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The map label for this gene is pepB

Identifier: 153946835

GI number: 153946835

Start: 1378441

End: 1379739

Strand: Direct

Name: pepB

Synonym: YpsIP31758_1175

Alternate gene names: 153946835

Gene position: 1378441-1379739 (Clockwise)

Preceding gene: 153949156

Following gene: 153950372

Centisome position: 29.18

GC content: 53.89

Gene sequence:

>1299_bases
ATGACAACAGAAATAATGCAAATATCCCTGTCTCACAACCCGGCAGATGCCCGCTGGGGTGAGAAAGCCCTGATCAGCAC
TAATGATCAAGGGGTGACTATCCACTTGACGAGTCACGATCAACTGGGGGGGATCCAACGTGCAGCCCGCAAAATTGACG
GTCAGGGCATTAAACAAGTCAAACTGGCTGGTGAAGGCTGGGGCCTGGAACAAAGCTGGGCCTTTTGGCAAGGCTTCCGT
GGGCCAAAAGGTCAGCGCAGCGTGGTGTGGGCAGAGCTGCCAGCGAATGAAAAAACAGAGCTGGAACAGCGTTTACAAAT
CATCGATTGGGTACGCGATACCATCAACGCACCTGCGGAAGATTTAGGGCCAGAACAACTGGCGAAAAATGCGATTGATT
TGCTGTGCGCGGTCTCCTGTGATGCGGTCAGCTACCGTATTACCAAAGGCGAAGATCTCCGTGAACAGAATTATGCCGGG
ATTTACACCGTGGGCCGTGGTTCTGATCGTGCGCCGGTATTGTTGGCGTTGGACTACAACCCAACCGGCAACCCAGATGC
GCCAGTCATGGCCTGTCTGGTGGGGAAAGGCATTACCTTTGATTCCGGCGGCTATAGCTTAAAGCAGAGCGCCTTTATGG
ATTCGATGAAGTCCGATATGGGCGGGGCAGCAACCTTGACCGGTGCATTGGCGCTGGCAGCCGCACGTGGGCTGAAAGAG
CGCGTGAAGTTGTATCTGTGTTGTGCCGATAACATGGTCAGTGGCAATGCCTTTAAGCTGGGCGATATTATTCGCTATCG
TAATGGCAAAACGGTCGAAATCATGAATACCGATGCTGAAGGGCGCTTGGTCTTGGCGGATGGTCTGATCGATGCCTCCG
AGCAAAATGCGCCGTTGATTATCGACGCAGCCACCTTAACCGGCGCGGCCAAAACTGCCTTGGGTAACGATTACCATGCC
CTGTTCAGCTTTGATGATGAACTGGCACAAGCGCTACTCACCAGTGCGCACAGTGAGCACGAGCTTTTCTGGCGTCTGCC
ACTGGCCGAATTCCACCGCAGCCAGTTGCCATCTAACTTTGCTGAGTTAAATAACGTGGCCGGTGGGGCCTACAGCGCAG
GGGCCAGCACCGCCGCCGCTTTCCTGTCGCATTTTGTGAAAAATTATCAGCAGGGCTGGTTACACATTGATTGCTCGGCG
ACATATCGCAAAAGCGCCGTTGATCAATGGTCTGCCGGAGCGACCGGCTTGGGTGTCCGCACCGTTGCCAACTTATTGTT
AGCGCAAGCAAAACAGTAA

Upstream 100 bases:

>100_bases
ATCTGATATTTTATGCCCAAATTATTGACGTCGCCGCTCACGCCCCTGTGGCTTGAAGCATGACGGGTATACAGCAAAAA
TAATAATGACGAGGTAGGCC

Downstream 100 bases:

>100_bases
TCTTATTGAATTGAGAAGACTCAAAGGGGCGCATTTGGCGTCCCTTCGTGCATCTTCTCGACGTTTTGGGAGTAAAAAAT
GAGTTTTCCGCCCCCATCTG

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQVKLAGEGWGLEQSWAFWQGFR
GPKGQRSVVWAELPANEKTELEQRLQIIDWVRDTINAPAEDLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAG
IYTVGRGSDRAPVLLALDYNPTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLIIDAATLTGAAKTALGNDYHA
LFSFDDELAQALLTSAHSEHELFWRLPLAEFHRSQLPSNFAELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSA
TYRKSAVDQWSAGATGLGVRTVANLLLAQAKQ

Sequences:

>Translated_432_residues
MTTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQVKLAGEGWGLEQSWAFWQGFR
GPKGQRSVVWAELPANEKTELEQRLQIIDWVRDTINAPAEDLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAG
IYTVGRGSDRAPVLLALDYNPTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLIIDAATLTGAAKTALGNDYHA
LFSFDDELAQALLTSAHSEHELFWRLPLAEFHRSQLPSNFAELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSA
TYRKSAVDQWSAGATGLGVRTVANLLLAQAKQ
>Mature_431_residues
TTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQVKLAGEGWGLEQSWAFWQGFRG
PKGQRSVVWAELPANEKTELEQRLQIIDWVRDTINAPAEDLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAGI
YTVGRGSDRAPVLLALDYNPTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKER
VKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLIIDAATLTGAAKTALGNDYHAL
FSFDDELAQALLTSAHSEHELFWRLPLAEFHRSQLPSNFAELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSAT
YRKSAVDQWSAGATGLGVRTVANLLLAQAKQ

Specific function: Probably plays an important role in intracellular peptide degradation

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=318, Percent_Identity=38.6792452830189, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI47155554, Length=276, Percent_Identity=36.5942028985507, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI87082123, Length=426, Percent_Identity=75.8215962441315, Blast_Score=676, Evalue=0.0,
Organism=Escherichia coli, GI1790710, Length=319, Percent_Identity=37.3040752351097, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=299, Percent_Identity=33.7792642140468, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=121, Percent_Identity=38.0165289256198, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221379063, Length=341, Percent_Identity=32.8445747800587, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI221379062, Length=341, Percent_Identity=32.8445747800587, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI21357381, Length=341, Percent_Identity=32.8445747800587, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21355725, Length=362, Percent_Identity=27.9005524861878, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24661038, Length=386, Percent_Identity=27.2020725388601, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24662227, Length=325, Percent_Identity=29.2307692307692, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI20129969, Length=292, Percent_Identity=30.4794520547945, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077148, Length=325, Percent_Identity=29.5384615384615, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI20130057, Length=325, Percent_Identity=29.5384615384615, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355645, Length=322, Percent_Identity=27.9503105590062, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24662223, Length=322, Percent_Identity=27.9503105590062, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922386, Length=291, Percent_Identity=28.8659793814433, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20129963, Length=288, Percent_Identity=30.2083333333333, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646701, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646703, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358201, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPB_YERP3 (A7FFX8)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400156.1
- ProteinModelPortal:   A7FFX8
- SMR:   A7FFX8
- STRING:   A7FFX8
- GeneID:   5386417
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1175
- NMPDR:   fig|349747.3.peg.1371
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   MLQLDYN
- ProtClustDB:   PRK05015
- BioCyc:   YPSE349747:YPSIP31758_1175-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00504
- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819
- PANTHER:   PTHR11963:SF3
- PIRSF:   PIRSF036388
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17

EC number: =3.4.11.23

Molecular weight: Translated: 46518; Mature: 46387

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 208-208 ACT_SITE 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQV
CCCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEE
KLAGEGWGLEQSWAFWQGFRGPKGQRSVVWAELPANEKTELEQRLQIIDWVRDTINAPAE
EEECCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
DLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAGIYTVGRGSDRAPVLLALDYN
HCCHHHHHHHHHHHHHHEECCCEEEEECCCCCHHHCCCCEEEEECCCCCCCCEEEEEECC
PTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
CCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHH
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLI
HEEEEEEECCCCCCCCCEEHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEE
IDAATLTGAAKTALGNDYHALFSFDDELAQALLTSAHSEHELFWRLPLAEFHRSQLPSNF
EEEHHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCHHH
AELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSATYRKSAVDQWSAGATGLGVR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCCHHH
TVANLLLAQAKQ
HHHHHHHHHCCC
>Mature Secondary Structure 
TTEIMQISLSHNPADARWGEKALISTNDQGVTIHLTSHDQLGGIQRAARKIDGQGIKQV
CCEEEEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEE
KLAGEGWGLEQSWAFWQGFRGPKGQRSVVWAELPANEKTELEQRLQIIDWVRDTINAPAE
EEECCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
DLGPEQLAKNAIDLLCAVSCDAVSYRITKGEDLREQNYAGIYTVGRGSDRAPVLLALDYN
HCCHHHHHHHHHHHHHHEECCCEEEEECCCCCHHHCCCCEEEEECCCCCCCCEEEEEECC
PTGNPDAPVMACLVGKGITFDSGGYSLKQSAFMDSMKSDMGGAATLTGALALAAARGLKE
CCCCCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHH
RVKLYLCCADNMVSGNAFKLGDIIRYRNGKTVEIMNTDAEGRLVLADGLIDASEQNAPLI
HEEEEEEECCCCCCCCCEEHHHHEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEE
IDAATLTGAAKTALGNDYHALFSFDDELAQALLTSAHSEHELFWRLPLAEFHRSQLPSNF
EEEHHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCHHH
AELNNVAGGAYSAGASTAAAFLSHFVKNYQQGWLHIDCSATYRKSAVDQWSAGATGLGVR
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHCCCCCCCCHHH
TVANLLLAQAKQ
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA