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Identifier: 153949261

GI number: 153949261

Start: 2177494

End: 2178498

Strand: Direct

Name: add

Synonym: YpsIP31758_1878

Alternate gene names: 153949261

Gene position: 2177494-2178498 (Clockwise)

Preceding gene: 153950537

Following gene: 153949264

Centisome position: 46.1

GC content: 50.55

Gene sequence:

>1005_bases
ATGATTGATCCTCGCCTTCCTCTGACCGACATTCATCGCCACCTTGATGGCAATATCCGAGCGCAAACCATTTTGGACTT
GGGTCAACAATTTAATTTGAATTTACCGGCCAATGAGCTTGATACGCTGAGACCACACGTACAAATCACCAAGACCGAGC
CAGATTTGGTCAGTTTCCTACAAAAGTTGGATTGGGGCGTTGCAGTTCTCGGATCACTGGATGCCTGTCGCCGAGTGGCT
TATGAGAATGTCGAAGACGCAGCACATGCTGGTTTACATTATGCTGAACTCCGCTTTTCCCCGTTTTATATGGCGATGAA
ACACCAACTACCGATTACCGGTGTTGTCGAAGCGGTTATTGATGGCATTGCGTCTGGTTGTCGCGATTTTAATATTGATA
TCCGTTTGATCGGCATTCTCAGCCGCACCTTCGGTGAACAAGCGTGTTTGCAAGAACTTGATAGCTTGCTGGCCCATCGC
GAAGGGATAACCGCGCTGGATTTAGCCGGTGACGAGTTAGGTTTTCCCGGTTCTCTGTTCCGCCGCCATTTTAATCGAGC
GAGGGATGCGGGCCTACGTATTACCGTCCATGCGGGTGAAGCGGCCGGTCCGGAGAGTATCTGGCAAGCTATTCGTGAAC
TGGGTGCTGAACGTATCGGCCACGGCGTTAAAGCCGTCGAAGACCGTAAGTTGATGGACTATCTGGCAGAACACAAAATA
GGTATCGAATCCTGCCTGACCTCCAATATCCAAACCAGCACTGTAGTCTCTCTGGCAACCCATCCATTAGCAACCTTCCT
ACGCCATGGCATCGTGGCATCAATTAACACTGATGACCCGGCGGTTCAGGGCATTGAAATTGCCCATGAATACCTTGTCG
CTGCACCGGCTGCGGGGCTAACGCCGCATGAAATCCGCCAAGCACAAGCGAATGGCCTGGAAATGGCATTTATCAGCGAA
CAAGAAAAGCAGGCACTGCGGGATAAAGTATTCCCTATTTCCTGA

Upstream 100 bases:

>100_bases
TTTTTTATGTAACACTATGGATATTTTCATTCGTTTGTTTTTATAATATTCTGCACCTTATCTACCGAAATCTATCTTTG
ATAAAAAGTGAGTGCACAGC

Downstream 100 bases:

>100_bases
GGTACGATAGAACCCGAAGATACGATAAAATAAAAAAGCGCCCATACCCTAGAGTGGTACCGGCGCTTTCTATTTTCATC
ACTAAGCCCTTTTTATCGCC

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MIDPRLPLTDIHRHLDGNIRAQTILDLGQQFNLNLPANELDTLRPHVQITKTEPDLVSFLQKLDWGVAVLGSLDACRRVA
YENVEDAAHAGLHYAELRFSPFYMAMKHQLPITGVVEAVIDGIASGCRDFNIDIRLIGILSRTFGEQACLQELDSLLAHR
EGITALDLAGDELGFPGSLFRRHFNRARDAGLRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRKLMDYLAEHKI
GIESCLTSNIQTSTVVSLATHPLATFLRHGIVASINTDDPAVQGIEIAHEYLVAAPAAGLTPHEIRQAQANGLEMAFISE
QEKQALRDKVFPIS

Sequences:

