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The map label for this gene is shlB [H]

Identifier: 153950209

GI number: 153950209

Start: 4594042

End: 4595712

Strand: Reverse

Name: shlB [H]

Synonym: YpsIP31758_4076

Alternate gene names: 153950209

Gene position: 4595712-4594042 (Counterclockwise)

Preceding gene: 153949762

Following gene: 153950511

Centisome position: 97.3

GC content: 46.68

Gene sequence:

>1671_bases
ATGCTTCCGTTTAAAGTTTTCGCTGAAACGGCGTTGCCAGAAATGGGCCTGCTTGAAATGGATATAGCCGAGCCACAGAT
CCCAAATAGTATTATTCCTCCTCTATCACATGCTCAACTGGCCAGTGAACCGACTCTGCCAGAGAATCTTTATAATGATG
AAGTACAATGTGTAGCAATTAAGAATGTCGAATTGATTAATATTGATGCCTTCCCAAATGCAGCACGCTTAAAAGAAAAG
GCTGAAGAAGCTCACGGGCGTTGCCTGGGGGAACAGGGGCTGTCAGTGCTTGTGGCTAACTTACAACAACAATTAGTGGT
TGATGGCTATATCACCTCTCGTGTGGTTTTTGTCGATGACAGTGAGCGTGACGGCACGTTAACGCTGAAATTAATGCCCG
GTAGGATTGAGGATATCAGGCATCATCAAGACAGCGCCGGCAATGCTCAGCTCAGCTCCCTTTTTCCCGGTAAACGTGGT
GATTTGGTTAATTTACGTCACCTTGAGCAAGGGTTAGAAAACTTGCAGCGCTTGACTTCAGTGAATGCCACCATGGATAT
CGAATTAAATCGGGACGATTTAAGTAGCCAGATTATCGTGAATCGCCAGCAATCACGTCTCTGGCGTATTAATGCCTACC
TTGATGATGCCGGGCATGATGCCGTTGGCCGCTATCGTACGGGCCTAATATTGTCTTTTGATAATCCATTATCCCGTTAT
AACCCCTTGTCTCTCAGTGATTTACTCTACTTCTCTGTTAACCGTGACCTTGATAGCCAACCCGATAAAGGGCACAACAG
CTACGGGATTCATTATTCTGTCCCGTATGGCAACTGGCTATTTAGCATGACGGGCAATCAAGGTGAGCATTATCAATCGT
TCTCTTTTGCCGGTAAAAGACTTGCCGGTAAAAAATTTGGCTATCGTTCCCATTGGTCTGTATTGGATACACAAATTCAA
CATTTACTCACCCGTGGAGTAAATTATAAAACAGTGGGTTATGCCGGGGTGTTAATTCGTCAGTCTGCCAGTTTTTGGAC
CCATCGGGAGATAGATATTCAGCGGTTCAATACCACGGACTGGCAGCTAGGGATTGAGCATCTACATTACATGCCATGGG
CGACTTTCAGAGGGGGGGTTCGTTATCAACAGGGGGCTTCATGGTTTGGTGCCCAACCTATTCCCGGTAAAATGAGCACT
GCACCGGCGAGGTTGGTCGATATCACCAGCTCACTGGATATCCCTTTTAAGATCGGAACACAGTCCTTCCAGTATCGGCC
CGCTTTCAGCCAGCAACATACCTACTCGGATATTAGTTCACTGGATAAATTTACGATTGGTGGCAGGAGTTCAGTGCGAG
GTTTTAATGAGAATAACGCTCTGACGGGGTCACGGGGGTGGTCTCTAAAAAATGACATTTCATGGATCAGCCCGATACCC
GGTCAGACATTCGTAGGCCAGCAACTTTATATCGGCATGGATTATGGTGAGGTGAGTGAGCAGGGCCAACCATTTCTTTT
GGGCGAGCGTTTAGCGGGTGCCGTGGTAGGGACTCGTGGAAATTATCATGCGTTTGGTTACGATTTTAATGTCGGCGTGC
CGATAACCAAACCCGCTGAATTTGATGCTGATCCGTTGGTTTTTGGGTTTACGCTAACTTGGCAATATTAG

Upstream 100 bases:

>100_bases
CATTGGCATGATGTTTAAAATAAATATGAGGGGGAGAGAAAAAATTGGAGATTCTTGGGGGGGTATATTTTGCCTATTAT
ACCTTCAAATTATGATTGGG

Downstream 100 bases:

>100_bases
GGGCTATACCTTCTCTGATGTTGAGTGTTTATTGTGCTGCCCTGATTAGGGGCATCATTATGGTGCACCTCTTTGGGAAG
CTATGTGGTTTCTTGGGTGA

Product: ShlB/FhaC/HecB family haemolysin secretion/activation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MLPFKVFAETALPEMGLLEMDIAEPQIPNSIIPPLSHAQLASEPTLPENLYNDEVQCVAIKNVELINIDAFPNAARLKEK
AEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDSERDGTLTLKLMPGRIEDIRHHQDSAGNAQLSSLFPGKRG
DLVNLRHLEQGLENLQRLTSVNATMDIELNRDDLSSQIIVNRQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRY
NPLSLSDLLYFSVNRDLDSQPDKGHNSYGIHYSVPYGNWLFSMTGNQGEHYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQ
HLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDWQLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMST
APARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSLDKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIP
GQTFVGQQLYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGNYHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY

Sequences:

>Translated_556_residues
MLPFKVFAETALPEMGLLEMDIAEPQIPNSIIPPLSHAQLASEPTLPENLYNDEVQCVAIKNVELINIDAFPNAARLKEK
AEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDSERDGTLTLKLMPGRIEDIRHHQDSAGNAQLSSLFPGKRG
DLVNLRHLEQGLENLQRLTSVNATMDIELNRDDLSSQIIVNRQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRY
NPLSLSDLLYFSVNRDLDSQPDKGHNSYGIHYSVPYGNWLFSMTGNQGEHYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQ
HLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDWQLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMST
APARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSLDKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIP
GQTFVGQQLYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGNYHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY
>Mature_556_residues
MLPFKVFAETALPEMGLLEMDIAEPQIPNSIIPPLSHAQLASEPTLPENLYNDEVQCVAIKNVELINIDAFPNAARLKEK
AEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDDSERDGTLTLKLMPGRIEDIRHHQDSAGNAQLSSLFPGKRG
DLVNLRHLEQGLENLQRLTSVNATMDIELNRDDLSSQIIVNRQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRY
NPLSLSDLLYFSVNRDLDSQPDKGHNSYGIHYSVPYGNWLFSMTGNQGEHYQSFSFAGKRLAGKKFGYRSHWSVLDTQIQ
HLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTDWQLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMST
APARLVDITSSLDIPFKIGTQSFQYRPAFSQQHTYSDISSLDKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIP
GQTFVGQQLYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGNYHAFGYDFNVGVPITKPAEFDADPLVFGFTLTWQY

Specific function: Member of a two partner secretion pathway (TPS) in which it mediates the secretion of hemolysin [H]

COG id: COG2831

COG function: function code U; Hemolysin activation/secretion protein

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tpsB (TC 1.B.20) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005565
- InterPro:   IPR013686 [H]

Pfam domain/function: PF08479 POTRA_2; PF03865 ShlB [H]

EC number: NA

Molecular weight: Translated: 62320; Mature: 62320

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFKVFAETALPEMGLLEMDIAEPQIPNSIIPPLSHAQLASEPTLPENLYNDEVQCVAI
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHCCCCEEEEEE
KNVELINIDAFPNAARLKEKAEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDD
CCEEEEEEECCCCHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHEEEEEEEEEEEEEEC
SERDGTLTLKLMPGRIEDIRHHQDSAGNAQLSSLFPGKRGDLVNLRHLEQGLENLQRLTS
CCCCCEEEEEECCCHHHHHHHCCCCCCCCCHHHCCCCCCCCEEEHHHHHHHHHHHHHHHH
VNATMDIELNRDDLSSQIIVNRQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRY
CCCEEEEEECHHCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCHHHC
NPLSLSDLLYFSVNRDLDSQPDKGHNSYGIHYSVPYGNWLFSMTGNQGEHYQSFSFAGKR
CCCCHHHEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHH
LAGKKFGYRSHWSVLDTQIQHLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTD
HCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECEEEEEEECCCCCCEEEEEEEEECCCCH
WQLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMSTAPARLVDITSSLDIPFKIGT
HHHHHHHHHCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECC
QSFQYRPAFSQQHTYSDISSLDKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIP
CCEEECCCCCCCCCHHHHHHHHHEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GQTFVGQQLYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGNYHAFGYDFNVGVPITKPAE
CCCCCCCEEEEECCCHHHCCCCCCEEEHHHHCCEEEECCCCEEEEEEEEECCCCCCCCCC
FDADPLVFGFTLTWQY
CCCCCEEEEEEEEEEC
>Mature Secondary Structure
MLPFKVFAETALPEMGLLEMDIAEPQIPNSIIPPLSHAQLASEPTLPENLYNDEVQCVAI
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHCCCCEEEEEE
KNVELINIDAFPNAARLKEKAEEAHGRCLGEQGLSVLVANLQQQLVVDGYITSRVVFVDD
CCEEEEEEECCCCHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHEEEEEEEEEEEEEEC
SERDGTLTLKLMPGRIEDIRHHQDSAGNAQLSSLFPGKRGDLVNLRHLEQGLENLQRLTS
CCCCCEEEEEECCCHHHHHHHCCCCCCCCCHHHCCCCCCCCEEEHHHHHHHHHHHHHHHH
VNATMDIELNRDDLSSQIIVNRQQSRLWRINAYLDDAGHDAVGRYRTGLILSFDNPLSRY
CCCEEEEEECHHCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCHHHC
NPLSLSDLLYFSVNRDLDSQPDKGHNSYGIHYSVPYGNWLFSMTGNQGEHYQSFSFAGKR
CCCCHHHEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHH
LAGKKFGYRSHWSVLDTQIQHLLTRGVNYKTVGYAGVLIRQSASFWTHREIDIQRFNTTD
HCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECEEEEEEECCCCCCEEEEEEEEECCCCH
WQLGIEHLHYMPWATFRGGVRYQQGASWFGAQPIPGKMSTAPARLVDITSSLDIPFKIGT
HHHHHHHHHCCCCHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEECC
QSFQYRPAFSQQHTYSDISSLDKFTIGGRSSVRGFNENNALTGSRGWSLKNDISWISPIP
CCEEECCCCCCCCCHHHHHHHHHEECCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GQTFVGQQLYIGMDYGEVSEQGQPFLLGERLAGAVVGTRGNYHAFGYDFNVGVPITKPAE
CCCCCCCEEEEECCCHHHCCCCCCEEEHHHHCCEEEECCCCEEEEEEEEECCCCCCCCCC
FDADPLVFGFTLTWQY
CCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3290200 [H]