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The map label for this gene is mutS2 [H]

Identifier: 153937741

GI number: 153937741

Start: 703879

End: 705774

Strand: Direct

Name: mutS2 [H]

Synonym: CLC_0685

Alternate gene names: 153937741

Gene position: 703879-705774 (Clockwise)

Preceding gene: 153935730

Following gene: 153936885

Centisome position: 18.72

GC content: 27.95

Gene sequence:

>1896_bases
ATGAATAAAGAAACATTAGAAAAATTACATTATTATGAATTAAAAGAAATGATAAAAGAATATTGCGTCAGCGGCTTAGG
AAAAAGATTAATAGACAAATTAGAACCTAGTAGTAATATAAAGATTGTAAATCAAAGACTAGATGAAACATCTGAGGGAA
GAAGGTTATTAGATGTTTCTTATAATATACCATTAGAGGGTATTTTTAATGTATTACCCCTTATTGAAAAAGTTGAAAAA
GGAGCATCTTTAGAACCGACTGATTTGACTATGATGTCAAATTTTTTAAGAGGATGTAGGAAAGTCAAGTTATTCATAAA
AGACAAAGAGGGATATGCACCTACATTGAGTGCTTATGGAGAGAATATTTGTGACCTGAGCTATATTGAAGAGGAAATAA
ATAGATCAATTAGAGGTAGTGTAGTTGACTCAAATGCTAGTAAGGAACTTAAAAAAATAAGAAGAAATATTGACATATGT
GAAAGTAGAATAAAGGAAAAATTAGATAAGTTCCTTAGAAATAGTGCAAATAAAGAGTATATTCAAGAATTCTTTGTTAG
TCAGCGAGATGGAAAACATACCATTGCAATTAAGGTAGCACATAAAAATAAAGTTCAAGGAACTATCGTTGAAACGTCTT
CAAAGGGAACAACAGTGTTTATGGAGCCAAATGTTATTTCAAAGCATACAAGTGAATTAGCAGTATTAAAAGCAGAAGAA
AGTGTGGAAGAATACAAAATCCTAGCCACTTTAACAGAGATGCTTTTTGAAAGAATAAAAGATTTGAAAATGAATGTTGA
TGTTATATCTGAATATGATATGATCTGGGCAAAAGCTAAATATAGTAAAGTAATAAATGGAATTAAACCTAAACTAAATG
ACTATGGATATATAAAAATAATTAAAGGGAAATATCCTCTTATTAAAGATAGTATACCTTTAGACTTTGAAATTGGAAAA
GATTATAGAGGATTAATAATAACAGGACCAAATGCAGGTGGTAAAACAGTAGTATTAAAGACAATTGGATTGTTAACATT
AGCAATACAATCTGGATTCCATATAGAAGCTGAGGAAGGAACAGAATTTTCAGTATTTAAAAAGTTATTTGTTGATATTG
GAGATAATCAAAGTGTTGAAAATGCATTAAGTACATTTTCATCTCATGTAAAAAATCTAGCTGAAATAATTAGAGAAAGT
ACAAAATCAACATTACTATTGTTTGATGAAATCGGTAGTGGAACAGAACCAAATGAGGGATCCGCTTTGGCTATTGCAAT
ATTAGAAGAATTGTATCATAAGGGCTCTATAACTATATCAACTACTCATTATGGAGAAATAAAAAACTTTTCAAAAGAAC
ATCCTGATTTTGAGAATGCAGCTATGGAGTTTGAGAAAGAAACTTTAGAACCATTATATAAACTTAGCATAGGAAAAGTT
GGAGATAGTAATGCTTTATATATTTCTAAAAAGATGGGATTATATGATTCAATTATTGATAGGGCAAGAAAATATATGGA
TACTAAAAGTTATAATTATAATTTAATAGAAGACAGCAAGATTATAAAAAATAAAGAGTTACAAGCAGAGGAAGATTTTT
ATGAATACTCTGTAGGGGATAAAGTTACTCTTTTAGAAAATAATGAATCAGCTATTGTATATAAAGAAAGAGATAGATTA
AATAATGTGACTATACTATACAATAAAGAATTTATTGACGTTAACTATAAAAGAATAAAACTAGAATTAAAGGCAAGTGA
ACTTTATCCAGAGGGGTATGATTTAAATCAGTTATTTATAAGTTATAAGGAAAGAAAGTTAGAAAAAGATATTAAGAGGG
GATCTAAAAAAGCATTAAAAAGAATAAAAAAAGAAACTTTAAAACGTTCTAAATAA

