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The map label for this gene is fabF [H]

Identifier: 153949505

GI number: 153949505

Start: 2879719

End: 2880993

Strand: Direct

Name: fabF [H]

Synonym: YpsIP31758_2547

Alternate gene names: 153949505

Gene position: 2879719-2880993 (Clockwise)

Preceding gene: 153950772

Following gene: 153949854

Centisome position: 60.97

GC content: 52.31

Gene sequence:

>1275_bases
ATGAGTACACGCCATGTAGTAATTACAGGTATGGGTGTCGTTTCCCCATTAGGCTGCGGTATCGAAACGGTCTGGCAACG
GCTCTTGGCAGGGCAATCAGGCATCCGTGTTCTATCGGATGAAATTGTCGGTGACTTGCCCGCTAAAATTGGTGGGCAAG
TGCCTACGTTAGCAGAAGACGCTAAAGTTGGTTTCGATCCAGATAAAGCGGTTACCCCAAAAGATCAAAAGAAAATGGAT
CGCTTTATTGAGTTTGCGATGGCGGCGGCCGATGAGGCAATTAGCCAGGCAGGCTGGCATGCGGATAACACAGAGAAACA
AGAGCGTACCGCGACAATCATAGGCGCGGGTATTGGTGGTTTTCCGGCCATTGCCCATGCAGTGCGGACTTCCGACAGCC
GTGGGCCAAAACGCCTCTCACCGTTTACTGTCCCTTCATTCTTAGTGAATTTGGCCGCTGGCCATGTTTCTATCAAACAT
CATTTTAAAGGCCCGATTGGCGCACCAGTCACTGCCTGTGCTGCCGGTGTACAGGCAATCGGTGACGCCGTGCGGATGAT
CCGCAACAATGAAGCAGATGTTGCCCTGTGCGGTGGCGCAGAAGCCGTGATCGATACCGTGAGTCTGGCCGGTTTTGCTG
CCGCTCGTGCGTTATCAACCCACTTTAATAGCACACCAGAAAAAGCCTCCCGCCCCTTCGACACTGCCCGTGACGGTTTC
GTGATGGGAGAAGGTGCTGGTTTACTGATTATTGAGGAGTTGGAGCATGCTTTAGCCAGAGGCGCGAAGCCACTAGCAGA
AATAGTCGGCTATGGTACCAGTGCCGATGTTTACCATATGACCTCTGGCGCTGAGGATGGCGACGGGGCCTATCGCGCCA
TGAAAATCGCTTTGCGTCAGGCCGGTATTACGCCCGAGCAAGTTCAGCATCTGAATGCCCACGCGACCTCAACACCGGTA
GGTGATCTCGGTGAAATTAATGCCATTAAACATTTGTTTGGCGAGAGTAATGCGTTAGCGATTACCTCAACAAAATCCGC
CACAGGGCACCTGTTGGGCGCTGCTGGTGGGCTGGAAACCATTTTCACTGTACTGGCATTGCGTGATCAAATCGTGCCCG
CAACGTTGAATCTGGAAAATCCAGATCCTGCAGCCAAGGGACTCAACATTATTGCAGGTAACGCACAACCTCATGACATG
ACGTATGCCCTTTCCAATGGTTTTGGCTTTGGTGGGGTGAACGCAAGTATCTTACTGAAACGCTGGGTGGACTAA

Upstream 100 bases:

>100_bases
CATTCATGCATAAAAACGGTCAGTAAAGATTAAATAACCGTCTTATGGAGAACGGCCTTCTAGGTTGTCTCCTGTTCAAT
CGAGTTTAAAAGGAAAAAGA

Downstream 100 bases:

>100_bases
CGCAATAAATGAAAACCTCCGCCTAATGCGGAGGTTACCCTTGATAATGACAGAGAGCCGCTTAAGCGGTCACAGCCCTG
TCTTCCATAGCCTGTCGCCA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSTRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAEDAKVGFDPDKAVTPKDQKKMD
RFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKH
HFKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADVYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPV
GDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDM
TYALSNGFGFGGVNASILLKRWVD

Sequences:

>Translated_424_residues
MSTRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAEDAKVGFDPDKAVTPKDQKKMD
RFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKH
HFKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADVYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPV
GDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDM
TYALSNGFGFGGVNASILLKRWVD
>Mature_423_residues
STRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAEDAKVGFDPDKAVTPKDQKKMDR
FIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHH
FKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFV
MGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADVYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVG
DLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMT
YALSNGFGFGGVNASILLKRWVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=45.2380952380952, Blast_Score=347, Evalue=9e-96,
Organism=Homo sapiens, GI223972627, Length=189, Percent_Identity=37.5661375661376, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=26.5588914549654, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1787337, Length=423, Percent_Identity=46.5721040189125, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1788663, Length=425, Percent_Identity=36.2352941176471, Blast_Score=234, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=38.0614657210402, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=42.4812030075188, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=430, Percent_Identity=26.5116279069767, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=280, Percent_Identity=25.3571428571429, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=37.8619153674833, Blast_Score=279, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=44.7867298578199, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI221330659, Length=433, Percent_Identity=25.4041570438799, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19920632, Length=433, Percent_Identity=25.4041570438799, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581345, Length=435, Percent_Identity=25.0574712643678, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44026; Mature: 43895

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAED
CCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCC
AKVGFDPDKAVTPKDQKKMDRFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCC
FPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQAI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHH
GDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCE
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADVYHMTSGAEDGDGAYRAMKIALRQ
EEECCCCEEEHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHH
AGITPEQVQHLNAHATSTPVGDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLET
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHH
IFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTYALSNGFGFGGVNASILLK
HHHHHHHHHHCCCEEEECCCCCHHHCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHH
RWVD
HHCC
>Mature Secondary Structure 
STRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAED
CCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCC
AKVGFDPDKAVTPKDQKKMDRFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCC
FPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQAI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHH
GDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCE
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADVYHMTSGAEDGDGAYRAMKIALRQ
EEECCCCEEEHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHH
AGITPEQVQHLNAHATSTPVGDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLET
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHH
IFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTYALSNGFGFGGVNASILLK
HHHHHHHHHHCCCEEEECCCCCHHHCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHH
RWVD
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]