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The map label for this gene is rnb [H]

Identifier: 153949985

GI number: 153949985

Start: 2207641

End: 2209575

Strand: Direct

Name: rnb [H]

Synonym: YpsIP31758_1904

Alternate gene names: 153949985

Gene position: 2207641-2209575 (Clockwise)

Preceding gene: 153948366

Following gene: 153949201

Centisome position: 46.74

GC content: 50.13

Gene sequence:

>1935_bases
ATGTTTCAAGATAACCCGCTGCTGGCGCAGCTAAAACAGCAACTTCACACTCAGACCCCACGCGTTGAAGGCGTCGTTAA
AGGTACTGAGAAAGGCTTTGGCTTTCTTGAGGTAGATGGGCAGAAAAGTTACTTTATTCCGCCTCCGCAGATGAAGAAGG
TCATGCACGGCGATCGTATTATTGCCACCCTGCATACGGATAAGGATCGTGAAATTGCTGAACCTGAAACATTGGTTGAG
CCATTTTTATCCCGCTTTGTTGGCCGGGTGCAACGAAAAGATGATCGTCTGTCTATCGTGCCCGACCACCCTTTATTACG
TGATGCTATTCAATGCCGCCCAGTACGTGAACTGACGCATAGCTTCCAAAACGGTGATTGGGCAGTGGCTGAGATGTGCC
GCCACCCATTAAAAGGCGACCGCGCCTTTCAGGCTGACCTAACCGCGTTTATTACCAATGGTGAAGACCACTTCGTTCCT
TGGTGGGTAACACTGGCTCGCCATAACCTTGAGCGTGAAGCCCCTGCTATGGTCGAATCGGCCTTAAATGACGCCGAGCT
TGAGCGAGAAGACTTAACCGCACTTAATTTTGTCACTATCGACAGCGCCAGCACTGAAGACATGGATGATGCGCTGTTTG
TCCAAGACAATGGCGACGGTTCATGGTTATTGACCATTGCCATTGCAGACCCAACAGCTTACGTCGTCGAAAACAGTGAA
TTGGATTTAACCGCCCGTAAGCGTGCTTTTACCAATTATCTGCCGGGTTTTAACATCCCGATGCTTCCGCGTGATTTGTC
CGACAACCTCTGTTCACTGCGCCCAAATGAACGTCGCACAGTATTGGTTTGCCGTGTGACGATCACAGAAGAAGGGGCGC
TAAGTAACGATATTCGTTTCTCCGCTGCTTGGGTTGAATCAAAAGCCAAACTGGTTTACGACGATGTCTCTGACTGGTTG
GAAGGAAATAATCGCTGGCAGCCACAAGATACCGCTATTGCAGAGCAGATTACGTTACTGAAACGTATCTGTGACGCCCG
TAGCAACTGGCGTCAACAACATGCGCTGGTCTTTAAAGACCGCCCAGATTATCGCTTCCTGTTGGGTGAAAAAGGCGAAG
TGCTGGATATCATTGTTGAGCATCGTCGTATCGCCAACCGCATTGTAGAAGAGTGTATGATTGCAGCGAACGTCTGTGCG
GCATTGGCGTTGCGGGATCACCTCGGTTTTGGTATTTATAACGTGCATACCGGTTTTGACCCGGCATTAGTCGAACAAGC
GGCTAGCGTATTGAAAGCCAATGGTGTTGATGCCGATCCTCAAGCCCTGCTGACGTTACCCGGTTTCTGTGAGTTACGCC
GTCACCTTGATGCCCTGCCAACACAGTTCCTCGACAGCCGTATTCGCCGTTTCCAGACATTTGCTGAAATTAGTACTGTC
CCCGGTCCGCATTTTGGCTTGGGGCTTGAAGCCTATGCCACCTGGACATCTCCAATCCGTAAATACGGCGACATGGTCAA
TCATCGCCTGCTGAAAGCGATGATTACTGGTCAACAAGCAGAAAAACCACAAGAAGAGATCACGGTCCAATTGGCTGAAC
GTCGCCGCCTGAATCGCATGGCTGAACGTGATGTCGGTGATTGGTTGTATGCCCGTTATCTGCAACCACAAGCAGGAACT
GACACTCGTTTCACGGCAGAGATTATTGATATCACCCGCGGTGGCTTGCGTGTGCGTTTACTGGATAACGGTGCCGTTGC
CTTTATTCCTGCGCCGTTTATTCACGCGGTGCGTGATGAAGTGGTCTGCAGCCAGGAAACCGGTACTGTGCAGATCAAAG
GCGAAACAGTTTATAGCCAAAGTGACAAAATCGAGGTACGTATTGCGGAAGTTCGCATGGAAACCCGTAATGTCATTGCT
CGCCCAGTAGCTTAA

Upstream 100 bases:

>100_bases
GAATTGCCATTCCGGATCATATCCACTTGCCCGACGGGGCTGATTCGCGTAAAACTGTCAGCCGGATTAAACCCTCTCAC
TACACCATTCACTGGACGAT

Downstream 100 bases:

>100_bases
TTTTCTTATGTTTTAACATGATAGCCGTCGGAGGAATTCCCCCGACGGCTTTTTTAATGTTATGTTTGCCGCCCTTCTTG
CTTAACGTCGCTGCTGTGTT

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVE
PFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHSFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVP
WWVTLARHNLEREAPAMVESALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRTVLVCRVTITEEGALSNDIRFSAAWVESKAKLVYDDVSDWL
EGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCA
ALALRDHLGFGIYNVHTGFDPALVEQAASVLKANGVDADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRMAERDVGDWLYARYLQPQAGT
DTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDEVVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIA
RPVA

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVE
PFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHSFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVP
WWVTLARHNLEREAPAMVESALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRTVLVCRVTITEEGALSNDIRFSAAWVESKAKLVYDDVSDWL
EGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCA
ALALRDHLGFGIYNVHTGFDPALVEQAASVLKANGVDADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRMAERDVGDWLYARYLQPQAGT
DTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDEVVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIA
RPVA
>Mature_644_residues
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRIIATLHTDKDREIAEPETLVE
PFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTHSFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVP
WWVTLARHNLEREAPAMVESALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRTVLVCRVTITEEGALSNDIRFSAAWVESKAKLVYDDVSDWL
EGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKDRPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCA
ALALRDHLGFGIYNVHTGFDPALVEQAASVLKANGVDADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRMAERDVGDWLYARYLQPQAGT
DTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDEVVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIA
RPVA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=373, Percent_Identity=24.3967828418231, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI219521928, Length=443, Percent_Identity=23.9277652370203, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI19115966, Length=443, Percent_Identity=23.7020316027088, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI190014625, Length=373, Percent_Identity=24.3967828418231, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI134288890, Length=362, Percent_Identity=25.1381215469613, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=74.2236024844721, Blast_Score=999, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=660, Percent_Identity=28.3333333333333, Blast_Score=209, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17553506, Length=444, Percent_Identity=26.5765765765766, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI212645896, Length=476, Percent_Identity=25.2100840336134, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24654592, Length=434, Percent_Identity=26.4976958525346, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI19922976, Length=434, Percent_Identity=26.4976958525346, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24654597, Length=434, Percent_Identity=26.4976958525346, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24649634, Length=395, Percent_Identity=27.0886075949367, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72894; Mature: 72894

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IATLHTDKDREIAEPETLVEPFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTH
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCHHHHHHH
SFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVPWWVTLARHNLEREAPAMVES
HHCCCCCHHHHHHCCCCCCCCCHHCCEEEEEECCCCCEEHHHHHHHHHCCCHHHHHHHHH
ALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
HCCHHHCCHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEECCC
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRTVLVCRVTITEEGALSNDIRF
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEEEEECCCCCCCCCEE
SAAWVESKAKLVYDDVSDWLEGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKD
EEHHHHCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
RPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCAALALRDHLGFGIYNVHTGFD
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
PALVEQAASVLKANGVDADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
HHHHHHHHHHHHCCCCCCCCHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARYLQPQAGTDTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDE
HHHCHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHHHH
VVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIARPVA
HEECCCCCEEEEECCEEECCCCCEEEEEEEHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHTQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IATLHTDKDREIAEPETLVEPFLSRFVGRVQRKDDRLSIVPDHPLLRDAIQCRPVRELTH
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCHHHHHHH
SFQNGDWAVAEMCRHPLKGDRAFQADLTAFITNGEDHFVPWWVTLARHNLEREAPAMVES
HHCCCCCHHHHHHCCCCCCCCCHHCCEEEEEECCCCCEEHHHHHHHHHCCCHHHHHHHHH
ALNDAELEREDLTALNFVTIDSASTEDMDDALFVQDNGDGSWLLTIAIADPTAYVVENSE
HCCHHHCCHHHCCEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEECCC
LDLTARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNERRTVLVCRVTITEEGALSNDIRF
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCEEEEEEEEEECCCCCCCCCEE
SAAWVESKAKLVYDDVSDWLEGNNRWQPQDTAIAEQITLLKRICDARSNWRQQHALVFKD
EEHHHHCCCCEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
RPDYRFLLGEKGEVLDIIVEHRRIANRIVEECMIAANVCAALALRDHLGFGIYNVHTGFD
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
PALVEQAASVLKANGVDADPQALLTLPGFCELRRHLDALPTQFLDSRIRRFQTFAEISTV
HHHHHHHHHHHHCCCCCCCCHHEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
PGPHFGLGLEAYATWTSPIRKYGDMVNHRLLKAMITGQQAEKPQEEITVQLAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
AERDVGDWLYARYLQPQAGTDTRFTAEIIDITRGGLRVRLLDNGAVAFIPAPFIHAVRDE
HHHCHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCEEEECCHHHHHHHHH
VVCSQETGTVQIKGETVYSQSDKIEVRIAEVRMETRNVIARPVA
HEECCCCCEEEEECCEEECCCCCEEEEEEEHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA