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The map label for this gene is patB [H]

Identifier: 153947884

GI number: 153947884

Start: 2152031

End: 2153209

Strand: Direct

Name: patB [H]

Synonym: YpsIP31758_1857

Alternate gene names: 153947884

Gene position: 2152031-2153209 (Clockwise)

Preceding gene: 153947593

Following gene: 153947425

Centisome position: 45.56

GC content: 45.21

Gene sequence:

>1179_bases
ATGAAACAGCCTAATTTTAGCGAAGTCATTGATCGTCATAATACCAGTTCGGTTAAATGGGATTTTTTAAATCAATACTT
ACAGCTAGACCAGTCAGATTTATTGCCTATGTGGGTATCTGATTTTGATTTTAGATGCCCCGATGAAGTGCTACAGGCAC
TACATACCCGTGTTGATCACGGTGTATTCGGCTATAGCGAAAGAAATGATGATTACTATCAAGCCGCGATTAATTGGTTT
GCCAATCGGCATCAGTTAGCGCTCAATCGAGATTGGTTTACCTCCGTTGAGGGCGTCGTCCCCGGTCTGGCTTTGTTGAT
TCAAATGTTGAGCGAACCTGGTGATGGGGTTGTCATTCAGGGACCGTATTATGGTTCATTCGCCAAGATTATCACGATGA
ATAATAGGGTGGTTTTAGAGAACCCACTCGTTGAGAGCTTAGAGGGTTATAAAATTGATTATGACCATTTAGAACAACTG
CTTCAGCGTGAGAAACCCCGGTTATTACTGCTGTGTAACCCGCACAATCCTACAGGTAGATGCTGGCGGTCAGAAGAGCT
TACCCAGCTATTGGCACTGTGCAAAAAGTACAATGTTATCGTGATTTCAGATGAGATTTGGGCTGACTTAACGTTGCCAG
GTGAGACATTCACATCGGTGTTACATTTAGGTCCTGAATGGCATGAGCATGTTATCGCGGCAACATCGGCAAGTAAGACA
TTTGGGTTATCTTCATTGAGAATTTCAAACTTTCTCATTCCTAACCCAGATATTCGCCATGCCTTTGTCAATCGGCTTAA
TGCACATGGCTTAGATGTATTTAATGCCTTATCTATGACTGCAGCTACGGCAGCATATAAATACGGTGCACCGTGGATGG
ATGCCTTACAGGTCTATTTAGCCGAGAACCGGCGCTGGCTTGAACAGGCATTAGCGTATGCAGCTCCTTGGTGTCACATG
GTCAAGGCAGAGGGCACTTATCTCGCCTGGCTGGATTGCCGTGACTTGGGGCTGGATGATGCAACGCTGAAGCAAGCTTT
ACTCGAGAAGGCGAAGATCGCCGCCTCCATGGGTGAAAGTTTCGGGCCGATGGGGTCTGGCTTTATTCGAATAAATTTAG
GATGTCCGCGTCGTTATCTAGAAAATGCAATTGAAGGGTTGTCACAATTGCACCTATGA

Upstream 100 bases:

>100_bases
TGTTATGCCGCTGTATTCTTTGCCCTTCTTTATGGTTTTACCGGTTTCGGTATAGCCAAAGTAAAACCTGAGAGTGCAGG
TCAGCGTCAGGAGGTGCAAC

Downstream 100 bases:

>100_bases
AATAATTGCACCTATGAAATGAATACTTGAAGTCAAAAGGTATCCGGTAATGGCCAAGACCAATATAAATCGGAACCTTA
CGTTATATTAAATGCCACAC

Product: aminotransferase, classes I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKQPNFSEVIDRHNTSSVKWDFLNQYLQLDQSDLLPMWVSDFDFRCPDEVLQALHTRVDHGVFGYSERNDDYYQAAINWF
ANRHQLALNRDWFTSVEGVVPGLALLIQMLSEPGDGVVIQGPYYGSFAKIITMNNRVVLENPLVESLEGYKIDYDHLEQL
LQREKPRLLLLCNPHNPTGRCWRSEELTQLLALCKKYNVIVISDEIWADLTLPGETFTSVLHLGPEWHEHVIAATSASKT
FGLSSLRISNFLIPNPDIRHAFVNRLNAHGLDVFNALSMTAATAAYKYGAPWMDALQVYLAENRRWLEQALAYAAPWCHM
VKAEGTYLAWLDCRDLGLDDATLKQALLEKAKIAASMGESFGPMGSGFIRINLGCPRRYLENAIEGLSQLHL

Sequences:

