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The map label for this gene is cvrA [H]

Identifier: 153948201

GI number: 153948201

Start: 1804592

End: 1806319

Strand: Reverse

Name: cvrA [H]

Synonym: YpsIP31758_1549

Alternate gene names: 153948201

Gene position: 1806319-1804592 (Counterclockwise)

Preceding gene: 153950220

Following gene: 153949171

Centisome position: 38.24

GC content: 49.83

Gene sequence:

>1728_bases
TTGGACGCCATCACGATTAATAGCCTTTTTTTGGTCGGCGCAGTGCTGGTGGCAGCCAGTATTTTACTCAGTTCATTTTC
ATCTCGGTTAGGGATCCCTATCCTGGTTATCTTCCTCGCTATCGGAATGTTAGCCGGTACCGACGGGTTGGGCGGAATCG
CGTTTGATAACTATCCGGCCGCTTATTTGGTCAGTAACCTCGCATTAGCCGTGATCCTGTTAGATGGTGGTATGCGGACG
CGGGCCTCATCCTTTCGTGTTGCGCTATGGCCAGCACTTTCCCTGGCGACATTCGGGGTCATCATTACCGCCGGGCTGAC
CGGTCTGGTGGCCGCCTGGCTATTCAACTTAGATATTATTCAGGGCTTATTAATAGGCGCAATTATTGGTTCAACGGATG
CCGCTGCCGTATTCTCTTTATTAGGTGGAAAAGGCCTCAACGAACGTGTCAGCGCTACCCTAGAGATTGAGTCAGGCAGT
AATGATCCAATGGCGGTCTTTTTGACCGTCACGCTGATCGCGATGATTGCCGCGGGTGAAACGAGCCTAAGCTGGATGTT
CTTGGTGCATTTGATCCAACAGTTTGGATTGGGCATCATAATTGGTCTGCTCGGCGGTGGGTTACTGCTGTTGTTAATCA
ACAGAATGGAATTGGCCAACGGCTTATACCCTTTGCTGGCCGTCAGTGGTGGGATTCTAGTGTTTGCTCTTGCGACCGCA
CTGAACGGCAGCGGCATTCTTGCTGTCTATCTCTGTGGATTGTTACTGGGTAACCGCCCTATTCGTAACCGTGCCGGGAT
ATTACAAACTTTCGATGGACTTGCCTGGCTCAGCCAGATTGGCATGTTCCTTGTCTTAGGGTTGCTGCTTAACCCAAGCG
ACCTGTTACCCATCGCCATTCCAGCGCTGCTTTTATCACTATGGATGATTTTGTTCGCCCGGCCACTCTCTGTCTTTATT
GGCCTACTCCCATTTCGTAGCTTCAATCTACGCGAGCGTGTCTTTATCTCGTGGGTTGGCTTACGCGGTGCGGTCCCGGT
TATTCTGGCGGTGTTCCCAATGATGGCGGGCTTGCCCAATGCCAACCTCTTCTTCAATGTGGCCTTCTTCGTCGTGCTGG
TATCACTACTTTTACAGGGTACCACCCTGTCATTTGCTGCCCGCAAAGCAAAATTAGTGGTGCCGCCTACGCTGGCCCCG
GTTTCCCGCATTGGCCTCGATATTGATATGAACAATCAATGGGAACAGTTTATTTATCAGCTTAGTTGCGATAAATGGTG
TATTGGTGCCACGTTGCGCGATTTAAAAATGCCACAAGGAACACGTATCGCCGCCCTGTTCCGTGGCAAAGATTTATTGC
ACCCCACCGGTAGCACCCGCCTAAAAGAAGGCGATATCTTGTGTGTTATCGGTCAGGAGCATGACTTACCGGCGCTAGGT
AAACTGTTCAGCCAATCACCCAACATCCAATTGGATGAACGTTTCTTCGGTGATTTTATTCTTGATGCGGATGCTAAACT
CCAAGATATTTCACAGATTTATGGTCTTAATCTGGAGCCTACCGTTGATAAACAACAAACTTTGGGTCAATTTGTTTTAT
ACCTCTTTGGCGGGGAACCCGTTATTGGTGACCAAATTGAGTGGGACGGTCTGACCTGGACGATTGCCGAAATGGAATCA
GATCGTGTCAGCCGGGTTGGCGTTAAGATCGTTACCGATAAGGCGTAA

Upstream 100 bases:

>100_bases
TTAGGTTATATCGTCTCATCGAAACTCATAATTCTGTGTATAATAACTTGATTGTAACATTCGCCTACCCCCACTTAATT
GCATCAGGAGAACGCCCATT

Downstream 100 bases:

>100_bases
TCTTTTTATTCACTGACGCGATTTCACGGTCAGTGAATTAGTTTTAAACTGCGGTATGCCTTAATTCGCTTTATTATTTA
ATTCCGTTTTGTCACTTAAT

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MDAITINSLFLVGAVLVAASILLSSFSSRLGIPILVIFLAIGMLAGTDGLGGIAFDNYPAAYLVSNLALAVILLDGGMRT
RASSFRVALWPALSLATFGVIITAGLTGLVAAWLFNLDIIQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGS
NDPMAVFLTVTLIAMIAAGETSLSWMFLVHLIQQFGLGIIIGLLGGGLLLLLINRMELANGLYPLLAVSGGILVFALATA
LNGSGILAVYLCGLLLGNRPIRNRAGILQTFDGLAWLSQIGMFLVLGLLLNPSDLLPIAIPALLLSLWMILFARPLSVFI
GLLPFRSFNLRERVFISWVGLRGAVPVILAVFPMMAGLPNANLFFNVAFFVVLVSLLLQGTTLSFAARKAKLVVPPTLAP
VSRIGLDIDMNNQWEQFIYQLSCDKWCIGATLRDLKMPQGTRIAALFRGKDLLHPTGSTRLKEGDILCVIGQEHDLPALG
KLFSQSPNIQLDERFFGDFILDADAKLQDISQIYGLNLEPTVDKQQTLGQFVLYLFGGEPVIGDQIEWDGLTWTIAEMES
DRVSRVGVKIVTDKA

Sequences:

>Translated_575_residues
MDAITINSLFLVGAVLVAASILLSSFSSRLGIPILVIFLAIGMLAGTDGLGGIAFDNYPAAYLVSNLALAVILLDGGMRT
RASSFRVALWPALSLATFGVIITAGLTGLVAAWLFNLDIIQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGS
NDPMAVFLTVTLIAMIAAGETSLSWMFLVHLIQQFGLGIIIGLLGGGLLLLLINRMELANGLYPLLAVSGGILVFALATA
LNGSGILAVYLCGLLLGNRPIRNRAGILQTFDGLAWLSQIGMFLVLGLLLNPSDLLPIAIPALLLSLWMILFARPLSVFI
GLLPFRSFNLRERVFISWVGLRGAVPVILAVFPMMAGLPNANLFFNVAFFVVLVSLLLQGTTLSFAARKAKLVVPPTLAP
VSRIGLDIDMNNQWEQFIYQLSCDKWCIGATLRDLKMPQGTRIAALFRGKDLLHPTGSTRLKEGDILCVIGQEHDLPALG
KLFSQSPNIQLDERFFGDFILDADAKLQDISQIYGLNLEPTVDKQQTLGQFVLYLFGGEPVIGDQIEWDGLTWTIAEMES
DRVSRVGVKIVTDKA
>Mature_575_residues
MDAITINSLFLVGAVLVAASILLSSFSSRLGIPILVIFLAIGMLAGTDGLGGIAFDNYPAAYLVSNLALAVILLDGGMRT
RASSFRVALWPALSLATFGVIITAGLTGLVAAWLFNLDIIQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGS
NDPMAVFLTVTLIAMIAAGETSLSWMFLVHLIQQFGLGIIIGLLGGGLLLLLINRMELANGLYPLLAVSGGILVFALATA
LNGSGILAVYLCGLLLGNRPIRNRAGILQTFDGLAWLSQIGMFLVLGLLLNPSDLLPIAIPALLLSLWMILFARPLSVFI
GLLPFRSFNLRERVFISWVGLRGAVPVILAVFPMMAGLPNANLFFNVAFFVVLVSLLLQGTTLSFAARKAKLVVPPTLAP
VSRIGLDIDMNNQWEQFIYQLSCDKWCIGATLRDLKMPQGTRIAALFRGKDLLHPTGSTRLKEGDILCVIGQEHDLPALG
KLFSQSPNIQLDERFFGDFILDADAKLQDISQIYGLNLEPTVDKQQTLGQFVLYLFGGEPVIGDQIEWDGLTWTIAEMES
DRVSRVGVKIVTDKA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=576, Percent_Identity=76.3888888888889, Blast_Score=813, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61637; Mature: 61637

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAITINSLFLVGAVLVAASILLSSFSSRLGIPILVIFLAIGMLAGTDGLGGIAFDNYPA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEECCCCH
AYLVSNLALAVILLDGGMRTRASSFRVALWPALSLATFGVIITAGLTGLVAAWLFNLDII
HHHHHHHHHEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVFLTVTLIAMIAAGE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCC
TSLSWMFLVHLIQQFGLGIIIGLLGGGLLLLLINRMELANGLYPLLAVSGGILVFALATA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHH
LNGSGILAVYLCGLLLGNRPIRNRAGILQTFDGLAWLSQIGMFLVLGLLLNPSDLLPIAI
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PALLLSLWMILFARPLSVFIGLLPFRSFNLRERVFISWVGLRGAVPVILAVFPMMAGLPN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHCCCC
ANLFFNVAFFVVLVSLLLQGTTLSFAARKAKLVVPPTLAPVSRIGLDIDMNNQWEQFIYQ
CHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCHHHHCEEECCCCHHHHHHHH
LSCDKWCIGATLRDLKMPQGTRIAALFRGKDLLHPTGSTRLKEGDILCVIGQEHDLPALG
HCCCCEECCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEECCCEEEEECCCCCCCHHH
KLFSQSPNIQLDERFFGDFILDADAKLQDISQIYGLNLEPTVDKQQTLGQFVLYLFGGEP
HHHCCCCCCEECHHHHCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
VIGDQIEWDGLTWTIAEMESDRVSRVGVKIVTDKA
CCCCCEEECCEEEEEEHHCCCHHHHCCEEEEECCC
>Mature Secondary Structure
MDAITINSLFLVGAVLVAASILLSSFSSRLGIPILVIFLAIGMLAGTDGLGGIAFDNYPA
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEECCCCH
AYLVSNLALAVILLDGGMRTRASSFRVALWPALSLATFGVIITAGLTGLVAAWLFNLDII
HHHHHHHHHEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVFLTVTLIAMIAAGE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCC
TSLSWMFLVHLIQQFGLGIIIGLLGGGLLLLLINRMELANGLYPLLAVSGGILVFALATA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHH
LNGSGILAVYLCGLLLGNRPIRNRAGILQTFDGLAWLSQIGMFLVLGLLLNPSDLLPIAI
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
PALLLSLWMILFARPLSVFIGLLPFRSFNLRERVFISWVGLRGAVPVILAVFPMMAGLPN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHCCCC
ANLFFNVAFFVVLVSLLLQGTTLSFAARKAKLVVPPTLAPVSRIGLDIDMNNQWEQFIYQ
CHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEECCCCCCHHHHCEEECCCCHHHHHHHH
LSCDKWCIGATLRDLKMPQGTRIAALFRGKDLLHPTGSTRLKEGDILCVIGQEHDLPALG
HCCCCEECCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEECCCEEEEECCCCCCCHHH
KLFSQSPNIQLDERFFGDFILDADAKLQDISQIYGLNLEPTVDKQQTLGQFVLYLFGGEP
HHHCCCCCCEECHHHHCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
VIGDQIEWDGLTWTIAEMESDRVSRVGVKIVTDKA
CCCCCEEECCEEEEEEHHCCCHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA