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The map label for this gene is macA [H]

Identifier: 153949946

GI number: 153949946

Start: 2966279

End: 2967391

Strand: Reverse

Name: macA [H]

Synonym: YpsIP31758_2611

Alternate gene names: 153949946

Gene position: 2967391-2966279 (Counterclockwise)

Preceding gene: 153947576

Following gene: 153949325

Centisome position: 62.82

GC content: 49.15

Gene sequence:

>1113_bases
ATGCAACTCAGTAGAGGTCAGCGCCGGTGGCTTGCCGCCATTGCGGTATTGCTTATCGGTGGTTTTTTCATCGCCAGGCA
TCTGATGGCACCGGTACCTGTTAACTATCAAACAGTCAAAGTGGTTCACCGTGATCTGCAACAAAATGTCTTGGCAACCG
GTAAGCTCGATGCGGTTCGTAAAGTTGATGTAGGTGCGCAGGTCACTGGTCAGTTGGAAAAACTGTATGTAGAAATTGGC
GATCACGTTAAGCGGGGGCAGTTGCTGGCGATGATCGATCCACAGCAGGCGCAAAACCAAATTAAGGAAGTGGAAGCCAC
ATTACAGGATTTGAACGCTCAACGGATACAGGCGAAGGCCGAATTACACTTGGCAACGGTTACGCTCGGTCGTCAACAAA
ATTTGGCTAAATTACAGGTGGTGTCACGGCAGGATCTGGACCAGGCAGTAACCGATTTGGCGGTTAAAAATGCGAAAGTT
GGCACGATTGATGCTCAAATCAACAAAGCGAAAGCCAGCTTAGATACGGCCAAAATCAATCTGGATTACACTCAAATTTC
TGCACCGATGGATGGTGATGTTGTACAAATCACCACGTTGCAAGGTCAGACGGTAATTGCCGCACAGCAAGCGCCCAATA
TTCTGACCCTGGCCGATATGAGTACCATGTTGGTACAAGCACAGGTATCAGAAGCGGATGTTATCAACCTGAAACCGGGG
ATGAAAGCCTCGTTCACGGTACTTGGCGATCCTGGCAAGCGTTTTTCTGGCGTACTAAAAGATATTCTGCCAACGCCAGA
GAAAGTCAATGACGCCATCTTTTATTCAGCCCGCTTTGAAGTACCAAACCCTGACAGATTATTGCGGTTACAAATGACGG
CTCAGGTATCCATACAGCTAGCCAATGTAGATCAGGCCGTGGTGATCCCACTAGCTGCGCTGGGTGATGAGTTAGGGAGT
AATCGCTATCAGGTTACGGTCCTGAAAGAGGGCAAAGAAGAGAAGCGTGAGGTGACCATTGGTATTCGTAATAATGTCGA
TGCTCAAGTTATTAGCGGGCTGAGTGTCGGCGAAGACGTCATCGTCAGCCGCGGTGGCACGGGGGATGCATAA

Upstream 100 bases:

>100_bases
TTTGATGGTATTTTCTGCGGGTATATTTTCTTTGTGTTGATATGATCCATTTTTCAACCACTTAACTGCCATGGAAATAA
GAATGAAGGTAATTGATTTG

Downstream 100 bases:

>100_bases
TGGCGGCATTGCTTGAATTAGAAGGCATCCGCCGTAGTTATCAGTCTGGCGAAGAAATTGTCGATGTGTTGCAGGATGTC
TCATTGACCATCAATGCGGG

Product: macrolide transporter subunit MacA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MQLSRGQRRWLAAIAVLLIGGFFIARHLMAPVPVNYQTVKVVHRDLQQNVLATGKLDAVRKVDVGAQVTGQLEKLYVEIG
DHVKRGQLLAMIDPQQAQNQIKEVEATLQDLNAQRIQAKAELHLATVTLGRQQNLAKLQVVSRQDLDQAVTDLAVKNAKV
GTIDAQINKAKASLDTAKINLDYTQISAPMDGDVVQITTLQGQTVIAAQQAPNILTLADMSTMLVQAQVSEADVINLKPG
MKASFTVLGDPGKRFSGVLKDILPTPEKVNDAIFYSARFEVPNPDRLLRLQMTAQVSIQLANVDQAVVIPLAALGDELGS
NRYQVTVLKEGKEEKREVTIGIRNNVDAQVISGLSVGEDVIVSRGGTGDA

Sequences:

>Translated_370_residues
MQLSRGQRRWLAAIAVLLIGGFFIARHLMAPVPVNYQTVKVVHRDLQQNVLATGKLDAVRKVDVGAQVTGQLEKLYVEIG
DHVKRGQLLAMIDPQQAQNQIKEVEATLQDLNAQRIQAKAELHLATVTLGRQQNLAKLQVVSRQDLDQAVTDLAVKNAKV
GTIDAQINKAKASLDTAKINLDYTQISAPMDGDVVQITTLQGQTVIAAQQAPNILTLADMSTMLVQAQVSEADVINLKPG
MKASFTVLGDPGKRFSGVLKDILPTPEKVNDAIFYSARFEVPNPDRLLRLQMTAQVSIQLANVDQAVVIPLAALGDELGS
NRYQVTVLKEGKEEKREVTIGIRNNVDAQVISGLSVGEDVIVSRGGTGDA
>Mature_370_residues
MQLSRGQRRWLAAIAVLLIGGFFIARHLMAPVPVNYQTVKVVHRDLQQNVLATGKLDAVRKVDVGAQVTGQLEKLYVEIG
DHVKRGQLLAMIDPQQAQNQIKEVEATLQDLNAQRIQAKAELHLATVTLGRQQNLAKLQVVSRQDLDQAVTDLAVKNAKV
GTIDAQINKAKASLDTAKINLDYTQISAPMDGDVVQITTLQGQTVIAAQQAPNILTLADMSTMLVQAQVSEADVINLKPG
MKASFTVLGDPGKRFSGVLKDILPTPEKVNDAIFYSARFEVPNPDRLLRLQMTAQVSIQLANVDQAVVIPLAALGDELGS
NRYQVTVLKEGKEEKREVTIGIRNNVDAQVISGLSVGEDVIVSRGGTGDA

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=364, Percent_Identity=64.8351648351648, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI87082036, Length=358, Percent_Identity=30.4469273743017, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1790519, Length=239, Percent_Identity=29.7071129707113, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789929, Length=237, Percent_Identity=28.2700421940928, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789637, Length=188, Percent_Identity=29.2553191489362, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40070; Mature: 40070

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSRGQRRWLAAIAVLLIGGFFIARHLMAPVPVNYQTVKVVHRDLQQNVLATGKLDAVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHE
KVDVGAQVTGQLEKLYVEIGDHVKRGQLLAMIDPQQAQNQIKEVEATLQDLNAQRIQAKA
EECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHH
ELHLATVTLGRQQNLAKLQVVSRQDLDQAVTDLAVKNAKVGTIDAQINKAKASLDTAKIN
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCEEEEE
LDYTQISAPMDGDVVQITTLQGQTVIAAQQAPNILTLADMSTMLVQAQVSEADVINLKPG
EEHEEECCCCCCCEEEEEEECCCEEEEECCCCCEEEEHHHHHHHHEEECCCCCEEEECCC
MKASFTVLGDPGKRFSGVLKDILPTPEKVNDAIFYSARFEVPNPDRLLRLQMTAQVSIQL
CCEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEEEEEEEE
ANVDQAVVIPLAALGDELGSNRYQVTVLKEGKEEKREVTIGIRNNVDAQVISGLSVGEDV
ECCCCEEEEEHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCCHHHHCCCCCCCCE
IVSRGGTGDA
EEECCCCCCC
>Mature Secondary Structure
MQLSRGQRRWLAAIAVLLIGGFFIARHLMAPVPVNYQTVKVVHRDLQQNVLATGKLDAVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHE
KVDVGAQVTGQLEKLYVEIGDHVKRGQLLAMIDPQQAQNQIKEVEATLQDLNAQRIQAKA
EECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHH
ELHLATVTLGRQQNLAKLQVVSRQDLDQAVTDLAVKNAKVGTIDAQINKAKASLDTAKIN
EEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCEEEEE
LDYTQISAPMDGDVVQITTLQGQTVIAAQQAPNILTLADMSTMLVQAQVSEADVINLKPG
EEHEEECCCCCCCEEEEEEECCCEEEEECCCCCEEEEHHHHHHHHEEECCCCCEEEECCC
MKASFTVLGDPGKRFSGVLKDILPTPEKVNDAIFYSARFEVPNPDRLLRLQMTAQVSIQL
CCEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEEEEEEEE
ANVDQAVVIPLAALGDELGSNRYQVTVLKEGKEEKREVTIGIRNNVDAQVISGLSVGEDV
ECCCCEEEEEHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCCHHHHCCCCCCCCE
IVSRGGTGDA
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]