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The map label for this gene is adhE [H]

Identifier: 153937530

GI number: 153937530

Start: 392520

End: 395108

Strand: Direct

Name: adhE [H]

Synonym: CLC_0403

Alternate gene names: 153937530

Gene position: 392520-395108 (Clockwise)

Preceding gene: 153936720

Following gene: 153935222

Centisome position: 10.44

GC content: 32.6

Gene sequence:

>2589_bases
ATGAAAATTACCACTACTGAGGAACTAATAAGAAAAATTGAAAAAATCAAAGAGGCACAAAAGATTTATTCCACATATTC
TCAAGATAAGGTAGACAAAATATTTAAAGCAGCAGCTATAGCAGCTAACAAAGAAAGAATAAAACTTGCAAAAATGGCAG
TAGAAGAAACTGGCATGGGTATTGTAGAAGATAAAGTTATAAAAAATCATTTTGCATCTGAATATATTTATAACAAATAT
AAAGATGAAAAAACCTGTGGTGTAATAGAAAAGGATGAAGCCTTTGGGTTAACAAAAATTGCAGAACCAATAGGTGTTAT
TGCGGCAATAGTTCCAACAACTAATCCAACCTCAACAGCTATTTTTAAAGCTTTAATAGCTTTAAAAACTAGAAATGGTA
TAATTTTTTCACCTCATCCAAGAGCTAAGAAATCTACAATAATGGCAGCTAAGATTGTTTTAGATGCAGCAGTACAAGCA
GGGGCACCAAAAGAAATAATAGGTTGGATAGATGAACCTACCTTAGAATTGTCTAATGCAGTAATGAGTAATTCAAATCT
AGTTCTTGCAACAGGTGGACCAGGTATGGTTAAAGCGGCATACTCTTCAGGAAAGCCAGCTATAGGAGTAGGACCTGGAA
ATGTACCAGCTATAATACACGAAACAGCAGATATTAAAATGGCTGTAAGCTCAGTGGTACTTTCTAAAACTTTTGATAAT
GGTATGATTTGTGCATCAGAACAATCAGTAATTGTGATGAATAGCATATATGAAGAAGTAAAAAAAGAATTTGTAATTAG
AGGAGCTTATGTATTAAATAAAGAAGAGATAGAAAAAGTTAAGAAAATAATTTTAGTTAATGGAAATGTAAATGCTAAAA
TTGTTGGTCAAACACCACAAAAGATAGGTGAAATGGCAGGAATACAAGTTCCAGATTGGGCTAAACTTTTAGTTGGAGAA
GTTCAATCTGTAGAATTAGAAGAACCATTCTCTCACGAAAAACTATCACCAGTTTTAGCAATGTATAAAGTTAAAACTTA
TGAAGAGGCTTTAACTAAAGCTGAAAGATTAGTAGAATTAGGAGGATTTGGACATACATCTTCATTGTATATAAACACAG
TAAAATGCAAAGAAGAAGTAGAAAAGTTCTCAAATAATATGAAAACAGGAAGAACAATTATAAATATGCCATCAGCCCAA
GGTGGTATAGGTGATATATATAACTTTAAATTGGCACCATCTCTAACTCTTGGTTGCGGATCCTGGGGTGGAAACTCAGT
ATCAGAGAATGTAGGACCAAAACACTTATTAAATATCAAAAATGTAGCTGAGAGGAGAGAGAATATGCTTTGGTTTAGAG
TACCAGAAAAAGTTTACTTTAAATATGGATGTCTTCCAATAGCTTTAAAAGAATTAAAAAGAATGAATAAGAAAAAGGCA
TTTATAGTTACAGATAAAGTATTATATGAATTAGGAGTTGCTAAAAAAGCAACAGATGTGTTAGATGAGATAGGAATAAA
TTATAAGGTATTCTTTGATGTAGCGCCAGATCCAACTTTAGAAACAGCAAAAAAAGGTGCAAAAGAAATGGTAGATTTTA
ATCCTGATACAATAATAGCTATAGGCGGAGGATCTGCTATGGATGCTGCTAAAATAATGTGGGTAATGTATGAACATCCA
GAAGTAGAATTCGAAGATTTAGCTATGAGATTTATGGATATAAGAAAAAGAGTATATGAGTTCCCACATATGGGAGATAA
AGCAATGATGATATCAGTAGCTACTTCAGCAGGTACTGGTTCAGAAGTAACTCCTTTTGCTGTTATAACTGATGAAAAAA
CAGGTGTGAAATATCCACTAGCAGATTATGAATTAACTCCAGATATGGCTATAGTAGATGCAGATTTAATGCTTAATATG
CCAAAGGGATTAACTGCTGCATCAGGAATTGATGCATTAACTCATGCGGTAGAAGCTTATGTATCAGTTATGGCATCAGA
GTATACAGATGGACTATGTTTAGAGGCTATAAAAACTATATTTGAATATCTACCAAAAGCTTATAAAGAAGGAGCCCAAG
ATATAGAAGCAAGAGAAAAAATGGCTCATGCATCAACTATAGCAGGTATGGCTTTTGCAAATGCCTTCTTAGGAGTATGC
CACTCTATGGCTCATAAATTAGGATCTATGCATCATGTACCACATGGTATAGCTAATGCTTTATTAATAAATGAAACAAT
TAAATTTAATTCTGAGGATATGCCAAGAAAGCAAACTGCTTTCCCACAATACAAATATCCAAATGCTAAGGCTAAATATG
CTAATATAGCAGATTATTTATCATTAGGTGGAAAAACTCCAGAAGAAAAAGTTGAGCTATTAATAAAAGCTATAGATAAA
TTAAAAGCAGAAGTAAATATTCCAACCTCTATAGAAGAGGCAGGGGTATCAAAGGATAAATTCTTTAAAACTTTAGATGA
GATGTCCGAACAAGCTTTTGATGATCAATGTACAGGAGCTAATCCAAGATACCCATTAATAAGTGAAATAAAAGAAATGT
ATACTAATGTTTTTAGTACCAAAAAATAG

