Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 153937338

GI number: 153937338

Start: 479686

End: 480549

Strand: Reverse

Name: comEC [H]

Synonym: CLC_0481

Alternate gene names: 153937338

Gene position: 480549-479686 (Counterclockwise)

Preceding gene: 153935017

Following gene: 153937855

Centisome position: 12.78

GC content: 27.43

Gene sequence:

>864_bases
ATGAAACTTAAGAAAAAAAATTTAATAATAACTTGCTTATTGATATTCTTATCGATTGTATTTACAGCTTGTTCTCAGCA
GTCCTCTAACGCTGTTAATACATCTAACAAATCTAATGAATTAAAAGTTCATTATATAGATGTTGGGCAAGGAGACAGTA
TTCTAGTTCAAACAAAGGACAAAAATATACTAATAGATGCTGGAACTCGTAAAAATTCTGATAATCTAATAAGTTATTTA
AAAAAACAGCATATAAAAAAATTAGATTATGTAATAGCCACTCATCCTCATGAAGATCATATAGGTGGAATGCCAAAAGT
TATTGAGGAATTTGAAATTAGTAATTTTTACGCTCCTAAAAAAACAGCCAACACTAAGATTTTCAAAGATATGATATTAC
AACTTAAAAAGAAAAATTTAAAAATTAATGTAGCTAAAAAAGGTATATCCTTAAATCTATCTAATAATAGCTCCTTAGAT
TTTTTAGCTCCAGTTAAAGATAATTATGAGAACACAAATGACTCTTCTGCAGTAGTAAAATTAACCCACGGAAATACGAA
ATTCTTATTTACAGGAGACGCAGAAAAAACAAGTGAAAAGGATATTCTAAATTCAAATGAGGATTTATCTTCTAATGTAC
TTAAAGTTGGTCACCACGGTAGCCATTCTTCATCCTCTAAGGAATTTTTAGATAAGATTAATCCTAAAATAGCTATAATA
AGTTGTGGTAAAAATAATGACTATGGACATCCACACAAAGAAACTATGAAAGAACTTAATAAAAGAAATATTGAAGTTTA
TAGAACAGATATAGATGGAAATATAGTTTTAACAAGTGATGGGGAAAATATTAAAAAGAATTAG

Upstream 100 bases:

>100_bases
CTATTATAATATATATAAAAAAACTTATCTACTTTTGGTTAATTTATGTTAGAATTAAATAATGTATACTTTATTTAACA
TAACACAGGGAGTTGGATTT

Downstream 100 bases:

>100_bases
TATATAGTTTAAATTTTAACACCGCAAAAATAAAAAAAACATTCATAAACATATGAATGTTTTTTTGCTATATTAAAATT
AACTCTGTATTGAAATTGAA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKLKKKNLIITCLLIFLSIVFTACSQQSSNAVNTSNKSNELKVHYIDVGQGDSILVQTKDKNILIDAGTRKNSDNLISYL
KKQHIKKLDYVIATHPHEDHIGGMPKVIEEFEISNFYAPKKTANTKIFKDMILQLKKKNLKINVAKKGISLNLSNNSSLD
FLAPVKDNYENTNDSSAVVKLTHGNTKFLFTGDAEKTSEKDILNSNEDLSSNVLKVGHHGSHSSSSKEFLDKINPKIAII
SCGKNNDYGHPHKETMKELNKRNIEVYRTDIDGNIVLTSDGENIKKN

Sequences:

>Translated_287_residues
MKLKKKNLIITCLLIFLSIVFTACSQQSSNAVNTSNKSNELKVHYIDVGQGDSILVQTKDKNILIDAGTRKNSDNLISYL
KKQHIKKLDYVIATHPHEDHIGGMPKVIEEFEISNFYAPKKTANTKIFKDMILQLKKKNLKINVAKKGISLNLSNNSSLD
FLAPVKDNYENTNDSSAVVKLTHGNTKFLFTGDAEKTSEKDILNSNEDLSSNVLKVGHHGSHSSSSKEFLDKINPKIAII
SCGKNNDYGHPHKETMKELNKRNIEVYRTDIDGNIVLTSDGENIKKN
>Mature_287_residues
MKLKKKNLIITCLLIFLSIVFTACSQQSSNAVNTSNKSNELKVHYIDVGQGDSILVQTKDKNILIDAGTRKNSDNLISYL
KKQHIKKLDYVIATHPHEDHIGGMPKVIEEFEISNFYAPKKTANTKIFKDMILQLKKKNLKINVAKKGISLNLSNNSSLD
FLAPVKDNYENTNDSSAVVKLTHGNTKFLFTGDAEKTSEKDILNSNEDLSSNVLKVGHHGSHSSSSKEFLDKINPKIAII
SCGKNNDYGHPHKETMKELNKRNIEVYRTDIDGNIVLTSDGENIKKN

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 32098; Mature: 32098

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKKKNLIITCLLIFLSIVFTACSQQSSNAVNTSNKSNELKVHYIDVGQGDSILVQTKD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECC
KNILIDAGTRKNSDNLISYLKKQHIKKLDYVIATHPHEDHIGGMPKVIEEFEISNFYAPK
CEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEECCCHHHCCCCHHHHHHHHHCCEECCC
KTANTKIFKDMILQLKKKNLKINVAKKGISLNLSNNSSLDFLAPVKDNYENTNDSSAVVK
CCCCHHHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCCEEEECCCCCCCCCCCCCEEEE
LTHGNTKFLFTGDAEKTSEKDILNSNEDLSSNVLKVGHHGSHSSSSKEFLDKINPKIAII
EECCCEEEEEECCCCCCCCHHHCCCCCCHHCCCEEECCCCCCCCHHHHHHHHCCCEEEEE
SCGKNNDYGHPHKETMKELNKRNIEVYRTDIDGNIVLTSDGENIKKN
ECCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCC
>Mature Secondary Structure
MKLKKKNLIITCLLIFLSIVFTACSQQSSNAVNTSNKSNELKVHYIDVGQGDSILVQTKD
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECC
KNILIDAGTRKNSDNLISYLKKQHIKKLDYVIATHPHEDHIGGMPKVIEEFEISNFYAPK
CEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEEECCCHHHCCCCHHHHHHHHHCCEECCC
KTANTKIFKDMILQLKKKNLKINVAKKGISLNLSNNSSLDFLAPVKDNYENTNDSSAVVK
CCCCHHHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCCEEEECCCCCCCCCCCCCEEEE
LTHGNTKFLFTGDAEKTSEKDILNSNEDLSSNVLKVGHHGSHSSSSKEFLDKINPKIAII
EECCCEEEEEECCCCCCCCHHHCCCCCCHHCCCEEECCCCCCCCHHHHHHHHCCCEEEEE
SCGKNNDYGHPHKETMKELNKRNIEVYRTDIDGNIVLTSDGENIKKN
ECCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]