Click here to switch to the map view.

The map label for this gene is cycA [H]

Identifier: 153949029

GI number: 153949029

Start: 2564294

End: 2565709

Strand: Direct

Name: cycA [H]

Synonym: YpsIP31758_2259

Alternate gene names: 153949029

Gene position: 2564294-2565709 (Clockwise)

Preceding gene: 153950271

Following gene: 153948039

Centisome position: 54.29

GC content: 46.61

Gene sequence:

>1416_bases
ATGGTAGACCAATCCAAAATAGTGGCAGAGCCGTTACAAGAACCTGAAGAACACCTCCAACGAAGCCTCTCCAATCGGCA
TATCCAACTCATCGCCATTGGCGGTGCCATAGGTACCGGGTTGTTTATGGGATCGGGCAAAACCATCAGCCTTGCCGGGC
CGTCGATCATTTTCGTCTATATGATCATTGGTTTTATGTTGTTTTTCGTGATGCGGGCAATGGGTGAACTGTTGCTATCG
AATCTGAACTATAAATCATTCAGTGATTTCTCCGCTGATTTACTTGGCCCTTGGGCTGGTTTTTTCACCGGTTGGACTTA
CTGGTTTTGTTGGGTCATCACCGGTATTGCTGATGTAGTGGCCATCACCGCTTATGCACAGTTCTGGTTCCCCGATTTCT
CTCAATGGGTTGCCTCGCTATTAGTCGTTTTACTGTTGTTGTCACTGAACTTGGCCACAGTAAAAATGTTTGGTGAGATG
GAGTTCTGGTTTGCCATGATTAAAATCGTGGCTATCGTGGCGCTAATTTTTGCCGGCCTAACTATGGTCTTAGTCAGCTA
TCAGTCACCATCTGGTACCACCGCTTCATTTACGCATTTATGGAGTGACGGAGGTATGTTCCCAAAAGGGATCAGTGGAT
TCTTTGCTGGCTTCCAAATTGCCGTTTTTGCCTTTGTAGGTATTGAACTGGTTGGGACCACAGCGGCAGAAACCAAAGAC
CCAGAGGTGGTTTTACCACGAGCCATTAACTCCATTCCGATTCGCATAATCATGTTTTATGTTTTCTCATTAATTATGAT
TATGTCGGTAACGCCGTGGAGTTCAGTCGTCGCGGATAAAAGCCCGTTTGTTGAGTTATTCGTCTTGGTCGGGCTGCCCG
CAGCGGCCAGTGTCATTAACTTTGTGGTATTAACCTCTGCGGCCTCCTCGGCCAACAGTGGCGTGTTCTCCACCAGCAGG
ATGTTGTTCGGGCTGGCGAAAGAAGGCGATGCACCTAAGCAATTTGGCAAGCTATCACGCCGTTCGGTTCCTGCCACTGG
CCTGACATTCTCTTGTATCTGTCTGTTAGGCGGGGTGGTGCTGATTTATCTTATCCCGAACGTGATGACGGTCTTTACCT
TGGTTACCACTGTTTCGGCCATTCTGTTTATGTTCGTCTGGACCATCATCCTTTGCTCTTATTTGGTGTATCGCAAAAGA
CGCCCAGCACTGCATAAAAAATCCATCTACAAAATGCCAGCCGGTATTTTTATGTCATGGGTTTGTATGGCGTTTTTCGC
CTTTGTTTTGGTACTGCTGACATTGGAAAGTGATACCCGTCAGGCGTTAATTGTTACACCGCTATGGTTTGTCATTTTGA
CTGCCAGCTATATCTTCCTGAAAAAACGCAGAGCCCGTTTATATAACAGTAAATAA

Upstream 100 bases:

>100_bases
TTAATGCATAAAAAACAGACAGACAGGTCAAACAGATAAAACCAAAGAGCCAATCTAGAGCTCAATAACTTCACAAATAC
AGGAAGAGGGAATGGGAAAG

Downstream 100 bases:

>100_bases
CCACAGTGTGATAAAACGGTGCCAGAGGTGTTCTGGTACCGTTTTATTTCCCCCTCTAATCACTTATTCCATAACGCCGA
CAACCCGCTACTGAATAAGG

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVVAITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMFGEM
EFWFAMIKIVAIVALIFAGLTMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAKEGDAPKQFGKLSRRSVPATGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKR
RPALHKKSIYKMPAGIFMSWVCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK

Sequences:

>Translated_471_residues
MVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVVAITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMFGEM
EFWFAMIKIVAIVALIFAGLTMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAKEGDAPKQFGKLSRRSVPATGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKR
RPALHKKSIYKMPAGIFMSWVCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK
>Mature_471_residues
MVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVVAITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMFGEM
EFWFAMIKIVAIVALIFAGLTMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAKEGDAPKQFGKLSRRSVPATGLTFSCICLLGGVVLIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKR
RPALHKKSIYKMPAGIFMSWVCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI114326544, Length=352, Percent_Identity=21.5909090909091, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI114326550, Length=352, Percent_Identity=21.5909090909091, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790653, Length=465, Percent_Identity=81.9354838709677, Blast_Score=779, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=39.0350877192982, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=40.958605664488, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI48994972, Length=463, Percent_Identity=40.1727861771058, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1786789, Length=463, Percent_Identity=36.9330453563715, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI87081915, Length=472, Percent_Identity=37.5, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1788480, Length=476, Percent_Identity=34.2436974789916, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789017, Length=439, Percent_Identity=32.1184510250569, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87081708, Length=392, Percent_Identity=32.9081632653061, Blast_Score=227, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=359, Percent_Identity=25.3481894150418, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324061, Length=454, Percent_Identity=32.8193832599119, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=481, Percent_Identity=30.5613305613306, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=403, Percent_Identity=30.7692307692308, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=449, Percent_Identity=29.6213808463252, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=478, Percent_Identity=28.2426778242678, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6324553, Length=390, Percent_Identity=29.7435897435897, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=456, Percent_Identity=27.8508771929825, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=415, Percent_Identity=27.2289156626506, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6319824, Length=413, Percent_Identity=26.1501210653753, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324059, Length=453, Percent_Identity=28.2560706401766, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=427, Percent_Identity=26.6978922716628, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=26.2295081967213, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320251, Length=429, Percent_Identity=26.3403263403263, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=25.5639097744361, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=437, Percent_Identity=24.9427917620137, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=435, Percent_Identity=28.0459770114943, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=435, Percent_Identity=27.1264367816092, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=495, Percent_Identity=23.6363636363636, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221512776, Length=412, Percent_Identity=22.3300970873786, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24666159, Length=412, Percent_Identity=22.3300970873786, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550968, Length=500, Percent_Identity=25.2, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19921172, Length=500, Percent_Identity=25.2, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51998; Mature: 51998

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMFGEMEFWFAMIKIVAIVALIFAGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVIN
CCEECCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAKEGDAPKQFGKLSRRSVPATGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKRRPALHKKSIYKMPAGIFMSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
VCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDQSKIVAEPLQEPEEHLQRSLSNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLNYKSFSDFSADLLGPWAGFFTGWTYWFCWVITGIADVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPDFSQWVASLLVVLLLLSLNLATVKMFGEMEFWFAMIKIVAIVALIFAGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMVLVSYQSPSGTTASFTHLWSDGGMFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PEVVLPRAINSIPIRIIMFYVFSLIMIMSVTPWSSVVADKSPFVELFVLVGLPAAASVIN
CCEECCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAKEGDAPKQFGKLSRRSVPATGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LIYLIPNVMTVFTLVTTVSAILFMFVWTIILCSYLVYRKRRPALHKKSIYKMPAGIFMSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
VCMAFFAFVLVLLTLESDTRQALIVTPLWFVILTASYIFLKKRRARLYNSK
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]