Upstream 100 bases:

>100_bases
AGAAGTTATAAGGTATTAGTAATATTAATATAAATTAATACTTTTTATATTTTAGATAAGTTTGTTAAAAAATAAACTAT
TATTAAAAGAGGTGTTATTA

Downstream 100 bases:

>100_bases
GATAGTTTAATTTATATAGCATAAAATATTATTATATATATTTTATAGAAAGCTAAAATTTTAATTTTACCCAAAACTAA
ACCATTTATACAAAAAATAA

Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH [H]

Number of amino acids: Translated: 862; Mature: 862

Protein sequence:

>862_residues
MKITTTEELIRKIEKIKEAQKIYSTYSQDKVDKIFKAAAIAANKERIKLAKMAVEETGMGIVEDKVIKNHFASEYIYNKY
KDEKTCGVIEKDEAFGLTKIAEPIGVIAAIVPTTNPTSTAIFKALIALKTRNGIIFSPHPRAKKSTIMAAKIVLDAAVQA
GAPKEIIGWIDEPTLELSNAVMSNSNLVLATGGPGMVKAAYSSGKPAIGVGPGNVPAIIHETADIKMAVSSVVLSKTFDN
GMICASEQSVIVMNSIYEEVKKEFVIRGAYVLNKEEIEKVKKIILVNGNVNAKIVGQTPQKIGEMAGIQVPDWAKLLVGE
VQSVELEEPFSHEKLSPVLAMYKVKTYEEALTKAERLVELGGFGHTSSLYINTVKCKEEVEKFSNNMKTGRTIINMPSAQ
GGIGDIYNFKLAPSLTLGCGSWGGNSVSENVGPKHLLNIKNVAERRENMLWFRVPEKVYFKYGCLPIALKELKRMNKKKA
FIVTDKVLYELGVAKKATDVLDEIGINYKVFFDVAPDPTLETAKKGAKEMVDFNPDTIIAIGGGSAMDAAKIMWVMYEHP
EVEFEDLAMRFMDIRKRVYEFPHMGDKAMMISVATSAGTGSEVTPFAVITDEKTGVKYPLADYELTPDMAIVDADLMLNM
PKGLTAASGIDALTHAVEAYVSVMASEYTDGLCLEAIKTIFEYLPKAYKEGAQDIEAREKMAHASTIAGMAFANAFLGVC
HSMAHKLGSMHHVPHGIANALLINETIKFNSEDMPRKQTAFPQYKYPNAKAKYANIADYLSLGGKTPEEKVELLIKAIDK
LKAEVNIPTSIEEAGVSKDKFFKTLDEMSEQAFDDQCTGANPRYPLISEIKEMYTNVFSTKK

Sequences:

>Translated_862_residues
MKITTTEELIRKIEKIKEAQKIYSTYSQDKVDKIFKAAAIAANKERIKLAKMAVEETGMGIVEDKVIKNHFASEYIYNKY
KDEKTCGVIEKDEAFGLTKIAEPIGVIAAIVPTTNPTSTAIFKALIALKTRNGIIFSPHPRAKKSTIMAAKIVLDAAVQA
GAPKEIIGWIDEPTLELSNAVMSNSNLVLATGGPGMVKAAYSSGKPAIGVGPGNVPAIIHETADIKMAVSSVVLSKTFDN
GMICASEQSVIVMNSIYEEVKKEFVIRGAYVLNKEEIEKVKKIILVNGNVNAKIVGQTPQKIGEMAGIQVPDWAKLLVGE
VQSVELEEPFSHEKLSPVLAMYKVKTYEEALTKAERLVELGGFGHTSSLYINTVKCKEEVEKFSNNMKTGRTIINMPSAQ
GGIGDIYNFKLAPSLTLGCGSWGGNSVSENVGPKHLLNIKNVAERRENMLWFRVPEKVYFKYGCLPIALKELKRMNKKKA
FIVTDKVLYELGVAKKATDVLDEIGINYKVFFDVAPDPTLETAKKGAKEMVDFNPDTIIAIGGGSAMDAAKIMWVMYEHP
EVEFEDLAMRFMDIRKRVYEFPHMGDKAMMISVATSAGTGSEVTPFAVITDEKTGVKYPLADYELTPDMAIVDADLMLNM
PKGLTAASGIDALTHAVEAYVSVMASEYTDGLCLEAIKTIFEYLPKAYKEGAQDIEAREKMAHASTIAGMAFANAFLGVC
HSMAHKLGSMHHVPHGIANALLINETIKFNSEDMPRKQTAFPQYKYPNAKAKYANIADYLSLGGKTPEEKVELLIKAIDK
LKAEVNIPTSIEEAGVSKDKFFKTLDEMSEQAFDDQCTGANPRYPLISEIKEMYTNVFSTKK
>Mature_862_residues
MKITTTEELIRKIEKIKEAQKIYSTYSQDKVDKIFKAAAIAANKERIKLAKMAVEETGMGIVEDKVIKNHFASEYIYNKY
KDEKTCGVIEKDEAFGLTKIAEPIGVIAAIVPTTNPTSTAIFKALIALKTRNGIIFSPHPRAKKSTIMAAKIVLDAAVQA
GAPKEIIGWIDEPTLELSNAVMSNSNLVLATGGPGMVKAAYSSGKPAIGVGPGNVPAIIHETADIKMAVSSVVLSKTFDN
GMICASEQSVIVMNSIYEEVKKEFVIRGAYVLNKEEIEKVKKIILVNGNVNAKIVGQTPQKIGEMAGIQVPDWAKLLVGE
VQSVELEEPFSHEKLSPVLAMYKVKTYEEALTKAERLVELGGFGHTSSLYINTVKCKEEVEKFSNNMKTGRTIINMPSAQ
GGIGDIYNFKLAPSLTLGCGSWGGNSVSENVGPKHLLNIKNVAERRENMLWFRVPEKVYFKYGCLPIALKELKRMNKKKA
FIVTDKVLYELGVAKKATDVLDEIGINYKVFFDVAPDPTLETAKKGAKEMVDFNPDTIIAIGGGSAMDAAKIMWVMYEHP
EVEFEDLAMRFMDIRKRVYEFPHMGDKAMMISVATSAGTGSEVTPFAVITDEKTGVKYPLADYELTPDMAIVDADLMLNM
PKGLTAASGIDALTHAVEAYVSVMASEYTDGLCLEAIKTIFEYLPKAYKEGAQDIEAREKMAHASTIAGMAFANAFLGVC
HSMAHKLGSMHHVPHGIANALLINETIKFNSEDMPRKQTAFPQYKYPNAKAKYANIADYLSLGGKTPEEKVELLIKAIDK
LKAEVNIPTSIEEAGVSKDKFFKTLDEMSEQAFDDQCTGANPRYPLISEIKEMYTNVFSTKK

Specific function: This enzyme has probably two activities:ADH, and ACDH [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=327, Percent_Identity=28.4403669724771, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI1787493, Length=862, Percent_Identity=62.4129930394432, Blast_Score=1110, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=405, Percent_Identity=34.320987654321, Blast_Score=231, Evalue=2e-61,
Organism=Escherichia coli, GI48994951, Length=406, Percent_Identity=35.7142857142857, Blast_Score=219, Evalue=8e-58,
Organism=Escherichia coli, GI87082107, Length=403, Percent_Identity=31.5136476426799, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI1788797, Length=375, Percent_Identity=32, Blast_Score=163, Evalue=4e-41,
Organism=Escherichia coli, GI1789386, Length=405, Percent_Identity=23.9506172839506, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=328, Percent_Identity=25.609756097561, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=401, Percent_Identity=33.9152119700748, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6323821, Length=371, Percent_Identity=23.1805929919137, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24657991, Length=324, Percent_Identity=26.5432098765432, Blast_Score=87, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 94652; Mature: 94652

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITTTEELIRKIEKIKEAQKIYSTYSQDKVDKIFKAAAIAANKERIKLAKMAVEETGMG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
IVEDKVIKNHFASEYIYNKYKDEKTCGVIEKDEAFGLTKIAEPIGVIAAIVPTTNPTSTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHEEEECCCCCHHHH
IFKALIALKTRNGIIFSPHPRAKKSTIMAAKIVLDAAVQAGAPKEIIGWIDEPTLELSNA
HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHH
VMSNSNLVLATGGPGMVKAAYSSGKPAIGVGPGNVPAIIHETADIKMAVSSVVLSKTFDN
HCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCC
GMICASEQSVIVMNSIYEEVKKEFVIRGAYVLNKEEIEKVKKIILVNGNVNAKIVGQTPQ
CEEEECCCCEEEHHHHHHHHHHHHHHHHHEEECHHHHHHHHEEEEECCCCCEEEECCCHH
KIGEMAGIQVPDWAKLLVGEVQSVELEEPFSHEKLSPVLAMYKVKTYEEALTKAERLVEL
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFGHTSSLYINTVKCKEEVEKFSNNMKTGRTIINMPSAQGGIGDIYNFKLAPSLTLGCG
CCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEECC
SWGGNSVSENVGPKHLLNIKNVAERRENMLWFRVPEKVYFKYGCLPIALKELKRMNKKKA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHCCHHHHHHHHHHHCCCCE
FIVTDKVLYELGVAKKATDVLDEIGINYKVFFDVAPDPTLETAKKGAKEMVDFNPDTIIA
EEEEHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEE
IGGGSAMDAAKIMWVMYEHPEVEFEDLAMRFMDIRKRVYEFPHMGDKAMMISVATSAGTG
ECCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCC
SEVTPFAVITDEKTGVKYPLADYELTPDMAIVDADLMLNMPKGLTAASGIDALTHAVEAY
CCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHEECCCCCCHHHHHHHHHHHHHHH
VSVMASEYTDGLCLEAIKTIFEYLPKAYKEGAQDIEAREKMAHASTIAGMAFANAFLGVC
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSMAHKLGSMHHVPHGIANALLINETIKFNSEDMPRKQTAFPQYKYPNAKAKYANIADYL
HHHHHHHCCCCCCCHHHHHHHHEECCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHH
SLGGKTPEEKVELLIKAIDKLKAEVNIPTSIEEAGVSKDKFFKTLDEMSEQAFDDQCTGA
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
NPRYPLISEIKEMYTNVFSTKK
CCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKITTTEELIRKIEKIKEAQKIYSTYSQDKVDKIFKAAAIAANKERIKLAKMAVEETGMG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
IVEDKVIKNHFASEYIYNKYKDEKTCGVIEKDEAFGLTKIAEPIGVIAAIVPTTNPTSTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHEEEECCCCCHHHH
IFKALIALKTRNGIIFSPHPRAKKSTIMAAKIVLDAAVQAGAPKEIIGWIDEPTLELSNA
HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHH
VMSNSNLVLATGGPGMVKAAYSSGKPAIGVGPGNVPAIIHETADIKMAVSSVVLSKTFDN
HCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCC
GMICASEQSVIVMNSIYEEVKKEFVIRGAYVLNKEEIEKVKKIILVNGNVNAKIVGQTPQ
CEEEECCCCEEEHHHHHHHHHHHHHHHHHEEECHHHHHHHHEEEEECCCCCEEEECCCHH
KIGEMAGIQVPDWAKLLVGEVQSVELEEPFSHEKLSPVLAMYKVKTYEEALTKAERLVEL
HHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGFGHTSSLYINTVKCKEEVEKFSNNMKTGRTIINMPSAQGGIGDIYNFKLAPSLTLGCG
CCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEECC
SWGGNSVSENVGPKHLLNIKNVAERRENMLWFRVPEKVYFKYGCLPIALKELKRMNKKKA
CCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHCCHHHHHHHHHHHCCCCE
FIVTDKVLYELGVAKKATDVLDEIGINYKVFFDVAPDPTLETAKKGAKEMVDFNPDTIIA
EEEEHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEE
IGGGSAMDAAKIMWVMYEHPEVEFEDLAMRFMDIRKRVYEFPHMGDKAMMISVATSAGTG
ECCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCC
SEVTPFAVITDEKTGVKYPLADYELTPDMAIVDADLMLNMPKGLTAASGIDALTHAVEAY
CCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHEECCCCCCHHHHHHHHHHHHHHH
VSVMASEYTDGLCLEAIKTIFEYLPKAYKEGAQDIEAREKMAHASTIAGMAFANAFLGVC
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSMAHKLGSMHHVPHGIANALLINETIKFNSEDMPRKQTAFPQYKYPNAKAKYANIADYL
HHHHHHHCCCCCCCHHHHHHHHEECCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHH
SLGGKTPEEKVELLIKAIDKLKAEVNIPTSIEEAGVSKDKFFKTLDEMSEQAFDDQCTGA
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
NPRYPLISEIKEMYTNVFSTKK
CCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226639; 8300540; 11466286 [H]