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The map label for this gene is nanT

Identifier: 153947886

GI number: 153947886

Start: 1517681

End: 1519213

Strand: Direct

Name: nanT

Synonym: YpsIP31758_1298

Alternate gene names: 153947886

Gene position: 1517681-1519213 (Clockwise)

Preceding gene: 153948582

Following gene: 153947437

Centisome position: 32.13

GC content: 50.88

Gene sequence:

>1533_bases
ATGAGTATTTCAGTAGGTCCATCTCGTGAAGATAAACCATTATCGGGTGGCGCTAAACCACCCCGTTGGTACAAACAACT
TACCCCGGCGCAATGGAAGGCCTTTGTTGCCGCTTGGATCGGTTACGCCCTGGATGGCTTTGACTTTGTTCTGATTACTC
TGGTTCTGACCGATATTAAACAAGAATTTGGCCTGACACTGATTCAGGCGACCAGCCTGATTTCTGCTGCCTTCATCTCA
CGCTGGTTTGGTGGGTTGGTACTGGGCGCGATGGGGGATCGCTATGGCCGTAAACTGGCCATGATCACCAGTATTGTGTT
GTTCTCCTTCGGTACGTTGGCCTGTGGCTTAGCACCTGGCTACACCACGCTGTTTATTGCTCGCTTGATTATCGGTATTG
GCATGGCGGGTGAGTATGGTTCCAGCTCGACCTATGTGATGGAAAGCTGGCCTAAAAACATGCGTAATAAAGCCAGTGGC
TTCCTGATTTCTGGCTTCTCTATCGGTGCGGTACTCGCGGCGCAAGCCTACAGCTACGTGGTGCCCGCATTTGGTTGGCG
TATGTTGTTCTACATTGGATTATTGCCAATTATCTTTGCACTGTGGTTGCGTAAAAATCTACCGGAAGCAGAGGACTGGG
AAAAGGCACAAAGTAAGCAGAAAAAAGGTAAACAGGTCACTGACCGGAATATGGTGGATATTCTGTATCGCAGTCACCTC
AGTTATCTGAATATTGGCCTGACGATATTTGCCGCCGTCTCACTTTACCTCTGTTTTACTGGCATGGTCTCGACGTTGCT
GGTGGTGGTTCTCGGTATTCTTTGCGCTGCAATATTTATCTATTTTATGGTTCAAACCAGTGGCGATCGCTGGCCTACGG
GCGTCATGCTGATGGTCGTGGTGTTCTGTGCGTTCCTCTACTCTTGGCCGATCCAGGCGTTGTTACCGACCTACCTGAAA
ATGGATCTCGGCTATGACCCACACACCGTAGGCAATATATTGTTCTTCAGTGGTTTTGGTGCGGCCGTGGGTTGTTGTGT
TGGCGGTTTCCTTGGCGATTGGTTGGGTACCCGCAAAGCCTATGTGACCAGTTTGCTGATATCACAGCTCTTGATCATCC
CGCTGTTTGCCATCCAAGGCAGCAGTATTTTGTTCCTGGGGGGATTACTGTTCTTACAACAGATGCTGGGGCAGGGGATT
GCGGGCCTGTTGCCGAAACTGTTGGGCGGTTATTTTGATACCGAACAGCGAGCCGCAGGACTGGGCTTTACCTACAACGT
CGGCGCATTGGGAGGGGCATTGGCCCCCATACTGGGGGCATCGATTGCTCAACATCTCAGTTTAGGCACCGCGTTGGGAT
CGCTCTCTTTCAGTCTGACATTCGTGGTGATCCTACTGATTGGTTTTGATATGCCATCCCGTGTACAGCGTTGGGTCCGC
CCATCAGGTTTACGGATGGTGGATGCCATCGATGGCAAACCATTCAGTGGTGCCATTACGGCCCAGCATGCGCGAGTAGT
GACACAGAAATAA

Upstream 100 bases:

>100_bases
AAAGTGATTATAAACAATCACATGCTATGGTTGTACATGCCTCGGGGAAAACCGTTACTGCTGGTGCCATCATTGCCAGT
GGGGAAGAGAGAGCGATGAT

Downstream 100 bases:

>100_bases
CGTTTTTTCAGCCAGAATTTACTTTTCATCCATCATTTATTTTTCATCCATAAACTGTTTTTCTTGCCCGGTGCGCGACA
ACCGGGCTTTTTTTTATTTG

Product: sialic acid transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: Sialic acid permease

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFIS
RWFGGLVLGAMGDRYGRKLAMITSIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASG
FLISGFSIGAVLAAQAYSYVVPAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHL
SYLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLK
MDLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGI
AGLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVR
PSGLRMVDAIDGKPFSGAITAQHARVVTQK

Sequences:

>Translated_510_residues
MSISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFIS
RWFGGLVLGAMGDRYGRKLAMITSIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASG
FLISGFSIGAVLAAQAYSYVVPAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHL
SYLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLK
MDLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGI
AGLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVR
PSGLRMVDAIDGKPFSGAITAQHARVVTQK
>Mature_509_residues
SISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIKQEFGLTLIQATSLISAAFISR
WFGGLVLGAMGDRYGRKLAMITSIVLFSFGTLACGLAPGYTTLFIARLIIGIGMAGEYGSSSTYVMESWPKNMRNKASGF
LISGFSIGAVLAAQAYSYVVPAFGWRMLFYIGLLPIIFALWLRKNLPEAEDWEKAQSKQKKGKQVTDRNMVDILYRSHLS
YLNIGLTIFAAVSLYLCFTGMVSTLLVVVLGILCAAIFIYFMVQTSGDRWPTGVMLMVVVFCAFLYSWPIQALLPTYLKM
DLGYDPHTVGNILFFSGFGAAVGCCVGGFLGDWLGTRKAYVTSLLISQLLIIPLFAIQGSSILFLGGLLFLQQMLGQGIA
GLLPKLLGGYFDTEQRAAGLGFTYNVGALGGALAPILGASIAQHLSLGTALGSLSFSLTFVVILLIGFDMPSRVQRWVRP
SGLRMVDAIDGKPFSGAITAQHARVVTQK

Specific function: May be a sugar-cation symporter involved in sialic acid uptake

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter family. Sialic acid transporter (TC 2.A.1.12.1) subfamily

Homologues:

Organism=Homo sapiens, GI24308167, Length=204, Percent_Identity=24.0196078431373, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87082231, Length=484, Percent_Identity=75.4132231404959, Blast_Score=734, Evalue=0.0,
Organism=Escherichia coli, GI87082404, Length=455, Percent_Identity=37.1428571428571, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1790550, Length=510, Percent_Identity=24.7058823529412, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1788292, Length=459, Percent_Identity=22.6579520697168, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788942, Length=283, Percent_Identity=27.5618374558304, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081723, Length=410, Percent_Identity=27.0731707317073, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787880, Length=218, Percent_Identity=27.0642201834862, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=193, Percent_Identity=25.9067357512953, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320595, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322632, Length=428, Percent_Identity=22.4299065420561, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NANT_YERP3 (A7FG99)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400277.1
- ProteinModelPortal:   A7FG99
- STRING:   A7FG99
- GeneID:   5386951
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1298
- eggNOG:   COG0477
- HOGENOM:   HBG417084
- OMA:   HEGKAPV
- ProtClustDB:   PRK03893
- BioCyc:   YPSE349747:YPSIP31758_1298-MONOMER
- HAMAP:   MF_01238
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004742

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 55263; Mature: 55132

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50850 MFS; PS00216 SUGAR_TRANSPORT_1; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ed3bee0)-; HASH(0x1f4a2744)-; HASH(0x1e514f9c)-; HASH(0x1eacf71c)-; HASH(0x1f3a89b4)-; HASH(0x1f398574)-; HASH(0x1ee21b80)-; HASH(0x1e9052e8)-; HASH(0x1ed2a46c)-; HASH(0x1c49c714)-; HASH(0x1f37bd50)-; HASH(0x1f3a893c)-; HASH(0x1f21d204)-; HASH(0x1ed61cb4)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCEEEECCCCCCCCCCHHHHHHHHHCCH
>Mature Secondary Structure 
SISVGPSREDKPLSGGAKPPRWYKQLTPAQWKAFVAAWIGYALDGFDFVLITLVLTDIK
CCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH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CCCCEEEECCCCCCCCCCHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA