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The map label for this gene is wecB [H]

Identifier: 153950612

GI number: 153950612

Start: 208148

End: 209278

Strand: Direct

Name: wecB [H]

Synonym: YpsIP31758_0184

Alternate gene names: 153950612

Gene position: 208148-209278 (Clockwise)

Preceding gene: 153948268

Following gene: 153947394

Centisome position: 4.41

GC content: 50.04

Gene sequence:

>1131_bases
GTGAAAGTGTTGACTGTTTTTGGCACCCGTCCTGAAGCGATAAAGATGGCTCCTCTGGTGCATGCCTTGGCTCAGGATGA
CGCCTTTGAATCGAGAGTCTGCGTAACGGCCCAGCATCGTGAGATGCTGGATCAGGTATTGCGTTTATTTGAGATTCAAC
CAGATTATGATTTAGACATCATGAGGCCAGGACAGGGATTGACGGAAATAACCTGCCGCATTCTGGAAGGGCTAAAGCCG
GTTCTCGAAGAGTTTAAGCCGGATGTTATCTTGGTGCATGGCGATACCACAACCACACTGTCGGCCAGTCTGGCCGGGTT
CTATCACCGCATACCTGTCGGCCATGTCGAGGCTGGGCTGCGGACCGGGGATCTCTATTCTCCATGGCCGGAGGAAGCTA
ACCGTCAACTGACTGGGCATCTTGCCATGTATCATTTTGCGCCGACCGAGAATTCTCGACAGAATTTGCTACGTGAATTG
GTGCCGGAGAACCGTATTTTTGTCACGGGTAATACGGTGATTGATGCGTTGTTCTGGGTCCGTGATCGGGTGATGAATAC
CCCTGATTTGCGAGCAAACTTGGCACAACGTTACGCCTTCCTTGATACCAATAAGAAGATGATTCTGGTTACTGGCCATC
GTCGTGAAAGCTTTGGTGGTGGTTTTGAGCGGATTTGCAGTGCGTTAGCGGAAATTGCCCGGAAACATCCCGAGGTGCAG
GTTGTTTATCCCGTGCATCTTAACCCCAACGTCAGCGAGCCGGTAAACCGTATCTTGAAGGGGATTGATAATATTATTCT
GATCGATCCGCAAGACTACCTGCCATTTGTTTACCTAATGAATCATGCGTATCTGATCCTGACTGACTCAGGGGGTATTC
AGGAAGAAGCGCCGTCATTGGGTAAACCTGTCTTGGTGATGCGTGACACCACCGAGCGCCCGGAAGCCGTAGATTCTGGC
ACTGTGCTGCTGGTGGGGACAAATATTAATAAAATTGTTGATGCAGTAACCCGCTTGCTGACTGATGAGACGGCTTATCA
TCAAATGACCCGGGCACACAATCCTTACGGTGACGGGTATGCCTGTCAACGCATCCTTAAAGCTTTAAAGAATCATCAGG
TGACGCTATGA

Upstream 100 bases:

>100_bases
TATCGAGTCACGCACTGAGCGACAAGAAATCGTTAATGGACGCATTGTGCGCCCAACTTGCAGGCATTGCCTGCGGCTAA
CTGACCTAAAGAGATTCACT

Downstream 100 bases:

>100_bases
GTTTTGAAACTATTTCTGTTATCGGTCTTGGGTATATTGGTCTGCCGACCGCGGCGGCTTTTGCTTCGCGTAAAAAGAAA
GTGATTGGCGTTGACGTCAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKP
VLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREL
VPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL

Sequences:

>Translated_376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKP
VLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREL
VPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL
>Mature_376_residues
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDIMRPGQGLTEITCRILEGLKP
VLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGLRTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLREL
VPENRIFVTGNTVIDALFWVRDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVDSG
TVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGYACQRILKALKNHQVTL

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=376, Percent_Identity=78.7234042553192, Blast_Score=608, Evalue=1e-175,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42306; Mature: 42306

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEE
MRPGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLRELVPENRIFVTGNTVIDALFWV
CCCCCCCCCCHHHCCHHEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHH
RDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
HHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEE
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHCCHHHHHCCEEEEEECCCCCCCCCCCC
GKPVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGY
CCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCH
ACQRILKALKNHQVTL
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKVLTVFGTRPEAIKMAPLVHALAQDDAFESRVCVTAQHREMLDQVLRLFEIQPDYDLDI
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEE
MRPGQGLTEITCRILEGLKPVLEEFKPDVILVHGDTTTTLSASLAGFYHRIPVGHVEAGL
ECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHHCCC
RTGDLYSPWPEEANRQLTGHLAMYHFAPTENSRQNLLRELVPENRIFVTGNTVIDALFWV
CCCCCCCCCCHHHCCHHEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHH
RDRVMNTPDLRANLAQRYAFLDTNKKMILVTGHRRESFGGGFERICSALAEIARKHPEVQ
HHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEE
VVYPVHLNPNVSEPVNRILKGIDNIILIDPQDYLPFVYLMNHAYLILTDSGGIQEEAPSL
EEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHCCHHHHHCCEEEEEECCCCCCCCCCCC
GKPVLVMRDTTERPEAVDSGTVLLVGTNINKIVDAVTRLLTDETAYHQMTRAHNPYGDGY
CCCEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCH
ACQRILKALKNHQVTL
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]