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The map label for this gene is hisC

Identifier: 153947135

GI number: 153947135

Start: 2739235

End: 2740383

Strand: Direct

Name: hisC

Synonym: YpsIP31758_2430

Alternate gene names: 153947135

Gene position: 2739235-2740383 (Clockwise)

Preceding gene: 153947701

Following gene: 153950620

Centisome position: 57.99

GC content: 51.78

Gene sequence:

>1149_bases
ATGAGCCAATCTAATAACGTCACGGACCTGGCCCGTGCCAACATCCGTGCTCTGACTCCCTATATGTCCGCACGTCGGTT
AGGCGGTAATGGCGATGTCTGGCTGAATGCCAACGAATATCCGCTGGGCACTGAATATCAGTTGACCACGCAAACCTTCA
ATCGCTATCCCGAGTGTCAGCCTAAGCACGTTATTGAGCGCTATGCCGCTTACGCCGGTTTACCGCCAGAGCAAGTACTG
GTTAGTCGTGGTGCTGATGAAGGGATCGAACTGCTGATCCGCGCGTTCTGTGAGCCGGGTCAGGATGCCATTTTATTCTG
CCCACCAACCTACGGTATGTACGCTGTCAGTGCTGAAACCTTTGGTGTAGAACGGCGCACCGTACCCGCTCAGGCTGACT
GGCAGTTAGATTTACCGGCCATTGCCAACAATCTGGAACAGGTAAAAGTGATCTATGTTTGCAGCCCAAATAACCCGACG
GGTAATTTAATCAACCCGGCTGATTTACAGGCGGTGCTGGCACTGGCGCAAGGCCGCGCGATTGTCGCCATCGACGAAGC
CTATATTGAGTTTTGTCCACAAGCATCGGTCAGTAATTGGCTAAAAGATTATCCGAATTTAGTGATTTTGCGCACCTTAT
CGAAAGCCTTTGCATTAGCGGGTTTACGTTGTGGCTTTACGTTAGCCAACAGCGATATCATCCAATTGTTGCTTAAAGTG
ATCGCCCCCTATCCGTTATCTACGCCAGTGGCGGATATTGCCGCGCAAGCACTCAGCCCACAGGGGATTGAGCAAATGCG
CCAACGGGTCAGTGAAGTACGAGCTAACCGCGCATGGCTACAATCCGCACTGCAAGATTGCGCCTGTGTCGAACAGGTGT
TCACCAGCGAAAGCAACTATTTGCTGGTCCGCTTTACCGCGTCCAGCAGCGTATTCAAGGTATTGTGGGATCAGGGCATT
ATTTTGCGCGATCAAAATAAACAACCGGGGTTAGCCAACTGCCTGCGCATCACCATTGGCACCCGTCAGGAGTGTGAGCG
AGTGATTGCCGCCCTTGCCCCCCTGGCCGGCATTGATAACTCAAATAACATTGATAACCAGAGTAAAACCCATTCTCAGA
CCTCCAGCATCCGTAAGGGAACGATATGA

Upstream 100 bases:

>100_bases
CACTGGCACAGGCCGAACAACTGACCGCACACAAAAATGCAGTTACCCTGCGCGTTACCGCCTTGAATAACGCCCTGACC
GCCGTGAATAAGGAGTAAGC

Downstream 100 bases:

>100_bases
GCCAGAAATTTCTTTTTATTGACCGCGACGGCACCATCATTGCCGAGCCACCAACTGATTATCAGGTTGACCGGTTGGAT
AAACTGGCGCTGGAGCCTGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSQSNNVTDLARANIRALTPYMSARRLGGNGDVWLNANEYPLGTEYQLTTQTFNRYPECQPKHVIERYAAYAGLPPEQVL
VSRGADEGIELLIRAFCEPGQDAILFCPPTYGMYAVSAETFGVERRTVPAQADWQLDLPAIANNLEQVKVIYVCSPNNPT
GNLINPADLQAVLALAQGRAIVAIDEAYIEFCPQASVSNWLKDYPNLVILRTLSKAFALAGLRCGFTLANSDIIQLLLKV
IAPYPLSTPVADIAAQALSPQGIEQMRQRVSEVRANRAWLQSALQDCACVEQVFTSESNYLLVRFTASSSVFKVLWDQGI
ILRDQNKQPGLANCLRITIGTRQECERVIAALAPLAGIDNSNNIDNQSKTHSQTSSIRKGTI

Sequences:

>Translated_382_residues
MSQSNNVTDLARANIRALTPYMSARRLGGNGDVWLNANEYPLGTEYQLTTQTFNRYPECQPKHVIERYAAYAGLPPEQVL
VSRGADEGIELLIRAFCEPGQDAILFCPPTYGMYAVSAETFGVERRTVPAQADWQLDLPAIANNLEQVKVIYVCSPNNPT
GNLINPADLQAVLALAQGRAIVAIDEAYIEFCPQASVSNWLKDYPNLVILRTLSKAFALAGLRCGFTLANSDIIQLLLKV
IAPYPLSTPVADIAAQALSPQGIEQMRQRVSEVRANRAWLQSALQDCACVEQVFTSESNYLLVRFTASSSVFKVLWDQGI
ILRDQNKQPGLANCLRITIGTRQECERVIAALAPLAGIDNSNNIDNQSKTHSQTSSIRKGTI
>Mature_381_residues
SQSNNVTDLARANIRALTPYMSARRLGGNGDVWLNANEYPLGTEYQLTTQTFNRYPECQPKHVIERYAAYAGLPPEQVLV
SRGADEGIELLIRAFCEPGQDAILFCPPTYGMYAVSAETFGVERRTVPAQADWQLDLPAIANNLEQVKVIYVCSPNNPTG
NLINPADLQAVLALAQGRAIVAIDEAYIEFCPQASVSNWLKDYPNLVILRTLSKAFALAGLRCGFTLANSDIIQLLLKVI
APYPLSTPVADIAAQALSPQGIEQMRQRVSEVRANRAWLQSALQDCACVEQVFTSESNYLLVRFTASSSVFKVLWDQGII
LRDQNKQPGLANCLRITIGTRQECERVIAALAPLAGIDNSNNIDNQSKTHSQTSSIRKGTI

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=347, Percent_Identity=74.3515850144092, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322075, Length=368, Percent_Identity=31.7934782608696, Blast_Score=173, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_YERP3 (A7FJH1)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401399.1
- ProteinModelPortal:   A7FJH1
- SMR:   A7FJH1
- STRING:   A7FJH1
- GeneID:   5385985
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2430
- NMPDR:   fig|349747.3.peg.113
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- ProtClustDB:   PRK01688
- BioCyc:   YPSE349747:YPSIP31758_2430-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41947; Mature: 41816

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSNNVTDLARANIRALTPYMSARRLGGNGDVWLNANEYPLGTEYQLTTQTFNRYPECQ
CCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEHHHHHCCCCCC
PKHVIERYAAYAGLPPEQVLVSRGADEGIELLIRAFCEPGQDAILFCPPTYGMYAVSAET
HHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHH
FGVERRTVPAQADWQLDLPAIANNLEQVKVIYVCSPNNPTGNLINPADLQAVLALAQGRA
HCCCCCCCCCCCCCEEECHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCE
IVAIDEAYIEFCPQASVSNWLKDYPNLVILRTLSKAFALAGLRCGFTLANSDIIQLLLKV
EEEEEHHHHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCEEECCHHHHHHHHHH
IAPYPLSTPVADIAAQALSPQGIEQMRQRVSEVRANRAWLQSALQDCACVEQVFTSESNY
HCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LLVRFTASSSVFKVLWDQGIILRDQNKQPGLANCLRITIGTRQECERVIAALAPLAGIDN
EEEEEECCCHHHHHHHCCCEEEECCCCCCCHHHEEEEECCCHHHHHHHHHHHHHHHCCCC
SNNIDNQSKTHSQTSSIRKGTI
CCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQSNNVTDLARANIRALTPYMSARRLGGNGDVWLNANEYPLGTEYQLTTQTFNRYPECQ
CCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEHHHHHCCCCCC
PKHVIERYAAYAGLPPEQVLVSRGADEGIELLIRAFCEPGQDAILFCPPTYGMYAVSAET
HHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHH
FGVERRTVPAQADWQLDLPAIANNLEQVKVIYVCSPNNPTGNLINPADLQAVLALAQGRA
HCCCCCCCCCCCCCEEECHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCE
IVAIDEAYIEFCPQASVSNWLKDYPNLVILRTLSKAFALAGLRCGFTLANSDIIQLLLKV
EEEEEHHHHHHCCCCHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCEEECCHHHHHHHHHH
IAPYPLSTPVADIAAQALSPQGIEQMRQRVSEVRANRAWLQSALQDCACVEQVFTSESNY
HCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LLVRFTASSSVFKVLWDQGIILRDQNKQPGLANCLRITIGTRQECERVIAALAPLAGIDN
EEEEEECCCHHHHHHHCCCEEEECCCCCCCHHHEEEEECCCHHHHHHHHHHHHHHHCCCC
SNNIDNQSKTHSQTSSIRKGTI
CCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA