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The map label for this gene is coaE

Identifier: 153948436

GI number: 153948436

Start: 3794080

End: 3794700

Strand: Direct

Name: coaE

Synonym: YpsIP31758_3374

Alternate gene names: 153948436

Gene position: 3794080-3794700 (Clockwise)

Preceding gene: 153948491

Following gene: 153947210

Centisome position: 80.33

GC content: 46.86

Gene sequence:

>621_bases
ATGACCTATATTGTGGCTCTCACAGGTGGGATCGGTAGCGGAAAGAGTACGGTGGCAAATGCATTCGCCAATTTAGGTGT
GCCGTTGGTTGATGCTGATATTATTGCTCGTCAGGTTGTTGAACCAGGGACATCTGCACTAGCGGCCATTGCATCCCGTT
ATGGTGAAAATATTTTGCAGCAAGATGGCTCATTAAATAGAGCGGCATTGCGACAAAAAATTTTCAGTGAGCAACAAGAA
AAAGCATGGTTAAATTCACTGTTACACCCCCTTATTCAGCAGGAAACACAACGCCAATTAGCCGGTATTGATCAACCTTA
TGCCCTTTGGGTTGTGCCTCTACTGGTTGAAAATGGTTTACATCACCGGGCAGATCGTGTGTTAGTAGTCGACGTAACAC
CAGACATACAGCTCGCACGGACCATGGCGAGAGATGGTATTACACGCCAACAGGCAGAAAATATTTTGGCTTCACAGGTT
TCGCGGCAACAACGCTTGGCCTGTGCTGATGACATTATTGACAATAGCGGCGACCCGTTAATGATCGCCCAGCATGTTGC
CTCACTACACCATCGGTACTTAAAATTGGCAACTGCGGCCCAACAGGATCTACATCAATGA

Upstream 100 bases:

>100_bases
TTTACTGCGCCGTACAGATAGAATGCATACCTTGGCTATGCCTTCGCCCAAGCTTTCAGATACAATTCTCCCATCCAATG
GCAGTACATAAGGCGAAGCA

Downstream 100 bases:

>100_bases
GTGACCTTACCTCAACAATACTTTTTGAACATCCGCTCAATGAAAAGATGCGCACTTGGCTAAGAATGGAGTTTTTATTA
CAACAGCTAGAAAGCCACCG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQQDGSLNRAALRQKIFSEQQE
KAWLNSLLHPLIQQETQRQLAGIDQPYALWVVPLLVENGLHHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQV
SRQQRLACADDIIDNSGDPLMIAQHVASLHHRYLKLATAAQQDLHQ

Sequences:

>Translated_206_residues
MTYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQQDGSLNRAALRQKIFSEQQE
KAWLNSLLHPLIQQETQRQLAGIDQPYALWVVPLLVENGLHHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQV
SRQQRLACADDIIDNSGDPLMIAQHVASLHHRYLKLATAAQQDLHQ
>Mature_205_residues
TYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQQDGSLNRAALRQKIFSEQQEK
AWLNSLLHPLIQQETQRQLAGIDQPYALWVVPLLVENGLHHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQVS
RQQRLACADDIIDNSGDPLMIAQHVASLHHRYLKLATAAQQDLHQ

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=194, Percent_Identity=34.5360824742268, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI191252795, Length=194, Percent_Identity=34.5360824742268, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI110227607, Length=187, Percent_Identity=25.1336898395722, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI110227605, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI110227603, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI110227601, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI205277394, Length=166, Percent_Identity=28.3132530120482, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1786292, Length=198, Percent_Identity=64.6464646464647, Blast_Score=249, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI17554944, Length=180, Percent_Identity=33.8888888888889, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320402, Length=194, Percent_Identity=36.0824742268041, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644728, Length=179, Percent_Identity=34.0782122905028, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24658602, Length=181, Percent_Identity=29.8342541436464, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_YERPE (Q8ZBI0)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AH0416
- RefSeq:   NP_668093.1
- RefSeq:   NP_991653.1
- RefSeq:   YP_002348322.1
- ProteinModelPortal:   Q8ZBI0
- SMR:   Q8ZBI0
- GeneID:   1145704
- GeneID:   1176247
- GeneID:   2766505
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3430
- KEGG:   ypk:y0757
- KEGG:   ypm:YP_0254
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   YPES187410:Y0757-MONOMER
- BioCyc:   YPES214092:YPO3430-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 22506; Mature: 22375

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQ
CEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QDGSLNRAALRQKIFSEQQEKAWLNSLLHPLIQQETQRQLAGIDQPYALWVVPLLVENGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
HHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQVSRQQRLACADDIIDNSGDPL
HHHHCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
MIAQHVASLHHRYLKLATAAQQDLHQ
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYIVALTGGIGSGKSTVANAFANLGVPLVDADIIARQVVEPGTSALAAIASRYGENILQ
EEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QDGSLNRAALRQKIFSEQQEKAWLNSLLHPLIQQETQRQLAGIDQPYALWVVPLLVENGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
HHRADRVLVVDVTPDIQLARTMARDGITRQQAENILASQVSRQQRLACADDIIDNSGDPL
HHHHCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
MIAQHVASLHHRYLKLATAAQQDLHQ
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430