| Definition | Yersinia pseudotuberculosis IP 31758, complete genome. |
|---|---|
| Accession | NC_009708 |
| Length | 4,723,306 |
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The map label for this gene is dkgA [H]
Identifier: 153949934
GI number: 153949934
Start: 689701
End: 690528
Strand: Reverse
Name: dkgA [H]
Synonym: YpsIP31758_0586
Alternate gene names: 153949934
Gene position: 690528-689701 (Counterclockwise)
Preceding gene: 153947121
Following gene: 153950738
Centisome position: 14.62
GC content: 49.64
Gene sequence:
>828_bases ATGCAACCCCTTATCAAGTTGCACGATGGGCGCTTGATGCCACAACTCGGCCTCGGCGTTTGGCAGGCAAGTATCCAAGA AACAGAGCTTGCAGTCAGTAAGGCGCTGGAAGTCGGTTACCGCTCAATTGATACCGCCGCTATTTATAAAAATGAAGAGG GTGTGGGCAAGGCGCTGAAGGCGGCGGCTGTTGCCCGTGATGAACTGTTTATCACCACAAAACTGTGGAACGATGATCAA CATAATCCTCAGCAAGCCCTGGAAACCAGCCTGCAAAAGCTCCAACTGGATTATGTAGATCTCTACCTGATCCATTGGCC GGATCCAAAACAAGACCATTATGTCAGTGCCTGGCGTGAACTCGTCACACTAAAAGAGCAAGGTTTGATCCGCAGTATCG GCGTGTGTAACTTCCATATTCCTCATCTGCAACGGTTGATTGATGAGACGGGTATCGCCCCTACCGTCAATCAGATTGAA CTGCATCCGTTGCTGCAACAACGTCAGCTCCATGCCTGGAATGCCACCCATCATATTGCAACCGAGTCTTGGAGCCCGTT AGCACAAGGTGGCAAAGGCGTTTTTGATCAAGAGATTATCCGCAAGCTCGCTCAGCAATATAATAAAACGCCTGCACAAA TCGTGATCCGTTGGCATCTGGACAGTGGGCTGATTGTTATCCCCAAATCCGTCACACCAGCACGTATCAGAGAAAACTTT GAGGTCTTTGATTTTAAGCTACAAAAAGAGGAGTTGCTGGCAATTGCCAAACTGGATTGCGGTAAACGGCTGGGGCCAGA CCCGGAAGTTTTCGGATCTGACCGCTGA
Upstream 100 bases:
>100_bases TAATTAGCAAGGTCATAAATAAAATGATAACGACTAAACTTACGTTATCAGCAACGGGCTAATACAGCCCAATCAGTAAG CCAAGGAGATCAACATGACA
Downstream 100 bases:
>100_bases TTTCAGGCCAACAATAACCCCTTAATGCTGCCTGTTTTTCCCTCTGGATCCGGCAGATGGCTTATTGACCGCAGCTTTAT TTGCGCCCGTTTTACCCGCT
Product: 2,5-diketo-D-gluconate reductase A
Products: NA
Alternate protein names: 2,5-DKG reductase A; 2,5-DKGR A; 25DKGR-A; AKR5C [H]
Number of amino acids: Translated: 275; Mature: 275
Protein sequence:
>275_residues MQPLIKLHDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALKAAAVARDELFITTKLWNDDQ HNPQQALETSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQIE LHPLLQQRQLHAWNATHHIATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRENF EVFDFKLQKEELLAIAKLDCGKRLGPDPEVFGSDR
Sequences:
>Translated_275_residues MQPLIKLHDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALKAAAVARDELFITTKLWNDDQ HNPQQALETSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQIE LHPLLQQRQLHAWNATHHIATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRENF EVFDFKLQKEELLAIAKLDCGKRLGPDPEVFGSDR >Mature_275_residues MQPLIKLHDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALKAAAVARDELFITTKLWNDDQ HNPQQALETSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRELVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQIE LHPLLQQRQLHAWNATHHIATESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRENF EVFDFKLQKEELLAIAKLDCGKRLGPDPEVFGSDR
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=288, Percent_Identity=36.8055555555556, Blast_Score=196, Evalue=1e-50, Organism=Homo sapiens, GI5174391, Length=288, Percent_Identity=36.8055555555556, Blast_Score=196, Evalue=1e-50, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=35.8361774744027, Blast_Score=190, Evalue=1e-48, Organism=Homo sapiens, GI93277124, Length=303, Percent_Identity=33.6633663366337, Blast_Score=177, Evalue=7e-45, Organism=Homo sapiens, GI310109922, Length=276, Percent_Identity=36.231884057971, Blast_Score=172, Evalue=3e-43, Organism=Homo sapiens, GI5453543, Length=294, Percent_Identity=35.0340136054422, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI310109920, Length=294, Percent_Identity=35.0340136054422, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI45446745, Length=294, Percent_Identity=35.0340136054422, Blast_Score=171, Evalue=8e-43, Organism=Homo sapiens, GI4503285, Length=294, Percent_Identity=35.0340136054422, Blast_Score=171, Evalue=8e-43, Organism=Homo sapiens, GI24497583, Length=298, Percent_Identity=34.5637583892617, Blast_Score=164, Evalue=6e-41, Organism=Homo sapiens, GI5174695, Length=300, Percent_Identity=34, Blast_Score=164, Evalue=1e-40, Organism=Homo sapiens, GI291291012, Length=263, Percent_Identity=34.9809885931559, Blast_Score=163, Evalue=1e-40, Organism=Homo sapiens, GI24497585, Length=301, Percent_Identity=33.2225913621262, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI4502049, Length=289, Percent_Identity=35.6401384083045, Blast_Score=158, Evalue=4e-39, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=33.8129496402878, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI300116271, Length=280, Percent_Identity=32.5, Blast_Score=130, Evalue=1e-30, Organism=Homo sapiens, GI310109926, Length=127, Percent_Identity=43.3070866141732, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI207028673, Length=127, Percent_Identity=43.3070866141732, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI310109924, Length=146, Percent_Identity=32.8767123287671, Blast_Score=89, Evalue=4e-18, Organism=Escherichia coli, GI87082198, Length=270, Percent_Identity=74.8148148148148, Blast_Score=427, Evalue=1e-121, Organism=Escherichia coli, GI1786400, Length=256, Percent_Identity=42.1875, Blast_Score=189, Evalue=2e-49, Organism=Escherichia coli, GI1788081, Length=276, Percent_Identity=31.1594202898551, Blast_Score=111, Evalue=4e-26, Organism=Caenorhabditis elegans, GI17537075, Length=298, Percent_Identity=37.9194630872483, Blast_Score=189, Evalue=2e-48, Organism=Caenorhabditis elegans, GI17537077, Length=293, Percent_Identity=37.2013651877133, Blast_Score=187, Evalue=7e-48, Organism=Caenorhabditis elegans, GI17550248, Length=292, Percent_Identity=38.6986301369863, Blast_Score=180, Evalue=7e-46, Organism=Caenorhabditis elegans, GI71998625, Length=273, Percent_Identity=35.1648351648352, Blast_Score=169, Evalue=2e-42, Organism=Caenorhabditis elegans, GI17562292, Length=280, Percent_Identity=34.6428571428571, Blast_Score=164, Evalue=5e-41, Organism=Caenorhabditis elegans, GI17564128, Length=299, Percent_Identity=34.1137123745819, Blast_Score=162, Evalue=2e-40, Organism=Caenorhabditis elegans, GI17566692, Length=283, Percent_Identity=32.8621908127208, Blast_Score=162, Evalue=2e-40, Organism=Caenorhabditis elegans, GI17561298, Length=273, Percent_Identity=32.2344322344322, Blast_Score=162, Evalue=2e-40, Organism=Caenorhabditis elegans, GI17538386, Length=273, Percent_Identity=31.8681318681319, Blast_Score=154, Evalue=4e-38, Organism=Caenorhabditis elegans, GI17561300, Length=272, Percent_Identity=31.9852941176471, Blast_Score=147, Evalue=4e-36, Organism=Caenorhabditis elegans, GI17552492, Length=275, Percent_Identity=30.5454545454545, Blast_Score=142, Evalue=1e-34, Organism=Caenorhabditis elegans, GI17537079, Length=298, Percent_Identity=27.8523489932886, Blast_Score=133, Evalue=9e-32, Organism=Saccharomyces cerevisiae, GI6324694, Length=283, Percent_Identity=38.5159010600707, Blast_Score=203, Evalue=2e-53, Organism=Saccharomyces cerevisiae, GI6320576, Length=275, Percent_Identity=37.4545454545455, Blast_Score=197, Evalue=2e-51, Organism=Saccharomyces cerevisiae, GI6319625, Length=284, Percent_Identity=35.9154929577465, Blast_Score=160, Evalue=3e-40, Organism=Saccharomyces cerevisiae, GI6321896, Length=316, Percent_Identity=32.5949367088608, Blast_Score=150, Evalue=3e-37, Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=30.3846153846154, Blast_Score=138, Evalue=1e-33, Organism=Saccharomyces cerevisiae, GI6320079, Length=284, Percent_Identity=31.3380281690141, Blast_Score=126, Evalue=4e-30, Organism=Drosophila melanogaster, GI24644950, Length=302, Percent_Identity=37.7483443708609, Blast_Score=202, Evalue=2e-52, Organism=Drosophila melanogaster, GI221378297, Length=322, Percent_Identity=35.4037267080745, Blast_Score=194, Evalue=4e-50, Organism=Drosophila melanogaster, GI20129731, Length=294, Percent_Identity=37.4149659863946, Blast_Score=193, Evalue=8e-50, Organism=Drosophila melanogaster, GI24663317, Length=298, Percent_Identity=35.5704697986577, Blast_Score=186, Evalue=2e-47, Organism=Drosophila melanogaster, GI24662789, Length=306, Percent_Identity=35.2941176470588, Blast_Score=183, Evalue=9e-47, Organism=Drosophila melanogaster, GI21356425, Length=297, Percent_Identity=35.6902356902357, Blast_Score=179, Evalue=1e-45, Organism=Drosophila melanogaster, GI24657054, Length=298, Percent_Identity=36.9127516778523, Blast_Score=179, Evalue=2e-45, Organism=Drosophila melanogaster, GI45553081, Length=295, Percent_Identity=36.6101694915254, Blast_Score=179, Evalue=2e-45, Organism=Drosophila melanogaster, GI24662781, Length=297, Percent_Identity=38.7205387205387, Blast_Score=169, Evalue=2e-42, Organism=Drosophila melanogaster, GI24662785, Length=297, Percent_Identity=38.3838383838384, Blast_Score=164, Evalue=7e-41, Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=35.6589147286822, Blast_Score=149, Evalue=2e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 31232; Mature: 31232
Theoretical pI: Translated: 6.74; Mature: 6.74
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 0.7 %Met (Translated Protein) 1.5 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 1.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQPLIKLHDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALK CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHH AAAVARDELFITTKLWNDDQHNPQQALETSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRE HHHHHHCEEEEEEEECCCCCCCHHHHHHHHHHHHEECEEEEEEEECCCCCCCHHHHHHHH LVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQIELHPLLQQRQLHAWNATHHIA HHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCHHEEC TESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRENF CCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHCCC EVFDFKLQKEELLAIAKLDCGKRLGPDPEVFGSDR EEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCC >Mature Secondary Structure MQPLIKLHDGRLMPQLGLGVWQASIQETELAVSKALEVGYRSIDTAAIYKNEEGVGKALK CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHHH AAAVARDELFITTKLWNDDQHNPQQALETSLQKLQLDYVDLYLIHWPDPKQDHYVSAWRE HHHHHHCEEEEEEEECCCCCCCHHHHHHHHHHHHEECEEEEEEEECCCCCCCHHHHHHHH LVTLKEQGLIRSIGVCNFHIPHLQRLIDETGIAPTVNQIELHPLLQQRQLHAWNATHHIA HHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHCCCHHEEC TESWSPLAQGGKGVFDQEIIRKLAQQYNKTPAQIVIRWHLDSGLIVIPKSVTPARIRENF CCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCHHHHHCCC EVFDFKLQKEELLAIAKLDCGKRLGPDPEVFGSDR EEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11586360; 12142430 [H]