>Translated_334_residues
MIDPRLPLTDIHRHLDGNIRAQTILDLGQQFNLNLPANELDTLRPHVQITKTEPDLVSFLQKLDWGVAVLGSLDACRRVA
YENVEDAAHAGLHYAELRFSPFYMAMKHQLPITGVVEAVIDGIASGCRDFNIDIRLIGILSRTFGEQACLQELDSLLAHR
EGITALDLAGDELGFPGSLFRRHFNRARDAGLRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRKLMDYLAEHKI
GIESCLTSNIQTSTVVSLATHPLATFLRHGIVASINTDDPAVQGIEIAHEYLVAAPAAGLTPHEIRQAQANGLEMAFISE
QEKQALRDKVFPIS
>Mature_334_residues
MIDPRLPLTDIHRHLDGNIRAQTILDLGQQFNLNLPANELDTLRPHVQITKTEPDLVSFLQKLDWGVAVLGSLDACRRVA
YENVEDAAHAGLHYAELRFSPFYMAMKHQLPITGVVEAVIDGIASGCRDFNIDIRLIGILSRTFGEQACLQELDSLLAHR
EGITALDLAGDELGFPGSLFRRHFNRARDAGLRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRKLMDYLAEHKI
GIESCLTSNIQTSTVVSLATHPLATFLRHGIVASINTDDPAVQGIEIAHEYLVAAPAAGLTPHEIRQAQANGLEMAFISE
QEKQALRDKVFPIS

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=342, Percent_Identity=30.9941520467836, Blast_Score=141, Evalue=8e-34,
Organism=Escherichia coli, GI1787910, Length=330, Percent_Identity=77.2727272727273, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI32565969, Length=338, Percent_Identity=30.4733727810651, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17538512, Length=338, Percent_Identity=30.4733727810651, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324188, Length=335, Percent_Identity=26.865671641791, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24645260, Length=331, Percent_Identity=25.9818731117825, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_YERP3 (A7FHX5)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400853.1
- ProteinModelPortal:   A7FHX5
- SMR:   A7FHX5
- STRING:   A7FHX5
- GeneID:   5386347
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1878
- NMPDR:   fig|349747.3.peg.657
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   PYYMAMN
- ProtClustDB:   PRK09358
- BioCyc:   YPSE349747:YPSIP31758_1878-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR006650
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 36673; Mature: 36673

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 200-200 BINDING 14-14 BINDING 16-16 BINDING 170-170 BINDING 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPRLPLTDIHRHLDGNIRAQTILDLGQQFNLNLPANELDTLRPHVQITKTEPDLVSFL
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEECCCHHHHHHH
QKLDWGVAVLGSLDACRRVAYENVEDAAHAGLHYAELRFSPFYMAMKHQLPITGVVEAVI
HHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHH
DGIASGCRDFNIDIRLIGILSRTFGEQACLQELDSLLAHREGITALDLAGDELGFPGSLF
HHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHH
RRHFNRARDAGLRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRKLMDYLAEHKI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GIESCLTSNIQTSTVVSLATHPLATFLRHGIVASINTDDPAVQGIEIAHEYLVAAPAAGL
CHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
TPHEIRQAQANGLEMAFISEQEKQALRDKVFPIS
CHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIDPRLPLTDIHRHLDGNIRAQTILDLGQQFNLNLPANELDTLRPHVQITKTEPDLVSFL
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEECCCHHHHHHH
QKLDWGVAVLGSLDACRRVAYENVEDAAHAGLHYAELRFSPFYMAMKHQLPITGVVEAVI
HHHCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHH
DGIASGCRDFNIDIRLIGILSRTFGEQACLQELDSLLAHREGITALDLAGDELGFPGSLF
HHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHH
RRHFNRARDAGLRITVHAGEAAGPESIWQAIRELGAERIGHGVKAVEDRKLMDYLAEHKI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GIESCLTSNIQTSTVVSLATHPLATFLRHGIVASINTDDPAVQGIEIAHEYLVAAPAAGL
CHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
TPHEIRQAQANGLEMAFISEQEKQALRDKVFPIS
CHHHHHHHHCCCCEEEEECHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA