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The map label for this gene is modE [H]

Identifier: 153948149

GI number: 153948149

Start: 3220350

End: 3221141

Strand: Direct

Name: modE [H]

Synonym: YpsIP31758_2852

Alternate gene names: 153948149

Gene position: 3220350-3221141 (Clockwise)

Preceding gene: 153947605

Following gene: 153947841

Centisome position: 68.18

GC content: 51.52

Gene sequence:

>792_bases
ATGCAGGCCGAAATTCTTCTTACACTAAAACTTCAACAGCGCCTGTTTGCCGATCCACGACGTATTGCGCTATTAAAGCA
AATTCAGCATACCGGTTCCATCAGCCAGGGGGCCAAGCTCGCGGGTATCAGCTATAAAAGTGCCTGGGATGCCATAAATG
AAATGAATACACTGTCCGAGGAGATACTGGTTGAGCGGGCCACTGGCGGCAAAGGGGGAGGGGGAGCACATCTGACCCGC
TACGGTGAACGCTTAATCCAGCTTTATGATTTACTCGCGACCATCCAGCAAAAAGCCTTTGATACCCTGAAAGATGATTC
ACTGCCGCTGGACAGCTTGCTGGCGGCAATTTCCCGCTTTTCACTGCAAACCAGCGCCCGTAATCAATTTTTCGGTACCC
TTATTGAACGCGACCACCAGCAGGTGCAACAGCATGTCAATATTCTGCTATCGGACGGCAAAACTCGCTTAACGGCGGCG
ATCACCCAGCAAAGTGCGGATCGCCTGCAACTTTCAGCAGGTAAAGAAGTGCTGGCATTGATTAAAGCACCCTGGGTAAA
ACTGGTTACCGATCCGGCACTGGCAGGTGCAGCGGATAACGCATTGCCGGGAATGGTCGCCAGCATTGAGCCGGGCAACG
ATCATAGCGAAGTTATTGTCACCTTAACTGGCGGGGCCAACCTGTGTTCAACCCAAAACAACAGCGAACTCCATGCGCTG
AATTTACGGGTTGGCAGTGCCGTCATCGCACAATTCAATGCAGATCGAGTGATTATCGCCACATTGTGTTGA

Upstream 100 bases:

>100_bases
TTGTTTAGCTATCTATGTTGTTTAGCTATCTATGCTGTTTAGCTATCTATGTCATTTAGCTATCTATGACAATAACTGTT
TCCCGCCGGAGCAAAAAACA

Downstream 100 bases:

>100_bases
ATGATTACTCCTAGTAATCACTGTTAGACCATACATTTGTTCGTTGACATTTTTCGTCTTTCGGCTTATCCCTAACATCT
TTACTACGTTGTAAAATATG

Product: ModE family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINEMNTLSEEILVERATGGKGGGGAHLTR
YGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIERDHQQVQQHVNILLSDGKTRLTAA
ITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGMVASIEPGNDHSEVIVTLTGGANLCSTQNNSELHAL
NLRVGSAVIAQFNADRVIIATLC

Sequences:

>Translated_263_residues
MQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINEMNTLSEEILVERATGGKGGGGAHLTR
YGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIERDHQQVQQHVNILLSDGKTRLTAA
ITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGMVASIEPGNDHSEVIVTLTGGANLCSTQNNSELHAL
NLRVGSAVIAQFNADRVIIATLC
>Mature_263_residues
MQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINEMNTLSEEILVERATGGKGGGGAHLTR
YGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRFSLQTSARNQFFGTLIERDHQQVQQHVNILLSDGKTRLTAA
ITQQSADRLQLSAGKEVLALIKAPWVKLVTDPALAGAADNALPGMVASIEPGNDHSEVIVTLTGGANLCSTQNNSELHAL
NLRVGSAVIAQFNADRVIIATLC

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=264, Percent_Identity=70.8333333333333, Blast_Score=318, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 28343; Mature: 28343

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINEMNTLSE
CCCEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
EILVERATGGKGGGGAHLTRYGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRF
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLQTSARNQFFGTLIERDHQQVQQHVNILLSDGKTRLTAAITQQSADRLQLSAGKEVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
IKAPWVKLVTDPALAGAADNALPGMVASIEPGNDHSEVIVTLTGGANLCSTQNNSELHAL
HHCCHHHEECCCHHCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEE
NLRVGSAVIAQFNADRVIIATLC
EEEHHHHHHEEECCCEEEEEEEC
>Mature Secondary Structure
MQAEILLTLKLQQRLFADPRRIALLKQIQHTGSISQGAKLAGISYKSAWDAINEMNTLSE
CCCEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHH
EILVERATGGKGGGGAHLTRYGERLIQLYDLLATIQQKAFDTLKDDSLPLDSLLAAISRF
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLQTSARNQFFGTLIERDHQQVQQHVNILLSDGKTRLTAAITQQSADRLQLSAGKEVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
IKAPWVKLVTDPALAGAADNALPGMVASIEPGNDHSEVIVTLTGGANLCSTQNNSELHAL
HHCCHHHEECCCHHCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEE
NLRVGSAVIAQFNADRVIIATLC
EEEHHHHHHEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]