Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 153946856

GI number: 153946856

Start: 177533

End: 179383

Strand: Direct

Name: ilvD [H]

Synonym: YpsIP31758_0157

Alternate gene names: 153946856

Gene position: 177533-179383 (Clockwise)

Preceding gene: 153947582

Following gene: 153949796

Centisome position: 3.76

GC content: 53.11

Gene sequence:

>1851_bases
ATGCCTAAGTACCGTTCCCATACCACCACCCATGGCCGCAATATGGCCGGCGCCCGCGCACTGTGGCGCGCAACCGGTAT
GACCGATGATGACTTCGGCAAACCGATTATTGCAGTCGTTAACTCCTTTACCCAATTTGTACCGGGCCACGTACATTTGC
GCGATTTAGGCAAGCTGGTTGCGGAGCAAATTGTAGCTTCTGGCGGTGTGGCTAAAGAGTTCAACACCATTGCGGTGGAT
GATGGTATCGCGATGGGCCACGGTGGCATGCTCTACTCTCTGCCATCGCGTGAATTGATCGCCGACTCCGTTGAGTACAT
GGTTAACGCCCACTGTGCGGATGCCATGGTGTGTATCTCTAACTGTGACAAAATTACCCCAGGGATGCTGATGGCGTCTC
TGCGCCTGAATATTCCGGTGATCTTTGTATCTGGTGGCCCGATGGAAGCCGGTAAGACCAAGCTGTCAGATAAAATCATC
AAGCTGGATTTGATCGATGCCATGATTCAGGGCGCGAATCCTAATGTGAGCGATGAAGAGAGCGCCCAGATTGAGCGTTC
TGCTTGCCCGACCTGTGGTTCTTGCTCCGGTATGTTTACGGCTAACTCGATGAACTGCCTGAATGAAGCGCTGGGTCTGG
CGTTGCCGGGTAACGGTTCATTGTTGGCAACCCACGCTGACCGTAAGCAACTGTTCTTGGATGCGGGTAAACACATTGTT
GCCTTGACCAAACGTTATTATGAACAAGATGACGTCAGCGCCTTGCCACGCAACATCGCGAATAAAGCGGCCTTTGAAAA
CGCCATGATATTGGATATCGCCATGGGCGGTTCCACGAATACCGTACTGCATTTGTTGGCGGCGGCGCAGGAAGGTGAAA
TTGATTTCAGCATGACCGATATCGATCGCCTGTCCCGTAAAGTCCCACATTTGTGCAAAGTGGCCCCGAGTACTCAGAAA
TACCACATGGAAGATGTGCACCGTGCGGGGGGGGTCATTGGTATTTTAGGTGAGTTGGATCGCGCTGGTTTGCTTAACCG
CGATGTCAGTAACGTGTTGGGGCTGAATCTGACACAAACGCTGGAAGCCTATGACGTGATGCTGACTCAGGATGAAGGCG
TGAAGCAGATGTACGCCGCAGGCCCAGCCGGTATTCGCACCACTAAAGCGTTCTCACAGGATTGCCGTTATCCGTCACTG
GATACCGATCGCGAAGAGGGTTGTATCCGTACCCGTGAACATGCCTACAGCCAGGATGGTGGTTTAGCGGTGTTGTACGG
CAATATTGCGGCAGACGGCTGTATTGTTAAAACTGCGGGTGTTGATAAAGACAGCCTGACGTTCCGTGGCCCGGCGAAAG
TATTTGAGAGCCAGGATGAGGCGGTAGAGGCGATCCTCGGTGGTAAAGTTGTGGCGGGTGATGTGGTTGTTATCCGTTAT
GAAGGGCCAAAAGGGGGGCCGGGTATGCAGGAAATGCTCTATCCGACCACTTATCTGAAATCCATGGGGTTGGGCAAGAG
TTGTGCCTTACTGACCGATGGCCGTTTCTCTGGCGGGACATCCGGTTTGTCTATCGGCCATGTGTCTCCAGAAGCCGCCA
GTGGTGGGTTGATTGGTTTGGTACAAGATGGCGATTTCATCAATATCGATATTCCGAACCGTGGCATTGTCTTGGATGTT
AGCGAAGCTGAACTGGCTGCTCGCCGTGAAACTGAAGAAGCGCATGGTGATGCGGCCTGGTCACCGAAGGGTCGTGAGCG
CCAGGTCTCTTATGCCTTACGCGCTTACGCGATGTTAGCAACCAGCGCTGATAAAGGCGCGGTGCGCGATAAAAGTAAGC
TGGGAGGCTAA

Upstream 100 bases:

>100_bases
GGTTCGTTCGCTACCTGCAATGCATAAAAGACATTTGCAACACGCAATCTATTTGCGACAGACATTGATTTGCAAAATAA
AAACGCGGAGTGAAGAGACA

Downstream 100 bases:

>100_bases
CACCCATGGCAGTTTCGCAACCCTTATCTGCTGCCCCCTGCGGGGCAGAATATCTGCGGGCGATATTACGTGCGCCGGTG
TATGAGGTGGCGCAAGTCAC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPKYRSHTTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIVASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLIDAMIQGANPNVSDEESAQIERSACPTCGSCSGMFTANSMNCLNEALGLALPGNGSLLATHADRKQLFLDAGKHIV
ALTKRYYEQDDVSALPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEIDFSMTDIDRLSRKVPHLCKVAPSTQK
YHMEDVHRAGGVIGILGELDRAGLLNRDVSNVLGLNLTQTLEAYDVMLTQDEGVKQMYAAGPAGIRTTKAFSQDCRYPSL
DTDREEGCIRTREHAYSQDGGLAVLYGNIAADGCIVKTAGVDKDSLTFRGPAKVFESQDEAVEAILGGKVVAGDVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHVSPEAASGGLIGLVQDGDFINIDIPNRGIVLDV
SEAELAARRETEEAHGDAAWSPKGRERQVSYALRAYAMLATSADKGAVRDKSKLGG

Sequences:

>Translated_616_residues
MPKYRSHTTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIVASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKII
KLDLIDAMIQGANPNVSDEESAQIERSACPTCGSCSGMFTANSMNCLNEALGLALPGNGSLLATHADRKQLFLDAGKHIV
ALTKRYYEQDDVSALPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEIDFSMTDIDRLSRKVPHLCKVAPSTQK
YHMEDVHRAGGVIGILGELDRAGLLNRDVSNVLGLNLTQTLEAYDVMLTQDEGVKQMYAAGPAGIRTTKAFSQDCRYPSL
DTDREEGCIRTREHAYSQDGGLAVLYGNIAADGCIVKTAGVDKDSLTFRGPAKVFESQDEAVEAILGGKVVAGDVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHVSPEAASGGLIGLVQDGDFINIDIPNRGIVLDV
SEAELAARRETEEAHGDAAWSPKGRERQVSYALRAYAMLATSADKGAVRDKSKLGG
>Mature_615_residues
PKYRSHTTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIVASGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIK
LDLIDAMIQGANPNVSDEESAQIERSACPTCGSCSGMFTANSMNCLNEALGLALPGNGSLLATHADRKQLFLDAGKHIVA
LTKRYYEQDDVSALPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEIDFSMTDIDRLSRKVPHLCKVAPSTQKY
HMEDVHRAGGVIGILGELDRAGLLNRDVSNVLGLNLTQTLEAYDVMLTQDEGVKQMYAAGPAGIRTTKAFSQDCRYPSLD
TDREEGCIRTREHAYSQDGGLAVLYGNIAADGCIVKTAGVDKDSLTFRGPAKVFESQDEAVEAILGGKVVAGDVVVIRYE
GPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHVSPEAASGGLIGLVQDGDFINIDIPNRGIVLDVS
EAELAARRETEEAHGDAAWSPKGRERQVSYALRAYAMLATSADKGAVRDKSKLGG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=87.5, Blast_Score=1118, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=567, Percent_Identity=30.3350970017637, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786464, Length=527, Percent_Identity=29.2220113851992, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI2367371, Length=536, Percent_Identity=29.1044776119403, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=616, Percent_Identity=37.6623376623377, Blast_Score=345, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65518; Mature: 65387

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSHTTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIVASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLIDAMIQGANPNVSDEE
CCCCCCHHHHHHEEECCCEEEEEECCCCCCCCHHHHCCEEEHHHHHHHHCCCCCCCCCCH
SAQIERSACPTCGSCSGMFTANSMNCLNEALGLALPGNGSLLATHADRKQLFLDAGKHIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCCEEEEECCCHHHHHHCCCHHH
ALTKRYYEQDDVSALPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEIDFSMTD
HHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEHHH
IDRLSRKVPHLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVSNVLGLNLTQT
HHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHCCCHHHH
LEAYDVMLTQDEGVKQMYAAGPAGIRTTKAFSQDCRYPSLDTDREEGCIRTREHAYSQDG
HHHHEEEEECCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCC
GLAVLYGNIAADGCIVKTAGVDKDSLTFRGPAKVFESQDEAVEAILGGKVVAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCCCCEEECCHHHHHCCHHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHVSPEAASGGLIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VQDGDFINIDIPNRGIVLDVSEAELAARRETEEAHGDAAWSPKGRERQVSYALRAYAMLA
EECCCEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSHTTTHGRNMAGARALWRATGMTDDDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIVASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLIDAMIQGANPNVSDEE
CCCCCCHHHHHHEEECCCEEEEEECCCCCCCCHHHHCCEEEHHHHHHHHCCCCCCCCCCH
SAQIERSACPTCGSCSGMFTANSMNCLNEALGLALPGNGSLLATHADRKQLFLDAGKHIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCCEEEEECCCHHHHHHCCCHHH
ALTKRYYEQDDVSALPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEIDFSMTD
HHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEHHH
IDRLSRKVPHLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVSNVLGLNLTQT
HHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHCCCHHHH
LEAYDVMLTQDEGVKQMYAAGPAGIRTTKAFSQDCRYPSLDTDREEGCIRTREHAYSQDG
HHHHEEEEECCCCHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCC
GLAVLYGNIAADGCIVKTAGVDKDSLTFRGPAKVFESQDEAVEAILGGKVVAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCCCCEEECCHHHHHCCHHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKSCALLTDGRFSGGTSGLSIGHVSPEAASGGLIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VQDGDFINIDIPNRGIVLDVSEAELAARRETEEAHGDAAWSPKGRERQVSYALRAYAMLA
EECCCEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA