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The map label for this gene is tatD [H]

Identifier: 153946831

GI number: 153946831

Start: 309578

End: 310360

Strand: Direct

Name: tatD [H]

Synonym: YpsIP31758_0277

Alternate gene names: 153946831

Gene position: 309578-310360 (Clockwise)

Preceding gene: 153948556

Following gene: 153947396

Centisome position: 6.55

GC content: 48.79

Gene sequence:

>783_bases
ATGTTTGATATTGGTGTTAATTTAACCAGCGTACAGTTTGCAAAAGATTATCATCAGGTAGTCAACCGGGCAAAAGAGGC
TGGGGTTCTCGGTATCCTGATTACCGGTACTGATGCAGATGAAAGCTTGGCAGCACAGATTTTGGCCGCTGAATACCCTG
GCTATTGTTGGTCGACTACAGGCGTTCATCCTCACCATGCGAGCAGTTGGCAAGATAGTGTCGAGCAGAAAATTCGAACC
TTGGCAGCCACTGCCCCCGTCGTCGCTATTGGTGAGTGCGGGTTAGACTTTAACCGTAACTTTTCCACCCCAGCGCAACA
AGAAGCCGCATTTACCGCTCAATTAGCTCTGGCTGCCGAACTTTCGCTGCCGGTATTTTTGCATTGTCGTGATGCCCATG
AGCGTTTTATTGATTTGCTGGTTCCTTGGCTAGATAAAATACCGGCGGCTGTTGTGCATTGTTTCACGGGTAACAGTGAT
GAGTTAGATGCCTGTTTAGCATTGGGTTTATCTATAGGTATCACGGGTTGGGTTTGCGATGAGCGTCGTGGCCTTGATCT
TAGAGCTTTGCTCCCGCGTATTCCTGTTCAGCAGCTATTGTTGGAAACTGATGCTCCCTATTTATTGCCAAGGGATTTGA
ATCCTAAACCTGCATCACGTCGCAATGAACCCTGTTTTCTGCCCCATATCGTCCAGCAGGTTGCAGCCTGGCGACAAGAA
GACCCTAATTGGCTAGGACAGAAAACTGATGAAAACGCCCGCCGGGTTTTCCGGCTGGTTTGA

Upstream 100 bases:

>100_bases
ACTGAAGAAGATGAAGGTATAGATAGCCATCCGAAAGCACCTTAAATCGATGCGTTGATATTTAGCCGCCCTTCTGGGCG
GCTTCTGTTTTGGAACACTT

Downstream 100 bases:

>100_bases
GTTAGGAGAACAATATGAGCTATGCATTTCCGGGCACCTTTCCTGGTCGCCGTATGCGCCGTGTACGCTGTCATGATTTC
AGCCGCCGTTTGGTTGCCGA

Product: DNase TatD

Products: NA

Alternate protein names: DNase tatD [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MFDIGVNLTSVQFAKDYHQVVNRAKEAGVLGILITGTDADESLAAQILAAEYPGYCWSTTGVHPHHASSWQDSVEQKIRT
LAATAPVVAIGECGLDFNRNFSTPAQQEAAFTAQLALAAELSLPVFLHCRDAHERFIDLLVPWLDKIPAAVVHCFTGNSD
ELDACLALGLSIGITGWVCDERRGLDLRALLPRIPVQQLLLETDAPYLLPRDLNPKPASRRNEPCFLPHIVQQVAAWRQE
DPNWLGQKTDENARRVFRLV

Sequences:

>Translated_260_residues
MFDIGVNLTSVQFAKDYHQVVNRAKEAGVLGILITGTDADESLAAQILAAEYPGYCWSTTGVHPHHASSWQDSVEQKIRT
LAATAPVVAIGECGLDFNRNFSTPAQQEAAFTAQLALAAELSLPVFLHCRDAHERFIDLLVPWLDKIPAAVVHCFTGNSD
ELDACLALGLSIGITGWVCDERRGLDLRALLPRIPVQQLLLETDAPYLLPRDLNPKPASRRNEPCFLPHIVQQVAAWRQE
DPNWLGQKTDENARRVFRLV
>Mature_260_residues
MFDIGVNLTSVQFAKDYHQVVNRAKEAGVLGILITGTDADESLAAQILAAEYPGYCWSTTGVHPHHASSWQDSVEQKIRT
LAATAPVVAIGECGLDFNRNFSTPAQQEAAFTAQLALAAELSLPVFLHCRDAHERFIDLLVPWLDKIPAAVVHCFTGNSD
ELDACLALGLSIGITGWVCDERRGLDLRALLPRIPVQQLLLETDAPYLLPRDLNPKPASRRNEPCFLPHIVQQVAAWRQE
DPNWLGQKTDENARRVFRLV

Specific function: Shows DNase activity [H]

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI14042943, Length=292, Percent_Identity=33.2191780821918, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI225903439, Length=250, Percent_Identity=32.4, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI225903424, Length=206, Percent_Identity=30.5825242718447, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI110349730, Length=269, Percent_Identity=24.907063197026, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI226061853, Length=273, Percent_Identity=24.9084249084249, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI110349734, Length=269, Percent_Identity=25.2788104089219, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI226061595, Length=226, Percent_Identity=26.1061946902655, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI48994985, Length=257, Percent_Identity=66.5369649805447, Blast_Score=355, Evalue=1e-99,
Organism=Escherichia coli, GI1787342, Length=245, Percent_Identity=29.7959183673469, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082439, Length=249, Percent_Identity=29.3172690763052, Blast_Score=87, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17559024, Length=281, Percent_Identity=38.0782918149466, Blast_Score=204, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71980746, Length=269, Percent_Identity=24.5353159851301, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565396, Length=171, Percent_Identity=32.7485380116959, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17543026, Length=222, Percent_Identity=28.3783783783784, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648690, Length=288, Percent_Identity=32.2916666666667, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI221330018, Length=302, Percent_Identity=29.1390728476821, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24586117, Length=278, Percent_Identity=29.136690647482, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 28754; Mature: 28754

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS01090 TATD_2 ; PS01091 TATD_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDIGVNLTSVQFAKDYHQVVNRAKEAGVLGILITGTDADESLAAQILAAEYPGYCWSTT
CEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEECC
GVHPHHASSWQDSVEQKIRTLAATAPVVAIGECGLDFNRNFSTPAQQEAAFTAQLALAAE
CCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSLPVFLHCRDAHERFIDLLVPWLDKIPAAVVHCFTGNSDELDACLALGLSIGITGWVCD
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCEEEEEC
ERRGLDLRALLPRIPVQQLLLETDAPYLLPRDLNPKPASRRNEPCFLPHIVQQVAAWRQE
CCCCCHHHHHHCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
DPNWLGQKTDENARRVFRLV
CCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MFDIGVNLTSVQFAKDYHQVVNRAKEAGVLGILITGTDADESLAAQILAAEYPGYCWSTT
CEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEECC
GVHPHHASSWQDSVEQKIRTLAATAPVVAIGECGLDFNRNFSTPAQQEAAFTAQLALAAE
CCCCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LSLPVFLHCRDAHERFIDLLVPWLDKIPAAVVHCFTGNSDELDACLALGLSIGITGWVCD
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHCCEEEEEC
ERRGLDLRALLPRIPVQQLLLETDAPYLLPRDLNPKPASRRNEPCFLPHIVQQVAAWRQE
CCCCCHHHHHHCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
DPNWLGQKTDENARRVFRLV
CCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Mg [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584020; 9649434; 1379743; 9278503; 10747959 [H]