Upstream 100 bases:

>100_bases
GTGGAAGTATCCATAGCTTTTTTTATTATATAAAAATAGAAATCTATCAAGATTTCGTAGACTTGTATTATAATAAAAAA
TACAAGGAGAGATCATTGAG

Downstream 100 bases:

>100_bases
TATTTATTAAACCTGTAGGTAATTTAATTAAAGATATAAAAAGTGTTAGAAAAAATTTATCTAAAGCAAAAATATTAAAT
GAATCAAGCAATAATTTTAA

Product: MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MNKETLEKLHYYELKEMIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNVLPLIEKVEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSANKEYIQEFFVSQRDGKHTIAIKVAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTVVLKTIGLLTLAIQSGFHIEAEEGTEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVTLLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK

Sequences:

>Translated_631_residues
MNKETLEKLHYYELKEMIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNVLPLIEKVEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSANKEYIQEFFVSQRDGKHTIAIKVAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTVVLKTIGLLTLAIQSGFHIEAEEGTEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVTLLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK
>Mature_631_residues
MNKETLEKLHYYELKEMIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNVLPLIEKVEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSANKEYIQEFFVSQRDGKHTIAIKVAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTVVLKTIGLLTLAIQSGFHIEAEEGTEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVTLLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=319, Percent_Identity=28.2131661442006, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI36949366, Length=266, Percent_Identity=28.9473684210526, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI26638666, Length=324, Percent_Identity=26.8518518518519, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI4505253, Length=324, Percent_Identity=26.8518518518519, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI26638664, Length=325, Percent_Identity=26.7692307692308, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI4557761, Length=293, Percent_Identity=26.6211604095563, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4504191, Length=276, Percent_Identity=25.3623188405797, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI262231786, Length=245, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1789089, Length=264, Percent_Identity=26.1363636363636, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17534743, Length=307, Percent_Identity=25.4071661237785, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=336, Percent_Identity=25.5952380952381, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17508447, Length=220, Percent_Identity=28.6363636363636, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=254, Percent_Identity=25.1968503937008, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=551, Percent_Identity=23.956442831216, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319935, Length=382, Percent_Identity=26.9633507853403, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=325, Percent_Identity=25.2307692307692, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=248, Percent_Identity=23.3870967741935, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=241, Percent_Identity=27.3858921161826, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664545, Length=299, Percent_Identity=27.0903010033445, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24584320, Length=204, Percent_Identity=25.9803921568627, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF05192 MutS_III; PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 72194; Mature: 72194

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKETLEKLHYYELKEMIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCEEEEEE
YNIPLEGIFNVLPLIEKVEKGASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYG
ECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCC
ENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDICESRIKEKLDKFLRNSANKEY
CCCCHHHHHHHHHCHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IQEFFVSQRDGKHTIAIKVAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
HHHHHHCCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEECCCHHHHCCCHHEEEECHH
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
IKGKYPLIKDSIPLDFEIGKDYRGLIITGPNAGGKTVVLKTIGLLTLAIQSGFHIEAEEG
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEEECCCC
TEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRESTKSTLLLFDEIGSGTEPNEG
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
CCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHCCCCC
KVTLLENNESAIVYKERDRLNNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFI
EEEEEECCCCEEEEECCCCCCCEEEEEECEEEECCEEEEEEEEEHHHCCCCCCCHHHHHH
SYKERKLEKDIKRGSKKALKRIKKETLKRSK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKETLEKLHYYELKEMIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCEEEEEE
YNIPLEGIFNVLPLIEKVEKGASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYG
ECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCC
ENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDICESRIKEKLDKFLRNSANKEY
CCCCHHHHHHHHHCHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IQEFFVSQRDGKHTIAIKVAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
HHHHHHCCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEECCCHHHHCCCHHEEEECHH
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
IKGKYPLIKDSIPLDFEIGKDYRGLIITGPNAGGKTVVLKTIGLLTLAIQSGFHIEAEEG
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEEECCCC
TEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRESTKSTLLLFDEIGSGTEPNEG
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
CCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHCCCCC
KVTLLENNESAIVYKERDRLNNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFI
EEEEEECCCCEEEEECCCCCCCEEEEEECEEEECCEEEEEEEEEHHHCCCCCCCHHHHHH
SYKERKLEKDIKRGSKKALKRIKKETLKRSK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA