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The map label for this gene is lon [H]

Identifier: 153947460

GI number: 153947460

Start: 3478837

End: 3481191

Strand: Reverse

Name: lon [H]

Synonym: YpsIP31758_3090

Alternate gene names: 153947460

Gene position: 3481191-3478837 (Counterclockwise)

Preceding gene: 153950055

Following gene: 153946890

Centisome position: 73.7

GC content: 48.32

Gene sequence:

>2355_bases
ATGAACCCTGAGCGTTCCGAACGCATAGAAATCCCCGTATTGCCTCTGCGCGATGTGGTGGTTTATCCGCATATGGTGAT
CCCACTATTTGTTGGCCGGGAAAAGTCGATTCGGTGCCTGGAAGCTGCGATGGACCATGATAAAAGAATCATGCTGGTTG
CGCAGAAAGAAGCTTCGACCGACGAACCTGGTATCAACGATCTGTTTTCGGTGGGTACCGTAGCCTCGATTTTGCAAATG
CTGAAGTTGCCTGACGGCACAGTAAAAGTGTTGGTTGAAGGTTTACAGCGTGCGCGTATCACCACGCTTTCTGACAGTGG
CGAGCATTTTGCTGCCCAAGCGGAATACCTTGAATCACCCGTGATGGATGATCGCGAGCAAGAAGTCTTGGTGCGTACCG
CGATTAATCAGTTTGAAGGTTATATCAAACTGAACAAAAAAATCCCGCCGGAAGTGCTGGCTTCGCTGCACAGTATTGAT
GATGCGGCACGTCTTGCTGATACCATCGCTGCACATATGCCATTGAAGTTAAATGATAAACAAGCTGTTCTGGAAATGTT
CGATATCACCGAACGTCTGGAATACTTGATGGCGATGATGGAGTCGGAAATCGATCTGTTACAGGTTGAAAAGCGGATCC
GTAATCGTGTTAAAAAACAGATGGAAAAGAGCCAGCGTGAGTACTATCTGAATGAGCAAATGAAAGCTATTCAGAAAGAA
CTGGGCGAGATGGACGATACGCCAGACGAGCATGAAGCGCTGAAGCGTAAAATTGAAGCGGCTAAAATGCCGAAAGATGC
GCGTGAAAAAACCGAAGCGGAACTGCAAAAACTGAAAATGATGTCGCCAATGTCTGCGGAAGCAACCGTGGTACGTGGTT
ACATCGACTGGATGTTGCAGGTTCCTTGGAATAGCCGCAGCAAAGTTAAAAAAGACCTGGTTAAAGCACAAGAAGTTCTG
GATACCGACCACTACGGTTTAGAGCGTGTTAAAGATCGTATCTTGGAATATCTCGCAGTCCAGAGCCGGGTCAGCAAAAT
TAAAGGGCCCATCCTCTGCTTGGTTGGGCCTCCTGGGGTCGGTAAAACCTCTCTAGGGCAGTCAATTGCTAAGGCAACGG
GCCGCCAGTATGTGCGTATGGCATTGGGTGGGGTGCGTGATGAAGCTGAAATCCGTGGTCACCGTCGTACGTATATTGGT
TCTATGCCGGGTAAATTGATCCAGAAGATGGCAAAAGTGGGTGTGAAAAACCCACTCTTCCTATTGGATGAGATCGATAA
AATGGCATCGGATATGCGCGGAGATCCTGCTTCTGCACTACTGGAGGTGCTGGATCCAGAACAAAACGTTGCATTTAACG
ATCACTACCTGGAAGTGGATTACGATCTCTCGGATGTGATGTTTGTGGCGACCTCTAACTCCATGAATATTCCCGCCCCG
TTGCTGGATCGTATGGAAGTTATTCGTCTGTCCGGCTATACCGAAGATGAGAAACTCAATATTGCTAAACAGCATTTGCT
GCCAAAACAATTTGAACGCAATGCCATCAAGAAAGGTGAGTTGACCATTGATGACAGCGCCATTATGAGCATTATCCGTT
ACTACACCCGTGAAGCTGGGGTGCGTAGTTTGGAACGTGAAATTTCTAAACTGTGTCGTAAGGCGGTAAAAAATCTGCTG
ATGGACAAAACGGTTAAGCACATTGAAATCAACGGGGATAACCTAAAAGATTTCCTTGGCGTTCAGAAGGTTGACTACGG
TCGTGCCGATACTGAAAACCGCGTAGGTCAGGTAACGGGTCTGGCATGGACTGAAGTGGGTGGTGACTTACTTACTATCG
AGACCGCTTGTGTTCCAGGTAAAGGTAAGTTGACTTATACCGGCTCACTGGGTGAAGTGATGCAGGAGTCGATTCAGGCG
GCTCTAACCGTGGTACGCGCGCGCGCGGATAAATTGGGTATCAACCCTGATTTCTATGAAAAACGCGACATCCACGTGCA
TGTGCCGGAAGGGGCGACACCTAAAGATGGCCCGAGCGCTGGTATTGCAATGTGCACAGCACTGGTTTCTTGTCTGACGG
GTAACCCCGTTCGTGCTGATGTTGCAATGACGGGTGAGATAACCTTACGTGGCTTAGTATTGCCGATTGGCGGTTTGAAA
GAGAAATTACTGGCCGCTCACCGTGGTGGGATCAAAGTGGTGTTGATTCCAGATGATAACAAACGTGATCTGGAAGAGAT
TCCTGACAATGTTATAGCTGATCTGGAGATCCACCCGGTTAAACGAATTGACGATGTTTTAGCCATTGCGTTGGAACACC
CGGCCTTTGGTGCCCAGCCAGTAGCGCCAAAATAG

Upstream 100 bases:

>100_bases
GTCCCCATATACTCAAATACCTATTTAGTGAAACTCGTGATGACTCGTGTTTCACGAGATTTCCAGTAATCTGGCGGAAG
CTAAACTAAGAGAGAGCTCT

Downstream 100 bases:

>100_bases
TGACGGATCGCAAGAAGTATTGATAAAACTAATGCTGGTAAGTGAAATCCTGCTTGCCAGCTATTTTTTGTGCCGCTAAG
TTAGTTCGGCTGTCCGGCAA

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEASTDEPGINDLFSVGTVASILQM
LKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYIKLNKKIPPEVLASLHSID
DAARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQVPWNSRSKVKKDLVKAQEVL
DTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAGVRSLEREISKLCRKAVKNLL
MDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGLVLPIGGLK
EKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQPVAPK

Sequences:

>Translated_784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEASTDEPGINDLFSVGTVASILQM
LKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYIKLNKKIPPEVLASLHSID
DAARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQVPWNSRSKVKKDLVKAQEVL
DTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAGVRSLEREISKLCRKAVKNLL
MDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGLVLPIGGLK
EKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQPVAPK
>Mature_784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEASTDEPGINDLFSVGTVASILQM
LKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESPVMDDREQEVLVRTAINQFEGYIKLNKKIPPEVLASLHSID
DAARLADTIAAHMPLKLNDKQAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQVPWNSRSKVKKDLVKAQEVL
DTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGVGKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAGVRSLEREISKLCRKAVKNLL
MDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARADKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGLVLPIGGLK
EKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQPVAPK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=45.7446808510638, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI21396489, Length=624, Percent_Identity=41.5064102564103, Blast_Score=503, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=91.0714285714286, Blast_Score=1454, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=696, Percent_Identity=38.5057471264368, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=785, Percent_Identity=32.8662420382166, Blast_Score=413, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319449, Length=678, Percent_Identity=40.117994100295, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI221513036, Length=680, Percent_Identity=43.5294117647059, Blast_Score=534, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=680, Percent_Identity=43.5294117647059, Blast_Score=534, Evalue=1e-151,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87434; Mature: 87434

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEAST
CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DEPGINDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESP
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCC
VMDDREQEVLVRTAINQFEGYIKLNKKIPPEVLASLHSIDDAARLADTIAAHMPLKLNDK
CCCCHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCH
QAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQ
HCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE
VPWNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGV
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHH
VRSLEREISKLCRKAVKNLLMDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTG
HHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHCCHHCCCCCCCCCCCCHHHCC
LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARADKLGINPDFYE
EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGLVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEEECCCCHH
EKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQP
HHHHHHHCCCEEEEEECCCCCCHHHHCCHHHEECCEECCHHHHHHHHHHHHCCCCCCCCC
VAPK
CCCC
>Mature Secondary Structure
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKRIMLVAQKEAST
CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DEPGINDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESP
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCC
VMDDREQEVLVRTAINQFEGYIKLNKKIPPEVLASLHSIDDAARLADTIAAHMPLKLNDK
CCCCHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCH
QAVLEMFDITERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEMDDTPDEHEALKRKIEAAKMPKDAREKTEAELQKLKMMSPMSAEATVVRGYIDWMLQ
HCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE
VPWNSRSKVKKDLVKAQEVLDTDHYGLERVKDRILEYLAVQSRVSKIKGPILCLVGPPGV
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIAKATGRQYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMASDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKQHLLPKQFERNAIKKGELTIDDSAIMSIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHH
VRSLEREISKLCRKAVKNLLMDKTVKHIEINGDNLKDFLGVQKVDYGRADTENRVGQVTG
HHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHCCHHCCCCCCCCCCCCHHHCC
LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARADKLGINPDFYE
EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGLVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEEEECCCCHH
EKLLAAHRGGIKVVLIPDDNKRDLEEIPDNVIADLEIHPVKRIDDVLAIALEHPAFGAQP
HHHHHHHCCCEEEEEECCCCCCHHHHCCHHHEECCEECCHHHHHHHHHHHHCCCCCCCCC
VAPK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA