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The map label for this gene is folP [H]

Identifier: 153937537

GI number: 153937537

Start: 909075

End: 910271

Strand: Direct

Name: folP [H]

Synonym: CLC_0883

Alternate gene names: 153937537

Gene position: 909075-910271 (Clockwise)

Preceding gene: 153934509

Following gene: 153935059

Centisome position: 24.17

GC content: 29.99

Gene sequence:

>1197_bases
GTGTTTAAAATAATTATAGAATTAAATAAAAATAGTTTCCCAGAAGAGTTCAATAAGATAGAAGTACATGAGGGTAGTAT
GAATATATTTATGAATAAAAATAATATTACCCCTTTAAAAATTTTTAATGTGCTAGCTCCTGCAGCCAATATAATAAAGC
AAGAAATACTGGCTTTAGGTGGAGATTGTGCTGTAAATAAATATTGTATAAATTGCAAAGTGGAAACTTCAGATATAATT
TTATTAGGAACCAAAAGACAGTACAAAAAATTATTGCAAAAGCTTAAATGCATGACTTTTTTTAGAATAGAAGAAATAGT
AGGGGAATTAGAAAACTATATTAAAAATAATGGAGCTGTTAAAACAGTTCTAAAGGATGAAAGAGAAATAAACTATGAAA
ATTTAAAGGTTATGGGAATTATAAATTGTACTCCAGATTCTTTTTATGAGGGTTCTAGAAAAGATTCTACAGAAGAAGCC
TTAAAAACTGCAGAAAAGATGTTAAAAGAAGGTGCAGAAATTTTAGATATAGGCGGAGAATCCACAAGACCAGGTTCTGA
CCCAGTAGATGAAGAGGAAGAAATAAAAAGAGTAGTTCCTGTTATAAGAGAGATAAAGAATAAATTTAAGGATGTCATAA
TTTCCATAGATACTTATAGAGCAAATACGGCAAAGTCTGCCATAGAGGCAGGTGCAGACATAGTAAATGATATAAGTGCT
ATGAAGTATGATGAAAATATGGTGAAAGTAGTTAAAGAATACAATGTACCTGTAATACTTATGCATGTAAAAGGAAAACC
AAAGGATATGCAAATAGATCCAGTTTATGAGAATTTAATGAAAGAAATTCATCTTTATTTTAATGAGAGAATAGAGTACT
GCAAATCTCATGGTATAACAGAGGATAAAATAATATTAGATCCAGGCATAGGTTTTGGAAAAACTGTAGAGCATAATCTA
AAAATAATGAATAGAATAGAAGAATTAAAAAGCTTTAATCTTCCAGTACTTTTAGCAGCCTCAAGAAAAGCTACCATAGG
AAAAGTTTTAGGAAACTTACCTACAGAAGAAAGATTAGAAGGAACCATAGCTTTATCCTGTTTAGCGGTAGATGTAGGAA
TTCAGATGGTGAGGGTACACGATGTAAAAGAAAATATAAGAGCCATAAGAATGTTAGAGGCAGTAAGAAAAATATAA

Upstream 100 bases:

>100_bases
GGATAATAATAAAGAATTTATGAGAAATAATTAAAGTAAATTTCAGTTTGAGATAGTTCAATGTTTATATAACTTAACAG
AATGGTTATAAAGAAAAGGG

Downstream 100 bases:

>100_bases
TTATATTATAAAAAATATAATCAAAATTAAATTATAATTTAAATTGTATCTTCTGATTTTTAGGGCTGTAAGATAAATTT
ATATAATAAAAGAAAAAATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MFKIIIELNKNSFPEEFNKIEVHEGSMNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDII
LLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEA
LKTAEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISA
MKYDENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNL
KIMNRIEELKSFNLPVLLAASRKATIGKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI

Sequences:

>Translated_398_residues
MFKIIIELNKNSFPEEFNKIEVHEGSMNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDII
LLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEA
LKTAEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISA
MKYDENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNL
KIMNRIEELKSFNLPVLLAASRKATIGKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI
>Mature_398_residues
MFKIIIELNKNSFPEEFNKIEVHEGSMNIFMNKNNITPLKIFNVLAPAANIIKQEILALGGDCAVNKYCINCKVETSDII
LLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYIKNNGAVKTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEA
LKTAEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISA
MKYDENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNL
KIMNRIEELKSFNLPVLLAASRKATIGKVLGNLPTEERLEGTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=265, Percent_Identity=42.6415094339623, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=33.8607594936709, Blast_Score=156, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 45095; Mature: 45095

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKIIIELNKNSFPEEFNKIEVHEGSMNIFMNKNNITPLKIFNVLAPAANIIKQEILALG
CEEEEEEECCCCCCCHHCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
GDCAVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYIKNNGAV
CCCEECEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
KTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEALKTAEKMLKEGAEILDIGGE
EEEHHHCHHCCCCCEEEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
STRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHH
MKYDENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGIT
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC
EDKIILDPGIGFGKTVEHNLKIMNRIEELKSFNLPVLLAASRKATIGKVLGNLPTEERLE
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHC
GTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI
HHHHHHHEEHHHCEEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFKIIIELNKNSFPEEFNKIEVHEGSMNIFMNKNNITPLKIFNVLAPAANIIKQEILALG
CEEEEEEECCCCCCCHHCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
GDCAVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYIKNNGAV
CCCEECEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
KTVLKDEREINYENLKVMGIINCTPDSFYEGSRKDSTEEALKTAEKMLKEGAEILDIGGE
EEEHHHCHHCCCCCEEEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
STRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKSAIEAGADIVNDISA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHH
MKYDENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGIT
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCC
EDKIILDPGIGFGKTVEHNLKIMNRIEELKSFNLPVLLAASRKATIGKVLGNLPTEERLE
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHC
GTIALSCLAVDVGIQMVRVHDVKENIRAIRMLEAVRKI
HHHHHHHEEHHHCEEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]