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The map label for this gene is ddhD [H]

Identifier: 153950337

GI number: 153950337

Start: 3436571

End: 3437560

Strand: Reverse

Name: ddhD [H]

Synonym: YpsIP31758_3052

Alternate gene names: 153950337

Gene position: 3437560-3436571 (Counterclockwise)

Preceding gene: 153950660

Following gene: 153950020

Centisome position: 72.78

GC content: 37.47

Gene sequence:

>990_bases
ATGTCATTAAATGTTAAGCTGCATCCATCAGGTATTATTTTTACTTCCGATGGAACATCTACAATATTAGATGCGGCTCT
GGATAGTAATATACATATTGAATATAGCTGCAAAGATGGAACCTGTGGTTCTTGTAAGGCAATATTGATTTCTGGTGAAG
TAGACAGTGCGGAAAATACCTTTTTAACTGAGGAAGATGTTGCTAAAGGTGCAATCCTCACTTGTTGCTCTAAGGCTAAA
TCTGATATTGAGTTAGATGTTAATTATTATCCAGAGTTAAGTCATATACAAAAAAAAACTTACCCATGTAAATTAGATAG
CATTGAATTTGTTGGTGAAGATATTGCCATTCTCTCCTTACGTTTGCCACCAACGGCCAAAATACAGTATCTAGCGGGCC
AATACATTGATTTAATTATTAATGGACAGCGTCGTAGTTACTCTATTGCTAATGCTCCAGGTGGTAATGGCAATATCGAA
TTACACGTACGTAAAGTCGTTAATGGTGTATTCAGCAACATCATTTTTAATGAGTTAAAATTACAGCAACTTTTACGAAT
TGAAGGTCCTCAAGGGACCTTTTTCGTTCGTGAAGATAATCTCCCTATTGTTTTTCTTGCTGGTGGAACAGGTTTTGCAC
CAGTGAAATCAATGGTTGAGGCGTTGATCAATAAAAATGACCAACGGCAGGTTCATATCTATTGGGGAATGCCAGCAGGG
CATAATTTCTATTCTGACATTGCCAATGAGTGGGCTATAAAACACCCTAACATTCATTATGTGCCTGTTGTATCAGGCGA
TGATAGTACTTGGACCGGAGCCACTGGTTTTGTACATCAAGCGGTGCTTGAAGATATACCCGATCTCAGCTTATTTAATG
TTTATGCCTGTGGTTCATTAGCGATGATTACTGCTGCTCGTAATGATTTCATCAATCATGGATTAGCTGAAAATAAATTT
TTCTCTGATGCCTTTGTGCCATCAAAATAA

Upstream 100 bases:

>100_bases
ATTTGCTTTTTTGTTTCTATTTTAGTCACTGAATTTTTTTGACTTAAGTTTGTATTGAGTACGTCTAATAAACCTTACAT
AATATATTTGGACTTATTTT

Downstream 100 bases:

>100_bases
CTTTGAGAGATCAAAGTAATACGTAATGGAGATTCAAGTGAAAGCAGTCATTTTGGCCGGAGGCCTTGGAACCCGTCTTA
GTGAAGAGACCGTAGTAAAA

Product: CDP-6-deoxy-delta-3,4-glucoseen reductase

Products: NAD(P); FMNH2; 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: CDP-6-deoxy-delta-3,4-glucoseen reductase; E3 [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSLNVKLHPSGIIFTSDGTSTILDAALDSNIHIEYSCKDGTCGSCKAILISGEVDSAENTFLTEEDVAKGAILTCCSKAK
SDIELDVNYYPELSHIQKKTYPCKLDSIEFVGEDIAILSLRLPPTAKIQYLAGQYIDLIINGQRRSYSIANAPGGNGNIE
LHVRKVVNGVFSNIIFNELKLQQLLRIEGPQGTFFVREDNLPIVFLAGGTGFAPVKSMVEALINKNDQRQVHIYWGMPAG
HNFYSDIANEWAIKHPNIHYVPVVSGDDSTWTGATGFVHQAVLEDIPDLSLFNVYACGSLAMITAARNDFINHGLAENKF
FSDAFVPSK

Sequences:

>Translated_329_residues
MSLNVKLHPSGIIFTSDGTSTILDAALDSNIHIEYSCKDGTCGSCKAILISGEVDSAENTFLTEEDVAKGAILTCCSKAK
SDIELDVNYYPELSHIQKKTYPCKLDSIEFVGEDIAILSLRLPPTAKIQYLAGQYIDLIINGQRRSYSIANAPGGNGNIE
LHVRKVVNGVFSNIIFNELKLQQLLRIEGPQGTFFVREDNLPIVFLAGGTGFAPVKSMVEALINKNDQRQVHIYWGMPAG
HNFYSDIANEWAIKHPNIHYVPVVSGDDSTWTGATGFVHQAVLEDIPDLSLFNVYACGSLAMITAARNDFINHGLAENKF
FSDAFVPSK
>Mature_328_residues
SLNVKLHPSGIIFTSDGTSTILDAALDSNIHIEYSCKDGTCGSCKAILISGEVDSAENTFLTEEDVAKGAILTCCSKAKS
DIELDVNYYPELSHIQKKTYPCKLDSIEFVGEDIAILSLRLPPTAKIQYLAGQYIDLIINGQRRSYSIANAPGGNGNIEL
HVRKVVNGVFSNIIFNELKLQQLLRIEGPQGTFFVREDNLPIVFLAGGTGFAPVKSMVEALINKNDQRQVHIYWGMPAGH
NFYSDIANEWAIKHPNIHYVPVVSGDDSTWTGATGFVHQAVLEDIPDLSLFNVYACGSLAMITAARNDFINHGLAENKFF
SDAFVPSK

Specific function: Participates in the conversion of CDP-6-deoxy-D-glycero- L-threo-4-hexulose to 3,6-dideoxy-D-glycero-D-glycero-4-hexulose together with CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) in two consecutive steps. The detailed mechanism of E3 is not

COG id: COG0543

COG function: function code HC; 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI2367314, Length=230, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322146, Length=194, Percent_Identity=28.8659793814433, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.5.1.29 [C]

Molecular weight: Translated: 36033; Mature: 35902

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNVKLHPSGIIFTSDGTSTILDAALDSNIHIEYSCKDGTCGSCKAILISGEVDSAENT
CCEEEEECCCEEEEECCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCC
FLTEEDVAKGAILTCCSKAKSDIELDVNYYPELSHIQKKTYPCKLDSIEFVGEDIAILSL
EECHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCHHCCCCCEEEEEE
RLPPTAKIQYLAGQYIDLIINGQRRSYSIANAPGGNGNIELHVRKVVNGVFSNIIFNELK
ECCCCCEEEEECCCEEEEEEECCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
LQQLLRIEGPQGTFFVREDNLPIVFLAGGTGFAPVKSMVEALINKNDQRQVHIYWGMPAG
HHHHHEECCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCC
HNFYSDIANEWAIKHPNIHYVPVVSGDDSTWTGATGFVHQAVLEDIPDLSLFNVYACGSL
CHHHHHHHHHCEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCE
AMITAARNDFINHGLAENKFFSDAFVPSK
EEEEEHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLNVKLHPSGIIFTSDGTSTILDAALDSNIHIEYSCKDGTCGSCKAILISGEVDSAENT
CEEEEECCCEEEEECCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCC
FLTEEDVAKGAILTCCSKAKSDIELDVNYYPELSHIQKKTYPCKLDSIEFVGEDIAILSL
EECHHHHHCCHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCCCCHHCCCCCEEEEEE
RLPPTAKIQYLAGQYIDLIINGQRRSYSIANAPGGNGNIELHVRKVVNGVFSNIIFNELK
ECCCCCEEEEECCCEEEEEEECCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
LQQLLRIEGPQGTFFVREDNLPIVFLAGGTGFAPVKSMVEALINKNDQRQVHIYWGMPAG
HHHHHEECCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCC
HNFYSDIANEWAIKHPNIHYVPVVSGDDSTWTGATGFVHQAVLEDIPDLSLFNVYACGSL
CHHHHHHHHHCEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCE
AMITAARNDFINHGLAENKFFSDAFVPSK
EEEEEHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD(P)H2; FMN [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; FMN; 2 2-octaprenylphenol; O2 [C]

Specific reaction: NAD(P)H2 + FMN = NAD(P) + FMNH2 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10931327; 11586360; 12142430 [H]