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The map label for this gene is bioD [H]

Identifier: 153949782

GI number: 153949782

Start: 3209724

End: 3210446

Strand: Reverse

Name: bioD [H]

Synonym: YpsIP31758_2841

Alternate gene names: 153949782

Gene position: 3210446-3209724 (Counterclockwise)

Preceding gene: 153948922

Following gene: 153950655

Centisome position: 67.97

GC content: 54.08

Gene sequence:

>723_bases
GTGACTAAACGTTGGTTTATCACCGGTATCGATACTGATGTCGGTAAAACCGTCGCCAGTTGTGCATTACTGCAAGCGGC
CACCGCTCAGGGGTACCGTACTGCTGGCTATAAACCGGTAGCATCCGGTAGCCAGATGACCGCTGACGGCTTGCGCAATA
GTGATGCCCTGGCGTTGCAGGCGAATAGCAGCCAGAGGCTCGGTTACTCACAAGTGAATCCGTTCACTTTTTTGGAAGCG
ACATCACCGCATATTGCCAGTGAAAGTGAAGGGAGGGCGATCCCTTTGACGGCGTTATCACAGGGTTTACGTCAACTGGA
ACCCTCCGCTGACTGGATATTGATAGAAGGGGCCGGCGGCTGGTTTACCCCGCTTTCTCCGCAGGCCACATTTGCCGATT
GGGTACAACAGGAACAATTGCCGGTCATTATGGTGGTTGGGGTGAAACTGGGGTGTATCAACCATGCGTTGCTCACGGCA
CAGGCGATTCAGCACGCCGGGCTGACACTGGCCGGTTGGGTTGCCAATGAGGTGACACCGGCAGGGAGACGGCAGGCCGA
ATATCAGGCCACATTGACCCGGATGATAACCGCGCCATTGCTGGGAATTATTCCCTATCTTTCTGATATAGAAGAAAATC
CGGTGACAACACGCCGTGATCTTGGGCACTACTTGGATTTGACGGTATTACGTGCAGCAGAACGGGAGGCTGTCAACATG
TGA

Upstream 100 bases:

>100_bases
TTACAGGGGCGTCAACGTCTGGCGGCGCTACAACGGGCCTATGTCATGCAATCTGGCGGCTATCCACTGAGTTATCATAT
GGTTTATGGGGTTATCTATC

Downstream 100 bases:

>100_bases
TGCTACATATATGGACGCCGCTACAAGCATGTGATGTGGCTTGCAATCAGAGGCCATCAGGGGCGATTAACCTTATGTAG
TTGATCTACCCGAGTGTAGT

Product: dithiobiotin synthetase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTKRWFITGIDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQANSSQRLGYSQVNPFTFLEA
TSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGGWFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTA
QAIQHAGLTLAGWVANEVTPAGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM

Sequences:

>Translated_240_residues
MTKRWFITGIDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQANSSQRLGYSQVNPFTFLEA
TSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGGWFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTA
QAIQHAGLTLAGWVANEVTPAGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM
>Mature_239_residues
TKRWFITGIDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQANSSQRLGYSQVNPFTFLEAT
SPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGGWFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTAQ
AIQHAGLTLAGWVANEVTPAGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1786995, Length=230, Percent_Identity=70.8695652173913, Blast_Score=330, Evalue=7e-92,
Organism=Escherichia coli, GI87081944, Length=232, Percent_Identity=49.1379310344828, Blast_Score=209, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004472
- InterPro:   IPR002586 [H]

Pfam domain/function: PF01656 CbiA [H]

EC number: =6.3.3.3 [H]

Molecular weight: Translated: 25833; Mature: 25701

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRWFITGIDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQ
CCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ANSSQRLGYSQVNPFTFLEATSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGG
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCEEEEECCCC
WFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTAQAIQHAGLTLAGWVANEVTP
CCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCC
AGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKRWFITGIDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQ
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
ANSSQRLGYSQVNPFTFLEATSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGG
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCEEEEECCCC
WFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTAQAIQHAGLTLAGWVANEVTP
CCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCC
AGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]