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The map label for this gene is ddc [H]

Identifier: 153948370

GI number: 153948370

Start: 3152332

End: 3153747

Strand: Reverse

Name: ddc [H]

Synonym: YpsIP31758_2788

Alternate gene names: 153948370

Gene position: 3153747-3152332 (Counterclockwise)

Preceding gene: 153948827

Following gene: 153949609

Centisome position: 66.77

GC content: 48.09

Gene sequence:

>1416_bases
ATGACTCCTGAAGAGTTTCGCCGCCATGGCTATGCCATGATCGACCTGATTGCTGATTACCGACAAAATATCGAATTGCG
TGGCGTTAATCCCACGACAGCACCCGGTGAGATTAAATCTCGTCTGTCGTTAAATGCACCTGAAAAAGCAGAACCTTTCG
AACACATTATTTCTGACATAGAAGAGCTCATCATGCCAGGGCTATTGCATTGGCAACATCCTGACTTTTTTGGTTATTTT
CCTTCTAATGTAGAGTTATCCTCCGTTCTTGGGGATTGCTTGAGTACTGGGCTGGGGGTGATAGGTCTGTCTTGGCAATC
CAGCCCGGCCCTGACAGAAATTGAAGAGGTGGCCACCAATTGGTTGCTAAAAATGCTTGGTCTTAGCGCTGCCTGGAGTG
GCGTGATTCAGGATTCCGCCTCAACCGCCACGTTAGTGGCGCTGATCAGCGGCCGAGAGCGAACATCTAACTATGCGTTA
ATGAATAAAGGGATGCAAAACAGTGATGCACCTTTGATTGTCTACACTTCATCAGAAGCCCATAGCGGAGTGAATAAAGC
CGCTCTGCTCGCTGGGTTTGGTCATAATAATATCCGTTTAGTGCCCACCGATGAGCACAATGCCATGTCACCCTTGGCAT
TAGAAAAGATCATTCAACAGGATTTGGTGAAGGGAAACCGGCCTTGTATCGTTGTTGCTACGACAGGTACTACCGCTGCG
ACAGCGATGGATCCCCTTGATGCGATTGGTGATATTACTCAGCGTTATGGTTTATGGCTGCATGTAGATTCTGCTATGGC
TGGTTCAGCGATGATTTTGCCAGAATGCCGTCATCTGTGGTGCGGTATAGAAAAGGCTGATTCTGTGGTGATAAATCCAC
ATAAATGGCTGGGTGCTGCTTTTGATTGTTCGGTTTATTGTGTACAAGATTCAGAGCATTTGATTCGTATCATGAGTACT
AACCCCAGTTTCTTACAATCCGATGCTGATGGGAAAGTGAGAAATTACCGCGATTGGGGGATCCCCCTGGGTCGCCGTTT
TCGTGCGCTTAAGCTATGGTTTCTAATCCGCGAGCAAGGGGTGGAAGGGCTGCAGGCGCGTTTGCGTCGTGATATTGCCA
ATGCTAATTGGTTAGCAGAACAAATTAAAAACAGCGATGACTGGAAACTGGTCGCACCTGTAGTGTTGCAAACCTTGTGT
ATTCGTCATGAACCGGGTGGGCTGATGGGCGACGCGTTGGATAATTATACCCGCAGTTGGGCCGAGAAACTCAATCAATC
TGGTAAGGGTTATGTTACACCAGCCACGCTTGGTGGCCGCTGGATGGTGCGGGTTTCCATCGGCACTTTGGGTACGGAAC
GTCATCACGTTGAGAAGTTGTGGTTGTTGTTGCAGTCTTTGGTTAAGGAGAGATAA

Upstream 100 bases:

>100_bases
TTGATTCAGGCAAACGAATCAGCATGCAGTCATTTATAGGTTACAACACGAACCAGCCGTTCTATTTCTGGTGTTAATGA
CTTCAAAATGAGAGCTTTTT

Downstream 100 bases:

>100_bases
AAGGGCCTTACCATATTAAGAATTGAACAATGAGCAATGAACAATGAACAATGAACAATGAACAATGAGCAATGAGCAAT
GAGCAATGAGCAATGAGTCA

Product: aromatic amino acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYF
PSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSAAWSGVIQDSASTATLVALISGRERTSNYAL
MNKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMST
NPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGVEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLC
IRHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER

Sequences:

>Translated_471_residues
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYF
PSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSAAWSGVIQDSASTATLVALISGRERTSNYAL
MNKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMST
NPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGVEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLC
IRHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
>Mature_470_residues
TPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDIEELIMPGLLHWQHPDFFGYFP
SNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATNWLLKMLGLSAAWSGVIQDSASTATLVALISGRERTSNYALM
NKGMQNSDAPLIVYTSSEAHSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAAT
AMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAAFDCSVYCVQDSEHLIRIMSTN
PSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQGVEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCI
RHEPGGLMGDALDNYTRSWAEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=491, Percent_Identity=37.2708757637475, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI132814448, Length=491, Percent_Identity=37.2708757637475, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI92110055, Length=480, Percent_Identity=35.2083333333333, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI194294551, Length=379, Percent_Identity=31.9261213720317, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI197383062, Length=424, Percent_Identity=30.8962264150943, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI58331246, Length=353, Percent_Identity=26.9121813031161, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI197276620, Length=324, Percent_Identity=28.0864197530864, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4503875, Length=324, Percent_Identity=28.0864197530864, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17534817, Length=461, Percent_Identity=38.8286334056399, Blast_Score=326, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17534819, Length=461, Percent_Identity=38.8286334056399, Blast_Score=326, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI71981211, Length=499, Percent_Identity=28.2565130260521, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI71981217, Length=508, Percent_Identity=28.1496062992126, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17551992, Length=500, Percent_Identity=28.6, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI133931025, Length=479, Percent_Identity=27.9749478079332, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI71993058, Length=394, Percent_Identity=26.6497461928934, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17555682, Length=394, Percent_Identity=26.6497461928934, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71993062, Length=323, Percent_Identity=27.8637770897833, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193205882, Length=389, Percent_Identity=23.1362467866324, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573972, Length=482, Percent_Identity=38.7966804979253, Blast_Score=328, Evalue=6e-90,
Organism=Drosophila melanogaster, GI24652373, Length=479, Percent_Identity=37.3695198329854, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24585139, Length=480, Percent_Identity=37.2916666666667, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI221476190, Length=480, Percent_Identity=37.2916666666667, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24585143, Length=480, Percent_Identity=37.2916666666667, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24586044, Length=485, Percent_Identity=35.0515463917526, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI17136190, Length=480, Percent_Identity=35.4166666666667, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24585135, Length=480, Percent_Identity=34.5833333333333, Blast_Score=281, Evalue=5e-76,
Organism=Drosophila melanogaster, GI17136594, Length=361, Percent_Identity=30.4709141274238, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24657193, Length=396, Percent_Identity=28.2828282828283, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24657185, Length=396, Percent_Identity=28.2828282828283, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24657188, Length=396, Percent_Identity=28.2828282828283, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI21356415, Length=380, Percent_Identity=26.5789473684211, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52142; Mature: 52011

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00123 ALKALINE_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDI
CCCHHHHHCCHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
EELIMPGLLHWQHPDFFGYFPSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATN
HHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WLLKMLGLSAAWSGVIQDSASTATLVALISGRERTSNYALMNKGMQNSDAPLIVYTSSEA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCEEEEECCHH
HSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
HCCCCHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAA
HHCCHHHHHHHHHHHCCEEEEECCCCCCCEEECHHHHHHHCCCCCCCEEEECCHHHHCCE
FDCSVYCVQDSEHLIRIMSTNPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQG
ECCEEEEEECCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
VEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCIRHEPGGLMGDALDNYTRSW
HHHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPEEFRRHGYAMIDLIADYRQNIELRGVNPTTAPGEIKSRLSLNAPEKAEPFEHIISDI
CCHHHHHCCHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
EELIMPGLLHWQHPDFFGYFPSNVELSSVLGDCLSTGLGVIGLSWQSSPALTEIEEVATN
HHHHCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHH
WLLKMLGLSAAWSGVIQDSASTATLVALISGRERTSNYALMNKGMQNSDAPLIVYTSSEA
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCEEEEECCHH
HSGVNKAALLAGFGHNNIRLVPTDEHNAMSPLALEKIIQQDLVKGNRPCIVVATTGTTAA
HCCCCHHHEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
TAMDPLDAIGDITQRYGLWLHVDSAMAGSAMILPECRHLWCGIEKADSVVINPHKWLGAA
HHCCHHHHHHHHHHHCCEEEEECCCCCCCEEECHHHHHHHCCCCCCCEEEECCHHHHCCE
FDCSVYCVQDSEHLIRIMSTNPSFLQSDADGKVRNYRDWGIPLGRRFRALKLWFLIREQG
ECCEEEEEECCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
VEGLQARLRRDIANANWLAEQIKNSDDWKLVAPVVLQTLCIRHEPGGLMGDALDNYTRSW
HHHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
AEKLNQSGKGYVTPATLGGRWMVRVSIGTLGTERHHVEKLWLLLQSLVKER
HHHHCCCCCCEEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]