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The map label for this gene is lspA

Identifier: 153947776

GI number: 153947776

Start: 3897465

End: 3897974

Strand: Reverse

Name: lspA

Synonym: YpsIP31758_3459

Alternate gene names: 153947776

Gene position: 3897974-3897465 (Counterclockwise)

Preceding gene: 153946992

Following gene: 153947325

Centisome position: 82.53

GC content: 44.71

Gene sequence:

>510_bases
ATGAATAAACCTATTTGCTCGACCGGATTGCGCTGGTTATGGCTGGCAGTTGTCGTTGTCATCTTGGATATCAGCAGCAA
GCAGTGGGTCATGGCCCACTTTGCTCTGTATGAATCGGTGCCACTGATTCCTTTTTTCAACCTAACCTATGCGCAGAATT
TTGGCGCAGCATTTAGCTTCTTGGCGGATAAAAGTGGTTGGCAGCGTTGGTTCTTTGCCGGTATTGCGATAGGCATCTCC
GTCGTATTAATGGTGATGATGTATCGCTCAACAGCAAAGCAACGCCTGATAAATTGTGCTTATGCATTAATTATCGGTGG
TGCACTCGGGAATTTATATGACCGTTTAGTGCATGGCGCAGTCAACGATTTTCTCGATTTTTACATCAATAACTGGCATT
TCCCGACGTTCAATTTGGCCGATGTGGCGATATCCATTGGTGCTGTATTGGTTATCTTTGAAGGCTTCTTAAGTCCGGCA
GAAAAAAACGCGGTGAATAAAAATGAGTGA

Upstream 100 bases:

>100_bases
ATTACACGCAAGATGTCGGTTTGGTAGCAGAGCACGCTGAACTGTGTGGTCGCTGTGTCACTAACGTTGCTGGTGATGGT
GAGGAGCGTAAGTTCGCCTG

Downstream 100 bases:

>100_bases
TATGTCCGAATCTGTGCAAGATACCGAATTGGTACAAAATACTGGAACGGTAAAAACGACTGACGCGGTGCAAAATAATA
GTGCTGTTTTAGTGCATTTC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSFLADKSGWQRWFFAGIAIGIS
VVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGAVNDFLDFYINNWHFPTFNLADVAISIGAVLVIFEGFLSPA
EKNAVNKNE

Sequences:

>Translated_169_residues
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSFLADKSGWQRWFFAGIAIGIS
VVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGAVNDFLDFYINNWHFPTFNLADVAISIGAVLVIFEGFLSPA
EKNAVNKNE
>Mature_169_residues
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSFLADKSGWQRWFFAGIAIGIS
VVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGAVNDFLDFYINNWHFPTFNLADVAISIGAVLVIFEGFLSPA
EKNAVNKNE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=163, Percent_Identity=66.8711656441718, Blast_Score=228, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_YERP3 (A7FMD6)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402414.1
- STRING:   A7FMD6
- GeneID:   5387317
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3459
- NMPDR:   fig|349747.3.peg.3256
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   ADSSGWQ
- ProtClustDB:   PRK00376
- BioCyc:   YPSE349747:YPSIP31758_3459-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18934; Mature: 18934

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x20ca3b40)-; HASH(0x231b2674)-; HASH(0x22f39308)-; HASH(0x22f393c8)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSF
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHH
LADKSGWQRWFFAGIAIGISVVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNDFLDFYINNWHFPTFNLADVAISIGAVLVIFEGFLSPAEKNAVNKNE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCH
>Mature Secondary Structure
MNKPICSTGLRWLWLAVVVVILDISSKQWVMAHFALYESVPLIPFFNLTYAQNFGAAFSF
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHH
LADKSGWQRWFFAGIAIGISVVLMVMMYRSTAKQRLINCAYALIIGGALGNLYDRLVHGA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNDFLDFYINNWHFPTFNLADVAISIGAVLVIFEGFLSPAEKNAVNKNE
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA