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The map label for this gene is tesB [H]

Identifier: 153948770

GI number: 153948770

Start: 3462358

End: 3463218

Strand: Direct

Name: tesB [H]

Synonym: YpsIP31758_3076

Alternate gene names: 153948770

Gene position: 3462358-3463218 (Clockwise)

Preceding gene: 153948771

Following gene: 153949753

Centisome position: 73.3

GC content: 48.78

Gene sequence:

>861_bases
ATGAGTCAGGCATTAGAAAAACTGCTCGATCTGCTCGATCTAGAGAAAATTGAAGAAGGCATTTTCCGTGGACAAAGCGA
AGATCTAGGTTTGCGGCAGGTATTTGGTGGTCAGGTTGTTGGTCAGGCGATTTATGCTGCGAAACAAACCGTCCCCGCAG
AACGGACTGTTCACTCATTTCATAGCTATTTTCTGCGCCCTGGAGACAGCAGTAAACCCATTATTTATGACGTAGAAACA
CTGCGTGATGGCAACAGTTTCAGCGCCCGCCGGGTCAGTGCGATTCAAAATGGTAAGCCTATCTTTTATATGACGGCCTC
GTTCCAGAGTCAGGAAGAAGGGTTTGAGCACCAAAATACAATGCCAGACGTCCCACCACCAGAAGGGTTAATGTCCGAAA
CGGATATTGCCCGCCAGTTTTCACACTTGATCCCCGAGAAAGTGCGAGAAAAGTTTATTGGCCCACAACCCATTGAAATG
CGTCCGGTAAAATTCCACAACCCGCTGCAAGGCAGTGTAGAAGAACCCAATCGCTATGTTTGGTTCCGCGCTAATGGCAA
AATGCCAGATGACCTACGGGTTCATCAATATTTACTGGGTTATGCCTCGGACTTTAATTTCCTGCCCACGGCTTTACAAC
CGCACGGCATTGGTTTCCTTGAACCCGGTATGCAAATCGCCACTATCGACCACTCGATGTGGTTCCATCGGCCATTCCGT
TTGGATGACTGGTTACTCTATGCCGTAGAAAGTACTTCTGCGTCAGGTGCCCGTGGCTTCGTTCGAGGGCAAATCTATAA
CCGGGAAGGGATGCTGGTAGCTTCTACTGTGCAGGAGGGTGTGATTCGTTTACATCGTTGA

Upstream 100 bases:

>100_bases
ATTAATTCATCACTTGAGTAATGGTTTCACGGCAATATATTGACGACTGGCGGGTTGATTCAGCACACTGTGTATGAACT
CAACCATCAGGGGCGACAAC

Downstream 100 bases:

>100_bases
TACGGGGGTACAGATCAGCGTGACGTTATCTCAACCAGTTGATGAATCAATGAAATAGCACAGGGGCGATGTCACCATCG
CCCCTGTAGTTCATCATTAT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSSKPIIYDVET
LRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREKFIGPQPIEM
RPVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDHSMWFHRPFR
LDDWLLYAVESTSASGARGFVRGQIYNREGMLVASTVQEGVIRLHR

Sequences:

>Translated_286_residues
MSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSSKPIIYDVET
LRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREKFIGPQPIEM
RPVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDHSMWFHRPFR
LDDWLLYAVESTSASGARGFVRGQIYNREGMLVASTVQEGVIRLHR
>Mature_285_residues
SQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSSKPIIYDVETL
RDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFSHLIPEKVREKFIGPQPIEMR
PVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDHSMWFHRPFRL
DDWLLYAVESTSASGARGFVRGQIYNREGMLVASTVQEGVIRLHR

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=288, Percent_Identity=41.3194444444444, Blast_Score=218, Evalue=5e-57,
Organism=Escherichia coli, GI1786657, Length=285, Percent_Identity=78.5964912280702, Blast_Score=460, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71988741, Length=293, Percent_Identity=35.4948805460751, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17558508, Length=304, Percent_Identity=36.5131578947368, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17531889, Length=273, Percent_Identity=35.8974358974359, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI115532456, Length=274, Percent_Identity=35.7664233576642, Blast_Score=167, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17531885, Length=274, Percent_Identity=35.7664233576642, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71982224, Length=295, Percent_Identity=31.5254237288136, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI212645202, Length=290, Percent_Identity=32.0689655172414, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322480, Length=122, Percent_Identity=34.4262295081967, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32495; Mature: 32364

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHCCCHHHHHHHH
HSYFLRPGDSSKPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNT
HHHHCCCCCCCCCEEEEHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHCCHHCCC
MPDVPPPEGLMSETDIARQFSHLIPEKVREKFIGPQPIEMRPVKFHNPLQGSVEEPNRYV
CCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEECCEECCCCCCCCCCCCCEEE
WFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDHSMWFHRPFR
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECHHHHCCCCC
LDDWLLYAVESTSASGARGFVRGQIYNREGMLVASTVQEGVIRLHR
CCCEEEEEEECCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHCCCC
>Mature Secondary Structure 
SQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHCCCHHHHHHHH
HSYFLRPGDSSKPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNT
HHHHCCCCCCCCCEEEEHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHCCHHCCC
MPDVPPPEGLMSETDIARQFSHLIPEKVREKFIGPQPIEMRPVKFHNPLQGSVEEPNRYV
CCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCEECCEECCCCCCCCCCCCCEEE
WFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDHSMWFHRPFR
EEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEECHHHHCCCCC
LDDWLLYAVESTSASGARGFVRGQIYNREGMLVASTVQEGVIRLHR
CCCEEEEEEECCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]