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The map label for this gene is macA [H]

Identifier: 153950248

GI number: 153950248

Start: 1537447

End: 1538652

Strand: Reverse

Name: macA [H]

Synonym: YpsIP31758_1312

Alternate gene names: 153950248

Gene position: 1538652-1537447 (Counterclockwise)

Preceding gene: 153949489

Following gene: 153949894

Centisome position: 32.58

GC content: 49.83

Gene sequence:

>1206_bases
ATGCAACATGTTACTGGTTCAAAACGACGCCTTATCGGGTGGGTAGTTTTGCTACTGATCATCGGTGGCCTGCTATTCTT
CAGATGGATTTCACCACCAGATAAACCAAGCTATATCACCGCCGTTGCTGAAATCCGCGATCTGGAACAAACAGTCTTAG
CAGATGGCACGATTAAAGCACAGAAGCAGGTGACTGTCGGTGCTCAGGTTTCAGGGCAAATAAAAGCCCTTCATGTCACA
TTGGGGCAACAAGTTGAAAAAAACCAATTAGTGGCTGAAATTGATGATCTTGCTCAACAAAATGCGCTGAAAGATGCGGA
AGAGGCCCTGAAGAACGTGCAGGCTCAACGGGCGGCTAAAATCGCAACACAAAAAAATAACCAACTCACCTACCAGCGTC
AGCAACAAATTCTGGCAAAAGGGGTTGGCGTACGTGCCGATTTCGATAGCATCAAGGCCATCTTAGAAGCAACGCAAGCG
GAAATCAGTGCGTTGGATGCGCAGATAGCTCAGGCCGAAATCGCCGTCAGTACGGCAAAACTTAATCTCGGCTATACCAA
AATCAGTTCCCCCATTGCGGGCACCGTGGTTGCCATTCCGGTTGAAGAGGGGCAAACCGTGAACGCCGTACAAAGTGCGC
CCACCATTATCAAAGTCGCCCAACTCGACACCATGACTGTCGAAGCGCAGATTTCCGAAGCCGATGTGGTCAAAGTCAAA
ACCGGGATGCCCGTCTATTTCACTATTTTAGGCGAACCAGAAAAACGTTTTAGTGCCACGCTGCGGGCGATAGAACCGGC
CCCTGACTCGATTAATGATGAAACCACAACCACATCGTCATCAACTTCAAGTAGCAGTTCCAGCAGTACGGCTATTTATT
ACAACGGCTTGTTTGATGTCGCCAATCCGACCGGTGCATTGCGTATCTCGATGACCGCTCAGGTATATATCCTGTTGAAT
CAAGCCAAAAATGCGGTGGTTATTCCAGCAACGGCATTGGAAAATGACCAAGGCCAATATCGGGTACAGGTGGTGGACAA
CAGCGGTAAAGTCAGCCAACGCACGGTGACTGTGGGCCTCAATAATAATGTGGATGCACAGATCCTCACCGGCCTGCAAG
CCGGAGAGCACGTGATTGTTAGTCAGGGCAGCACCACCTCCACCAACAATAAGGCCCCACGTATGGGCCCACCGATGGGG
ATGTAA

Upstream 100 bases:

>100_bases
ATCTCACTTAACCCACATGATCCAACCTTAGCGGTAAATTACGCCTCTGTGTTTTATTACCTCGCAGCCTTCATTGTCGT
TCAAGGATTTTTGATTAATT

Downstream 100 bases:

>100_bases
CTGATGACAGGACCACAACAAGGTAAAATTTTGCTCCGGCTCGAAAATGTCAGTCGTGAATTTATAACGGGCGAACAGAC
CGTCCGCGTGCTGAATAATA

Product: RND efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQHVTGSKRRLIGWVVLLLIIGGLLFFRWISPPDKPSYITAVAEIRDLEQTVLADGTIKAQKQVTVGAQVSGQIKALHVT
LGQQVEKNQLVAEIDDLAQQNALKDAEEALKNVQAQRAAKIATQKNNQLTYQRQQQILAKGVGVRADFDSIKAILEATQA
EISALDAQIAQAEIAVSTAKLNLGYTKISSPIAGTVVAIPVEEGQTVNAVQSAPTIIKVAQLDTMTVEAQISEADVVKVK
TGMPVYFTILGEPEKRFSATLRAIEPAPDSINDETTTTSSSTSSSSSSSTAIYYNGLFDVANPTGALRISMTAQVYILLN
QAKNAVVIPATALENDQGQYRVQVVDNSGKVSQRTVTVGLNNNVDAQILTGLQAGEHVIVSQGSTTSTNNKAPRMGPPMG
M

Sequences:

>Translated_401_residues
MQHVTGSKRRLIGWVVLLLIIGGLLFFRWISPPDKPSYITAVAEIRDLEQTVLADGTIKAQKQVTVGAQVSGQIKALHVT
LGQQVEKNQLVAEIDDLAQQNALKDAEEALKNVQAQRAAKIATQKNNQLTYQRQQQILAKGVGVRADFDSIKAILEATQA
EISALDAQIAQAEIAVSTAKLNLGYTKISSPIAGTVVAIPVEEGQTVNAVQSAPTIIKVAQLDTMTVEAQISEADVVKVK
TGMPVYFTILGEPEKRFSATLRAIEPAPDSINDETTTTSSSTSSSSSSSTAIYYNGLFDVANPTGALRISMTAQVYILLN
QAKNAVVIPATALENDQGQYRVQVVDNSGKVSQRTVTVGLNNNVDAQILTGLQAGEHVIVSQGSTTSTNNKAPRMGPPMG
M
>Mature_401_residues
MQHVTGSKRRLIGWVVLLLIIGGLLFFRWISPPDKPSYITAVAEIRDLEQTVLADGTIKAQKQVTVGAQVSGQIKALHVT
LGQQVEKNQLVAEIDDLAQQNALKDAEEALKNVQAQRAAKIATQKNNQLTYQRQQQILAKGVGVRADFDSIKAILEATQA
EISALDAQIAQAEIAVSTAKLNLGYTKISSPIAGTVVAIPVEEGQTVNAVQSAPTIIKVAQLDTMTVEAQISEADVVKVK
TGMPVYFTILGEPEKRFSATLRAIEPAPDSINDETTTTSSSTSSSSSSSTAIYYNGLFDVANPTGALRISMTAQVYILLN
QAKNAVVIPATALENDQGQYRVQVVDNSGKVSQRTVTVGLNNNVDAQILTGLQAGEHVIVSQGSTTSTNNKAPRMGPPMG
M

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=380, Percent_Identity=38.1578947368421, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082036, Length=332, Percent_Identity=28.0120481927711, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789929, Length=328, Percent_Identity=26.219512195122, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42762; Mature: 42762

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHVTGSKRRLIGWVVLLLIIGGLLFFRWISPPDKPSYITAVAEIRDLEQTVLADGTIKA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
QKQVTVGAQVSGQIKALHVTLGQQVEKNQLVAEIDDLAQQNALKDAEEALKNVQAQRAAK
CEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATQKNNQLTYQRQQQILAKGVGVRADFDSIKAILEATQAEISALDAQIAQAEIAVSTAK
HHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
LNLGYTKISSPIAGTVVAIPVEEGQTVNAVQSAPTIIKVAQLDTMTVEAQISEADVVKVK
EECCHHHHCCCCCCEEEEEECCCCCEEHHHHCCCCEEEEEEECEEEEEEEECCCEEEEEE
TGMPVYFTILGEPEKRFSATLRAIEPAPDSINDETTTTSSSTSSSSSSSTAIYYNGLFDV
CCCCEEEEEECCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEC
ANPTGALRISMTAQVYILLNQAKNAVVIPATALENDQGQYRVQVVDNSGKVSQRTVTVGL
CCCCCEEEEEEEEEEEEEEECCCCEEEEEEHHCCCCCCCEEEEEEECCCCCEEEEEEEEC
NNNVDAQILTGLQAGEHVIVSQGSTTSTNNKAPRMGPPMGM
CCCCCHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQHVTGSKRRLIGWVVLLLIIGGLLFFRWISPPDKPSYITAVAEIRDLEQTVLADGTIKA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
QKQVTVGAQVSGQIKALHVTLGQQVEKNQLVAEIDDLAQQNALKDAEEALKNVQAQRAAK
CEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IATQKNNQLTYQRQQQILAKGVGVRADFDSIKAILEATQAEISALDAQIAQAEIAVSTAK
HHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
LNLGYTKISSPIAGTVVAIPVEEGQTVNAVQSAPTIIKVAQLDTMTVEAQISEADVVKVK
EECCHHHHCCCCCCEEEEEECCCCCEEHHHHCCCCEEEEEEECEEEEEEEECCCEEEEEE
TGMPVYFTILGEPEKRFSATLRAIEPAPDSINDETTTTSSSTSSSSSSSTAIYYNGLFDV
CCCCEEEEEECCCHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEC
ANPTGALRISMTAQVYILLNQAKNAVVIPATALENDQGQYRVQVVDNSGKVSQRTVTVGL
CCCCCEEEEEEEEEEEEEEECCCCEEEEEEHHCCCCCCCEEEEEEECCCCCEEEEEEEEC
NNNVDAQILTGLQAGEHVIVSQGSTTSTNNKAPRMGPPMGM
CCCCCHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]