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The map label for this gene is ribA

Identifier: 153948061

GI number: 153948061

Start: 2220241

End: 2220831

Strand: Direct

Name: ribA

Synonym: YpsIP31758_1919

Alternate gene names: 153948061

Gene position: 2220241-2220831 (Clockwise)

Preceding gene: 153950096

Following gene: 153950840

Centisome position: 47.01

GC content: 46.87

Gene sequence:

>591_bases
ATGCAGCTAAAACGTGTAGCAGAAGCAAAGTTACCCACTCCTTGGGGTGACTTTTTAATGGTCGGTTTTGAAGAATTGGC
CACCGGGCATGACCACCTGGCCTTGATATTCGGTGATATCTCCGGTGATAAACCGGTTCTGTCCCGTGTACATTCTGAAT
GCCTGACTGGTGATGCTTTATTTAGCCTGCGTTGTGACTGTGGTTTTCAGTTAGAGGTTGCACTGACGCGTATCGCGGAA
GAAGGCCGTGGTGTGCTGATTTATCATCGTCAGGAGGGCCGTAATATTGGCTTGCTGAATAAAATTCGTGCTTATGCATT
GCAGGATTTAGGGGCTGATACGGTAGAAGCCAATCATCAGCTTGGTTTTGCTGCGGATGAACGTGATTTCACACTCTGTT
CTGATATGTATAAATTATTAGGCATCAAAGCGGTTCGTCTGCTGACCAACAACCCTAAAAAGGTCGAGATCCTCACCCAA
GCGGGGATCAATATCGTCGAACGTGTGCCACTGATCGTGGGCGAAAACCCAAAAAACGAACATTATCTGGCAACCAAAGC
GGCCAAAATGGGGCATTTACTCACCAAATAA

Upstream 100 bases:

>100_bases
TCTCCAAGTAGAAAGGTCTATATCTGGTTAAAACGGACATCCGGCAGTAGGATGCGCCACAACATACTCTAAGAGCCTAA
GTCATAATATGAACAATGAT

Downstream 100 bases:

>100_bases
TCAGTACGGGTGAGTCGCGAAATAAGAATAAGGGTAGGTTCAATAATTATACCTACCCTTTAGAGGCTGATAATCTCGGT
GGCTCAATCCAAATGACACT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDALFSLRCDCGFQLEVALTRIAE
EGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQ
AGINIVERVPLIVGENPKNEHYLATKAAKMGHLLTK

Sequences:

>Translated_196_residues
MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDALFSLRCDCGFQLEVALTRIAE
EGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQ
AGINIVERVPLIVGENPKNEHYLATKAAKMGHLLTK
>Mature_196_residues
MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDALFSLRCDCGFQLEVALTRIAE
EGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQLGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQ
AGINIVERVPLIVGENPKNEHYLATKAAKMGHLLTK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=196, Percent_Identity=88.265306122449, Blast_Score=366, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319438, Length=197, Percent_Identity=44.1624365482233, Blast_Score=132, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_YERPE (Q8ZEF0)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AI0270
- RefSeq:   NP_669377.1
- RefSeq:   NP_993359.1
- RefSeq:   YP_002347194.1
- ProteinModelPortal:   Q8ZEF0
- SMR:   Q8ZEF0
- GeneID:   1147011
- GeneID:   1175056
- GeneID:   2767137
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO2222
- KEGG:   ypk:y2064
- KEGG:   ypm:YP_2020
- HOGENOM:   HBG735778
- OMA:   QGFILYL
- ProtClustDB:   PRK00393
- BioCyc:   YPES187410:Y2064-MONOMER
- BioCyc:   YPES214092:YPO2222-MONOMER
- BRENDA:   3.5.4.25
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 21677; Mature: 21677

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00626 RCC1_2

Important sites: ACT_SITE 126-126 ACT_SITE 128-128 BINDING 70-70 BINDING 114-114 BINDING 149-149 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDAL
CCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCE
FSLRCDCGFQLEVALTRIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
LGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQAGINIVERVPLIVGENPKNE
CCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCHHHHHCCEEECCCCCCC
HYLATKAAKMGHLLTK
CEEEHHHHHHHHHCCC
>Mature Secondary Structure
MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHLALIFGDISGDKPVLSRVHSECLTGDAL
CCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCE
FSLRCDCGFQLEVALTRIAEEGRGVLIYHRQEGRNIGLLNKIRAYALQDLGADTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
LGFAADERDFTLCSDMYKLLGIKAVRLLTNNPKKVEILTQAGINIVERVPLIVGENPKNE
CCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCHHHHHCCEEECCCCCCC
HYLATKAAKMGHLLTK
CEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430