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The map label for this gene is aroP2 [H]

Identifier: 153946961

GI number: 153946961

Start: 3784377

End: 3785774

Strand: Direct

Name: aroP2 [H]

Synonym: YpsIP31758_3366

Alternate gene names: 153946961

Gene position: 3784377-3785774 (Clockwise)

Preceding gene: 153947320

Following gene: 153950740

Centisome position: 80.12

GC content: 48.35

Gene sequence:

>1398_bases
ATGAGTGATCAACAAGAGGGTGCTGAGCTAAAACGGGGGCTTAAAAACCGCCATATTCAGCTTATTGCCCTAGGTGGTGC
AATTGGTACCGGACTATTCCTCGGCATAGCACAGACCATCAAAATGGCTGGGCCTTCGGTTTTACTGGGGTACGCAATTG
GGGGTTTTATTGCGTTTCTGATAATGCGCCAGCTAGGCGAAATGGTGGTTGAAGAACCTGTAGCCGGTTCCTTTAGCCAC
TTTGCGTATAAATATTGGGGACACTTTGCCGGTTTTGCTTCTGGCTGGAACTACTGGGTGCTGTATGTGTTGGTGGCGAT
GGCCGAACTAACCGCAGTGGGGATCTATGTGCAATATTGGTGGCCAGAAATCCCTACTTGGGTCTCCGCCGCCGTCTTCT
TCTTGGCCATCAACGCCATCAACCTGGCTAACGTAAAAGTCTATGGTGAGATGGAATTTTGGTTTGCCATCATTAAAGTG
ATCGCGATTATTGCGATGATTTTATTTGGCGGTTACCTGCTCATCAGTGGCCGGGGTGGCCCAGAAGCCACGGTAACCAA
CTTATGGGCCCAAGGCGGTTTCTTCCCGAATGGCATCATGGGTCTGGTGATGGCAATGGCGGTAATTATGTTCTCTTTCG
GTGGCCTTGAATTAGTGGGTATCACCGCAGCAGAAGCAGAAAACCCGGCCAAAAGCATTCCGAAGGCAACCAATCAGGTT
ATCTACCGTATTCTTCTGTTTTATATTGGTTCTCTGGCAATCTTGTTATCACTCTACCCATGGGGAAAAGTGGTCGAAGG
CGGCAGCCCATTCGTATTGATTTTCGATGCGCTGGACAGTAATTCAGTCGCCACTGTCTTGAATATTGTCGTACTGACGG
CGGCACTCTCGGTCTACAACAGTTGCGTATACTGTAACAGCCGCATGTTGTTTGGTTTAGCTAAACAAGGTAATGGCCCG
AAAATCCTGTTGAAAGTGGATGGCCGAGGTGTTCCAGTCATTGCGATTGCTGTTTCTGCGTTTGCTACCGCGTTTTGTGT
ACTGATTAACTACCTGTTACCTGGCCGTGCCTTTGAATTACTGATGGCATTAGTGGTATCCGCGTTGGTGATCAACTGGG
CGATGATTAGCCTGGCACACCTGAAATTCCGTGCGGCGAAAAACCGCCAGGGCGTAATACCAAAATTCAAAGCATTTTGG
TATCCGTTCGGTAACTGTTTGTGTTTGTTGTTCCTGACCGGCATCTTAGTGATCATGTTTCTGACACCCAGCATCCGGAT
TTCAGTGATACTTATTCCTGTCTGGGTAGTCGTCCTAGCGATTGGTTATATTCTGAAGAATCAGAGCCAACGTCAGAATC
AGCAACTGAGCGCTAGCAGCAGGAAAGCAACCAAGTAA

Upstream 100 bases:

>100_bases
ATGAATATCGCTAGCGTCTCTGTAACGTCCAATGATGAAGGGTATAGCAAAAAACTAAGATTAAGCCCGCGAGTAGTCAC
AACGACAAAGGATGTAATTG

Downstream 100 bases:

>100_bases
AGAACAACCCATTTCCTTATAAATCAGCTAGTTAACCCTATCTAGGCCAGCACTTAGTGCTGGCCTAGGCTATTGACAAA
GTACCGATGGCGAAGAGAAC

Product: aromatic amino acid transport protein AroP

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKV
IAIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAENPAKSIPKATNQV
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNGP
KILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFW
YPFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK

Sequences:

>Translated_465_residues
MSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKV
IAIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAENPAKSIPKATNQV
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNGP
KILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFW
YPFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK
>Mature_464_residues
SDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSHF
AYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYWWPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVI
AIIAMILFGGYLLISGRGGPEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAENPAKSIPKATNQVI
YRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYNSCVYCNSRMLFGLAKQGNGPK
ILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFELLMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWY
PFGNCLCLLFLTGILVIMFLTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=284, Percent_Identity=25.3521126760563, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258645169, Length=397, Percent_Identity=21.9143576826196, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=76.2749445676275, Blast_Score=696, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=442, Percent_Identity=66.289592760181, Blast_Score=590, Evalue=1e-170,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=45.916114790287, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI48994972, Length=433, Percent_Identity=41.5704387990762, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=38.4782608695652, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI87081915, Length=449, Percent_Identity=36.9710467706013, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=36.405529953917, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87081708, Length=471, Percent_Identity=34.6072186836518, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1788480, Length=444, Percent_Identity=34.9099099099099, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=26.0115606936416, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=35.8574610244989, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6324061, Length=436, Percent_Identity=34.6330275229358, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6322892, Length=398, Percent_Identity=35.427135678392, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=489, Percent_Identity=31.4928425357873, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=32.994923857868, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=33.6343115124154, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319824, Length=404, Percent_Identity=31.9306930693069, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6321053, Length=423, Percent_Identity=32.1513002364066, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320717, Length=408, Percent_Identity=29.9019607843137, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=412, Percent_Identity=30.8252427184466, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=406, Percent_Identity=29.064039408867, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=441, Percent_Identity=28.1179138321995, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=29.1044776119403, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=30.25, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=396, Percent_Identity=29.040404040404, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319542, Length=412, Percent_Identity=29.126213592233, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.2828282828283, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=25.748502994012, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24667468, Length=373, Percent_Identity=24.3967828418231, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24668806, Length=379, Percent_Identity=24.2744063324538, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356285, Length=379, Percent_Identity=24.2744063324538, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24668802, Length=379, Percent_Identity=24.2744063324538, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666159, Length=288, Percent_Identity=23.9583333333333, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221512776, Length=344, Percent_Identity=22.6744186046512, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50581; Mature: 50450

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEE
WPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVIAIIAMILFGGYLLISGRGG
CCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAENPAKSIPKATNQV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCHHHCCHHHHHH
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAKQGNGPKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFEL
HHHEECCHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWYPFGNCLCLLFLTGILVIMF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
LTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK
HCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDQQEGAELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGHFAGFASGWNYWVLYVLVAMAELTAVGIYVQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEEEE
WPEIPTWVSAAVFFLAINAINLANVKVYGEMEFWFAIIKVIAIIAMILFGGYLLISGRGG
CCCCCHHHHHHHHHHHHHHEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PEATVTNLWAQGGFFPNGIMGLVMAMAVIMFSFGGLELVGITAAEAENPAKSIPKATNQV
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCHHHCCHHHHHH
IYRILLFYIGSLAILLSLYPWGKVVEGGSPFVLIFDALDSNSVATVLNIVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAKQGNGPKILLKVDGRGVPVIAIAVSAFATAFCVLINYLLPGRAFEL
HHHEECCHHHEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMALVVSALVINWAMISLAHLKFRAAKNRQGVIPKFKAFWYPFGNCLCLLFLTGILVIMF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHH
LTPSIRISVILIPVWVVVLAIGYILKNQSQRQNQQLSASSRKATK
HCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]