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The map label for this gene is frwC [H]

Identifier: 153948837

GI number: 153948837

Start: 3984623

End: 3985705

Strand: Direct

Name: frwC [H]

Synonym: YpsIP31758_3529

Alternate gene names: 153948837

Gene position: 3984623-3985705 (Clockwise)

Preceding gene: 153949684

Following gene: 153949085

Centisome position: 84.36

GC content: 53.83

Gene sequence:

>1083_bases
ATGAAAGAGCTGATAAATATACTTAAAAATACGCGCCAACATCTGATGACGGGCGTTTCATATATGATCCCTTTTGTGGT
TGCTGGCGGTATTTTGCTAGCACTTTCTGTGATGCTTTACGGTAAAGGTGCGGTGCCAGAGGTTGCCAGTGACCCTAATC
TGAAAAAGCTATTCGATATTGGTGTCGTGGGCTTGACGTTGATGGTGCCATTTTTGGCAGCCTATATCGGTTACGCCATT
GCGGATCGTGCGGCGCTCGCCCCGGCGGCTATCGGTGCTTGGGTAGGGGCTTCTTTCGGGGCTGGTTTTTTTGGTGCCAT
TATCGCGGGCTTGCTGGGCGGTATTATCGTTTTCTATCTGAAGAAGATCTCCGTGCCAAAGACGCTGCGTTCGGTGATGC
CGATCTTCGTGATCCCGATAGTCGGTACCCTTCTCACCGCTGGGATCATGATGTGGGGCTTGGGTGAACCCATCGGCATC
CTGACAGCCAACCTCACGCAATGGCTACAGGGTATGCAGCAAGGAAGCGTTATATTACTGGCAATTATTATGGGCCTGAT
GCTGGCGTTTGATATGGGCGGGCCGGTCAACAAGGTGGCTTATGCCTTTATGTTGATCTGTGTGGCGCAGGGTGTTTATA
CCTTGGTGGCCGTCGCCGCCGTCGCCATTGCAACCCCGCCGTTGGGCATGGGCCTTGCCACGCTGATTGGCCGTAAATAT
TACTCGGTGGAAGAACGTGAAGCAGGTAAGGCCGCGATGCTGATGGGCTGCGTTGGCATTACTGAGGGGGCTATCCCGTT
TGCCGCCGCCGATCCACTGCGTGTCATTCCTGCCAATATGATCGGTTCCGCCTGCGCCGCCGTGACTGCCGTGTTGTTCG
GTGCCCAATGCTATGCCGCTTGGGGAGGGTTGATCGTGCTACCGGTGGTCGACGGTAAACTGGGCTTTGTGGTGGCCTTG
TTCGTCGGCATGGTCGTTACCGCGTTGATAGCCAATCTATTAAAGCGTTTCACCGCCCAAAAGCAGCCGGGAAGGTCATC
AGCAGAGGGCGATGTGGACATGGATTTCGATATTAAAAATTAG

Upstream 100 bases:

>100_bases
CCAACAGCATCAAAAACATTTCGCGATTTCAATATTAAGGGGAATAAGCCCTGACGCCTGCGGAACTCATCGCACACGGA
TGAACGCTATGGAGTGAATG

Downstream 100 bases:

>100_bases
CGGTACACCCGATGAGCGTTATTTATTTTAAGGTCAACGACATTTTAAGGTCAACGACCGGTAAGTGATTCGGGCGAGTG
AGCGCAGCTAACCCCCCTGT

Product: fructose-like permease EIIC subunit 2

Products: protein histidine; sugar phosphate

Alternate protein names: PTS system fructose-like EIIC component 2 [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKELINILKNTRQHLMTGVSYMIPFVVAGGILLALSVMLYGKGAVPEVASDPNLKKLFDIGVVGLTLMVPFLAAYIGYAI
ADRAALAPAAIGAWVGASFGAGFFGAIIAGLLGGIIVFYLKKISVPKTLRSVMPIFVIPIVGTLLTAGIMMWGLGEPIGI
LTANLTQWLQGMQQGSVILLAIIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTLVAVAAVAIATPPLGMGLATLIGRKY
YSVEEREAGKAAMLMGCVGITEGAIPFAAADPLRVIPANMIGSACAAVTAVLFGAQCYAAWGGLIVLPVVDGKLGFVVAL
FVGMVVTALIANLLKRFTAQKQPGRSSAEGDVDMDFDIKN

Sequences:

>Translated_360_residues
MKELINILKNTRQHLMTGVSYMIPFVVAGGILLALSVMLYGKGAVPEVASDPNLKKLFDIGVVGLTLMVPFLAAYIGYAI
ADRAALAPAAIGAWVGASFGAGFFGAIIAGLLGGIIVFYLKKISVPKTLRSVMPIFVIPIVGTLLTAGIMMWGLGEPIGI
LTANLTQWLQGMQQGSVILLAIIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTLVAVAAVAIATPPLGMGLATLIGRKY
YSVEEREAGKAAMLMGCVGITEGAIPFAAADPLRVIPANMIGSACAAVTAVLFGAQCYAAWGGLIVLPVVDGKLGFVVAL
FVGMVVTALIANLLKRFTAQKQPGRSSAEGDVDMDFDIKN
>Mature_360_residues
MKELINILKNTRQHLMTGVSYMIPFVVAGGILLALSVMLYGKGAVPEVASDPNLKKLFDIGVVGLTLMVPFLAAYIGYAI
ADRAALAPAAIGAWVGASFGAGFFGAIIAGLLGGIIVFYLKKISVPKTLRSVMPIFVIPIVGTLLTAGIMMWGLGEPIGI
LTANLTQWLQGMQQGSVILLAIIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTLVAVAAVAIATPPLGMGLATLIGRKY
YSVEEREAGKAAMLMGCVGITEGAIPFAAADPLRVIPANMIGSACAAVTAVLFGAQCYAAWGGLIVLPVVDGKLGFVVAL
FVGMVVTALIANLLKRFTAQKQPGRSSAEGDVDMDFDIKN

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane [H]

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790386, Length=359, Percent_Identity=76.8802228412256, Blast_Score=536, Evalue=1e-154,
Organism=Escherichia coli, GI1788492, Length=329, Percent_Identity=41.0334346504559, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1786951, Length=278, Percent_Identity=36.6906474820144, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI87082348, Length=293, Percent_Identity=36.8600682593857, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788729, Length=372, Percent_Identity=25.8064516129032, Blast_Score=108, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013014
- InterPro:   IPR006327 [H]

Pfam domain/function: NA

EC number: 2.7.1.69

Molecular weight: Translated: 37460; Mature: 37460

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELINILKNTRQHLMTGVSYMIPFVVAGGILLALSVMLYGKGAVPEVASDPNLKKLFDI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GVVGLTLMVPFLAAYIGYAIADRAALAPAAIGAWVGASFGAGFFGAIIAGLLGGIIVFYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KKISVPKTLRSVMPIFVIPIVGTLLTAGIMMWGLGEPIGILTANLTQWLQGMQQGSVILL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHH
AIIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTLVAVAAVAIATPPLGMGLATLIGRKY
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YSVEEREAGKAAMLMGCVGITEGAIPFAAADPLRVIPANMIGSACAAVTAVLFGAQCYAA
CCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
WGGLIVLPVVDGKLGFVVALFVGMVVTALIANLLKRFTAQKQPGRSSAEGDVDMDFDIKN
HCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKELINILKNTRQHLMTGVSYMIPFVVAGGILLALSVMLYGKGAVPEVASDPNLKKLFDI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GVVGLTLMVPFLAAYIGYAIADRAALAPAAIGAWVGASFGAGFFGAIIAGLLGGIIVFYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
KKISVPKTLRSVMPIFVIPIVGTLLTAGIMMWGLGEPIGILTANLTQWLQGMQQGSVILL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHH
AIIMGLMLAFDMGGPVNKVAYAFMLICVAQGVYTLVAVAAVAIATPPLGMGLATLIGRKY
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YSVEEREAGKAAMLMGCVGITEGAIPFAAADPLRVIPANMIGSACAAVTAVLFGAQCYAA
CCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHH
WGGLIVLPVVDGKLGFVVALFVGMVVTALIANLLKRFTAQKQPGRSSAEGDVDMDFDIKN
HCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N(pi)-phosphohistidine; sugar

Specific reaction: protein N(pi)-phosphohistidine + sugar = protein histidine + sugar phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 7773398 [H]