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The map label for this gene is exuT [H]

Identifier: 153948424

GI number: 153948424

Start: 1109966

End: 1111273

Strand: Reverse

Name: exuT [H]

Synonym: YpsIP31758_0926

Alternate gene names: 153948424

Gene position: 1111273-1109966 (Counterclockwise)

Preceding gene: 153950360

Following gene: 153949651

Centisome position: 23.53

GC content: 49.39

Gene sequence:

>1308_bases
ATGAGTATTGATATTAATCAATCAGCTAAAGTTGTAGGACGGCGGAAAATAAAGTCATTACGTTGGTGGATGCTGGCCTT
ATTTTTACTTGGGGTCACCGTTAACTATATAACCCGTAATTCTCTAGGGATTTTAGCCCCTGAGTTAAAAACCAGTCTGA
ATATGACTACCGAGCAATACTCATGGATTGTAGCCTCTTTCCAACTGGCTTATACCGTGTTCCAACCACTTTGTGGCTGG
TTGATCGATGTCATCGGTTTAAAAATGGGGTTCCTGGTTTGCGCCAGTGTCTGGGCGGTGGTGTGCATGATGCATGCCGG
AGCGGGTACCTGGTTCCAACTGGCAGTATTACGCTTCTTTATGGGCAGTGCCGAAGCCGCAGCCACCCCCGCAAACGCCA
AAGCCATTTCGGATTGGTTCCCGAAAAAAGAACGGCCCATTGCCGCTGGATGGGCTGGGGTGGGGTTCTCTATCGGTGCG
ATGTTGGCCCCCCCGATTATCGTACTGGCGCATGTGGCACTCGGTTGGCAAGGGGCATTCTTGTTCTCCGGCGCATTAGC
CATGATTTGGGTTCTGCTGTGGTGGCGTTTTTACCATTCACCGGATACTCATCCAAATCTGAGTCAAGAAGAGTTTGAAC
TGATTCACCAAGATAATGAACCCGTATTACCACGACTGCCATTCCTTAAATCCTTAGCCATTCTAAGTAAAAATAAGAAA
TTTTACGGTATTGCTATTCCCGCGTTTCTGGCGGAACCGGCCTGGGCTGTGTTTAGTTTCTGGGTACCGCTGTATTTAGC
CACCGAACGCGGCATGGACCTGAAACAGATCGCCATGTTCGCCTGGCTGCCATTCCTGGCAGCAGATATTGGCAGTGTCG
CCAGTGGCTATTTAACCAAACTCTATCAGAAATGGTTTGGTTGCAGCCGGGTCAACTCGGTGGTTGCCAGTTCGGTAACC
GGTGCTTTTATGATGGTGTCATTGGCCTTTGTTGCCGTCACCAAAGACCCTTATCTGGCAATCGCTTTAATCTCCATTGG
CGGCTTTGGGCACCAAGTCATCTCCTGCATGCTCAGTGCATTAGTGGTTGACTCTTTTGATAAAAATCAGGTTGCTACCG
TCAATGGCCTACGTGGTTCTTCCGCCTGGATCGCCAGCTTCCTGTTTACATTATTAATCGGGGCCGTTTCAGACACTATC
GGCTTTAACCCGCTGTTTATCGCTATGGGGTTCTTCGATCTGATTGGGGCCGTATTCCTGATTGCTCTGTTCGCTGAGCG
CCGTAATAAACCCCAACCGACGGTCTGA

Upstream 100 bases:

>100_bases
ACATTATAACGCAGCGTAATCTTAATAACTGAAGATGGAACATACCAAAATAACAAGTTGGTCCAATTCATTTTATATGG
ACTAACACAAGGGGACTGGG

Downstream 100 bases:

>100_bases
TGTTGTTAGACCAACGGATGTTGTTAGACCAACTGATGTGATTAACCAAACTAATGTTGTTAACTAAATTGATGCGATTA
CCCCATCAGATGCGATTAAC

Product: hexuronate transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSIDINQSAKVVGRRKIKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQYSWIVASFQLAYTVFQPLCGW
LIDVIGLKMGFLVCASVWAVVCMMHAGAGTWFQLAVLRFFMGSAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGA
MLAPPIIVLAHVALGWQGAFLFSGALAMIWVLLWWRFYHSPDTHPNLSQEEFELIHQDNEPVLPRLPFLKSLAILSKNKK
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKQIAMFAWLPFLAADIGSVASGYLTKLYQKWFGCSRVNSVVASSVT
GAFMMVSLAFVAVTKDPYLAIALISIGGFGHQVISCMLSALVVDSFDKNQVATVNGLRGSSAWIASFLFTLLIGAVSDTI
GFNPLFIAMGFFDLIGAVFLIALFAERRNKPQPTV

Sequences:

>Translated_435_residues
MSIDINQSAKVVGRRKIKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQYSWIVASFQLAYTVFQPLCGW
LIDVIGLKMGFLVCASVWAVVCMMHAGAGTWFQLAVLRFFMGSAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGA
MLAPPIIVLAHVALGWQGAFLFSGALAMIWVLLWWRFYHSPDTHPNLSQEEFELIHQDNEPVLPRLPFLKSLAILSKNKK
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKQIAMFAWLPFLAADIGSVASGYLTKLYQKWFGCSRVNSVVASSVT
GAFMMVSLAFVAVTKDPYLAIALISIGGFGHQVISCMLSALVVDSFDKNQVATVNGLRGSSAWIASFLFTLLIGAVSDTI
GFNPLFIAMGFFDLIGAVFLIALFAERRNKPQPTV
>Mature_434_residues
SIDINQSAKVVGRRKIKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQYSWIVASFQLAYTVFQPLCGWL
IDVIGLKMGFLVCASVWAVVCMMHAGAGTWFQLAVLRFFMGSAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGAM
LAPPIIVLAHVALGWQGAFLFSGALAMIWVLLWWRFYHSPDTHPNLSQEEFELIHQDNEPVLPRLPFLKSLAILSKNKKF
YGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKQIAMFAWLPFLAADIGSVASGYLTKLYQKWFGCSRVNSVVASSVTG
AFMMVSLAFVAVTKDPYLAIALISIGGFGHQVISCMLSALVVDSFDKNQVATVNGLRGSSAWIASFLFTLLIGAVSDTIG
FNPLFIAMGFFDLIGAVFLIALFAERRNKPQPTV

Specific function: Aldohexuronate transport system [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI6912666, Length=326, Percent_Identity=25.4601226993865, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI2367193, Length=430, Percent_Identity=46.2790697674419, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI87082320, Length=438, Percent_Identity=24.4292237442922, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789152, Length=449, Percent_Identity=23.3853006681514, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1789515, Length=418, Percent_Identity=25.1196172248804, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI2367379, Length=420, Percent_Identity=23.5714285714286, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573708, Length=359, Percent_Identity=24.7910863509749, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573707, Length=359, Percent_Identity=24.7910863509749, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28573299, Length=289, Percent_Identity=24.2214532871972, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24658666, Length=304, Percent_Identity=24.0131578947368, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584153, Length=397, Percent_Identity=23.1738035264484, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550495, Length=447, Percent_Identity=23.7136465324385, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24658658, Length=462, Percent_Identity=20.7792207792208, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20130135, Length=320, Percent_Identity=24.0625, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550364, Length=306, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639764, Length=348, Percent_Identity=22.7011494252874, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45550460, Length=318, Percent_Identity=23.2704402515723, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47794; Mature: 47663

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDINQSAKVVGRRKIKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
SWIVASFQLAYTVFQPLCGWLIDVIGLKMGFLVCASVWAVVCMMHAGAGTWFQLAVLRFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MGSAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGAMLAPPIIVLAHVALGWQGAF
HCCCHHCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LFSGALAMIWVLLWWRFYHSPDTHPNLSQEEFELIHQDNEPVLPRLPFLKSLAILSKNKK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKQIAMFAWLPFLAADIGSVASGYLTK
EEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYQKWFGCSRVNSVVASSVTGAFMMVSLAFVAVTKDPYLAIALISIGGFGHQVISCMLSA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHHH
LVVDSFDKNQVATVNGLRGSSAWIASFLFTLLIGAVSDTIGFNPLFIAMGFFDLIGAVFL
HHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IALFAERRNKPQPTV
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIDINQSAKVVGRRKIKSLRWWMLALFLLGVTVNYITRNSLGILAPELKTSLNMTTEQY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHH
SWIVASFQLAYTVFQPLCGWLIDVIGLKMGFLVCASVWAVVCMMHAGAGTWFQLAVLRFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MGSAEAAATPANAKAISDWFPKKERPIAAGWAGVGFSIGAMLAPPIIVLAHVALGWQGAF
HCCCHHCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
LFSGALAMIWVLLWWRFYHSPDTHPNLSQEEFELIHQDNEPVLPRLPFLKSLAILSKNKK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCC
FYGIAIPAFLAEPAWAVFSFWVPLYLATERGMDLKQIAMFAWLPFLAADIGSVASGYLTK
EEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYQKWFGCSRVNSVVASSVTGAFMMVSLAFVAVTKDPYLAIALISIGGFGHQVISCMLSA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCHHHHHHHHHHH
LVVDSFDKNQVATVNGLRGSSAWIASFLFTLLIGAVSDTIGFNPLFIAMGFFDLIGAVFL
HHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IALFAERRNKPQPTV
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]