>Translated_392_residues
MKQPNFSEVIDRHNTSSVKWDFLNQYLQLDQSDLLPMWVSDFDFRCPDEVLQALHTRVDHGVFGYSERNDDYYQAAINWF
ANRHQLALNRDWFTSVEGVVPGLALLIQMLSEPGDGVVIQGPYYGSFAKIITMNNRVVLENPLVESLEGYKIDYDHLEQL
LQREKPRLLLLCNPHNPTGRCWRSEELTQLLALCKKYNVIVISDEIWADLTLPGETFTSVLHLGPEWHEHVIAATSASKT
FGLSSLRISNFLIPNPDIRHAFVNRLNAHGLDVFNALSMTAATAAYKYGAPWMDALQVYLAENRRWLEQALAYAAPWCHM
VKAEGTYLAWLDCRDLGLDDATLKQALLEKAKIAASMGESFGPMGSGFIRINLGCPRRYLENAIEGLSQLHL
>Mature_392_residues
MKQPNFSEVIDRHNTSSVKWDFLNQYLQLDQSDLLPMWVSDFDFRCPDEVLQALHTRVDHGVFGYSERNDDYYQAAINWF
ANRHQLALNRDWFTSVEGVVPGLALLIQMLSEPGDGVVIQGPYYGSFAKIITMNNRVVLENPLVESLEGYKIDYDHLEQL
LQREKPRLLLLCNPHNPTGRCWRSEELTQLLALCKKYNVIVISDEIWADLTLPGETFTSVLHLGPEWHEHVIAATSASKT
FGLSSLRISNFLIPNPDIRHAFVNRLNAHGLDVFNALSMTAATAAYKYGAPWMDALQVYLAENRRWLEQALAYAAPWCHM
VKAEGTYLAWLDCRDLGLDDATLKQALLEKAKIAASMGESFGPMGSGFIRINLGCPRRYLENAIEGLSQLHL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI187936925, Length=294, Percent_Identity=24.8299319727891, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI14211921, Length=294, Percent_Identity=24.8299319727891, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI56713254, Length=186, Percent_Identity=27.9569892473118, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI56713256, Length=186, Percent_Identity=27.9569892473118, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI149944424, Length=238, Percent_Identity=26.890756302521, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=37.3711340206186, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI1788722, Length=364, Percent_Identity=23.9010989010989, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786816, Length=305, Percent_Identity=24.9180327868852, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17567663, Length=356, Percent_Identity=21.6292134831461, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=299, Percent_Identity=24.7491638795987, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573069, Length=142, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24646114, Length=142, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28573067, Length=142, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI28573065, Length=142, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44472; Mature: 44472

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQPNFSEVIDRHNTSSVKWDFLNQYLQLDQSDLLPMWVSDFDFRCPDEVLQALHTRVDH
CCCCCHHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHC
GVFGYSERNDDYYQAAINWFANRHQLALNRDWFTSVEGVVPGLALLIQMLSEPGDGVVIQ
CCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GPYYGSFAKIITMNNRVVLENPLVESLEGYKIDYDHLEQLLQREKPRLLLLCNPHNPTGR
CCCCCCEEEEEEECCEEEECCCHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC
CWRSEELTQLLALCKKYNVIVISDEIWADLTLPGETFTSVLHLGPEWHEHVIAATSASKT
CCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHCCCHHHHHEEEECCCCCC
FGLSSLRISNFLIPNPDIRHAFVNRLNAHGLDVFNALSMTAATAAYKYGAPWMDALQVYL
CCCCHHHHCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AENRRWLEQALAYAAPWCHMVKAEGTYLAWLDCRDLGLDDATLKQALLEKAKIAASMGES
HHHHHHHHHHHHHHCCHHHEEECCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHC
FGPMGSGFIRINLGCPRRYLENAIEGLSQLHL
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQPNFSEVIDRHNTSSVKWDFLNQYLQLDQSDLLPMWVSDFDFRCPDEVLQALHTRVDH
CCCCCHHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHC
GVFGYSERNDDYYQAAINWFANRHQLALNRDWFTSVEGVVPGLALLIQMLSEPGDGVVIQ
CCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GPYYGSFAKIITMNNRVVLENPLVESLEGYKIDYDHLEQLLQREKPRLLLLCNPHNPTGR
CCCCCCEEEEEEECCEEEECCCHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC
CWRSEELTQLLALCKKYNVIVISDEIWADLTLPGETFTSVLHLGPEWHEHVIAATSASKT
CCCHHHHHHHHHHHHHCCEEEEECCCEEEEECCHHHHHHHHHCCCHHHHHEEEECCCCCC
FGLSSLRISNFLIPNPDIRHAFVNRLNAHGLDVFNALSMTAATAAYKYGAPWMDALQVYL
CCCCHHHHCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AENRRWLEQALAYAAPWCHMVKAEGTYLAWLDCRDLGLDDATLKQALLEKAKIAASMGES
HHHHHHHHHHHHHHCCHHHEEECCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHC
FGPMGSGFIRINLGCPRRYLENAIEGLSQLHL
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]