=36.1660079051383, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI41393575, Length=506, Percent_Identity=36.3636363636364, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI88196792, Length=515, Percent_Identity=28.5436893203883, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=40.1622718052738, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1789168, Length=487, Percent_Identity=23.6139630390144, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1789987, Length=447, Percent_Identity=26.3982102908277, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790005, Length=499, Percent_Identity=25.6513026052104, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17535599, Length=448, Percent_Identity=30.8035714285714, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71986140, Length=515, Percent_Identity=24.0776699029126, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71986147, Length=257, Percent_Identity=29.9610894941634, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321755, Length=547, Percent_Identity=27.4223034734918, Blast_Score=179, Evalue=8e-46,
Organism=Drosophila melanogaster, GI17864214, Length=515, Percent_Identity=34.1747572815534, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24654573, Length=464, Percent_Identity=33.6206896551724, Blast_Score=251, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24655555, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655560, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655570, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655574, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655565, Length=510, Percent_Identity=31.1764705882353, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24656367, Length=514, Percent_Identity=28.5992217898833, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21357867, Length=533, Percent_Identity=27.9549718574109, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19922058, Length=518, Percent_Identity=28.1853281853282, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24652871, Length=491, Percent_Identity=28.1059063136456, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24656372, Length=347, Percent_Identity=30.835734870317, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45552909, Length=261, Percent_Identity=29.5019157088123, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 53262; Mature: 53131

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQVV
CCCCEEEEECCCCCCCEEEEEECCCCEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHH
EGCLNQLAGAQVAGIAISNQRESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAA
HHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHCCHHH
MVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCVGTLDCWLTWQFSEGQSFSTD
HHHHHCCCEECCCCCHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEEEEEECCCCCCCCC
FSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
CCHHHHHEEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHCCEECCCCCEEE
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQASAPSHGLSTTIAWHDGELRYAL
EEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEE
EGNITHTGSGVAWVSRILGISDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGL
ECCEEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEE
FCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRLERLRVDGGATSNRWLMQFQA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHH
DLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHCCCCCCCCCCCCH
SLWQTAIARARFQPK
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
STPIILAIDEGTTNAKAIAVDRAGRVLAKASVPLQLEHPQPGWAEQDPLAIWLAVSQVV
CCCEEEEECCCCCCCEEEEEECCCCEEEECCCCEEECCCCCCCCCCCCHHHHHHHHHHH
EGCLNQLAGAQVAGIAISNQRESVLIWERETGTPLTPVVSWQCRRSEAFCLALRQLPAAA
HHHHHHHCCCEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHCCHHH
MVAERTGLQIDPLFPAAKIHGMLAQIPHGAERAAHGELCVGTLDCWLTWQFSEGQSFSTD
HHHHHCCCEECCCCCHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEEEEEECCCCCCCCC
FSNAARTQLFNIHSGQWDPDLLALFGIPSLCLPAVLPSASIHGHTARTGILGLEQGVPIV
CCHHHHHEEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHCCEECCCCCEEE
AHIGDSHAALYGQGGDQAGEIKATYGTGSSLMMTLKQASAPSHGLSTTIAWHDGELRYAL
EEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEE
EGNITHTGSGVAWVSRILGISDLSRLTDMAESQSGNQGVYFVPALSGLGAPYWDSQARGL
ECCEEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEE
FCGLTDATTPAVLARAALESVAYQIADVFFAMENAAHHRLERLRVDGGATSNRWLMQFQA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHH
DLLQRTLIRNHTAEVSALGAAYLGGKTLGWWQDSQQLAALPREVEYIEPRIHSAEMQDNY
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHCCHHHHHHCCCCCCCCCCCCH
SLWQTAIARARFQPK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]