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The map label for this gene is tcmA [H]

Identifier: 153950075

GI number: 153950075

Start: 2464149

End: 2465789

Strand: Reverse

Name: tcmA [H]

Synonym: YpsIP31758_2142

Alternate gene names: 153950075

Gene position: 2465789-2464149 (Counterclockwise)

Preceding gene: 153950533

Following gene: 153947613

Centisome position: 52.2

GC content: 52.1

Gene sequence:

>1641_bases
ATGGCAAATCAATCAGTTTCTCGTACAGGTACGGAAGTTAAGGAGTCCTGGGTGCCGATGATTACCATCGCGCTGGCCCA
GATCCTGATGTCATTCAACGTGGCCTCCCTACCTGTTGCGTTGGGCGGGATGGTAAAGAGCTTTAATGTGCCACCAACCA
CTATTGCCACGGCGATAGTCATGTACTCATTGTCGGTTGCAGGCTTTGTGATGTTGGGTGCCAAACTCAACCAACGCTTT
GGGCCATTGATAGTATTCCGCTGTACAGTTCTGTTATTCGGCCTGGCTCAGACCATGATGACATTCAGCCCGAATGTCAC
TGTAATGATCGGTGCGCAGGCACTGAGTGGTCTGGCAGGTGCGGCATTGGTACCGGCACTGGTGGCGTTAATTGCTGAAA
ACTACCGTGGGCCTCAACAGGCCACCGCACTGGGGGCATTAGGTTCTGCTCGCGCAGGGGCGGGTGTTGCTGCGTTCCTG
ATCGGCGGTATTTTGGGAACCCATATCGGCTGGCGTCCAGCGTTCGGTATTTTGATTGTGTTGTCTGTTATCGTTTTTGT
ACTGAGTTTCCGTCTGAAAGCAGATAAAGGCCGCCCAGAAGTGGGTATTGATGTTATCGGTGTCGTTTTAGCTGCATCTG
CGATTATTTTGTTGTCGTTCGGCTTTAATAACCTGAACCGTTGGGGCTTTGGTCTGGTTCGTGACGGCGCGCCGTTTGAC
CTGCTCGGTTTCTCACCAGCGCCGTTTATGATCGTGTTGGGTATCGTCTTGGGTCAGGCATTTGTGGTCTGGACCCGCCG
CCGTCAGGAGCAAGGTAAAACGCCATTACTGGCGCTGGACGTGATTACATCACCCAGTGAGCGGGCGGCGGTATTTGCCA
TGTTTGCGGTGGTTGCGCTGGAAGCCATGCTGAACTTTTCTGTTCCGCTGTATATACAAATCGTGCAGGGCAGTTCGCCG
ATGGCAACAGCTATCGCTATGATGCCGTTTAACCTATCGGTATTCTTCTCTGCGATGTTGATTGTACGTTTCTACAAGAA
ACTGACTCCGCGTAAAATTGGTCGTTACGGTTTCATCACTTGTACTTTGGCGCTGTTGTGGCTGGCATTCGTGGTACGTA
ATAACTGGAGTGAGTGGTCGGTCTTGATTGGTTTGGTGGTGTTCGGTATCGGACAAGGCTCACTCGTCACCTTGCTGTTC
AACGTACTGGTCAGTGCATCACCAAAAGAATTGGCAGGCGATGTGGGTTCTTTACGTGGTACGACCAACAACCTGGCAAG
CGCCATCGGTACAGCGGTTGCAGGTGCCTTGCTGGTGGGCTTGTTAAGTGCCAACGTGATGCGCGGTGTCGCTGAAACGC
CGATTCTGACGGATGAGATCCAAGCTCAGGTCAATATGGATAGCATCAACTTCGTCAGTAATGATCGCCTGAACAGTGTA
TTGGCTCAAACCTCCGCGACCCAAGAACAGGTTGCCGAAGCGGTGCGGGTGAATGAAGAAGCACGGTTACGTGCGCTGAA
ATTCGGTTTGCTGGTTATGGCGCTGCTATCGCTGTTGGCTATCTTCCCTGCTGGCCGCTTACCTGACTATCTGCCGGGTG
AACTGCCTGCTGATAATCTGGATAAAAAAGCCAGCAAGTAA

Upstream 100 bases:

>100_bases
ATCGATGTTGTTCTGAAAGCCAGGCGGTCTTGGCAATCAGGTTATATCGAAAATTAAGTTGTTCTAAAAACAAAAAATAG
ATCAAAAGGATAGAAAATTT

Downstream 100 bases:

>100_bases
GTTGCTGGAGGTTATTGACAAAGTGCCCGCGACGGAGAGAACAGGCAGATCGTAAAGACGCCGTAAATACATCCATGTAG
GCTCGAGCCGCGCCATCCTT

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MANQSVSRTGTEVKESWVPMITIALAQILMSFNVASLPVALGGMVKSFNVPPTTIATAIVMYSLSVAGFVMLGAKLNQRF
GPLIVFRCTVLLFGLAQTMMTFSPNVTVMIGAQALSGLAGAALVPALVALIAENYRGPQQATALGALGSARAGAGVAAFL
IGGILGTHIGWRPAFGILIVLSVIVFVLSFRLKADKGRPEVGIDVIGVVLAASAIILLSFGFNNLNRWGFGLVRDGAPFD
LLGFSPAPFMIVLGIVLGQAFVVWTRRRQEQGKTPLLALDVITSPSERAAVFAMFAVVALEAMLNFSVPLYIQIVQGSSP
MATAIAMMPFNLSVFFSAMLIVRFYKKLTPRKIGRYGFITCTLALLWLAFVVRNNWSEWSVLIGLVVFGIGQGSLVTLLF
NVLVSASPKELAGDVGSLRGTTNNLASAIGTAVAGALLVGLLSANVMRGVAETPILTDEIQAQVNMDSINFVSNDRLNSV
LAQTSATQEQVAEAVRVNEEARLRALKFGLLVMALLSLLAIFPAGRLPDYLPGELPADNLDKKASK

Sequences:

>Translated_546_residues
MANQSVSRTGTEVKESWVPMITIALAQILMSFNVASLPVALGGMVKSFNVPPTTIATAIVMYSLSVAGFVMLGAKLNQRF
GPLIVFRCTVLLFGLAQTMMTFSPNVTVMIGAQALSGLAGAALVPALVALIAENYRGPQQATALGALGSARAGAGVAAFL
IGGILGTHIGWRPAFGILIVLSVIVFVLSFRLKADKGRPEVGIDVIGVVLAASAIILLSFGFNNLNRWGFGLVRDGAPFD
LLGFSPAPFMIVLGIVLGQAFVVWTRRRQEQGKTPLLALDVITSPSERAAVFAMFAVVALEAMLNFSVPLYIQIVQGSSP
MATAIAMMPFNLSVFFSAMLIVRFYKKLTPRKIGRYGFITCTLALLWLAFVVRNNWSEWSVLIGLVVFGIGQGSLVTLLF
NVLVSASPKELAGDVGSLRGTTNNLASAIGTAVAGALLVGLLSANVMRGVAETPILTDEIQAQVNMDSINFVSNDRLNSV
LAQTSATQEQVAEAVRVNEEARLRALKFGLLVMALLSLLAIFPAGRLPDYLPGELPADNLDKKASK
>Mature_545_residues
ANQSVSRTGTEVKESWVPMITIALAQILMSFNVASLPVALGGMVKSFNVPPTTIATAIVMYSLSVAGFVMLGAKLNQRFG
PLIVFRCTVLLFGLAQTMMTFSPNVTVMIGAQALSGLAGAALVPALVALIAENYRGPQQATALGALGSARAGAGVAAFLI
GGILGTHIGWRPAFGILIVLSVIVFVLSFRLKADKGRPEVGIDVIGVVLAASAIILLSFGFNNLNRWGFGLVRDGAPFDL
LGFSPAPFMIVLGIVLGQAFVVWTRRRQEQGKTPLLALDVITSPSERAAVFAMFAVVALEAMLNFSVPLYIQIVQGSSPM
ATAIAMMPFNLSVFFSAMLIVRFYKKLTPRKIGRYGFITCTLALLWLAFVVRNNWSEWSVLIGLVVFGIGQGSLVTLLFN
VLVSASPKELAGDVGSLRGTTNNLASAIGTAVAGALLVGLLSANVMRGVAETPILTDEIQAQVNMDSINFVSNDRLNSVL
AQTSATQEQVAEAVRVNEEARLRALKFGLLVMALLSLLAIFPAGRLPDYLPGELPADNLDKKASK

Specific function: Resistance to tetracenomycin C by an active tetracenomycin C efflux system which is probably energized by transmembrane electrochemical gradients [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 57846; Mature: 57715

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQSVSRTGTEVKESWVPMITIALAQILMSFNVASLPVALGGMVKSFNVPPTTIATAIV
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
MYSLSVAGFVMLGAKLNQRFGPLIVFRCTVLLFGLAQTMMTFSPNVTVMIGAQALSGLAG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCHHH
AALVPALVALIAENYRGPQQATALGALGSARAGAGVAAFLIGGILGTHIGWRPAFGILIV
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LSVIVFVLSFRLKADKGRPEVGIDVIGVVLAASAIILLSFGFNNLNRWGFGLVRDGAPFD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCC
LLGFSPAPFMIVLGIVLGQAFVVWTRRRQEQGKTPLLALDVITSPSERAAVFAMFAVVAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
EAMLNFSVPLYIQIVQGSSPMATAIAMMPFNLSVFFSAMLIVRFYKKLTPRKIGRYGFIT
HHHHHCCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHCCHHHHH
CTLALLWLAFVVRNNWSEWSVLIGLVVFGIGQGSLVTLLFNVLVSASPKELAGDVGSLRG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCHHHCCC
TTNNLASAIGTAVAGALLVGLLSANVMRGVAETPILTDEIQAQVNMDSINFVSNDRLNSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHH
LAQTSATQEQVAEAVRVNEEARLRALKFGLLVMALLSLLAIFPAGRLPDYLPGELPADNL
HHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DKKASK
CCCCCC
>Mature Secondary Structure 
ANQSVSRTGTEVKESWVPMITIALAQILMSFNVASLPVALGGMVKSFNVPPTTIATAIV
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
MYSLSVAGFVMLGAKLNQRFGPLIVFRCTVLLFGLAQTMMTFSPNVTVMIGAQALSGLAG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHCCHHH
AALVPALVALIAENYRGPQQATALGALGSARAGAGVAAFLIGGILGTHIGWRPAFGILIV
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
LSVIVFVLSFRLKADKGRPEVGIDVIGVVLAASAIILLSFGFNNLNRWGFGLVRDGAPFD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCC
LLGFSPAPFMIVLGIVLGQAFVVWTRRRQEQGKTPLLALDVITSPSERAAVFAMFAVVAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
EAMLNFSVPLYIQIVQGSSPMATAIAMMPFNLSVFFSAMLIVRFYKKLTPRKIGRYGFIT
HHHHHCCCCEEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHCCHHHHH
CTLALLWLAFVVRNNWSEWSVLIGLVVFGIGQGSLVTLLFNVLVSASPKELAGDVGSLRG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCHHHCCC
TTNNLASAIGTAVAGALLVGLLSANVMRGVAETPILTDEIQAQVNMDSINFVSNDRLNSV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHHH
LAQTSATQEQVAEAVRVNEEARLRALKFGLLVMALLSLLAIFPAGRLPDYLPGELPADNL
HHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DKKASK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1592819 [H]