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The map label for this gene is arnA

Identifier: 153948868

GI number: 153948868

Start: 1994939

End: 1996942

Strand: Direct

Name: arnA

Synonym: YpsIP31758_1727

Alternate gene names: 153948868

Gene position: 1994939-1996942 (Clockwise)

Preceding gene: 153947753

Following gene: 153949484

Centisome position: 42.24

GC content: 45.66

Gene sequence:

>2004_bases
ATGAAAGCGATTGTATTTGCCTATCATGATATTGGTTGCGTGGGTCTAAACGCATTAGCAGAGGCGGGTTACGATATTCA
GGCGGTATTTACCCATACTGATAATCCTGGCGAGAATCGCTTTTTCTCTTCGGTCGCTAGAGTGGCAGCCGATCTGGCAC
TGCCAGTATTTGCACCGGAAGATGTCAACCACCCTTTGTGGGTTGAGCGTATTCGTGAGTTACAGCCGGATATCATTTTC
TCCTTCTATTACCGCAACATGCTTAGTGATGAAATATTGTCATTGGCCCCACAAGGCGGATTTAACTTACACGGTTCGTT
ATTGCCCCAGTATCGTGGTCGAGCCCCAATTAACTGGGTATTGGTCAATGGGGAAACAGAGACGGGTGTGACGCTTCATC
AGATGGTAAAAAAAGCGGATGCAGGTCCGATTGCCGGTCAGTATAAAGTTGCCATCAGTGATGTTGATACGGCATTGACG
TTGCATGCCAAAATGCGTGATGCCGCTCAAGAATTGTTGCGTAACTTATTACCTAGAATGAAAGAGGGCCCACTGCCGCT
GACTCCGCAAAAAGAGGCAGATGCCAGTTATTTTGGTCGGCGCACGGCGGCTGATGGTGAAATTCATTGGCAGAAATCTG
CATTTACCATCAACAATTTAGTTCGTGCAGTGACTGAGCCTTACCCTGGCGCATTCAGTTATCTGGGGCAGCGCAAACTT
ACGATTTGGCGCTCACGTCCATTAGATTTAGTACATAACAAATTGCCAGGCACCGTGTTATCGACGGCCCCACTCACTGT
GGCATGTGGCGAGGGGGCGCTGGAGATTATTACGGGGCAAGGTGAGGCCGGTCTGTATGTCCAAGGGGATCGTTTAGCAC
AAGAGATGGGCATTGTAACGGATGTGCGTTTGGGTAATAAGCCAAGCAATACGTTGAAAAGACGTACCCGTGTGTTAATT
CTGGGGGTAAATGGTTTTATTGGTAATCATTTGACTGAACGCTTATTACAAGATGATCGCTACGAAGTATATGGTTTGGA
TATTGGCTCTGACGCGATAAGTCGCTTCTTAGGTAACCCTGCTTTCCACTTTGTGGAAGGGGATATCAGTATTCATTCGG
AATGGATTGAATACCATATTAAAAAATGCGACGTCATCTTGCCATTAGTGGCTATTGCGACACCCATTGAATACACCCGT
AATCCGCTGCGTGTCTTTGAGCTAGATTTTGAAGAAAACCTGAAAATTGTGCGAGATTGCGTTAAGTACAATAAGCGTAT
TGTCTTCCCATCGACCTCTGAAGTGTATGGTATGTGCGATGACAAAGAGTTTGATGAGGATACTTCACGGCTGATTGTTG
GCCCAATTAATAAGCAACGCTGGATTTACTCTGTATCAAAACAGTTATTAGACCGGGTTATCTGGGCTTACGGCGTGAAA
GAAGGTTTGAAGTTTACGCTGTTCCGTCCATTTAACTGGATGGGGCCACGTTTAGATAACCTTGATGCTGCGCGTATCGG
TAGTTCACGTGCGATTACACAGCTTATTCTGAATTTGGTCGAAGGCTCACCAATCAAGCTGGTCGATGGTGGTGCCCAAA
AACGTTGTTTTACTGATATCCACGATGGCATTGAAGCGTTATTCCGTATTATTGAAAACCGGGATGGTTGCTGTGATGGT
CAGATCATTAATATTGGTAATCCAACTAACGAAGCCAGTATTCGTGAATTAGCCGAAATGCTGTTAACGAGCTTCGAAAA
TCATGAATTACGTGATCACTTTCCGCCATTTGCAGGTTTTAAAGATATTGAGAGCAGTGCATATTATGGGAAAGGTTATC
AGGATGTTGAGTACCGCACGCCAAGTATTAAGAATGCGCGCCGAATATTGCACTGGCAGCCAGAAATTGCTATGCAACAA
ACGGTCACTGAGACGCTGGACTTTTTCTTGCGCGCTGCCGTAATTGAGAAAACTGCAGCCCCTAAAGATGAGTTGAACGC
ATGA

Upstream 100 bases:

>100_bases
ATATCGGTCGTATTTATAACGATGTGCGCGCTCGCCCACGTTACTTTGTTCAGAAAGTGGTCGGCGCGGAGCAGACCGAA
AATAATCAGGATGTAGAAAA

Downstream 100 bases:

>100_bases
AGCAAGTTGGCCTGAGGATTGATGTCGATACCTACCGAGGAACGCAGTACGGGGTGCCATCATTACTGACTGTTTTAGAA
AAACATGACATTCGTGCCAG

Product: bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MKAIVFAYHDIGCVGLNALAEAGYDIQAVFTHTDNPGENRFFSSVARVAADLALPVFAPEDVNHPLWVERIRELQPDIIF
SFYYRNMLSDEILSLAPQGGFNLHGSLLPQYRGRAPINWVLVNGETETGVTLHQMVKKADAGPIAGQYKVAISDVDTALT
LHAKMRDAAQELLRNLLPRMKEGPLPLTPQKEADASYFGRRTAADGEIHWQKSAFTINNLVRAVTEPYPGAFSYLGQRKL
TIWRSRPLDLVHNKLPGTVLSTAPLTVACGEGALEIITGQGEAGLYVQGDRLAQEMGIVTDVRLGNKPSNTLKRRTRVLI
LGVNGFIGNHLTERLLQDDRYEVYGLDIGSDAISRFLGNPAFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYNKRIVFPSTSEVYGMCDDKEFDEDTSRLIVGPINKQRWIYSVSKQLLDRVIWAYGVK
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLVDGGAQKRCFTDIHDGIEALFRIIENRDGCCDG
QIINIGNPTNEASIRELAEMLLTSFENHELRDHFPPFAGFKDIESSAYYGKGYQDVEYRTPSIKNARRILHWQPEIAMQQ
TVTETLDFFLRAAVIEKTAAPKDELNA

Sequences:

>Translated_667_residues
MKAIVFAYHDIGCVGLNALAEAGYDIQAVFTHTDNPGENRFFSSVARVAADLALPVFAPEDVNHPLWVERIRELQPDIIF
SFYYRNMLSDEILSLAPQGGFNLHGSLLPQYRGRAPINWVLVNGETETGVTLHQMVKKADAGPIAGQYKVAISDVDTALT
LHAKMRDAAQELLRNLLPRMKEGPLPLTPQKEADASYFGRRTAADGEIHWQKSAFTINNLVRAVTEPYPGAFSYLGQRKL
TIWRSRPLDLVHNKLPGTVLSTAPLTVACGEGALEIITGQGEAGLYVQGDRLAQEMGIVTDVRLGNKPSNTLKRRTRVLI
LGVNGFIGNHLTERLLQDDRYEVYGLDIGSDAISRFLGNPAFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYNKRIVFPSTSEVYGMCDDKEFDEDTSRLIVGPINKQRWIYSVSKQLLDRVIWAYGVK
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLVDGGAQKRCFTDIHDGIEALFRIIENRDGCCDG
QIINIGNPTNEASIRELAEMLLTSFENHELRDHFPPFAGFKDIESSAYYGKGYQDVEYRTPSIKNARRILHWQPEIAMQQ
TVTETLDFFLRAAVIEKTAAPKDELNA
>Mature_667_residues
MKAIVFAYHDIGCVGLNALAEAGYDIQAVFTHTDNPGENRFFSSVARVAADLALPVFAPEDVNHPLWVERIRELQPDIIF
SFYYRNMLSDEILSLAPQGGFNLHGSLLPQYRGRAPINWVLVNGETETGVTLHQMVKKADAGPIAGQYKVAISDVDTALT
LHAKMRDAAQELLRNLLPRMKEGPLPLTPQKEADASYFGRRTAADGEIHWQKSAFTINNLVRAVTEPYPGAFSYLGQRKL
TIWRSRPLDLVHNKLPGTVLSTAPLTVACGEGALEIITGQGEAGLYVQGDRLAQEMGIVTDVRLGNKPSNTLKRRTRVLI
LGVNGFIGNHLTERLLQDDRYEVYGLDIGSDAISRFLGNPAFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYNKRIVFPSTSEVYGMCDDKEFDEDTSRLIVGPINKQRWIYSVSKQLLDRVIWAYGVK
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLVDGGAQKRCFTDIHDGIEALFRIIENRDGCCDG
QIINIGNPTNEASIRELAEMLLTSFENHELRDHFPPFAGFKDIESSAYYGKGYQDVEYRTPSIKNARRILHWQPEIAMQQ
TVTETLDFFLRAAVIEKTAAPKDELNA

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily

Homologues:

Organism=Homo sapiens, GI42516563, Length=347, Percent_Identity=25.3602305475504, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI21614513, Length=241, Percent_Identity=26.1410788381743, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI238814322, Length=287, Percent_Identity=24.0418118466899, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788589, Length=651, Percent_Identity=71.5821812596006, Blast_Score=995, Evalue=0.0,
Organism=Escherichia coli, GI1789683, Length=283, Percent_Identity=30.3886925795053, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17539532, Length=345, Percent_Identity=25.2173913043478, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI133930964, Length=260, Percent_Identity=24.6153846153846, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356223, Length=342, Percent_Identity=26.3157894736842, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45550868, Length=204, Percent_Identity=28.921568627451, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571984, Length=213, Percent_Identity=28.6384976525822, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARNA_YERP3 (A7FHH4)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400702.1
- ProteinModelPortal:   A7FHH4
- SMR:   A7FHH4
- STRING:   A7FHH4
- GeneID:   5385461
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1727
- eggNOG:   COG0451
- HOGENOM:   HBG298638
- OMA:   KAVVFAY
- ProtClustDB:   PRK08125
- BioCyc:   YPSE349747:YPSIP31758_1727-MONOMER
- HAMAP:   MF_01166
- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF036506

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.13; =1.1.1.305

Molecular weight: Translated: 74893; Mature: 74893

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: ACT_SITE 104-104 ACT_SITE 434-434 ACT_SITE 619-619 BINDING 114-114 BINDING 347-347 BINDING 393-393 BINDING 398-398 BINDING 460-460 BINDING 492-492 BINDING 613-613

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIVFAYHDIGCVGLNALAEAGYDIQAVFTHTDNPGENRFFSSVARVAADLALPVFAPE
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEECCC
DVNHPLWVERIRELQPDIIFSFYYRNMLSDEILSLAPQGGFNLHGSLLPQYRGRAPINWV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
LVNGETETGVTLHQMVKKADAGPIAGQYKVAISDVDTALTLHAKMRDAAQELLRNLLPRM
EECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
KEGPLPLTPQKEADASYFGRRTAADGEIHWQKSAFTINNLVRAVTEPYPGAFSYLGQRKL
HCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCHHHHHCCCEE
TIWRSRPLDLVHNKLPGTVLSTAPLTVACGEGALEIITGQGEAGLYVQGDRLAQEMGIVT
EEECCCCHHHHHCCCCCCEEECCCEEEEECCCCEEEEECCCCCCEEEEHHHHHHHHCCEE
DVRLGNKPSNTLKRRTRVLILGVNGFIGNHLTERLLQDDRYEVYGLDIGSDAISRFLGNP
EEECCCCCHHHHHHCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCC
AFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLKIVRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYNKRIVFPSTSEVYGMCDDKEFDEDTSRLIVGPINKQRWIYSVSKQLLDRVIWAYGVK
HHHCCEEECCCCCHHEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLVDGGAQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
HDGIEALFRIIENRDGCCDGQIINIGNPTNEASIRELAEMLLTSFENHELRDHFPPFAGF
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
KDIESSAYYGKGYQDVEYRTPSIKNARRILHWQPEIAMQQTVTETLDFFLRAAVIEKTAA
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PKDELNA
CHHHCCC
>Mature Secondary Structure
MKAIVFAYHDIGCVGLNALAEAGYDIQAVFTHTDNPGENRFFSSVARVAADLALPVFAPE
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEECCC
DVNHPLWVERIRELQPDIIFSFYYRNMLSDEILSLAPQGGFNLHGSLLPQYRGRAPINWV
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
LVNGETETGVTLHQMVKKADAGPIAGQYKVAISDVDTALTLHAKMRDAAQELLRNLLPRM
EECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
KEGPLPLTPQKEADASYFGRRTAADGEIHWQKSAFTINNLVRAVTEPYPGAFSYLGQRKL
HCCCCCCCCCCCCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCHHHHHCCCEE
TIWRSRPLDLVHNKLPGTVLSTAPLTVACGEGALEIITGQGEAGLYVQGDRLAQEMGIVT
EEECCCCHHHHHCCCCCCEEECCCEEEEECCCCEEEEECCCCCCEEEEHHHHHHHHCCEE
DVRLGNKPSNTLKRRTRVLILGVNGFIGNHLTERLLQDDRYEVYGLDIGSDAISRFLGNP
EEECCCCCHHHHHHCEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCC
AFHFVEGDISIHSEWIEYHIKKCDVILPLVAIATPIEYTRNPLRVFELDFEENLKIVRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYNKRIVFPSTSEVYGMCDDKEFDEDTSRLIVGPINKQRWIYSVSKQLLDRVIWAYGVK
HHHCCEEECCCCCHHEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
EGLKFTLFRPFNWMGPRLDNLDAARIGSSRAITQLILNLVEGSPIKLVDGGAQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
HDGIEALFRIIENRDGCCDGQIINIGNPTNEASIRELAEMLLTSFENHELRDHFPPFAGF
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
KDIESSAYYGKGYQDVEYRTPSIKNARRILHWQPEIAMQQTVTETLDFFLRAAVIEKTAA
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PKDELNA
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA